EKS-POA-00382

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00382

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	345.3	2.8E-103	650	906	257

Status

Unreviewed

Ensembl Protein

ENSPPYP00000001923

UniProt Accession

H2N8D4;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K6

Gene Synonyms/Alias

MAP3K6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000001665	ENSPPYP00000001923	ENSPPYT00000001983

Organism

Pongo abelii

Functional Description

Protein Length

1288

Protein Sequence
(FASTA)

MAGPCPRSGA ERAGSCWQDP LAVALSRGRP LAAPPGRGCA RSRPLSVVYV LTREPQPGLE 60

PREGTEGEPL PLRCLREACA QVPRPRPPPQ LRSLPFGTLE LGDTAALDAF YNADVVVLEV 120

SSSLVQPSLF YHLGVRESFS MTNNVLLCSQ ANLPDLQALR EDVFQKNSDC VGSYTLIPYV 180

VTATGRVLCG DAGLLRGLAD GLVQAGVGTE ALLTPLVGRL ARLLEATPTD SCGYFRETIR 240

RDIRQARERF SGPQLRQELA RLQRRLDSVE LLSPDIIMNL LLSYRDVQDY SAIIELVETL 300

QALPTCDVAE QHNVCFHYTF ALNRRNRPGD RAKALAVLLP LVQLEGSVAP DLYCMCGRIY 360

KDMFFSSGFQ DAGHREQAYH WYRKAFDVEP SLHSGINAAV LLIAAGQHFE DSKELRLIGM 420

KLGCLLARKG CVEKMQYYWD VGFYLGAQIL ANDPTQVVLA AEQLYKLNAP IWYLVSVMET 480

FLLYQHFRPM PEPPGGPQRR AHFWLHFLLQ SCQPFKTACP QGDQCLVLVL ERNKVLLPAK 540

LEVRGTDPVS TVTLSLLEPE TQDIPSSWTF PVASICGVSA SKRDERCCFL YALPPAQDVQ 600

LCFPSVGHCQ WFCGLIQAWV TNPDSTAPAE EAEGVGEMLE FDYEYTETGE RLVLGKGTYG 660

VMYAGRDRHT RVRIAIKEIP ERDSRFSQPL HEEIALHKRL RHKNIVRYLG SASQGGYLKI 720

FMEEVPGGSL SSLLRSVWGP LKDNESTISF YTRQILQGLG YLHDNHIVHR DIKGDNVLIN 780

TFSGLLKISD FGTSKRLAGI TPCTETFTGT LQYMAPEIID QGPRGYGKAA DIWSLGCTVI 840

EMATGHPPFH ELGSPQAAMF QVGMYKVHPP MPSSLSAEAQ AFLLRTFEPD PRLRASAQTL 900

LGDPFLQPGK RSRSPSSPQH APRPSDAPSA SPTPSANSTT QSQTFPRPQA PSQHPPSPPK 960

RCLSYGGTSQ LRVPEEPAAE EPASPEESSG LSLLHQESKR RAMLAAVLEQ ELPALAENLH 1020

QEQEQEQGAR LGRNHVEELL RCLGAHIHTP NRRQLAQELR ALQGRLRAQG LGPALLHRPL 1080

FAFPDAVKQI LRKRQIRPHW MFVLDSLLSR AVRAALAVLG PEVEKEAVSP RSEELSKEGD 1140

SQQSPGQQSL LPVEPEQGPA PLMVQLSLLR AETDRLREVL AGKEREYQAL VQRALQRLNE 1200

EARTYALAPE PPTALSTDQG LVQWLQELNV DSGTIQMLLN HSFTLHTLLT YATRDDLIYT 1260

RIRGGMVCRI WRAILAQRAG STPVTPGP 1288

Nucleotide Sequence
(FASTA)

