EKS-POA-00209
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00209
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF2621.92.7E-187156512357
StatusUnreviewed
Ensembl ProteinENSPPYP00000002052
UniProt AccessionH2N8R0;
Protein Name
Protein Synonyms/Alias
Gene NamePINK1
Gene Synonyms/Alias PINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000001769ENSPPYP00000002052ENSPPYT00000002114
OrganismPongo abelii
Functional Description
Protein Length581
Protein Sequence
(FASTA)
MAVRQALGRG LQLGRALLLR FTGKPGRAYG LGRPGPAAGC VRGERPGWAA GPGAEPRRVG 60
LGLPNRLRFF RQSVAGLAAR LQRQFVARAW GCAGPCGRAV FLAFGLGLGL IEEKQAESRR 120
AVSACQEIQA IFTQKSKPGP DPLDTRRWQG FRLEEYLIGQ SIGKGCSAAV YEATMPTLPQ 180
NLEVTKSTGL LPGRGPGTSA PGEEQERAPG APAFPLAIKM MWNISAGSSS EAILNTMSQE 240
LVPASRVALA GEYGAVTYRK SKRGPKQLAP HPNIIRVLRA FTSSVPLLPG ALVDYPDVLP 300
SRLHPEGLGH GRTLFLVMKN YPCTLRQYLC VNTPSPRLAT MMLLQLLEGV DHLVQQGIAH 360
RDLKSDNILV ELDPDGCPWL VIADFGCCLA DESIGLQLPF SSWYVDRGGN GCLMAPEVST 420
ARPGPRAVID YSKADAWAVG AIAYEIFGLV NPFYGQGRAH LESRSYQEAQ LPALPESVPP 480
DVRELVRALL QRDASKRPSA RVAANVLHLS LWGEHILALK NLKLDKMVGW LLQQSAATLL 540
ANRLTEKCCV ETKMKMLFLA NLECETLCQA ALLLCSWRAA L 581
Nucleotide Sequence
(FASTA)
ATGGCGGTGC GACAGGCGCT GGGCCGCGGC CTGCAGCTGG GTCGAGCGCT GCTGCTGCGC 60
TTCACGGGCA AGCCGGGCCG GGCCTACGGC TTGGGGCGGC CGGGCCCGGC GGCGGGCTGT 120
GTCCGCGGGG AGCGTCCGGG CTGGGCCGCA GGACCGGGCG CGGAGCCTCG CAGGGTCGGG 180
CTCGGGCTCC CCAACCGTCT CCGCTTCTTC CGCCAGTCGG TGGCCGGGCT GGCGGCGCGG 240
TTGCAGCGGC AGTTCGTGGC GCGGGCCTGG GGCTGCGCGG GCCCTTGCGG CCGGGCAGTC 300
TTTCTGGCCT TCGGGCTAGG GCTGGGCCTC ATCGAGGAGA AGCAGGCGGA GAGCCGGCGG 360
GCGGTCTCGG CCTGTCAGGA GATCCAGGCA ATTTTTACCC AGAAAAGCAA GCCGGGGCCT 420
GACCCGTTGG ACACGAGACG CTGGCAGGGC TTTCGGCTGG AGGAGTATCT GATAGGGCAG 480
TCCATTGGCA AGGGCTGCAG TGCCGCTGTG TATGAAGCCA CCATGCCTAC ATTGCCCCAG 540
AACCTGGAGG TGACAAAGAG CACCGGGTTG CTTCCAGGGA GAGGCCCAGG TACCAGTGCA 600
CCAGGAGAAG AGCAGGAGCG AGCTCCGGGG GCCCCTGCCT TCCCGTTGGC CATCAAGATG 660
ATGTGGAACA TCTCGGCAGG TTCCTCCAGC GAAGCCATCT TGAACACAAT GAGCCAGGAG 720
CTGGTCCCAG CGAGCCGAGT GGCCTTGGCT GGGGAGTATG GAGCAGTCAC TTACAGGAAA 780
TCCAAGAGAG GTCCCAAGCA ACTAGCCCCT CACCCCAACA TCATCCGGGT TCTCCGCGCC 840
TTCACCTCTT CCGTGCCGCT GCTGCCAGGG GCCCTGGTTG ACTACCCTGA TGTGCTGCCC 900
TCACGCCTCC ACCCTGAAGG CCTGGGCCAC GGCCGGACGC TGTTCCTCGT TATGAAGAAC 960
TATCCCTGTA CCCTGCGCCA GTACCTTTGT GTGAACACAC CCAGCCCCCG CCTCGCCACC 1020
ATGATGCTGC TGCAGCTGCT GGAAGGCGTG GACCATTTGG TTCAACAGGG CATCGCACAC 1080
AGAGACCTGA AATCCGACAA CATCCTTGTG GAGCTGGACC CAGACGGCTG CCCCTGGCTG 1140
GTGATCGCAG ATTTTGGCTG CTGCCTGGCT GATGAAAGCA TCGGCCTGCA GTTGCCCTTC 1200
AGCAGCTGGT ACGTGGATCG GGGCGGAAAC GGCTGCCTGA TGGCCCCAGA GGTGTCCACG 1260
GCCCGTCCTG GCCCCAGGGC AGTGATCGAC TACAGCAAGG CTGATGCCTG GGCAGTGGGA 1320
GCCATCGCCT ATGAAATCTT CGGGCTTGTC AATCCCTTCT ACGGCCAGGG CAGGGCCCAC 1380
CTTGAAAGCC GCAGCTACCA AGAGGCTCAG CTACCTGCAC TGCCCGAGTC AGTGCCTCCA 1440
GACGTGAGAG AGCTGGTGAG GGCACTGCTC CAGCGAGACG CCAGCAAGAG ACCATCTGCC 1500
CGAGTAGCTG CAAATGTGCT TCATCTAAGC CTCTGGGGTG AACATATTCT AGCCCTGAAG 1560
AATCTGAAGT TAGACAAGAT GGTTGGCTGG CTCCTCCAAC AATCGGCCGC CACTTTGTTG 1620
GCCAACAGGC TCACAGAGAA GTGTTGTGTG GAAACAAAAA TGAAGATGCT CTTTCTGGCT 1680
AACCTGGAGT GTGAAACGCT CTGCCAGGCA GCCCTCCTCC TCTGCTCATG GAGGGCAGCC 1740
CTGTGA 1746
Domain Profile
S: 1     yligealgkgcnaavyeatlatldqelekakhlgll.gkevtvvlaeidqesavaakkfp  59
