EKS-POA-00168
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00168
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC438.01.4E-131380634255
StatusUnreviewed
Ensembl ProteinENSPPYP00000002397
UniProt AccessionH2N9P8;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCQ
Gene Synonyms/Alias PRKCQ;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000002071ENSPPYP00000002397ENSPPYT00000002470
OrganismPongo abelii
Functional Description
Protein Length706
Protein Sequence
(FASTA)
MSPFLRIGLS NFDCGSCQSC QGEAVNPYCA VLVKEYVESE NGQMYIQKKP TMYPPWDSTF 60
DAHINKGRVM QIIVKGKNVD LISETTVELY SLAERCRKNN GKTEIWLELK PQGRMLMNAR 120
YFLEMSDTKD MSEFEMEGFF ALHQRRGAIK QAKVHHVKCH EFTATFFPQP TFCSVCHEFV 180
WGLNKQGYQC RQCNAAIHKK CIDKVIAKCT GSAINSRETM FHKERFKIDM PHRFKVYNYK 240
SPTFCEHCGT LLWGLARQGL KCDACGMNVH HRCQTKVANL CGINQKLMAE ALAMIESTQQ 300
ARCLRDTEQI FREGPVEIGL PCSIKNEARP LCLPTPGKRE PQGISWESPL DEVDKMCHLP 360
EPELTIERPS LQMKLKIEDF ILHKMLGKGS FGKVFLAEFK KTNQFFAIKT LKKDVVLMDD 420
DVECTMVEKR VLSLAWEHPF LTHMFCTFQT KENLFFVMEY LNGGDLMYHI QSCHKFDLSR 480
ATFYAAEIIL GLQFLHSKGI VYRDLKLDNI LLDKDGHIKI ADFGMCKENM LGDAKTNTFC 540
GTPDYIAPEI LLGQKYNHSV DWWSFGVLLY EMLIGQSPFH GQDEEELFHS IRMDNPFYPR 600
WLEKEAKDLL VKLFVREPEK RLGVRGDIRQ HPLFREINWE ELERKEIDPP FRPKVKSPYD 660
CSNFDKEFLN EKPRLSFADR ALINSMDQNM FRNFSFMNPG MERLIS 706
Nucleotide Sequence
(FASTA)
ATGTCGCCAT TTCTTCGGAT TGGCTTGTCC AACTTTGACT GCGGGTCCTG CCAGTCTTGT 60
CAGGGCGAGG CTGTTAACCC TTACTGTGCT GTGCTCGTCA AAGAGTATGT CGAATCAGAG 120
AACGGGCAGA TGTATATCCA GAAAAAGCCT ACCATGTACC CACCCTGGGA CAGCACTTTT 180
GATGCCCATA TCAACAAGGG AAGAGTCATG CAGATCATTG TGAAAGGCAA AAACGTGGAC 240
CTCATCTCTG AAACCACTGT GGAGCTCTAC TCGCTGGCTG AGAGGTGCAG GAAGAACAAC 300
GGGAAGACAG AAATATGGTT AGAGCTGAAA CCTCAAGGCC GAATGCTAAT GAATGCAAGA 360
TACTTTCTGG AAATGAGTGA CACAAAGGAC ATGAGTGAAT TTGAGATGGA AGGCTTCTTT 420
GCTTTGCATC AGCGCCGGGG TGCCATCAAG CAGGCAAAGG TCCACCACGT CAAGTGCCAC 480
GAGTTCACCG CCACCTTCTT CCCACAGCCC ACATTTTGCT CTGTCTGCCA CGAGTTTGTC 540
TGGGGCCTGA ACAAACAGGG CTACCAGTGC CGACAATGCA ATGCAGCAAT TCACAAGAAG 600
TGTATTGATA AAGTTATAGC AAAGTGCACA GGATCAGCTA TCAATAGCCG AGAAACCATG 660
TTCCACAAGG AGAGATTCAA AATTGACATG CCACACAGAT TTAAGGTCTA CAATTACAAG 720
AGCCCAACCT TCTGTGAACA CTGTGGGACC CTGCTGTGGG GACTGGCACG GCAAGGGCTC 780
AAGTGTGATG CATGTGGCAT GAATGTGCAT CACAGATGCC AGACAAAGGT GGCCAACCTT 840
TGTGGCATAA ACCAGAAGCT AATGGCTGAA GCGCTGGCCA TGATTGAGAG CACTCAACAG 900
GCTCGCTGCT TAAGAGATAC TGAACAGATC TTCAGAGAAG GTCCGGTTGA AATTGGTCTC 960
CCATGCTCCA TCAAAAATGA AGCAAGGCCG CTATGTTTAC CAACACCGGG AAAAAGAGAG 1020
CCTCAGGGCA TTTCCTGGGA GTCTCCGTTG GATGAGGTGG ATAAAATGTG CCATCTTCCA 1080
GAACCTGAAC TGACCATAGA AAGACCATCT CTGCAGATGA AACTAAAAAT CGAGGATTTT 1140
ATCTTGCACA AAATGTTGGG GAAAGGAAGT TTTGGCAAGG TCTTCCTGGC AGAATTCAAG 1200
AAAACTAATC AATTTTTCGC AATAAAGACC TTAAAGAAAG ATGTGGTCTT GATGGATGAT 1260
GATGTTGAGT GCACAATGGT AGAGAAGAGA GTTCTTTCCT TGGCCTGGGA GCATCCATTT 1320
CTGACGCATA TGTTTTGTAC GTTCCAGACC AAGGAAAACC TCTTTTTTGT GATGGAGTAC 1380
CTCAACGGAG GGGACTTAAT GTACCACATC CAAAGCTGCC ACAAGTTCGA CCTTTCCAGA 1440
GCGACGTTTT ATGCTGCTGA AATCATTCTT GGTCTGCAGT TCCTTCATTC CAAAGGAATA 1500
GTCTACAGGG ACCTGAAGCT AGATAACATC CTGTTAGACA AAGATGGACA TATCAAGATC 1560
GCGGATTTTG GAATGTGCAA AGAGAACATG TTAGGAGATG CCAAGACGAA TACCTTCTGT 1620
GGGACACCCG ACTACATTGC CCCAGAGATC TTGCTGGGTC AGAAATACAA CCACTCTGTG 1680
