EKS-POA-00010
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00010
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph419.15.0E-126614854241
StatusUnreviewed
Ensembl ProteinENSPPYP00000002121
UniProt AccessionH2N8X8;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA2
Gene Synonyms/Alias EPHA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000001827ENSPPYP00000002121ENSPPYT00000002184
OrganismPongo abelii
Functional Description
Protein Length959
Protein Sequence
(FASTA)
MELQAARACF ALLWGCALAA AAAAQGKEVV LLDFAAAGGE LGWLTHPYGK GWDLMQNIMN 60
DMPIYMYSVC NVMSGDQDNW LRTNWVYRGE AERIFIELKF TVRDCNSFPG GASSCKETFN 120
LYYAESDLDY GTNFQKRLFT KIDTIAPDEI TVSSDFEARH VKLNVEERSV GPLTRKGFYL 180
AFQDIGACVA LLSVRVYYKK CPELLQGLAH FPETIAGSDA PSLATVAGTC VDHAVVPPGG 240
EEPRMHCAVD GEWLVPIGQC LCQAGYEKVE DACQACSPGF FKFEASESPC LECPEHTLPS 300
PEGATSCECE EGFFRAPQDP ASMPCTRPPS APHYLTAVGM GAKVELRWTP PQDSGGREDI 360
VYSVTCEQCW PESGECGPCE ASVRYSEPPH GLTRTSVTVS DLEPHMNYTF TVEARNGVSG 420
LVTSRSFRTA SVSINQTEPP KVRLEGRSTT SLSVSWSIPP PQQSRVWKYE VTYRKKGDSN 480
SYNVRRTEGF SVTLDDLAPD TTYLVQVQAL TQEGQGAGSK VHEFQTLSPE GSGNLAVISG 540
VAVGVVLLLV LAGVGFFIHR RRKNLRARQS PEDVYFSKSE QLKPLKTYVD PHTYEDPNQA 600
VLKFTTEIHP SCVTRQKVIG AGEFGEVYKG TLKTSFGKKE VPVAIKTLKA GLTEKQRVDF 660
LGEAGIMGKP MMIITEYMEN GALDKFLREK DGEFSVLQLV GMLRGIAAGM KYLANMNYVH 720
RDLAARNILV NSNLVCKVSD FGLSRVLEDD PEATYTTSGG KIPIRWTAPE AISYRKFTSA 780
SDVWSFGIVM WEVMTYGERP YWELSNHEVM KAINDGFRLP TPMDCPSAIY QLMMQCWQQE 840
RARRPKFADI VSILDKLIRA PDSLKTLADF DPRVSIRLPS TSGSEGVPFR TVSEWLESIK 900
MQQYTEHFMA AGYTAIEKVV QMTNDDIKRI GVRLPGHQKR IAYSLLGLKD QVNTVGIPI 959
Nucleotide Sequence
(FASTA)
ATGGAGCTCC AGGCAGCCCG CGCCTGCTTC GCCCTGCTGT GGGGCTGTGC GCTGGCCGCG 60
GCCGCGGCGG CACAGGGCAA GGAAGTGGTA CTGCTGGACT TTGCTGCAGC TGGAGGGGAG 120
CTCGGCTGGC TCACACACCC GTATGGCAAA GGGTGGGACC TGATGCAGAA CATCATGAAT 180
GACATGCCGA TCTACATGTA CTCCGTGTGC AACGTGATGT CTGGTGACCA GGACAACTGG 240
CTCCGCACCA ACTGGGTGTA CCGAGGAGAG GCTGAGCGTA TCTTCATTGA GCTCAAGTTT 300
ACTGTACGTG ACTGCAACAG CTTCCCTGGC GGCGCCAGCT CCTGCAAGGA GACTTTCAAC 360
CTCTACTATG CCGAGTCGGA CCTGGACTAT GGCACCAACT TCCAGAAGCG CCTGTTCACC 420
AAGATTGACA CCATTGCGCC CGATGAGATC ACCGTCAGCA GCGACTTCGA GGCACGCCAC 480
GTGAAGCTGA ACGTGGAGGA GCGCTCCGTG GGGCCGCTCA CCCGCAAAGG CTTCTACCTG 540
GCCTTCCAGG ATATCGGTGC CTGTGTGGCG CTGCTCTCCG TCCGTGTCTA CTACAAGAAG 600
TGCCCCGAGC TGCTGCAGGG CCTGGCCCAC TTCCCTGAGA CCATCGCCGG CTCTGATGCA 660
CCCTCCCTGG CCACTGTGGC CGGCACCTGT GTGGACCATG CCGTGGTGCC ACCGGGCGGT 720
GAAGAGCCCC GTATGCACTG TGCAGTGGAC GGCGAGTGGC TGGTGCCCAT TGGGCAGTGC 780
CTGTGCCAGG CAGGCTATGA GAAGGTGGAG GATGCCTGCC AGGCCTGCTC TCCTGGATTC 840
TTTAAGTTTG AGGCATCTGA GAGCCCCTGC TTGGAGTGCC CTGAGCACAC GCTGCCATCC 900