ATGGCGGGGC CGTGTCCCCG GTCCGGGGCG GAGCGCGCCG GCAGCTGCTG GCAGGACCCG 60

CTGGCCGTGG CGCTGAGCCG GGGCCGGCCG CTCGCGGCGC CCCCGGGCCG GGGCTGCGCG 120

CGGAGCCGGC CACTCAGCGT GGTCTACGTG CTGACCCGGG AGCCGCAGCC CGGGCTGGAG 180

CCTCGGGAGG GAACCGAGGG GGAGCCGCTG CCCCTGCGCT GCCTGCGCGA GGCTTGCGCG 240

CAGGTCCCTC GGCCGCGGCC GCCCCCGCAG CTGCGCAGCC TGCCCTTCGG GACGCTGGAG 300

CTAGGCGACA CCGCGGCTCT GGATGCCTTC TACAACGCGG ACGTGGTGGT GCTGGAGGTG 360

AGCAGCTCGC TGGTACAGCC CTCCCTGTTC TACCACCTTG GTGTGCGTGA GAGCTTCAGC 420

ATGACCAACA ATGTGCTCCT CTGCTCCCAG GCCAACCTCC CTGACCTACA GGCCCTGCGG 480

GAGGATGTTT TCCAGAAGAA CTCGGATTGC GTTGGCAGCT ACACACTGAT CCCCTATGTG 540

GTGACGGCCA CTGGTCGGGT GCTGTGTGGT GATGCAGGCC TTCTGCGGGG CCTGGCTGAT 600

GGGCTGGTAC AGGCCGGAGT GGGGACCGAG GCCCTGCTCA CTCCCCTGGT GGGCCGGCTT 660

GCCCGCCTGC TGGAGGCCAC ACCCACAGAC TCTTGTGGCT ATTTCCGGGA GACCATTCGG 720

CGGGACATCC GGCAGGCACG GGAGCGGTTC AGTGGGCCAC AGCTGCGGCA GGAGCTGGCT 780

CGCCTGCAGC GGAGACTGGA CAGCGTGGAG CTGCTGAGCC CCGACATCAT CATGAACTTG 840

CTGCTCTCCT ACCGCGATGT GCAGGACTAC TCGGCCATCA TTGAGCTGGT GGAGACGCTG 900

CAGGCCTTGC CCACCTGTGA TGTGGCCGAG CAGCATAATG TCTGCTTCCA CTACACTTTT 960

GCCCTCAACC GGAGGAACAG GCCTGGGGAC CGGGCGAAGG CCCTGGCCGT GCTGCTGCCG 1020

CTGGTACAGC TTGAGGGCTC TGTGGCGCCT GATCTGTACT GCATGTGTGG CCGTATCTAC 1080

AAGGACATGT TCTTCAGCTC GGGTTTCCAG GATGCTGGGC ACCGGGAGCA GGCCTATCAC 1140

TGGTATCGCA AGGCTTTTGA CGTAGAGCCT AGCCTCCACT CAGGCATCAA CGCAGCTGTG 1200

CTCCTCATTG CTGCCGGGCA GCACTTTGAG GATTCCAAGG AGCTCCGGTT AATAGGCATG 1260

AAGCTGGGCT GCCTGCTGGC CCGCAAAGGC TGCGTGGAGA AGATGCAGTA TTACTGGGAT 1320

GTGGGTTTCT ACCTGGGAGC CCAGATCCTC GCCAATGACC CCACCCAGGT GGTGCTGGCT 1380

GCAGAGCAGC TGTATAAGCT CAATGCCCCC ATATGGTACC TGGTATCTGT GATGGAGACC 1440

TTCCTGCTCT ACCAGCACTT CAGGCCCATG CCAGAGCCCC CTGGAGGGCC ACAACGCCGT 1500

GCCCACTTCT GGCTCCACTT CTTGCTACAG TCCTGCCAAC CATTCAAGAC GGCCTGTCCC 1560

CAGGGCGACC AGTGCTTGGT GCTGGTCCTG GAGAGGAACA AGGTGCTACT GCCTGCAAAG 1620

CTCGAGGTTC GGGGTACTGA CCCAGTAAGC ACAGTGACCC TGAGCCTGCT GGAGCCTGAG 1680

ACCCAGGACA TTCCCTCCAG CTGGACCTTC CCAGTCGCCT CCATATGCGG AGTCAGCGCC 1740

