EKS-POA-00157

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00157

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	495.9	2.4E-149	418	675	258

Status

Unreviewed

Ensembl Protein

ENSPPYP00000001941

UniProt Accession

H2N8F2;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA1

Gene Synonyms/Alias

RPS6KA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000001681	ENSPPYP00000001941	ENSPPYT00000002002

Organism

Pongo abelii

Functional Description

Protein Length

735

Protein Sequence
(FASTA)

MPLAQLKEPW PLMELVPLDP ENGQTSGEEA GLQLSKDEGV LKEISITHHV KAGSEKADPS 60

HFELLKVLGQ GSFGKVFLVR KVTRPDSGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN 120

HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS 180

LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHS 240

HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN 300

PANRLGSGPD GAEEIKRHVF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP 360

KDSPGIPPSA GAHQLFRGFS FVATGLMEDD GKPRAPQAPL HSVVQQLHGK NLVFSDGYVV 420

KETIGVGSYS ECKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD 480

DGKHVYLVTE LMRGGELLDK ILRQKFFSER EASFVLHTIS KTVEYLHSQG VVHRDLKPSN 540

ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL 600

GILLYTMLAG YTPFANGPSD TPEEILTRIG SGKFTLSGGN WNTVSETAKD LVSKMLHVDP 660

HQRLTAKQVL QHPWVTQKDK LPQSQLSHQD LQLVKGAMAA TYSALNSSKP TPQLKPIESS 720

ILAQRRVRKL PSTTL 735

Nucleotide Sequence
(FASTA)

