EKS-POA-00287

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00287

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IKK	436.4	4.6E-131	15	288	274

Status

Unreviewed

Ensembl Protein

ENSPPYP00000002975

UniProt Accession

H2NBA4;

Protein Name

Protein Synonyms/Alias

Gene Name

CHUK

Gene Synonyms/Alias

CHUK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000002562	ENSPPYP00000002975	ENSPPYT00000003078

Organism

Pongo abelii

Functional Description

Protein Length

746

Protein Sequence
(FASTA)

MERPPGLRPG AGGPWEMRER LGTGGFGNVC LYQHRELDLK IAIKSCRLEL STKNRERWCH 60

EIQIMKKLNH ANVVKACDVP EELNILIHDV PLLAMEYCSG GDLRKLLNKP ENCCGLKESQ 120

ILSLLSDIGS GIRYLHENKI IHRDLKPENI VLQDVGGKII HKIIDLGYAK DVDQGSLCTS 180

FVGTLQYLAP ELFENKPYTA TVDYWSFGTM VFECIAGYRP FLHHLQPFTW HEKIKKKDPK 240

CIFACEEMSG EVRFSSHLPQ PNSLCSLIVE PMENWLQLML NWDPQQRGGP VDLTLKQPRC 300

FVLMDHILNL KIVHILNMTS AKIISFLLPP DESLHSLQSR IERETGINTG SQELLSETGI 360

SLDPRKPASQ CVLDGVRGCD SYMVYLFDKS KTVYEGPFAS RSLSDCVNYI VQDRQNTSFQ 420

LYRLRKVWAE AVHYVSGTKK NYSRLFQGQK GLGLSLLRYN ANLTKMKNTL ISASQQLKAK 480

LEFFHKSIQL DLERYSEQMT YGICQKKMLK AWKEMEEKAI HYAEVGVIGY LEDQIMSLHA 540

EIMELQKEPL WKRQGDLMES LEQRAIDLYK QLKHRPSDHS YSDSTEMVKI IVHTVQSQDR 600

VLKELFGHLS KLLGCKQKII DLLPKVEVAL SNIKEADNTV MFMQGKRQKE IWHLLKIACT 660

QSSARSLVGS SLEGAVTPQA SAWLPPTSAE HDHSLSCVVT PQDGETSAQM IAENLNCLGH 720

LSTIIHEANE EQGSSMMNLD WSWLTE 746

Nucleotide Sequence
(FASTA)

