EKS-POA-00017

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00017

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	515.7	2.2E-155	978	1245	268

Status

Unreviewed

Ensembl Protein

ENSPPYP00000000809

UniProt Accession

H2N5B3;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

INSRR

Gene Synonyms/Alias

INSRR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000000699	ENSPPYP00000000809	ENSPPYT00000000840

Organism

Pongo abelii

Functional Description

Protein Length

1296

Protein Sequence
(FASTA)

MAVPSLWPWG ACLPVIFLSL GFGLDTVEVC PSLDIRSEVA ELRQLENCSV VEGHLQILLM 60

FTATGEDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGMRLF LGYALVIFEM 120

PHLRDVALPA LGAVLRGAVR VEKNQELCHL STIDWGLLQP APGANHIVGN KLGEECADVC 180

PGVLGAAGEP CAKTTFSGHT DYRCWTSSHC QRVCPCPHGM ACTARGECCH TECLGGCSQP 240

EDSCCVACRH LYFQGACLWA CPPGTYQYES WRCVTAERCA SLHSVPGRAS TFGIHQGSCL 300

AQCPSGFTRN GSSIFCHKCE GLCPKECKVG IKTIDSIQAA QDLVGCTHVE GSLILNLRQG 360

YNLEPQLQHS LGLVETITGF LKIKHSFALV SLGFFKNLKL IRGDAMVDGN YTLYVLDNQN 420

LQQLGSWVAA GLTIPVGKIY FAFNPRLCLE HIYRLEEVTG TRGRQNKAEI NPRTNGDRAA 480

CQTRTLRFVS NVTEADRILL RWERYEPLEA RDLLSFIVYY KESPFQNATE HVGPDACGTQ 540

SWNLLDVELP LSRTQEPGVT LASLKPWTQY AVFVRAITLT TEEDSPHQGA QSPIIYLRTL 600

PAAPTVPQDV ISTSNSSSHL LVRWKPPTQR NGNLTYYLVL WQRLAEDGDL YLNDYCHRGL 660

RLPTSNNDPR FDREDGDPEA EMESNCCPCQ HPPPGQVLPP LEAQEASFQK KFENFLHNAI 720

TIPISPWKVT SINKSPQRDS GRHRRAAGPL RLGGNSSDFE IQEDKVPRER AVLSGLRHFT 780

EYRIDIHACN HAAHTVGCSA ATFVFARTMP HREADGIPGK VAWEASSKNS VLLRWLEPPD 840

PNGLILKYEI KYRRLGEEAT VLCVSRLRYA KFGGVHLALL PPGNYSARVR ATSLAGNGSW 900

TDSVAFYILG PEEEDAGGLH VLLTATPVGI TLLIVLAALG FFYGKKRNRT LYASVNPEYF 960

SASDMYIPDE WEVPREQISI IRELGQGSFG MVYEGLARGL EAGEESTPVA LKTVNELASP 1020

RECIEFLKEA SVMKAFKCHH VVRLLGVVSQ GQPTLVIMEL MTRGDLKSHL RSLRPEAENN 1080

PGLPQPALGE MIQMAGEIAD GMAYLAANKF VHRDLAARNC MVSQDFTVKI GDFGMTRDVY 1140

ETDYYRKGGK GLLPVRWMAP ESLKDGIFTT HSDVWSFGVV LWEIVTLAEQ PYQGLSNEQV 1200

LKFVMDGGVL EELDGCPLQL QELMSRCWQP NPRLRPSFTH ILDSIQEELR PSFRLLSFYY 1260

SPECRGTRGS LPPTDAEPDS SPTPRDCSPQ NGGPGH 1296

Nucleotide Sequence
(FASTA)

