EKS-POA-00360
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00360
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src431.97.3E-130263512250
StatusUnreviewed
Ensembl ProteinENSPPYP00000001917
UniProt AccessionH2N8C8;
Protein Name
Protein Synonyms/Alias
Gene NameFGR
Gene Synonyms/Alias FGR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000001659ENSPPYP00000001917ENSPPYT00000001977
OrganismPongo abelii
Functional Description
Protein Length529
Protein Sequence
(FASTA)
MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK AQPASSFAHI PNYSNFSSQA 60
INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL 120
SSGQTGYIPS NYVAPVDSIQ AEEWYFGKIG RKDAERQLLS PGNPQGAFLI RESETTKGAY 180
SLSIRDWDQT RGNHVKHYKI RKLDMGGYYI TTRVQFSSVQ ELVQHYMEVN DGLCNLLIAP 240
CTIMKPQTLG LAKDAWEISR SSITLERRLG TGCFGDVWLG TWNGSTKVAV KTLKPGTMSP 300
KAFLEEAQVM KLLRHDKLVQ LYAVVSEEPI YIVTEFMCHG SLLDFLKNPE GQDLRLPQLV 360
DMAAQVAEGM AYMERMNYIH RDLRAANILV GERLACKIAD FGLARLIKDD EYNPCQGSKF 420
PIKWTAPEAA LFGRFTVKSD VWSFGILLTE LITKGRIPYP GMNKREVLEQ VEQGYHMPCP 480
PGCPASLYEA MEQTWRLDPE ERPTFEYLQS FLEDYFTSAE PQYQPGDQT 529
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGTTCTGCAA GAAATTGGAG CCAGTGGCCA CGGCCAAGGA GGATGCTGGC 60
CTGGAAGGGG ACTTCAGAAG CTACGGGGCA GCAGACCACT ATGGGCCTGA CCCCACTAAG 120
GCCCAGCCTG CATCCTCATT TGCCCACATC CCCAACTACA GCAACTTCTC CTCTCAGGCC 180
ATCAACCCTG GGTTCCTTGA TAGTGGCACC ATCAGGGGTG TGTCAGGGAT TGGGGTGACC 240
CTGTTCATTG CCCTGTATGA CTATGAGGCT CGAACTGAGG ATGACCTCAC CTTCACCAAG 300
GGCGAGAAGT TCCACATCCT GAACAACACT GAAGGTGACT GGTGGGAGGC TCGGTCTCTC 360
AGCTCCGGAC AAACTGGCTA CATTCCGAGC AACTATGTGG CCCCTGTTGA CTCCATCCAG 420
GCTGAAGAGT GGTACTTTGG AAAGATTGGG AGAAAGGATG CAGAGAGGCA GCTGCTCTCA 480
CCAGGCAACC CCCAGGGGGC CTTTCTCATT CGGGAAAGCG AGACCACCAA AGGTGCCTAC 540
TCCCTGTCCA TCCGGGACTG GGATCAGACC AGAGGCAATC ATGTGAAGCA TTACAAGATC 600
CGCAAACTGG ACATGGGCGG CTACTATATC ACCACACGGG TTCAGTTCAG CTCGGTGCAG 660
GAGCTGGTGC AGCACTACAT GGAGGTGAAT GACGGGCTGT GCAACCTGCT CATCGCGCCC 720
TGCACCATCA TGAAGCCGCA GACGCTGGGC CTGGCCAAGG ACGCCTGGGA GATCAGCCGC 780
AGCTCCATCA CGCTGGAGCG CCGGCTGGGC ACCGGCTGCT TCGGGGATGT GTGGCTGGGC 840
ACGTGGAACG GCAGCACTAA GGTGGCGGTG AAGACGCTGA AGCCGGGCAC CATGTCCCCG 900
AAGGCCTTCC TGGAGGAGGC GCAGGTCATG AAGCTGCTGC GGCACGACAA GCTGGTGCAG 960
CTGTACGCCG TGGTGTCGGA GGAGCCCATC TACATCGTGA CCGAGTTCAT GTGTCACGGG 1020
AGCTTGCTGG ATTTTCTCAA GAACCCGGAG GGCCAGGATT TGAGGCTGCC CCAATTGGTG 1080
GACATGGCAG CCCAGGTAGC TGAGGGCATG GCCTACATGG AACGCATGAA CTACATTCAC 1140
CGCGACCTGA GGGCAGCCAA CATCCTGGTT GGGGAGCGGC TGGCGTGCAA GATCGCAGAC 1200
