EKS-POA-00011

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00011

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	411.8	8.2E-124	309	564	256

Status

Unreviewed

Ensembl Protein

ENSPPYP00000001761

UniProt Accession

H2N7X8;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA10

Gene Synonyms/Alias

EPHA10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000001525	ENSPPYP00000001761	ENSPPYT00000001818

Organism

Pongo abelii

Functional Description

Protein Length

672

Protein Sequence
(FASTA)

PPSAPRDLQY SLSRSPLALR LRWLPPADSG GRSDVTYSLL CLRCGREGPA GACEPCGPRV 60

AFVPRQAGLR ERAATLLHLR PGARYTVRVA ALNGVSGPAA AAGTTYAQVT VSTGPGAPWE 120

EDEIRRDRVE PQSVSLSWRE PIPAGAPGAN DTEYEIRYYE KGQSEQTYSM VKTGAPTVTV 180

TNLKPATRYV FQIRAASPGP SWEAQSFNPS IEVQTLGEAA SGSRDQSPAV VITVVTISAL 240

LVLGSVMSVL AIWRRPCSYG KGGGDAHDEE ELYFHFKVPT RRTFLDPQSC GDPLQAVHLF 300

AKELDAKSVT LERSLGAGRF GELCCGCLQL PGRQELPVAV HTLRDSASDS QRLGFLAEAL 360

TLGQFDHSHI VRLEGVVTRG STLMIVTEYM SHGALDGFLR RHEGQLVAGQ LMGLLPGLAS 420

AMKYLSEMGY VHRGLAARRV LVSSDLVCKI SGFGRGPRDR SEAVYTTMGG RSPALWAAPE 480

TLQFGHFSSA SDVWSFGIIM WEVMAFGERP YWDMSGQDVI KAVEDGFRLP PPRNCPNPLH 540

RLMLDCWQKD PGERPRFSQI HSILSKMVQD PEPPKCAPTT CPRPPTPLSD RAFSTFPSFG 600

SVGAWLEALD LCRYKDSFTA AGCGSLEAVA EMTAQDLVSL GISSAEHREA LLTGISALQA 660

RVLQLQGQGV QV 672

Nucleotide Sequence
(FASTA)