ATGGCAGTGC CTAGTCTGTG GCCCTGGGGA GCATGCCTGC CTGTGATCTT CCTCTCCTTG 60

GGATTTGGCC TGGATACAGT AGAGGTGTGC CCCAGCCTGG ACATTCGCTC AGAGGTGGCA 120

GAGCTTCGTC AGCTGGAGAA CTGCAGCGTG GTGGAGGGCC ACCTGCAGAT CCTGCTCATG 180

TTCACAGCCA CCGGGGAGGA CTTCCGCGGC CTCAGCTTCC CTCGCCTCAC CCAGGTCACC 240

GACTACCTGC TGCTCTTCCG TGTCTACGGA CTGGAGAGCC TGCGCGACCT CTTCCCCAAC 300

CTAGCAGTCA TCCGCGGGAT GCGCCTCTTC CTGGGCTATG CACTGGTCAT CTTTGAGATG 360

CCACATCTGC GTGACGTGGC ACTGCCTGCG CTTGGGGCCG TGCTGCGTGG GGCTGTGCGT 420

GTGGAGAAGA ACCAGGAGCT CTGCCACCTC TCCACCATTG ACTGGGGACT GCTGCAGCCA 480

GCACCTGGCG CCAACCACAT CGTGGGCAAC AAGCTGGGCG AGGAGTGTGC TGACGTGTGC 540

CCTGGTGTGC TGGGTGCTGC TGGTGAGCCC TGTGCCAAGA CCACCTTCAG CGGGCACACT 600

GACTACAGAT GCTGGACCTC CAGCCACTGC CAGAGAGTGT GCCCCTGCCC CCATGGGATG 660

GCTTGCACAG CAAGGGGCGA GTGCTGCCAC ACCGAATGCC TGGGGGGCTG CAGCCAGCCA 720

GAAGACTCGT GCTGTGTAGC TTGCCGCCAC CTCTACTTCC AGGGTGCCTG CCTGTGGGCC 780

TGCCCGCCAG GCACCTACCA GTATGAGTCC TGGCGCTGTG TCACAGCTGA GCGCTGTGCC 840

AGCCTGCACT CTGTGCCCGG CCGCGCCTCC ACCTTCGGCA TACACCAGGG CAGTTGCCTG 900

GCCCAGTGCC CTTCTGGCTT CACCCGTAAC GGCAGCAGCA TATTCTGCCA CAAGTGCGAG 960

GGGCTGTGCC CTAAAGAGTG CAAGGTAGGC ATCAAGACCA TCGACTCCAT CCAGGCGGCA 1020

CAGGATCTTG TGGGCTGCAC GCATGTGGAG GGAAGCCTCA TCCTCAACCT TCGCCAGGGC 1080

TACAACCTGG AGCCACAGCT GCAGCACAGC CTGGGGCTGG TAGAAACCAT TACTGGCTTC 1140

CTCAAAATCA AGCACTCCTT TGCCCTCGTG TCCCTGGGCT TTTTCAAGAA CCTCAAACTA 1200

ATCCGGGGAG ACGCCATGGT GGATGGGAAC TACACTCTCT ACGTGCTGGA CAACCAGAAC 1260

CTACAACAGC TAGGGTCCTG GGTGGCCGCG GGGCTCACCA TTCCCGTGGG CAAGATCTAC 1320

TTCGCCTTCA ACCCCCGCCT CTGCTTGGAG CACATCTACC GACTGGAGGA GGTGACAGGC 1380

ACGCGAGGTC GGCAGAACAA GGCTGAGATC AACCCCCGCA CCAACGGAGA CCGCGCCGCC 1440

TGCCAGACTC GCACCCTGCG CTTCGTGTCC AACGTGACGG AGGCAGACCG CATCCTGCTA 1500

CGCTGGGAGC GCTATGAGCC ACTGGAGGCC CGCGACCTGC TCAGCTTCAT CGTGTACTAC 1560

AAGGAGTCCC CATTCCAGAA TGCCACAGAG CACGTGGGTC CAGATGCTTG TGGAACCCAG 1620

AGCTGGAACC TGCTGGATGT GGAGCTGCCC CTAAGCCGCA CCCAGGAGCC AGGGGTGACC 1680

CTAGCCTCCC TCAAGCCTTG GACACAGTAC GCAGTGTTTG TGCGGGCCAT CACGCTAACC 1740

ACTGAGGAGG ACAGCCCCCA TCAAGGAGCC CAGAGTCCCA TCATCTACCT CCGAACGCTG 1800

CCTGCAGCTC CCACGGTGCC CCAAGACGTC ATCTCCACGT CCAACTCCTC TTCCCACCTC 1860

CTGGTGCGCT GGAAGCCACC GACCCAGCGC AATGGGAACC TCACCTACTA CCTGGTGCTC 1920

TGGCAGCGGC TGGCAGAGGA CGGCGACCTC TACCTCAATG ACTACTGCCA CCGCGGCTTG 1980

CGGCTGCCCA CCAGCAACAA CGATCCGCGC TTCGACCGCG AAGACGGGGA TCCTGAGGCC 2040

GAGATGGAGT CTAACTGCTG CCCTTGCCAG CACCCACCTC CTGGTCAGGT TCTGCCCCCG 2100

CTGGAGGCGC AAGAGGCCTC GTTCCAGAAG AAGTTTGAAA ACTTTCTACA CAACGCAATC 2160

ACCATCCCCA TATCCCCTTG GAAGGTGACG TCCATCAACA AGAGCCCCCA AAGGGACTCA 2220

GGGCGGCACC GCCGGGCAGC TGGGCCCCTC CGGCTGGGGG GCAACAGCTC GGATTTCGAG 2280

ATCCAGGAGG ACAAGGTGCC CCGTGAGCGA GCGGTGCTGA GCGGCCTGCG CCACTTCACG 2340

GAATACCGGA TCGACATCCA TGCCTGCAAC CACGCGGCGC ACACCGTGGG CTGCAGCGCC 2400

GCCACCTTCG TCTTTGCGCG CACCATGCCC CACAGAGAGG CTGATGGTAT TCCAGGAAAG 2460

GTGGCCTGGG AAGCCTCCAG CAAAAACAGT GTCCTCCTGC GCTGGCTAGA GCCACCAGAC 2520

