EKS-POA-00373

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00373

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	294.6	6.5E-88	564	820	257

Status

Unreviewed

Ensembl Protein

ENSPPYP00000001439

UniProt Accession

H2N716;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase TNNI3K;

Gene Name

TNNI3K

Gene Synonyms/Alias

TNNI3K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000001237	ENSPPYP00000001439	ENSPPYT00000001484

Organism

Pongo abelii

Functional Description

Protein Length

936

Protein Sequence
(FASTA)

MAAAGVPPVV SLREATQRKL RRFSELRGKL VAPGEFWDIV AITAADEKQE LAYNQQLSEK 60

LKRKELPLGV QYHVFVDPAG AKIGNGGSTL CALQCLEKLY GDKWNSFTIL LIHSDEWKKK 120

VSESYVITIE RLEDDLKIKE KEPTELRNIF GSDEAFSKVN LNYHTENGLS LLHLCCICGG 180

NKSHIRTLML KGLRPSRLTR NGFTALHLAV YKDNAELITS LLHGGADIQQ VGYGGLTALH 240

IATIAGHLEA ADVLLQHGAN VNIQDAVFFT PLHIAAYYGH EQVTRLLLKF GADVNVSGEV 300

GDRPLHLASA KGFLNIAKLL MEEGSKADVN AQDNEDHVPL HFCSRFGHHD IVKYLLQNDL 360

EVQPHVVNIY GDTPLHLACY NGKFEVAKEI IQISGTESLT KENIFSETAF HSACTYGKSI 420

DLVKFLLDQN VININHQGRD GHTGLHSACY HGHIHLVQFL LDNGADMNLV ACDPSRSSGE 480

KDEQTCLMWA YEKGHDAIVT LLKHYKRPQD ELPCNEYSQP GGDGSYVSVP SPLGKIKSMT 540

KEKADILLLR AGLPSHFHLQ LSEIEFHEII GSGSFGKVYK GRCRNKIVAI KRYRANTYCS 600

KSDVDMFCRE VSILCQLNHP CVIQFVGACL NDPSQFAIVT QYISGGSLFS LLHEQKRILD 660

LQSKLIIAVD VARGMEYLHN LTQPIIHRDL NSHNILLYED GHAVVADFGE SRFLQSLDED 720

NMTKQPGNLR WMAPEVFTQC TRYTIKADVF SYALCLWEIL TGEIPFAHLK PAAAAADMAY 780

HHIRPPIGYS IPKPISSLLI RGWNACPEGR PEFSEVVMKL EECLCNIELM SPASSNSSGS 840

LSPSSSSDCL VSRGGPGRSH VAALRSRFEL EYALNARSYA ALSQSAGQYS SQGLSLEEMK 900

RSLQYTPIDK YGYVSDPMSP MHFHSCRNSS SFEDSS 936

Nucleotide Sequence
(FASTA)