CCGCCGTCGG CGCCGCGGGA CCTGCAGTAC AGCCTGAGCC GCTCGCCGCT GGCGCTGCGA 60

CTGCGCTGGC TGCCACCGGC CGACTCGGGA GGTCGCTCGG ACGTCACCTA CTCGCTGCTG 120

TGCCTGCGCT GCGGCCGCGA GGGCCCGGCG GGCGCGTGCG AGCCGTGCGG GCCGCGCGTG 180

GCGTTCGTAC CGCGCCAGGC AGGGCTGCGG GAGCGAGCCG CCACGCTGCT GCACCTGCGG 240

CCCGGCGCGC GCTACACCGT GCGCGTGGCC GCGCTGAACG GCGTCTCGGG CCCGGCGGCC 300

GCCGCGGGAA CCACCTACGC ACAGGTCACC GTCTCCACCG GGCCCGGGGC GCCCTGGGAG 360

GAGGATGAGA TCCGCAGGGA CCGAGTGGAA CCCCAGAGCG TGTCCCTGTC GTGGCGGGAG 420

CCCATCCCTG CCGGAGCCCC TGGGGCCAAT GACACGGAGT ACGAGATCCG ATACTACGAG 480

AAGGGTCAGA GTGAGCAGAC TTACTCCATG GTGAAGACAG GGGCGCCCAC AGTCACTGTC 540

ACTAACCTGA AGCCGGCTAC CCGCTACGTC TTTCAGATCC GGGCCGCTTC CCCGGGGCCA 600

TCCTGGGAGG CCCAGAGCTT TAACCCCAGC ATTGAAGTGC AGACACTGGG GGAAGCTGCC 660

TCAGGGTCCA GGGACCAGAG CCCCGCCGTT GTCATCACCG TAGTGACCAT CTCGGCCCTC 720

CTCGTCCTGG GCTCCGTGAT GAGTGTGCTG GCCATTTGGA GGAGGCCCTG CAGCTATGGC 780

AAAGGAGGAG GGGATGCCCA TGATGAAGAG GAGCTGTATT TCCACTTCAA AGTCCCAACA 840

CGTCGCACGT TCCTGGACCC CCAGAGCTGT GGGGACCCGC TGCAGGCTGT GCATCTGTTT 900

GCCAAGGAAC TGGATGCGAA AAGCGTCACG CTGGAAAGGA GCCTTGGAGC AGGGCGGTTT 960

GGGGAGCTGT GCTGTGGCTG CTTGCAGCTC CCCGGTCGCC AGGAGCTGCC TGTAGCCGTG 1020

CACACGCTGA GGGACAGCGC CTCCGACTCA CAGAGGCTCG GCTTCCTGGC CGAGGCCCTC 1080

ACGCTGGGCC AGTTTGACCA TAGCCACATC GTGCGGCTGG AGGGCGTTGT TACCCGAGGA 1140

AGCACCTTGA TGATTGTCAC CGAGTATATG AGCCATGGGG CCCTGGACGG CTTCCTCAGG 1200

CGGCATGAGG GGCAGCTGGT GGCTGGGCAA CTGATGGGGT TGCTGCCTGG GCTGGCATCA 1260

GCCATGAAGT ATCTGTCAGA GATGGGCTAT GTTCACCGGG GCCTGGCAGC TCGCCGTGTG 1320

CTGGTCAGCA GCGACCTTGT CTGCAAGATC TCTGGCTTCG GGCGGGGCCC CCGGGACCGA 1380

TCAGAGGCTG TCTACACCAC TATGGGTGGC CGGAGCCCAG CGCTATGGGC CGCACCCGAG 1440

ACGCTTCAGT TTGGCCACTT CAGCTCCGCC AGTGACGTGT GGAGCTTCGG CATTATCATG 1500

TGGGAGGTGA TGGCCTTTGG GGAGCGGCCT TACTGGGACA TGTCTGGCCA AGACGTGATC 1560

AAGGCTGTGG AGGATGGCTT CCGGCTGCCA CCCCCCAGGA ACTGTCCTAA CCCTCTGCAC 1620

CGACTAATGC TCGACTGCTG GCAGAAGGAC CCAGGTGAGC GGCCCAGGTT CTCCCAGATC 1680

CACAGCATCC TGAGCAAGAT GGTGCAGGAC CCAGAGCCCC CCAAGTGTGC CCCGACTACC 1740

TGTCCCAGGC CTCCCACCCC GCTATCGGAC CGTGCCTTCT CCACCTTCCC CTCCTTTGGC 1800

TCTGTGGGCG CGTGGCTGGA GGCCCTGGAC CTGTGCCGCT ACAAGGACAG CTTCACGGCT 1860

GCTGGCTGTG GGAGCCTGGA GGCCGTGGCC GAGATGACTG CCCAGGACCT GGTGAGCCTA 1920

GGCATCTCTT CGGCTGAACA TCGAGAGGCC CTCCTCACTG GGATCAGCGC CCTGCAGGCA 1980

CGAGTGCTCC AGCTGCAGGG CCAGGGGGTG CAGGTGTGA 2019

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         v++e+ +GaG+fGe+c+G+l+lpg++e++va++tl+++++++qr  fl+ea +lGqfdh+

Q: 309   VTLERSLGAGRFGELCCGCLQLPGRQELPVAVHTLRDSASDSQRLGFLAEALTLGQFDHS  368

         6899********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         +i+rleGvvt+++++mivteym++gald flr+++gq+++ ql+g+l G+as+mkyls+m

Q: 369   HIVRLEGVVTRGSTLMIVTEYMSHGALDGFLRRHEGQLVAGQLMGLLPGLASAMKYLSEM  428

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         gyvhr laar++lv+s+lvck+s fG+++   d sea+ytt+gg++p  w+ape++++++

Q: 429   GYVHRGLAARRVLVSSDLVCKISGFGRGPR--DRSEAVYTTMGGRSPALWAAPETLQFGH  486

         ****************************98..889*************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         f+sasdvws+Gi++wev+++Gerpywdms qdvika+e+g+rlppp++cp+ l++lmldc

Q: 487   FSSASDVWSFGIIMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPNPLHRLMLDC  546

         ************************************************************

S: 241   wqkdraerpkfeqivsil  258

         wqkd  erp+f+qi+sil

Q: 547   WQKDPGERPRFSQIHSIL  564

         ***************985

Domain Sequence
(FASTA)

VTLERSLGAG RFGELCCGCL QLPGRQELPV AVHTLRDSAS DSQRLGFLAE ALTLGQFDHS 60

HIVRLEGVVT RGSTLMIVTE YMSHGALDGF LRRHEGQLVA GQLMGLLPGL ASAMKYLSEM 120

GYVHRGLAAR RVLVSSDLVC KISGFGRGPR DRSEAVYTTM GGRSPALWAA PETLQFGHFS 180

SASDVWSFGI IMWEVMAFGE RPYWDMSGQD VIKAVEDGFR LPPPRNCPNP LHRLMLDCWQ 240

KDPGERPRFS QIHSIL 256

Keyword

ATP-binding; Complete proteome; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005005	; F:transmembrane-ephrin receptor activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR011510	; SAM_2.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF07647	; SAM_2; 1.

SMARTs

SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013