EKS-POA-00259
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00259
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK453.83.4E-136190518329
StatusUnreviewed
Ensembl ProteinENSPPYP00000001172
UniProt AccessionH2N6B1;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK1
Gene Synonyms/Alias HIPK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000001004ENSPPYP00000001172ENSPPYT00000001211
OrganismPongo abelii
Functional Description
Protein Length1209
Protein Sequence
(FASTA)
MASQLQVFSP PSVSSSAFCS AKKLKIEPSG WDVSGQSSND KYYTHSKTLP ATQGQANSSH 60
QVANFNIPAY DQGLLLPAPA VEHIVVTAAD SSGSAATSTF QSSQTLTHRS NVSLLEPYQK 120
CGLKRKSEEV DSNGSVQIIE EHPPLMLQNR TVVGAAATTT TVTTKSSSSS GEGDYQLVQH 180
EILCSMTNSY EVLEFLGRGT FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR 240
LSSENADEYN FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA 300
TALMKLKSLG LIHADLKPEN IMLVDPVRQP YRVKVIDFGS ASHVSKAVCS TYLQSRYYRA 360
PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ IRYISQTQGL PAEYLLSAGT 420
KTTRFFNRDP NLGYPLWRLK TPEEHELETG IKSKEARKYI FNCLDDMAQV NMSTDLEGTD 480
MLAEKADRRE YIDLLKKMLT IDADKRITPL KTLNHQFVTM THLLDFPHSN HVKSCFQNME 540
ICKRRVHMYD TVSQIKSPFT THVAPNTSTN LTMSFSNQLN TVHNQASVLA SSSTAAAATL 600
SLANSDVSLL NYQSALYPSS AAPVPGVAQQ GVSLQPGTTQ ICTQTDPFQQ TFIVCPPAFQ 660
TGLQATTKHS GFPVRMDNAV PIVPQAPAAQ LQIQSGVLTQ GSCTPLMVAT LHPQVATITP 720
QYAVPFTLSC AAGRPALVEQ TAAVLQAWPG GTQQILLPST WQQLPGVALH NSVQPTAMIP 780
EAMGSGQQLA DWRNAHSHGN QYSTIMQQPS LLTNHVTLAT AQPLNVGVAH VVRQQQSSSL 840
PSKKNKQSAP VSSKSSLDVL PSQVYSLVGS SPLRTTSSYN SLVPVQDQHQ PIIIPDTPSP 900
PVSVITIRSD TDEEEDNKYK PSSSGLKPRS NVISYVTVND SPDSDSSLSS PYSTDTLSAL 960
RGNSGPVLEG PGRVVADGTG TRTIIVPPLK TQLGDCTVAT QASGLLSNKT KPVASVSGQS 1020
SGCCITPTGY RAQRGGTSAA QPLNLSQNQQ SSAAPTSQER SSNPAPRRQQ AFVAPLSQAP 1080
YTFQHGSPLH STGHPHLAPA PAHLPSQAHL YTYAAPTSAA ALGSTSSIAH LFSPQGSSRH 1140
AAAYTTHPST LVHQVPVSVG PSLLTSASVA PAQYQHQFAT QSYIGSSRGS AIYTGYPLSP 1200
TKISQYSYL 1209
Nucleotide Sequence
(FASTA)
ATGGCATCAC AGCTGCAAGT GTTTTCGCCC CCATCAGTGT CGTCGAGTGC CTTCTGCAGT 60
GCGAAGAAAC TGAAAATAGA GCCCTCTGGC TGGGATGTTT CAGGACAGAG TAGCAACGAC 120
AAATATTATA CCCACAGCAA AACCCTCCCA GCCACACAAG GGCAAGCCAA CTCCTCTCAC 180
CAGGTAGCAA ATTTCAACAT CCCTGCTTAC GACCAGGGCC TCCTCCTCCC AGCTCCTGCA 240
GTGGAGCATA TTGTTGTAAC AGCCGCTGAT AGCTCGGGCA GTGCTGCTAC ATCAACCTTC 300
CAAAGCAGCC AGACCCTGAC TCACAGAAGC AACGTTTCTT TGCTTGAGCC ATATCAAAAA 360
TGTGGATTGA AACGAAAAAG TGAGGAAGTT GACAGCAACG GTAGTGTGCA GATCATAGAA 420
GAACATCCCC CTCTCATGCT GCAAAACAGG ACTGTGGTGG GTGCTGCTGC CACAACCACC 480
ACTGTGACCA CAAAGAGTAG CAGTTCCAGC GGAGAAGGGG ATTACCAGCT GGTCCAGCAT 540
GAGATCCTTT GCTCTATGAC CAATAGCTAT GAAGTCTTGG AGTTCCTAGG CCGGGGGACA 600
TTTGGACAGG TGGCTAAGTG CTGGAAGAGG AGCACCAAGG AAATTGTGGC TATTAAAATC 660
TTGAAGAACC ACCCCTCCTA TGCCAGACAA GGACAGATTG AAGTGAGCAT CCTTTCCCGC 720
CTAAGCAGTG AAAATGCTGA TGAGTATAAT TTTGTCCGTT CATACGAGTG CTTTCAGCAT 780
AAGAATCACA CCTGCCTTGT TTTTGAGATG TTGGAGCAGA ACTTATATGA TTTTCTAAAG 840
CAAAACAAAT TTAGCCCACT GCCACTCAAG TACATCAGAC CAATCTTGCA GCAGGTGGCT 900
