EKS-POA-00229

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00229

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	402.6	7.6E-121	43	327	285

Status

Unreviewed

Ensembl Protein

ENSPPYP00000001614

UniProt Accession

H2N7I7;

Protein Name

Protein Synonyms/Alias

Gene Name

MKNK1

Gene Synonyms/Alias

MKNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000001392	ENSPPYP00000001614	ENSPPYT00000001669

Organism

Pongo abelii

Functional Description

Protein Length

418

Protein Sequence
(FASTA)

MQNIPEMGSS EPLPIADGDR RRKKKRRARA TDSLPGKFED MYKLTSELLG EGAYAKVQGA 60

VSLQNGKEYA VKIIEKQAGH SRSRVFREVE TLYQCQGNKN ILELIEFFED DTRFYLVFEK 120

LQGGSILAHI QKQKHFNERE ASRVVRDVAA ALDFLHTKGI AHRDLKPENI LCESPEKVSP 180

VKICDFDLGS GVKLNNSCTP ITTPELTTPC GSAEYMAPEV VEVFTDQATF YDKRCDLWSL 240

GVVLYIMLSG YPPFVGHCGA DCGWDRGEVC RVCQNKLFES IQEGKYEFPD KDWAHISSEA 300

KDLISKLLVR DAKQRLSAAQ VLQHPWVQGE APEKGLPTPQ VLQRNSSTMD LTLFAAEAIA 360

LNRQLSQHEE NELAEEPEAL ADGLCSMKLS PPCKSRLARR RALAQAGRGE DRSPPTAL 418

Nucleotide Sequence
(FASTA)

ATGCAGAATA TACCAGAGAT GGGCAGTAGC GAACCCCTTC CCATCGCAGA TGGTGACAGG 60

AGGAGGAAGA AGAAGCGGAG GGCCCGGGCC ACTGACTCCT TGCCAGGAAA GTTTGAAGAT 120

ATGTACAAGC TGACCTCTGA ATTGCTTGGA GAGGGAGCCT ATGCCAAAGT TCAAGGTGCC 180

GTGAGCCTAC AGAATGGCAA AGAGTATGCC GTCAAAATCA TCGAGAAACA AGCAGGGCAC 240

AGTCGGAGTA GGGTGTTTCG AGAGGTGGAG ACGCTGTATC AGTGTCAGGG AAACAAGAAC 300

ATTTTGGAGC TGATTGAGTT CTTTGAAGAT GACACAAGGT TTTACTTGGT CTTTGAGAAA 360

TTGCAAGGAG GTTCCATCTT AGCCCACATC CAGAAGCAAA AGCACTTCAA TGAGCGAGAA 420

GCCAGCCGAG TGGTGCGGGA CGTTGCTGCT GCCCTTGACT TCCTGCATAC CAAAGGCATT 480

GCTCATCGTG ATCTGAAACC AGAAAATATA TTGTGTGAAT CTCCAGAAAA GGTGTCTCCA 540

GTGAAAATCT GTGACTTTGA CTTGGGCAGT GGGGTGAAAC TGAACAACTC CTGTACTCCC 600

ATAACCACAC CAGAGCTGAC CACCCCATGT GGCTCTGCAG AATACATGGC CCCTGAGGTA 660

GTGGAGGTCT TCACAGACCA GGCCACGTTC TACGACAAGC GCTGTGACCT GTGGAGCCTA 720

GGCGTGGTCC TCTACATCAT GCTGAGCGGC TACCCGCCCT TCGTGGGTCA CTGCGGGGCC 780

GACTGTGGCT GGGACCGGGG CGAGGTCTGC AGGGTGTGCC AGAACAAGCT GTTTGAAAGC 840

ATCCAGGAAG GCAAGTATGA GTTTCCTGAC AAGGACTGGG CACACATCTC CAGTGAGGCC 900

AAAGACCTCA TCTCCAAGCT CCTGGTGCGA GATGCGAAGC AGAGACTTAG CGCCGCCCAA 960

GTTCTGCAGC ACCCATGGGT GCAGGGGGAA GCTCCAGAAA AGGGACTCCC CACGCCGCAA 1020

GTCCTCCAGA GGAACAGCAG CACAATGGAC CTGACGCTCT TCGCAGCTGA GGCCATCGCC 1080

CTTAACCGCC AGCTATCTCA GCACGAAGAG AACGAACTAG CAGAGGAGCC AGAGGCACTA 1140

GCTGATGGCC TCTGCTCCAT GAAGCTTTCC CCTCCTTGCA AGTCACGCCT GGCCCGGAGA 1200

CGGGCCCTGG CCCAGGCAGG CCGTGGTGAA GACAGGAGCC CGCCCACAGC ACTCTGA 1257

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkil.....kdrkkvrrevelhvqasghkniv  55

         klt+e+lGeG+++kv+ +v+ ++g++ya+ki+     ++r++v+reve+++q++g+kni+

Q: 43    KLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIekqagHSRSRVFREVETLYQCQGNKNIL  102

         5799********************************************************

S: 56    elidvfensfedekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhsk  115

         eli++fe    d++r++lv+ekl+GG++l++iq++k+f+e+eas+vv+d+a+al+flh+k

Q: 103   ELIEFFE----DDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTK  158

         *******....*************************************************

S: 116   niahrDlkpenlLyeskeknapvklcDfglaket.eee........eelktpcltaeyva  166

         +iahrDlkpen+L+es+ek++pvk+cDf+l++++   +        +el+tpc++aey+a

Q: 159   GIAHRDLKPENILCESPEKVSPVKICDFDLGSGVkL-NnsctpittPELTTPCGSAEYMA  217

         ********************************9952.345899999**************

S: 167   PevleaekeeallydksCDlWslGvilyillcGypPfyskkg...........raiskkl  215

         Pev+e+++++a++ydk+CDlWslGv+lyi+l+GypPf++++g           r +++kl

Q: 218   PEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGadcgwdrgevcRVCQNKL  277

         *****************************************99*****************

S: 216   keriqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         +e+iqegkyefP+++W+++s+eakdli+klL+rd+k+rl++++vl+hpwv

Q: 278   FESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWV  327

         *************************************************8

Domain Sequence
(FASTA)

KLTSELLGEG AYAKVQGAVS LQNGKEYAVK IIEKQAGHSR SRVFREVETL YQCQGNKNIL 60

ELIEFFEDDT RFYLVFEKLQ GGSILAHIQK QKHFNEREAS RVVRDVAAAL DFLHTKGIAH 120

RDLKPENILC ESPEKVSPVK ICDFDLGSGV KLNNSCTPIT TPELTTPCGS AEYMAPEVVE 180

VFTDQATFYD KRCDLWSLGV VLYIMLSGYP PFVGHCGADC GWDRGEVCRV CQNKLFESIQ 240

EGKYEFPDKD WAHISSEAKD LISKLLVRDA KQRLSAAQVL QHPWV 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013