         ylig+++gkgc+aavyeat++tl+q+le++k++gll g+++++++++++qe+a++a++fp
Q: 156   YLIGQSIGKGCSAAVYEATMPTLPQNLEVTKSTGLLpGRGPGTSAPGEEQERAPGAPAFP  215
         99*********************************99***********************
S: 60    laiklmfnieadssseallksmsqelvpasrvaldgeygav........pkllakhPniv  111
         laik+m+ni+a+sssea+l++msqelvpasrval+geygav        pk+la+hPni+
Q: 216   LAIKMMWNISAGSSSEAILNTMSQELVPASRVALAGEYGAVtyrkskrgPKQLAPHPNII  275
         ************************************************************
S: 112   rvlrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqdrs  171
         rvlraf++sv+llP+al+dyPd+lp+rl+peglg+g+tl+lvmk+y++tlr+yl+++++s
Q: 276   RVLRAFTSSVPLLPGALVDYPDVLPSRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPS  335
         ************************************************************
S: 172   trlaalllaqlleavdhlvkhgvahrdlksdnilveldddeiPvlviadfGCcladkvdg  231
         +rla+++l+qlle+vdhlv++g+ahrdlksdnilveld+d++P+lviadfGCclad+++g
Q: 336   PRLATMMLLQLLEGVDHLVQQGIAHRDLKSDNILVELDPDGCPWLVIADFGCCLADESIG  395
         ************************************************************
S: 232   lrlpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfyg  291
         l+lp++s++vd+GGn++lmaPe+sta+pGp+avi+y+kad+WavGa+ayeifgl+nPfyg
Q: 396   LQLPFSSWYVDRGGNGCLMAPEVSTARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYG  455
         ************************************************************
S: 292   egkaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348
         +g+a+les+syqeaqlPalpesvpp++r+lv++ll+r+askr+sa++aanvl+lsl+
Q: 456   QGRAHLESRSYQEAQLPALPESVPPDVRELVRALLQRDASKRPSARVAANVLHLSLW  512
         ********************************************************9
Domain Sequence
(FASTA)
YLIGQSIGKG CSAAVYEATM PTLPQNLEVT KSTGLLPGRG PGTSAPGEEQ ERAPGAPAFP 60
LAIKMMWNIS AGSSSEAILN TMSQELVPAS RVALAGEYGA VTYRKSKRGP KQLAPHPNII 120
RVLRAFTSSV PLLPGALVDY PDVLPSRLHP EGLGHGRTLF LVMKNYPCTL RQYLCVNTPS 180
PRLATMMLLQ LLEGVDHLVQ QGIAHRDLKS DNILVELDPD GCPWLVIADF GCCLADESIG 240
LQLPFSSWYV DRGGNGCLMA PEVSTARPGP RAVIDYSKAD AWAVGAIAYE IFGLVNPFYG 300
QGRAHLESRS YQEAQLPALP ESVPPDVREL VRALLQRDAS KRPSARVAAN VLHLSLW 357
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00200
EKS-BOT-00215
EKS-CAE-00184
EKS-CAJ-00221
EKS-CAF-00221
EKS-CAP-00240
EKS-CHH-00045
EKS-CIS-00247
EKS-DAR-00520
EKS-DIO-00111
EKS-DRM-00108
EKS-ECT-00082
EKS-EQC-00209
EKS-FEC-00202
EKS-GAM-00122
EKS-GAG-00181
EKS-GAA-00264
EKS-GOG-00211
EKS-HOS-00221
EKS-ICT-00205
EKS-LAC-00227
EKS-LOA-00212
EKS-MAM-00217
EKS-MOD-00214
EKS-MUM-00218
EKS-MUP-00216
EKS-MYL-00218
EKS-NOL-00201
EKS-OCP-00140
EKS-ORN-00275
EKS-ORA-00189
EKS-ORC-00196
EKS-ORL-00255
EKS-OTG-00221
EKS-PAT-00204
EKS-PES-00192
EKS-RAN-00210
EKS-SAH-00204
EKS-SOA-00066
EKS-SUS-00188
EKS-TAG-00234
EKS-TAR-00275
EKS-TEN-00271
EKS-TUB-00057
EKS-XIM-00267
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0010857; F:calcium-dependent protein kinase activity
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0000422; P:mitochondrion degradation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0033603; P:positive regulation of dopamine secretion
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254; P:regulation of protein complex assembly
GO:0031396; P:regulation of protein ubiquitination
GO:0006950; P:response to stress
KEGG
pon:100443445;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013