ACAGCCTTGA TGAAGCTCAA GAGTCTTGGT CTGATCCACG CTGACCTTAA GCCTGAAAAC 960
ATCATGCTGG TTGATCCAGT TCGCCAACCC TACCGAGTGA AGGTCATTGA CTTTGGTTCT 1020
GCTAGTCACG TTTCCAAAGC TGTGTGCTCA ACCTACTTAC AGTCACGTTA CTACAGAGCT 1080
CCTGAAATTA TTCTTGGGTT ACCATTTTGT GAAGCTATTG ATATGTGGTC ACTGGGCTGT 1140
GTGATAGCTG AGCTGTTCCT GGGATGGCCT CTTTACCCTG GTGCTTCAGA ATATGACCAG 1200
ATTCGTTATA TTTCACAAAC ACAAGGCTTG CCAGCTGAAT ATCTTCTCAG TGCCGGAACA 1260
AAAACAACCA GGTTTTTCAA CAGAGATCCT AATTTGGGGT ACCCACTGTG GAGGCTTAAG 1320
ACACCTGAAG AACATGAACT GGAGACTGGA ATAAAATCAA AAGAAGCTCG GAAGTACATT 1380
TTTAATTGCT TAGATGACAT GGCTCAGGTG AATATGTCTA CAGACCTAGA GGGAACAGAT 1440
ATGTTGGCAG AGAAGGCAGA CCGAAGAGAA TACATTGATC TGTTAAAGAA AATGCTCACA 1500
ATTGACGCAG ATAAGAGAAT TACCCCTCTA AAAACTCTTA ACCATCAGTT TGTGACAATG 1560
ACTCACCTTT TGGATTTTCC ACATAGCAAT CATGTTAAGT CTTGTTTTCA GAACATGGAG 1620
ATCTGCAAGC GGAGGGTTCA CATGTATGAT ACAGTGAGTC AGATCAAGAG TCCCTTCACT 1680
ACACATGTTG CCCCAAATAC AAGCACAAAT CTAACGATGA GCTTCAGCAA TCAGCTCAAT 1740
ACAGTGCACA ATCAGGCCAG TGTTCTAGCT TCCAGTTCTA CTGCAGCAGC TGCTACTCTT 1800
TCTCTGGCTA ATTCAGATGT CTCACTACTA AACTACCAGT CAGCTTTGTA CCCATCATCT 1860
GCTGCACCAG TTCCTGGAGT TGCCCAGCAG GGTGTTTCCT TGCAGCCTGG AACCACCCAG 1920
ATTTGCACTC AGACAGATCC ATTCCAACAG ACATTTATAG TATGTCCACC TGCGTTTCAA 1980
ACTGGACTAC AAGCAACAAC AAAGCATTCT GGATTCCCTG TGAGGATGGA TAATGCTGTA 2040
CCAATTGTAC CCCAGGCACC AGCTGCTCAG CTACAGATTC AGTCAGGAGT TCTCACGCAG 2100
GGAAGCTGTA CACCACTAAT GGTAGCAACT CTCCACCCTC AAGTAGCCAC CATCACACCG 2160
CAGTATGCGG TGCCCTTTAC TCTGAGCTGC GCAGCCGGCC GGCCGGCGCT GGTTGAACAG 2220
ACTGCTGCTG TACTGCAGGC GTGGCCTGGA GGGACTCAGC AAATTCTCCT GCCTTCAACT 2280
TGGCAACAGT TGCCTGGGGT AGCTCTACAC AACTCTGTCC AGCCCACAGC AATGATTCCA 2340
GAGGCCATGG GGAGTGGACA GCAGCTAGCC GACTGGAGGA ATGCCCACTC TCATGGCAAC 2400
CAGTACAGCA CTATCATGCA GCAGCCATCC TTGCTGACTA ACCATGTGAC ATTGGCCACT 2460
GCTCAGCCTC TGAATGTTGG TGTTGCCCAT GTTGTCAGAC AACAACAATC CAGTTCTCTC 2520
CCTTCGAAGA AGAATAAGCA GTCAGCTCCA GTCTCTTCAA AGTCCTCTCT AGATGTTCTG 2580
CCTTCCCAAG TCTATTCTCT GGTTGGGAGC AGTCCTCTCC GCACCACATC TTCTTATAAT 2640
TCCTTAGTCC CTGTCCAAGA TCAGCATCAG CCCATCATCA TTCCAGATAC TCCCAGCCCT 2700
CCTGTGAGTG TCATCACTAT CCGAAGTGAC ACTGATGAGG AAGAGGACAA CAAATACAAG 2760
CCCAGTAGCT CTGGCCTGAA GCCAAGGTCT AATGTCATCA GTTATGTCAC AGTCAATGAT 2820
TCTCCAGACT CTGACTCTTC TTTGAGCAGC CCTTATTCCA CTGATACCCT GAGTGCTCTC 2880
CGAGGCAATA GTGGACCCGT TTTGGAGGGG CCTGGCAGAG TTGTGGCAGA TGGCACTGGC 2940
ACCCGCACCA TCATTGTGCC TCCACTGAAA ACTCAGCTTG GTGACTGCAC TGTAGCAACC 3000
CAGGCCTCAG GTCTCCTGAG CAATAAGACC AAGCCAGTAG CTTCAGTGAG TGGGCAGTCA 3060
TCTGGATGCT GTATCACCCC CACAGGGTAT CGAGCTCAAC GCGGGGGGAC CAGTGCAGCA 3120
CAACCACTCA ACCTTAGCCA GAACCAGCAG TCATCGGCGG CTCCAACCTC GCAGGAGAGA 3180
AGCAGCAACC CAGCCCCCCG CAGGCAGCAG GCGTTTGTGG CCCCTCTCTC CCAAGCCCCT 3240
TACACCTTCC AGCATGGCAG CCCGCTACAC TCGACGGGGC ACCCACACCT TGCCCCAGCC 3300
CCTGCTCACC TGCCAAGCCA GGCTCATCTG TATACGTATG CTGCCCCGAC TTCTGCTGCT 3360
GCACTGGGCT CAACCAGCTC CATTGCTCAT CTTTTCTCCC CACAGGGTTC CTCAAGGCAT 3420