CCCAATGGAC TCATCCTCAA GTACGAAATC AAGTACCGCC GCTTGGGAGA GGAGGCCACA 2580

GTGCTGTGTG TGTCCCGTCT TCGATATGCG AAGTTTGGGG GAGTCCACCT GGCCCTGCTG 2640

CCCCCTGGAA ACTACTCTGC CAGGGTTAGG GCAACCTCGC TGGCTGGCAA TGGCTCTTGG 2700

ACAGACAGTG TTGCCTTCTA CATCCTTGGC CCAGAGGAGG AGGATGCTGG GGGGCTGCAT 2760

GTCCTCCTCA CTGCCACCCC TGTGGGGATC ACGCTGCTCA TCGTTCTTGC TGCCCTTGGT 2820

TTCTTCTACG GCAAGAAGAG AAATAGAACC CTGTATGCTT CTGTGAATCC GGAGTACTTC 2880

AGCGCCTCTG ATATGTACAT CCCTGATGAA TGGGAGGTGC CTCGGGAGCA GATCTCGATA 2940

ATCCGGGAAC TGGGCCAGGG CTCTTTTGGG ATGGTATATG AGGGGCTGGC ACGAGGACTT 3000

GAGGCTGGAG AGGAGTCCAC ACCCGTGGCC CTGAAGACAG TGAATGAGCT GGCCAGCCCA 3060

CGGGAATGCA TTGAGTTCCT CAAGGAAGCT TCTGTCATGA AAGCCTTCAA GTGTCACCAT 3120

GTGGTGCGTC TCCTGGGTGT GGTGTCTCAG GGCCAGCCAA CTCTGGTCAT CATGGAGTTA 3180

ATGACCCGTG GGGACCTCAA GAGCCATCTT CGATCTTTGC GGCCTGAGGC AGAGAACAAC 3240

CCTGGGCTCC CACAGCCAGC ATTGGGGGAA ATGATCCAAA TGGCTGGTGA GATTGCGGAC 3300

GGCATGGCCT ACCTTGCTGC CAACAAGTTT GTGCACCGAG ATCTAGCAGC CCGCAACTGC 3360

ATGGTGTCCC AGGACTTCAC CGTCAAGATC GGGGACTTCG GGATGACTCG GGACGTGTAT 3420

GAGACAGACT ATTACCGCAA GGGTGGGAAG GGGCTGCTGC CCGTGCGCTG GATGGCCCCC 3480

GAGTCCCTCA AAGATGGGAT CTTCACCACC CACTCGGATG TCTGGTCCTT CGGCGTGGTA 3540

CTCTGGGAGA TTGTGACCCT GGCTGAACAA CCCTACCAGG GCCTGTCCAA TGAGCAGGTG 3600

CTGAAGTTTG TCATGGATGG CGGGGTCCTG GAGGAGCTGG ATGGCTGTCC CCTTCAGCTG 3660

CAGGAGCTGA TGAGCCGCTG CTGGCAGCCG AACCCACGCC TGCGCCCATC TTTCACACAC 3720

ATCCTGGACA GCATACAGGA GGAGCTGCGG CCCTCCTTTC GCCTCCTCTC CTTCTACTAC 3780

AGCCCGGAGT GCCGGGGGAC CCGGGGCTCC CTGCCTCCCA CCGATGCAGA GCCTGACTCC 3840

TCACCCACCC CAAGAGACTG CAGCCCTCAA AATGGGGGTC CGGGGCAC 3888

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeG+a+++++gee+t+va+ktvne as re+ieflkeasvmk+fk

Q: 978   ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFK  1037

         6799********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++pal+++iqma+e

Q: 1038  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGE  1097

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmv++d+tvkiGdfGmtrd+yetdyyrkggkgllpvrw

Q: 1098  IADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1157

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdG+ft++sdvwsfGvvlweivtlaeqpyqGlsneqvlkfv+dggvle+++ cp

Q: 1158  MAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELDGCP  1217

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

          +l+elm++cwq np+lrpsf++i++++

Q: 1218  LQLQELMSRCWQPNPRLRPSFTHILDSI  1245

         ************************9976

Domain Sequence
(FASTA)

ISIIRELGQG SFGMVYEGLA RGLEAGEEST PVALKTVNEL ASPRECIEFL KEASVMKAFK 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRPEA ENNPGLPQPA LGEMIQMAGE 120

IADGMAYLAA NKFVHRDLAA RNCMVSQDFT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180

MAPESLKDGI FTTHSDVWSF GVVLWEIVTL AEQPYQGLSN EQVLKFVMDG GVLEELDGCP 240

LQLQELMSRC WQPNPRLRPS FTHILDSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0071469	; P:cellular response to alkalinity
GO:0030238	; P:male sex determination
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013