TTTGGCTTGG CGCGTCTCAT CAAGGACGAT GAGTACAACC CCTGCCAAGG GTCCAAGTTC 1260
CCCATCAAGT GGACAGCCCC AGAAGCTGCT CTCTTTGGCA GATTCACCGT CAAGTCAGAT 1320
GTGTGGTCCT TTGGGATCCT GCTCACTGAA CTCATCACCA AGGGCCGAAT CCCCTACCCA 1380
GGCATGAATA AACGGGAAGT GTTGGAACAG GTGGAGCAGG GCTACCACAT GCCGTGCCCT 1440
CCAGGCTGCC CAGCATCCCT GTACGAAGCC ATGGAACAGA CCTGGCGTCT GGACCCGGAG 1500
GAGAGGCCTA CCTTCGAGTA CCTGCAGTCC TTCCTGGAGG ACTACTTCAC CTCTGCTGAA 1560
CCACAGTACC AGCCCGGGGA TCAGACATAG 1590
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         ++l+++lG+G+fG+vwlg+w+gs+kvavktlk+gt+sp+afleeaq++k lrh+klv+ly
Q: 263   ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLY  322
         5799********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m +Gslldflk+ eg+ l+lp+lvd+aaqvaeGmay+e++n+ihr
Q: 323   AVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHR  381
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+l++k+adfGlarli+ddey++ +g+k+PikWtaPea+ +g+ft+ksdv
Q: 382   DLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTVKSDV  441
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG++PypGm+++evleqve+gy++p+p  cp++lye+++++w+ dpee
Q: 442   WSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEE  501
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 502   RPTFEYLQSFL  512
         ********986
Domain Sequence
(FASTA)
ITLERRLGTG CFGDVWLGTW NGSTKVAVKT LKPGTMSPKA FLEEAQVMKL LRHDKLVQLY 60
AVVSEEPIYI VTEFMCHGSL LDFLKNPEGQ DLRLPQLVDM AAQVAEGMAY MERMNYIHRD 120
LRAANILVGE RLACKIADFG LARLIKDDEY NPCQGSKFPI KWTAPEAALF GRFTVKSDVW 180
SFGILLTELI TKGRIPYPGM NKREVLEQVE QGYHMPCPPG CPASLYEAME QTWRLDPEER 240
PTFEYLQSFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>
EKS-AIM-00344
EKS-BOT-00371
EKS-CAJ-00374
EKS-CAF-00373
EKS-CAP-00403
EKS-EQC-00362
EKS-FEC-00357
EKS-GOG-00361
EKS-HOS-00377
EKS-ICT-00349
EKS-LOA-00379
EKS-MAM-00370
EKS-MUM-00402
EKS-MUP-00364
EKS-NOL-00341
EKS-ORA-00323
EKS-ORC-00348
EKS-OTG-00373
EKS-PAT-00350
EKS-RAN-00385
EKS-SAH-00341
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0032587; C:ruffle membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0007229; P:integrin-mediated signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0030335; P:positive regulation of cell migration
GO:0050715; P:positive regulation of cytokine secretion
GO:0043306; P:positive regulation of mast cell degranulation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045088; P:regulation of innate immune response
GO:0050764; P:regulation of phagocytosis
GO:0045859; P:regulation of protein kinase activity
KEGG
pon:100442468;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013