GCTGCAGCCT ATACCACTCA CCCTAGCACT TTGGTGCACC AGGTCCCTGT CAGTGTTGGG 3480
CCCAGCCTCC TCACTTCTGC CAGCGTGGCC CCTGCTCAGT ACCAACACCA GTTTGCCACC 3540
CAATCCTACA TTGGGTCTTC CCGAGGCTCA GCAATTTACA CTGGATACCC GCTGAGTCCT 3600
ACCAAGATCA GCCAGTATTC CTACTTATAG 3630
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevle++g+G+fgqV+k+++++tkeivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 190   YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENADE  248
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr +e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+
Q: 249   YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS  308
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 309   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  368
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff  
Q: 369   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFnr  428
         **********************************************************66
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
           + ++p ++lkt          ks++++k+++n+ +++++++++++ e +++l+ek+d+
Q: 429   dPNLGYPLWRLKTPeeheletgiKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADR  488
         556778889998889********************************************9
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + ++dllk+ml++d++kRitp ++l+h+fv
Q: 489   ReYIDLLKKMLTIDADKRITPLKTLNHQFV  518
         99***************************7
Domain Sequence
(FASTA)
YEVLEFLGRG TFGQVAKCWK RSTKEIVAIK ILKNHPSYAR QGQIEVSILS RLSSENADEY 60
NFVRSYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPILQQV ATALMKLKSL 120
GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTTRFFNRD 240
PNLGYPLWRL KTPEEHELET GIKSKEARKY IFNCLDDMAQ VNMSTDLEGT DMLAEKADRR 300
EYIDLLKKML TIDADKRITP LKTLNHQFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00250
EKS-ANC-00257
EKS-BOT-00268
EKS-CAE-00238
EKS-CAJ-00274
EKS-CAF-00275
EKS-CAP-00303
EKS-CII-00160
EKS-DRM-00137
EKS-ECT-00028
EKS-EQC-00260
EKS-FEC-00254
EKS-GAM-00168
EKS-GAG-00225
EKS-GOG-00268
EKS-HOS-00274
EKS-LAC-00279
EKS-LOA-00278
EKS-MAM-00270
EKS-MEG-00213
EKS-MOD-00265
EKS-MUP-00265
EKS-MYL-00270
EKS-NOL-00245
EKS-ORC-00253
EKS-ORL-00328
EKS-OTG-00274
EKS-PAT-00253
EKS-PES-00238
EKS-PEM-00141
EKS-PTV-00035
EKS-RAN-00283
EKS-SAH-00252
EKS-SUS-00239
EKS-TAG-00284
EKS-TUT-00033
EKS-VIP-00011
EKS-XET-00343
EKS-XIM-00339
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016607; C:nuclear speck
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0009952; P:anterior/posterior pattern specification
GO:0048596; P:embryonic camera-type eye morphogenesis
GO:0060059; P:embryonic retina morphogenesis in camera-type eye
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0061072; P:iris morphogenesis
GO:0060235; P:lens induction in camera-type eye
GO:0030182; P:neuron differentiation
GO:0008284; P:positive regulation of cell proliferation
GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0010842; P:retina layer formation
GO:0007224; P:smoothened signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013