TCCAAGCGCG ACGAGCGCTG CTGCTTCCTC TATGCACTCC CCCCGGCTCA GGACGTCCAG 1800

CTGTGCTTCC CCAGCGTAGG GCACTGCCAG TGGTTCTGCG GCCTGATCCA GGCCTGGGTG 1860

ACGAACCCGG ATTCCACGGC GCCCGCGGAG GAGGCGGAGG GCGTGGGGGA GATGTTGGAG 1920

TTTGATTATG AGTACACGGA GACGGGCGAG CGGCTGGTGC TGGGCAAGGG CACGTATGGG 1980

GTGATGTACG CGGGCCGCGA TCGCCACACG AGGGTGCGCA TCGCCATCAA GGAGATCCCG 2040

GAGCGGGACA GCAGGTTCTC TCAGCCCCTG CATGAAGAGA TCGCTCTTCA CAAACGCCTG 2100

CGCCACAAGA ACATAGTGCG CTATCTGGGC TCAGCTAGCC AGGGCGGCTA CCTTAAGATC 2160

TTCATGGAGG AAGTGCCTGG AGGCAGCCTG TCCTCCTTGC TGCGGTCAGT GTGGGGACCC 2220

CTGAAGGACA ACGAGAGCAC CATCAGTTTC TACACCCGCC AGATCCTGCA GGGACTTGGC 2280

TACTTGCACG ACAACCACAT CGTGCACAGG GACATCAAGG GGGACAATGT GCTGATCAAC 2340

ACCTTCAGTG GGCTGCTCAA GATTTCTGAC TTCGGCACCT CCAAGCGGCT GGCAGGCATC 2400

ACACCTTGCA CTGAGACCTT CACAGGAACT CTGCAGTATA TGGCCCCAGA AATCATTGAC 2460

CAGGGCCCAC GCGGGTATGG GAAAGCAGCT GACATCTGGT CGCTGGGCTG CACTGTCATT 2520

GAGATGGCCA CAGGTCACCC CCCCTTCCAC GAGCTAGGGA GCCCACAGGC TGCCATGTTT 2580

CAGGTGGGTA TGTACAAGGT CCATCCGCCA ATGCCCAGCT CTCTGTCGGC CGAGGCCCAA 2640

GCCTTTCTCC TCCGAACTTT TGAGCCAGAC CCCCGCCTCC GAGCCAGCGC CCAGACACTG 2700

CTGGGGGACC CCTTCCTGCA GCCTGGGAAA AGGAGCCGCA GCCCCAGCTC CCCACAACAT 2760

GCTCCACGGC CCTCAGATGC CCCTTCCGCC AGTCCCACTC CTTCAGCCAA CTCAACCACC 2820

CAGTCTCAGA CATTCCCACG CCCTCAGGCA CCCTCTCAGC ACCCGCCCAG CCCCCCGAAG 2880

CGCTGCCTCA GTTATGGGGG CACCAGCCAG CTCCGGGTGC CCGAGGAGCC TGCGGCCGAG 2940

GAGCCTGCGT CTCCGGAGGA GAGCTCGGGG CTGAGCCTGC TGCACCAGGA GAGCAAGCGT 3000

CGGGCCATGC TGGCCGCGGT ATTGGAGCAG GAACTGCCAG CGCTGGCGGA GAATCTGCAC 3060

CAGGAGCAGG AGCAAGAGCA GGGGGCCCGT CTGGGCAGAA ACCATGTGGA AGAGCTGCTG 3120

CGCTGCCTCG GGGCACACAT CCACACTCCC AACCGCCGGC AGCTGGCCCA GGAGCTGCGG 3180

GCGCTGCAAG GACGGCTGAG GGCCCAGGGC CTTGGGCCTG CGCTTCTGCA CAGACCGCTG 3240

TTTGCCTTCC CGGATGCGGT GAAGCAGATC CTCCGCAAGC GCCAGATCCG TCCACACTGG 3300

ATGTTCGTTC TGGACTCACT GCTCAGCCGT GCTGTGCGGG CAGCCCTGGC TGTGCTAGGC 3360

CCGGAGGTGG AGAAGGAGGC GGTCTCACCG AGGTCAGAGG AGCTGAGTAA AGAAGGGGAC 3420

TCCCAGCAGA GCCCAGGCCA GCAGAGCCTG CTTCCAGTGG AGCCCGAGCA GGGCCCCGCT 3480