ATGCCGCTCG CCCAGCTCAA GGAGCCCTGG CCGCTCATGG AGCTAGTGCC GCTGGACCCG 60

GAGAATGGAC AGACCTCAGG GGAAGAAGCT GGACTTCAGC TGTCCAAGGA TGAGGGCGTC 120

CTCAAGGAGA TCTCCATCAC GCACCACGTC AAGGCTGGCT CTGAGAAGGC TGATCCATCC 180

CATTTCGAGC TCCTCAAGGT TCTGGGCCAG GGATCCTTTG GCAAAGTCTT CCTGGTGCGG 240

AAAGTCACCC GGCCTGACAG TGGGCACCTG TATGCTATGA AGGTGCTGAA GAAGGCGACG 300

CTGAAAGTAC GTGACCGCGT CCGGACCAAG ATGGAGAGAG ACATCCTGGC TGATGTAAAT 360

CACCCATTCG TGGTGAAGCT GCACTATGCC TTCCAGACCG AGGGCAAGCT CTATCTCATT 420

CTGGACTTCC TGCGTGGTGG GGACCTCTTC ACACGGCTCT CAAAAGAGGT GATGTTCACG 480

GAGGAGGATG TGAAGTTTTA CTTGGCCGAG CTGGCTCTGG GCCTGGATCA CCTGCACAGC 540

CTGGGTATCA TTTACAGAGA CCTCAAGCCT GAGAACATCC TTCTGGATGA GGAGGGCCAC 600

ATCAAACTCA CTGACTTTGG CCTGAGCAAG GAGGCCATTG ACCACGAGAA GAAGGCCTAT 660

TCTTTCTGCG GGACAGTGGA GTACATGGCC CCCGAGGTCG TCAACCGCCA GGGCCACTCG 720

CACAGTGCGG ATTGGTGGTC CTATGGGGTG TTGATGTTTG AGATGCTGAC GGGCTCCCTG 780

CCCTTCCAGG GGAAGGACCG GAAAGAGACC ATGACATTGA TTCTGAAGGC GAAGCTAGGC 840

ATGCCCCAGT TTCTGAGTAC TGAAGCCCAG AGCCTCTTGC GGGCCCTGTT CAAGCGGAAT 900

CCTGCCAACC GGCTCGGCTC CGGCCCTGAT GGGGCAGAGG AAATCAAGCG GCATGTCTTC 960

TACTCCACCA TTGACTGGAA TAAGCTATAT CGTCGTGAGA TCAAGCCACC CTTCAAGCCA 1020

GCAGTGGCTC AGCCTGATGA CACCTTCTAC TTTGACACTG AGTTCACATC CCGCACACCC 1080

AAGGATTCCC CAGGCATCCC CCCCAGCGCT GGGGCCCATC AGCTGTTCCG GGGCTTCAGC 1140

TTCGTGGCCA CCGGCCTGAT GGAGGACGAC GGCAAGCCTC GTGCCCCGCA GGCACCCCTG 1200

CACTCGGTGG TACAGCAACT GCATGGGAAG AATCTGGTTT TTAGCGACGG CTACGTGGTA 1260

AAGGAGACAA TTGGTGTGGG CTCCTACTCT GAGTGCAAGC GCTGTGTCCA CAAGGCCACC 1320

AACATGGAGT ATGCTGTCAA GGTCATTGAT AAGAGCAAGC GGGATCCTTC AGAAGAGATT 1380

GAGATTCTTC TGCGGTACGG CCAGCACCCC AACATCATCA CTCTGAAAGA TGTGTATGAT 1440

GATGGCAAAC ACGTGTACCT GGTGACAGAG CTGATGCGGG GTGGGGAGCT GCTGGACAAG 1500

ATCCTGCGGC AGAAGTTCTT CTCGGAGCGG GAGGCCAGCT TTGTCCTGCA CACCATCAGC 1560

AAAACTGTGG AGTATCTGCA CTCACAGGGG GTTGTGCACA GGGACCTGAA GCCCAGCAAC 1620

ATCCTGTATG TGGACGAGTC CGGGAATCCC GAGTGCCTGC GCATCTGTGA CTTTGGTTTT 1680

GCCAAACAGC TGCGGGCTGA GAATGGGCTC CTCATGACAC CTTGCTACAC AGCCAACTTC 1740

GTGGCGCCCG AGGTGCTGAA GCGCCAGGGC TATGATGAAG GCTGCGACAT CTGGAGCCTG 1800

GGCATTCTGC TCTACACCAT GCTGGCAGGA TACACTCCAT TTGCCAACGG TCCCAGTGAC 1860

ACACCAGAGG AAATCCTAAC CAGGATCGGC AGTGGGAAGT TTACCCTCAG TGGGGGAAAT 1920

TGGAACACAG TTTCAGAGAC AGCCAAGGAC CTGGTGTCCA AGATGCTACA CGTGGATCCC 1980

CACCAGCGCC TCACAGCTAA GCAGGTTCTG CAGCATCCAT GGGTCACCCA GAAAGACAAG 2040

CTTCCCCAAA GCCAGCTGTC CCACCAGGAC CTACAGCTTG TGAAGGGAGC CATGGCTGCC 2100

ACGTACTCCG CACTCAACAG CTCCAAGCCC ACCCCCCAGC TGAAGCCCAT CGAGTCATCC 2160

ATCCTGGCCC AGAGGCGAGT GAGGAAGTTG CCATCCACCA CCCTGTGA 2208

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y+vke++GvGsys ckrcvhkatn+e+avk+idkskrd+seeieillry+qhpni+tlkd

Q: 418   YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  477

         689*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgk+vylv+el++GGelld+i+++kffsereas +l+t++k+veylh+qGvvhrdlk

Q: 478   VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLK  537

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+e+++i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+

Q: 538   PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI  597

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslG+llytmlaGy+pfangp+dt+eeil++i++Gkf+lsG++w++vse+akdlvsk+l+

Q: 598   WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLH  657

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+l+h+w+

Q: 658   VDPHQRLTAKQVLQHPWV  675

         *****************7

Domain Sequence
(FASTA)

YVVKETIGVG SYSECKRCVH KATNMEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60

VYDDGKHVYL VTELMRGGEL LDKILRQKFF SEREASFVLH TISKTVEYLH SQGVVHRDLK 120

PSNILYVDES GNPECLRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180

WSLGILLYTM LAGYTPFANG PSDTPEEILT RIGSGKFTLS GGNWNTVSET AKDLVSKMLH 240

VDPHQRLTAK QVLQHPWV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043066	; P:negative regulation of apoptotic process
GO:2000491	; P:positive regulation of hepatic stellate cell activation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter

KEGG

pon:100459459

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013