CCTGAGGGTG CCACCTCCTG CGAGTGTGAG GAAGGCTTCT TCCGGGCACC TCAGGACCCA 960
GCGTCGATGC CTTGCACACG ACCCCCCTCC GCCCCACACT ACCTCACGGC CGTGGGCATG 1020
GGTGCCAAGG TGGAGCTGCG CTGGACGCCC CCTCAGGACA GCGGAGGCCG CGAGGACATT 1080
GTCTACAGCG TCACCTGTGA ACAGTGCTGG CCCGAGTCTG GGGAGTGCGG GCCGTGTGAG 1140
GCCAGTGTGC GCTACTCGGA GCCTCCGCAC GGATTGACCC GAACCAGTGT GACAGTCAGC 1200
GACCTGGAGC CCCACATGAA CTACACCTTT ACCGTGGAGG CCCGCAATGG CGTCTCAGGC 1260
CTGGTGACCA GCCGCAGCTT CCGTACTGCC AGTGTCAGCA TCAACCAGAC AGAGCCCCCC 1320
AAGGTGAGGC TGGAGGGCCG CAGCACCACC TCTCTTAGCG TCTCCTGGAG CATCCCCCCG 1380
CCGCAGCAGA GCCGCGTGTG GAAGTACGAG GTCACCTACC GCAAGAAGGG AGACTCCAAC 1440
AGCTACAACG TGCGCCGCAC TGAGGGTTTC TCCGTGACCC TGGATGACCT GGCTCCGGAC 1500
ACCACCTACC TGGTCCAGGT GCAGGCACTG ACGCAGGAGG GCCAGGGGGC CGGCAGCAAG 1560
GTGCACGAAT TCCAGACGCT GTCCCCGGAG GGATCTGGCA ACTTGGCGGT GATTAGCGGC 1620
GTGGCTGTCG GTGTGGTCCT GCTTCTGGTG CTGGCAGGAG TTGGCTTCTT TATCCACCGC 1680
AGGAGGAAGA ACCTGCGTGC CCGCCAGTCC CCAGAGGACG TTTACTTCTC CAAGTCAGAA 1740
CAACTGAAGC CCCTGAAGAC ATACGTGGAC CCCCACACAT ATGAGGACCC CAACCAGGCT 1800
GTGTTGAAGT TCACTACGGA GATCCATCCA TCCTGTGTCA CTCGGCAGAA GGTGATTGGA 1860
GCAGGAGAGT TTGGGGAGGT GTACAAGGGC ACGCTGAAGA CATCCTTCGG GAAGAAGGAG 1920
GTGCCGGTGG CCATCAAGAC GCTGAAAGCC GGATTGACAG AAAAGCAGCG AGTGGACTTC 1980
CTTGGCGAGG CCGGCATCAT GGGCAAGCCC ATGATGATCA TCACTGAGTA CATGGAGAAT 2040
GGGGCCCTGG ACAAGTTCCT TCGGGAGAAG GATGGTGAGT TCAGCGTGCT GCAGCTGGTG 2100
GGCATGCTGC GGGGCATCGC AGCTGGCATG AAGTACCTGG CCAACATGAA CTATGTGCAC 2160
CGTGACCTGG CTGCCCGCAA CATCCTCGTC AACAGCAACC TGGTCTGCAA GGTGTCTGAC 2220
TTTGGCCTGT CCCGCGTGCT GGAGGACGAC CCCGAGGCCA CCTACACCAC CAGTGGCGGC 2280
AAGATCCCCA TCCGCTGGAC CGCCCCAGAG GCCATTTCCT ACCGCAAGTT CACCTCTGCC 2340
AGCGACGTGT GGAGCTTTGG CATTGTCATG TGGGAGGTGA TGACCTACGG CGAGCGGCCC 2400
TACTGGGAGC TGTCCAACCA CGAGGTAATG AAAGCCATCA ATGATGGCTT CCGGCTCCCC 2460
ACGCCCATGG ACTGCCCCTC CGCCATCTAC CAGCTCATGA TGCAGTGCTG GCAGCAGGAG 2520
CGTGCCCGCC GCCCCAAGTT CGCTGACATC GTCAGCATCC TGGACAAGCT CATTCGTGCC 2580
CCTGACTCCC TCAAGACCCT GGCTGACTTC GACCCCCGGG TGTCTATCCG GCTCCCCAGC 2640
ACGAGCGGCT CAGAGGGGGT GCCTTTCCGC ACGGTGTCCG AGTGGCTGGA GTCCATCAAG 2700
ATGCAGCAGT ATACGGAGCA CTTCATGGCG GCCGGCTACA CTGCCATCGA GAAGGTGGTG 2760
CAGATGACCA ACGACGACAT CAAGAGGATT GGGGTGCGGC TGCCCGGCCA CCAGAAGCGC 2820
ATCGCCTACA GCCTGCTGGG ACTCAAGGAC CAGGTGAACA CTGTGGGGAT CCCCATCTGA 2880
Domain Profile
S: 2     kiekviGaGefGevcsGrlkl.pgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         + +kviGaGefGev++G+lk+  gk+e++vaiktlkag tekqr+dfl ea i+G     
Q: 614   TRQKVIGAGEFGEVYKGTLKTsFGKKEVPVAIKTLKAGLTEKQRVDFLGEAGIMG-----  668
         6789****************9568******************************9.....