GACTGGTGGT CCTTCGGGGT TCTCCTTTAT GAGATGCTGA TTGGTCAGTC GCCTTTCCAC 1740
GGGCAGGATG AGGAGGAGCT CTTCCACTCC ATCCGCATGG ACAATCCCTT TTATCCACGG 1800
TGGCTGGAGA AGGAGGCAAA GGACCTTCTG GTGAAGCTCT TTGTGCGAGA ACCTGAGAAG 1860
AGGCTGGGCG TGAGGGGAGA CATCCGCCAG CACCCTTTGT TTCGGGAGAT CAACTGGGAG 1920
GAACTTGAAC GGAAGGAGAT TGACCCACCG TTCCGGCCGA AAGTGAAATC ACCATATGAC 1980
TGCAGCAATT TCGACAAAGA ATTCTTAAAC GAGAAGCCCC GGCTGTCATT TGCCGACAGA 2040
GCACTGATCA ACAGCATGGA CCAGAATATG TTCAGGAACT TTTCCTTCAT GAACCCCGGG 2100
ATGGAGCGGC TGATATCCTG A 2121
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f l+k+lGkGsfgkv+lae kkt++++aik lkkdvvl+dddve+t+vekrvl+la+++p
Q: 380   FILHKMLGKGSFGKVFLAEFKKTNQFFAIKTLKKDVVLMDDDVECTMVEKRVLSLAWEHP  439
         7899********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+++f++fqt+++lffv+ey+nGGdlm+hiq+++k++ +ra+fyaaeiil+l+flh+kg
Q: 440   FLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKG  499
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         i+yrdlkldn+lld++Ghik+adfG+cke++l +++t+tfcGtPdyiaPeil +++y++s
Q: 500   IVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHS  559
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdww++Gvllyeml+gqsPf+g+de+elf+si++++++yP++l+kea+++l +l+ ++pe
Q: 560   VDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLLVKLFVREPE  619
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlGv  +g  di++h++f
Q: 620   KRLGV--RG--DIRQHPLF  634
         *****..55..89999987
Domain Sequence
(FASTA)
FILHKMLGKG SFGKVFLAEF KKTNQFFAIK TLKKDVVLMD DDVECTMVEK RVLSLAWEHP 60
FLTHMFCTFQ TKENLFFVME YLNGGDLMYH IQSCHKFDLS RATFYAAEII LGLQFLHSKG 120
IVYRDLKLDN ILLDKDGHIK IADFGMCKEN MLGDAKTNTF CGTPDYIAPE ILLGQKYNHS 180
VDWWSFGVLL YEMLIGQSPF HGQDEEELFH SIRMDNPFYP RWLEKEAKDL LVKLFVREPE 240
KRLGVRGDIR QHPLF 255
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00175
EKS-CAF-00182
EKS-CAP-00174
EKS-DAR-00470
EKS-EQC-00171
EKS-FEC-00165
EKS-GAM-00093
EKS-GAG-00151
EKS-GAA-00211
EKS-GOG-00174
EKS-HOS-00181
EKS-LAC-00186
EKS-LOA-00174
EKS-MAM-00171
EKS-MOD-00173
EKS-MUM-00181
EKS-MUP-00179
EKS-MYL-00184
EKS-NOL-00167
EKS-ORN-00220
EKS-ORA-00152
EKS-ORC-00162
EKS-ORL-00206
EKS-OTG-00180
EKS-PAT-00165
EKS-PES-00155
EKS-PEM-00089
EKS-RAN-00171
EKS-SUS-00153
EKS-TAG-00203
EKS-TEN-00220
EKS-XIM-00215
Gene Ontology
GO:0005737; C:cytoplasm
GO:0001772; C:immunological synapse
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004697; F:protein kinase C activity
GO:0035556; P:intracellular signal transduction
GO:0006509; P:membrane protein ectodomain proteolysis
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0070233; P:negative regulation of T cell apoptotic process
GO:0032740; P:positive regulation of interleukin-17 production
GO:0045086; P:positive regulation of interleukin-2 biosynthetic process
GO:0032753; P:positive regulation of interleukin-4 production
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0042102; P:positive regulation of T cell proliferation
GO:2000318; P:positive regulation of T-helper 17 type immune response
GO:2000570; P:positive regulation of T-helper 2 cell activation
GO:0090330; P:regulation of platelet aggregation
KEGG
pon:100443896;
InterPros
IPR000961; AGC-kinase_C.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR014376; Prot_kin_PKC_delta.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013