ATGGCAGCTG CTGGGGTCCC TCCGGTAGTA TCGCTGCGAG AAGCCACCCA GCGAAAATTG 60

CGGAGGTTTT CCGAGCTGAG AGGCAAACTT GTAGCACCTG GAGAATTCTG GGACATAGTT 120

GCAATAACAG CGGCTGATGA AAAACAGGAA CTTGCTTACA ACCAACAGCT GTCAGAAAAG 180

CTGAAAAGAA AGGAGTTACC CCTTGGAGTT CAATATCACG TTTTTGTAGA TCCTGCTGGA 240

GCCAAAATTG GAAATGGAGG ATCAACACTT TGTGCCCTTC AATGTTTGGA AAAGCTATAT 300

GGAGATAAAT GGAATTCTTT TACCATCTTA TTAATTCACT CTGATGAATG GAAGAAAAAA 360

GTCAGTGAAT CATATGTTAT CACAATAGAA AGATTAGAAG ATGACCTGAA GATCAAGGAA 420

AAAGAACCGA CAGAACTAAG GAATATATTT GGCTCTGATG AAGCCTTCAG TAAAGTCAAT 480

TTAAATTACC ACACTGAAAA TGGGCTGTCT CTACTTCATT TATGTTGCAT TTGTGGAGGC 540

AACAAATCAC ATATTCGAAC TCTTATGTTA AAAGGGCTCC GCCCATCTCG ACTGACAAGA 600

AATGGATTTA CAGCCTTGCA TTTAGCAGTT TACAAGGATA ATGCAGAATT GATCACTTCT 660

CTGCTTCATG GTGGAGCTGA TATACAGCAG GTTGGATACG GTGGCCTCAC TGCCCTCCAT 720

ATTGCTACAA TAGCTGGCCA CCTAGAGGCT GCTGATGTGC TGTTGCAACA TGGAGCTAAT 780

GTCAATATTC AAGATGCAGT TTTTTTCACT CCATTGCACA TTGCAGCGTA CTATGGGCAT 840

GAACAGGTAA CTCGCCTTCT TTTGAAATTT GGTGCTGATG TAAATGTAAG TGGTGAAGTT 900

GGAGATAGAC CCCTCCACCT AGCATCTGCA AAAGGATTCT TGAATATTGC AAAACTCTTG 960

ATGGAAGAAG GCAGCAAAGC AGATGTGAAT GCTCAAGATA ATGAAGACCA TGTCCCACTC 1020

CATTTCTGTT CTCGATTTGG ACACCATGAT ATAGTTAAGT ACCTGCTGCA AAATGATTTG 1080

GAAGTTCAAC CTCATGTGGT TAATATCTAT GGAGATACCC CCTTGCACCT GGCATGCTAC 1140

AATGGCAAAT TTGAAGTTGC CAAGGAAATC ATCCAAATAT CAGGAACAGA AAGTCTGACT 1200

AAGGAAAACA TCTTCAGTGA AACAGCTTTT CATAGTGCTT GTACCTATGG CAAAAGCATT 1260

GACCTAGTCA AATTTCTTCT TGATCAGAAT GTCATAAACA TCAACCACCA AGGAAGGGAT 1320

GGGCACACTG GATTACACTC TGCTTGCTAC CACGGTCACA TTCACCTGGT TCAGTTCTTA 1380

CTGGATAATG GAGCTGATAT GAATCTAGTG GCTTGTGATC CCAGCAGGTC TAGTGGTGAA 1440

AAAGATGAGC AGACATGTTT GATGTGGGCT TATGAAAAAG GGCATGATGC CATTGTCACA 1500

CTCCTGAAGC ATTATAAGAG ACCGCAAGAT GAATTGCCCT GTAATGAATA TTCTCAGCCT 1560

GGAGGAGATG GCTCCTATGT GTCTGTTCCA TCACCCTTGG GGAAGATTAA AAGCATGACA 1620

AAAGAGAAGG CAGATATTCT CCTCCTAAGA GCTGGATTGC CTTCACATTT CCATCTTCAG 1680

CTCTCAGAAA TTGAGTTCCA TGAGATTATT GGCTCAGGTT CTTTTGGGAA AGTATATAAA 1740

GGACGATGCA GAAATAAAAT AGTGGCTATA AAACGTTATC GAGCCAATAC CTACTGCTCC 1800

AAGTCAGATG TGGATATGTT TTGCCGAGAG GTGTCCATTC TCTGCCAGCT CAATCATCCC 1860

TGCGTAATTC AGTTTGTGGG CGCTTGCTTG AATGATCCCA GCCAGTTTGC CATTGTCACT 1920

CAATACATAT CAGGGGGTTC TCTGTTCTCC CTCCTTCATG AGCAGAAGAG GATTCTTGAT 1980

TTGCAGTCTA AATTAATTAT TGCAGTAGAT GTTGCCAGAG GCATGGAGTA TCTTCACAAC 2040

CTGACACAGC CAATTATACA TCGTGACTTG AACAGTCACA ATATTCTTCT CTATGAGGAT 2100

GGACATGCTG TGGTGGCAGA TTTTGGAGAA TCAAGATTTC TACAGTCTCT GGATGAAGAC 2160

