EKS-POA-00359
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00359
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src435.08.0E-131223472250
StatusUnreviewed
Ensembl ProteinENSPPYP00000001840
UniProt AccessionH2N854;
Protein Name
Protein Synonyms/Alias
Gene NameLCK
Gene Synonyms/Alias LCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000001596ENSPPYP00000001840ENSPPYT00000001899
OrganismPongo abelii
Functional Description
Protein Length487
Protein Sequence
(FASTA)
CHYPIVPLDG KGKLPIRNGS EVRDPLVTYE GCNPPASPLQ DNLVIALHSY EPSHDGDLGF 60
EKGEQLRILE ESGEWWKAQS LTTGQEGFIP FNFVAKANSL EPEPWFFKNL SRKDAERQLL 120
APGNTHGSFL IRESESTAGS FSLSVRDFDQ NQGEVVKHYK IRNLDNGGFY ISPRITFSGL 180
HELVRHYTNA SDGLCTRLSR PCQTQKPQKP WWEDEWEVPR ETLKLVERLG AGQFGEVWMG 240
YYNGHTKVAV KSLKQGSMSP DAFLAEANLM KQLQHQRLVR LYAVVTQEPI YIITEYMENG 300
SLVDFLKTPS GIKLTINKLL DMAAQIAEGM AFIEERNYIH RDLRAANILV SDTLSCKIAD 360
FGLARLIEDN EYTAREGAKF PIKWTAPEAI NYGTFTIKSD VWSFGILLTE IVTHGRIPYP 420
GMTNPEVIQN LERGYRMVCP DNCPEELYQL MRLCWKERPE DRPTFDYLRS VLEDFFTATE 480
GQYQPQP 487
Nucleotide Sequence
(FASTA)
TGCCATTATC CCATAGTCCC ACTGGATGGC AAGGGCAAGC TGCCCATCCG AAATGGCTCT 60
GAGGTGCGGG ACCCACTGGT TACCTACGAA GGCTGCAATC CACCGGCTTC CCCACTGCAA 120
GACAACCTGG TTATCGCCCT GCACAGCTAT GAGCCCTCTC ACGACGGAGA CCTGGGCTTT 180
GAGAAGGGGG AACAGCTCCG CATCCTGGAG GAGAGCGGCG AGTGGTGGAA GGCGCAGTCC 240
CTGACCACGG GTCAGGAAGG CTTCATCCCC TTCAATTTTG TGGCCAAAGC GAACAGCCTG 300
GAGCCCGAAC CCTGGTTCTT CAAGAACCTT AGCCGCAAGG ACGCGGAGCG GCAGCTCCTG 360
GCGCCCGGGA ACACTCACGG CTCCTTCCTC ATCCGGGAGA GCGAGAGCAC CGCGGGATCG 420
TTTTCACTGT CGGTCCGGGA CTTCGACCAG AACCAGGGAG AGGTGGTGAA ACATTACAAG 480
ATCCGTAATC TGGACAACGG TGGCTTCTAC ATCTCCCCCC GAATCACTTT TTCCGGCCTG 540
CATGAACTGG TCCGCCATTA CACCAATGCT TCAGATGGGC TCTGTACACG GTTGAGCCGC 600
CCCTGCCAGA CCCAGAAGCC CCAGAAGCCG TGGTGGGAGG ACGAGTGGGA GGTTCCCAGG 660
GAGACGCTGA AGCTGGTGGA GCGGCTGGGG GCTGGACAGT TCGGGGAGGT GTGGATGGGG 720
TACTACAACG GGCACACGAA GGTGGCGGTG AAGAGCCTGA AGCAGGGCAG CATGTCCCCG 780
GACGCCTTCC TGGCCGAGGC CAACCTCATG AAGCAGCTGC AACACCAGCG GCTGGTTCGG 840
CTCTACGCTG TGGTCACCCA GGAGCCCATC TACATCATCA CTGAATACAT GGAGAACGGG 900
AGTCTAGTGG ATTTTCTCAA GACCCCTTCA GGCATCAAGT TGACCATCAA CAAACTCCTG 960
GACATGGCAG CCCAAATTGC AGAAGGCATG GCATTCATTG AAGAGCGGAA TTATATTCAT 1020
CGTGACCTTC GGGCTGCCAA CATTCTGGTG TCTGACACCC TGAGCTGCAA GATTGCAGAC 1080
TTTGGCCTAG CACGCCTCAT TGAGGACAAC GAGTACACAG CTAGGGAGGG GGCCAAGTTT 1140
CCCATTAAGT GGACAGCACC AGAAGCCATT AACTATGGGA CATTCACCAT CAAGTCGGAT 1200