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
                     kp+mi+teymengald+flr+kdg+f+v+qlvgmlrGia+gmkyl++m
Q: 669   ------------KPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANM  716
         ............69**********************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         +yvhrdlaarnilvnsnlvckvsdfGlsrvledd+ea+yttsggkipirwtapeai+yrk
Q: 717   NYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRK  776
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvws+Giv+wev++yGerpyw++sn++v+kai++g+rlp+pmdcp+a+yqlm++c
Q: 777   FTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQC  836
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wq++ra+rpkf++ivsil
Q: 837   WQQERARRPKFADIVSIL  854
         ***************985
Domain Sequence
(FASTA)
TRQKVIGAGE FGEVYKGTLK TSFGKKEVPV AIKTLKAGLT EKQRVDFLGE AGIMGKPMMI 60
ITEYMENGAL DKFLREKDGE FSVLQLVGML RGIAAGMKYL ANMNYVHRDL AARNILVNSN 120
LVCKVSDFGL SRVLEDDPEA TYTTSGGKIP IRWTAPEAIS YRKFTSASDV WSFGIVMWEV 180
MTYGERPYWE LSNHEVMKAI NDGFRLPTPM DCPSAIYQLM MQCWQQERAR RPKFADIVSI 240
L 241
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00009
EKS-ANC-00009
EKS-BOT-00008
EKS-CAJ-00009
EKS-CAF-00010
EKS-CAP-00007
EKS-DAR-00015
EKS-EQC-00010
EKS-FEC-00007
EKS-GAM-00004
EKS-GAA-00015
EKS-GOG-00009
EKS-HOS-00011
EKS-ICT-00009
EKS-LAC-00010
EKS-LOA-00010
EKS-MAM-00009
EKS-MAE-00001
EKS-MEG-00012
EKS-MUM-00010
EKS-MUP-00010
EKS-MYL-00011
EKS-NOL-00009
EKS-OCP-00002
EKS-ORN-00018
EKS-ORA-00008
EKS-ORC-00009
EKS-ORL-00015
EKS-OTG-00010
EKS-PAT-00012
EKS-PES-00008
EKS-RAN-00009
EKS-SAH-00008
EKS-SUS-00007
EKS-TAR-00014
EKS-TEN-00014
EKS-XIM-00015
Gene Ontology
GO:0005925; C:focal adhesion
GO:0005887; C:integral to plasma membrane
GO:0031256; C:leading edge membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0032863; P:activation of Rac GTPase activity
GO:0006915; P:apoptotic process
GO:0048320; P:axial mesoderm formation
GO:0046849; P:bone remodeling
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0060326; P:cell chemotaxis
GO:0030216; P:keratinocyte differentiation
GO:0070309; P:lens fiber cell morphogenesis
GO:0033598; P:mammary gland epithelial cell proliferation
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0021915; P:neural tube development
GO:0030182; P:neuron differentiation
GO:0060035; P:notochord cell development
GO:0014028; P:notochord formation
GO:0001649; P:osteoblast differentiation
GO:0030316; P:osteoclast differentiation
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane
GO:0043491; P:protein kinase B signaling cascade
GO:0045765; P:regulation of angiogenesis
GO:0043535; P:regulation of blood vessel endothelial cell migration
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0010591; P:regulation of lamellipodium assembly
GO:0070848; P:response to growth factor stimulus
GO:0001501; P:skeletal system development
GO:0001570; P:vasculogenesis
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013