AACATGACAA AACAACCTGG GAACCTCCGT TGGATGGCTC CTGAGGTGTT CACACAGTGC 2220

ACTCGGTACA CCATCAAAGC AGACGTCTTC AGCTATGCTC TGTGTCTGTG GGAAATTCTC 2280

ACCGGCGAAA TTCCATTCGC TCATCTCAAG CCAGCGGCTG CGGCAGCAGA CATGGCTTAC 2340

CACCACATCA GACCTCCCAT TGGCTATTCC ATTCCCAAGC CCATATCATC TCTGCTGATA 2400

CGAGGGTGGA ACGCATGTCC TGAAGGAAGA CCCGAGTTTT CTGAAGTTGT CATGAAGTTA 2460

GAAGAGTGTC TCTGCAACAT TGAGCTGATG TCTCCTGCAT CAAGTAACAG CAGTGGGTCT 2520

CTCTCACCTT CTTCTTCTTC TGATTGCCTG GTGAGCCGGG GAGGACCTGG CCGGAGTCAT 2580

GTGGCAGCTT TAAGAAGTCG TTTCGAATTG GAATATGCTC TAAATGCAAG GTCCTATGCT 2640

GCTTTGTCCC AAAGTGCTGG ACAATATTCC TCTCAAGGTC TGTCTTTGGA GGAGATGAAA 2700

AGAAGTCTTC AATACACACC CATTGACAAA TATGGCTATG TATCCGATCC CATGAGCCCA 2760

ATGCATTTTC ATTCTTGCCG AAATAGTAGC AGCTTTGAGG ACAGCAGCTG A 2811

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e+igsg+fgkvyk+++r+k va+K++r+++++ k+++++++re+++l++l+hp++i

Q: 564   IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCsKSDVDMFCREVSILCQLNHPCVI  623

         5899****************************99998999********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhsea  118

         +++G+cl++p+ +++v++y++ggsL+++lhe +kr +dl+  + +a+++ArGm+YLh+ +

Q: 624   QFVGACLNDPSqFAIVTQYISGGSLFSLLHE-QKRILDLQSKLIIAVDVARGMEYLHNLT  682

         ***********99******************.99*************************6

S: 119   pkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.ke  174

         + +iihrdL+s+n+Ll  e+ ++ ++dFG++r+l++  +++m+++ g+l+wmaPEv+ ++

Q: 683   Q-PIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSldEDNMTKQpGNLRWMAPEVFtQC  740

         6.9*************.9*****************99877777777**************

S: 175   ekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmk  234

         ++++ k+Dv+Sy+++LWe+lt+e+P+++l+++a+a+++a++++r+pi+ s+p+++++L+

Q: 741   TRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLI  800

         ************************************************************

S: 235   ecwnedpekRpsfseivksl  254

         + wn++pe Rp+fse+v++l

Q: 801   RGWNACPEGRPEFSEVVMKL  820

         ****************9875

Domain Sequence
(FASTA)

IEFHEIIGSG SFGKVYKGRC RNKIVAIKRY RANTYCSKSD VDMFCREVSI LCQLNHPCVI 60

QFVGACLNDP SQFAIVTQYI SGGSLFSLLH EQKRILDLQS KLIIAVDVAR GMEYLHNLTQ 120

PIIHRDLNSH NILLYEDGHA VVADFGESRF LQSLDEDNMT KQPGNLRWMA PEVFTQCTRY 180

TIKADVFSYA LCLWEILTGE IPFAHLKPAA AAADMAYHHI RPPIGYSIPK PISSLLIRGW 240

NACPEGRPEF SEVVMKL 257

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 2.
PF12796	; Ank_2; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 6.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013