GTGTGGTCTT TTGGGATCCT GCTGACGGAA ATTGTCACCC ATGGCCGCAT CCCTTACCCA 1260
GGGATGACCA ACCCGGAGGT GATTCAGAAC CTGGAGCGAG GCTACCGCAT GGTGTGCCCT 1320
GACAACTGTC CAGAGGAGCT GTACCAACTC ATGAGGCTGT GCTGGAAGGA GCGCCCAGAG 1380
GACCGGCCCA CCTTTGACTA CCTGCGCAGT GTGCTGGAGG ACTTCTTCAC GGCCACAGAG 1440
GGCCAGTACC AGCCTCAGCC TTGA 1464
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv++lG+GqfGevw+g+++g++kvavk+lk+g++sp+afl+ea+++k+l+h++lv+ly
Q: 223   LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY  282
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+m++Gsl+dflk+ +g kl+++kl+d+aaq+aeGma++ee+n+ihr
Q: 283   AVVTQ-EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHR  341
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+++l +k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 342   DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  401
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGmtn ev++++ergyr+ +p++cpeely+l+  cwk++pe+
Q: 402   WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVCPDNCPEELYQLMRLCWKERPED  461
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++l++vl
Q: 462   RPTFDYLRSVL  472
         *******9876
Domain Sequence
(FASTA)
LKLVERLGAG QFGEVWMGYY NGHTKVAVKS LKQGSMSPDA FLAEANLMKQ LQHQRLVRLY 60
AVVTQEPIYI ITEYMENGSL VDFLKTPSGI KLTINKLLDM AAQIAEGMAF IEERNYIHRD 120
LRAANILVSD TLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180
SFGILLTEIV THGRIPYPGM TNPEVIQNLE RGYRMVCPDN CPEELYQLMR LCWKERPEDR 240
PTFDYLRSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00347
EKS-BOT-00370
EKS-CAJ-00376
EKS-CAF-00371
EKS-CAP-00402
EKS-DAR-00750
EKS-DIO-00065
EKS-EQC-00361
EKS-ERE-00004
EKS-FEC-00358
EKS-GAM-00223
EKS-GAA-00453
EKS-GOG-00391
EKS-HOS-00376
EKS-ICT-00351
EKS-LAC-00385
EKS-LOA-00383
EKS-MEG-00303
EKS-MIM-00060
EKS-MOD-00357
EKS-MUM-00403
EKS-MUP-00365
EKS-MYL-00368
EKS-OCP-00080
EKS-ORN-00480
EKS-ORC-00349
EKS-ORL-00441
EKS-OTG-00374
EKS-PAT-00349
EKS-PES-00333
EKS-RAN-00384
EKS-SAH-00340
EKS-SOA-00006
EKS-SUS-00324
EKS-TAR-00475
EKS-TUT-00115
EKS-XET-00485
EKS-XIM-00468
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045588; P:positive regulation of gamma-delta T cell differentiation
GO:0010628; P:positive regulation of gene expression
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0050856; P:regulation of T cell receptor signaling pathway
GO:0051209; P:release of sequestered calcium ion into cytosol
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013