CCTCTGATGG TGCAGCTGAG CCTCTTGAGA GCAGAGACTG ATCGGCTGCG CGAAGTCCTG 3540

GCGGGGAAGG AACGGGAGTA CCAGGCCCTG GTGCAGCGGG CTCTACAGCG GCTGAATGAG 3600

GAAGCCCGGA CCTATGCCCT GGCCCCAGAG CCTCCAACTG CTCTTTCAAC CGACCAAGGC 3660

CTGGTGCAGT GGCTACAGGA ACTGAATGTG GATTCAGGCA CCATCCAAAT GCTGTTGAAC 3720

CATAGCTTCA CCCTCCACAC CCTGCTCACC TATGCCACTC GAGATGACCT CATCTACACC 3780

CGCATCAGGG GAGGGATGGT ATGCCGCATC TGGAGGGCCA TCTTGGCACA GCGAGCAGGA 3840

TCTACACCAG TCACCCCTGG ACCCTGA 3867

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g +ya++d +t+ ++a+Ke+   pe++s+   +++l+eEi+l+k+l+H+n

Q: 650   ERLVLGKGTYGVMYAGRDRHTRVRIAIKEI---PERDSR--FSQPLHEEIALHKRLRHKN  704

         5779**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHe  119

         iv+y+G++++ ++lkif+E v+gGslssll+  +g+l+  es+i++yt+qil+gl yLH+

Q: 705   IVRYLGSASQGGYLKIFMEEVPGGSLSSLLRsVWGPLKdnESTISFYTRQILQGLGYLHD  764

         *******************************99****9999*******************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         ++ivHRDiKg+N+l+++ sg++k+sDFG+skrla ++++   +e++tGtl+ymaPE+i++

Q: 765   NHIVHRDIKGDNVLINTfSGLLKISDFGTSKRLAGITPC---TETFTGTLQYMAPEIIDQ  821

         *****************9*********************...8*****************

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         + +gyg++aDiWslgc+viem+tg++Pf+el++++a+mf+vg+ k++P++p++ls+e+++

Q: 822   GPRGYGKAADIWSLGCTVIEMATGHPPFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQA  881

         ************************************************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl +++e dp+ r+sa+ LL ++fl

Q: 882   FLLRTFEPDPRLRASAQTLLGDPFL  906

         **********************996

Domain Sequence
(FASTA)

ERLVLGKGTY GVMYAGRDRH TRVRIAIKEI PERDSRFSQP LHEEIALHKR LRHKNIVRYL 60

GSASQGGYLK IFMEEVPGGS LSSLLRSVWG PLKDNESTIS FYTRQILQGL GYLHDNHIVH 120

RDIKGDNVLI NTFSGLLKIS DFGTSKRLAG ITPCTETFTG TLQYMAPEII DQGPRGYGKA 180

ADIWSLGCTV IEMATGHPPF HELGSPQAAM FQVGMYKVHP PMPSSLSAEA QAFLLRTFEP 240

DPRLRASAQT LLGDPFL 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity

KEGG

pon:100445147

;

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013