ATGGAGCGGC CCCCGGGGCT GCGGCCGGGC GCGGGCGGGC CCTGGGAGAT GCGGGAGCGG 60

CTGGGCACCG GCGGCTTCGG GAACGTCTGT CTGTACCAGC ATCGGGAACT TGATCTCAAA 120

ATAGCAATTA AGTCTTGTCG CCTAGAGCTA AGTACCAAAA ACAGAGAACG ATGGTGCCAT 180

GAAATCCAGA TTATGAAGAA GTTGAACCAT GCCAATGTTG TAAAGGCCTG TGATGTTCCT 240

GAAGAACTGA ATATTTTGAT TCATGATGTG CCTCTTCTAG CAATGGAATA CTGTTCTGGA 300

GGAGATCTCC GAAAGCTGCT CAACAAACCA GAAAATTGTT GTGGACTTAA AGAAAGCCAG 360

ATACTTTCTT TACTAAGTGA TATAGGGTCT GGGATTCGAT ATTTGCATGA AAACAAAATT 420

ATACATCGAG ATCTAAAACC TGAAAACATA GTTCTTCAGG ATGTTGGTGG AAAGATAATA 480

CATAAAATAA TTGATCTGGG ATATGCCAAA GATGTTGATC AAGGAAGTCT GTGTACATCT 540

TTTGTGGGAA CACTGCAGTA TCTGGCCCCA GAGCTCTTTG AGAATAAGCC TTACACAGCC 600

ACTGTTGATT ATTGGAGCTT TGGGACCATG GTATTTGAAT GTATTGCTGG ATATAGGCCT 660

TTTTTGCATC ATCTGCAACC ATTTACCTGG CATGAGAAGA TTAAGAAGAA GGATCCAAAG 720

TGTATATTTG CATGTGAAGA GATGTCAGGA GAAGTTCGGT TTAGTAGCCA TTTACCTCAA 780

CCAAATAGCC TTTGTAGTTT AATAGTAGAA CCCATGGAAA ACTGGCTACA GTTGATGTTG 840

AATTGGGACC CACAGCAGAG AGGAGGACCT GTTGACCTTA CTTTGAAGCA GCCAAGATGT 900

TTTGTATTAA TGGATCACAT TTTGAATTTG AAGATAGTAC ACATCCTAAA TATGACTTCT 960

GCAAAGATAA TTTCTTTTCT GTTACCACCT GATGAAAGTC TTCATTCACT ACAGTCTCGT 1020

ATTGAGCGTG AAACTGGAAT AAATACTGGT TCTCAAGAAC TTCTTTCAGA GACAGGAATT 1080

TCTCTGGATC CTCGGAAACC AGCCTCTCAA TGTGTTCTAG ATGGAGTTAG AGGCTGTGAT 1140

AGCTATATGG TTTATTTGTT TGATAAAAGT AAAACTGTAT ATGAAGGGCC ATTTGCTTCC 1200

AGAAGTTTAT CTGATTGTGT AAATTATATT GTACAGGACA GGCAAAATAC AAGCTTCCAA 1260

TTATACAGGC TGCGTAAAGT GTGGGCTGAA GCAGTGCACT ATGTGTCTGG AACTAAGAAG 1320

AACTATAGCA GGCTCTTTCA GGGACAAAAG GGTTTAGGGT TAAGTCTTCT TAGATATAAT 1380

GCTAACTTAA CAAAAATGAA GAACACTTTG ATCTCAGCAT CACAACAACT GAAAGCTAAA 1440

TTGGAGTTTT TTCACAAAAG CATTCAGCTT GACTTGGAGA GATACAGTGA GCAGATGACG 1500

TATGGGATAT GTCAGAAAAA AATGCTAAAA GCATGGAAAG AAATGGAAGA AAAGGCCATC 1560

CACTATGCTG AGGTTGGTGT CATTGGATAC CTGGAGGATC AGATTATGTC TTTGCATGCT 1620

GAAATCATGG AGCTACAGAA AGAGCCCCTA TGGAAGCGTC AGGGAGACTT GATGGAATCT 1680

CTGGAACAGC GTGCCATTGA TCTATATAAG CAGTTAAAAC ACAGACCTTC AGATCACTCC 1740

TACAGTGACA GCACAGAGAT GGTGAAAATC ATTGTGCACA CTGTGCAGAG TCAGGACCGT 1800

GTGCTCAAGG AGCTGTTTGG TCATTTGAGC AAGTTGTTGG GCTGTAAGCA GAAGATTATT 1860

GATCTACTCC CTAAGGTGGA AGTGGCCCTC AGTAATATCA AAGAAGCTGA CAATACTGTC 1920

ATGTTCATGC AGGGAAAAAG GCAGAAAGAA ATATGGCATC TCCTTAAAAT TGCCTGTACA 1980

CAGAGTTCTG CCCGGTCCCT TGTAGGATCC AGTCTAGAAG GTGCAGTAAC CCCTCAGGCA 2040

TCAGCATGGC TGCCCCCGAC TTCAGCAGAA CATGATCATT CTCTGTCATG TGTGGTAACT 2100

CCTCAAGATG GGGAGACTTC AGCACAAATG ATAGCAGAAA ATTTGAACTG CCTTGGCCAT 2160

TTAAGCACTA TTATTCATGA GGCAAATGAG GAACAGGGCA GTAGTATGAT GAATCTTGAT 2220

TGGAGTTGGT TAACAGAA 2238

Domain Profile

S: 1     WelkelLGeGafgnvikarnkktgekiavkvikeesslrprevqvrelevlrklnhkniv  60

         We++e+LG+G+fgnv+ +++++ + kia+k+++ e+s+++re++++e+++++klnh+n+v

Q: 15    WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVV  74

         ************************************************************

S: 61    klvdveeelnlasarlkvlvleyCsgGdlrkvLeepenayGLkesevlvvLsdvvaglry  120

         k++dv+eeln++ +++++l++eyCsgGdlrk+L++pen++GLkes++l++Lsd+ +g+ry

Q: 75    KACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRY  134

         ************************************************************

S: 121   LrenkivhRDlkPenivllkgedgksiykltDlGaareldddekvvslvGteeYlaPely  180

         L+enki+hRDlkPenivl+++ +gk i+k++DlG+a+++d++++++s+vGt++YlaPel+

Q: 135   LHENKIIHRDLKPENIVLQDV-GGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELF  193

         ********************9.**************************************

S: 181   eqkkytatvDlWsiGvllyeaitGslPflpfegprrlykkitkkpakaiagtekangeve  240

         e+k ytatvD+Ws+G++++e+i+G++Pfl++ +p+++++ki+kk++k+i+++e+++gev+

Q: 194   ENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVR  253

         ************************************************************

S: 241   fssslPlsaslssglqeklekllanllevdeekrw  275

         fss+lP+++sl+s+++e +e++l+++l++d+++r+

Q: 254   FSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRG  288

         ********************************986

Domain Sequence
(FASTA)

WEMRERLGTG GFGNVCLYQH RELDLKIAIK SCRLELSTKN RERWCHEIQI MKKLNHANVV 60

KACDVPEELN ILIHDVPLLA MEYCSGGDLR KLLNKPENCC GLKESQILSL LSDIGSGIRY 120

LHENKIIHRD LKPENIVLQD VGGKIIHKII DLGYAKDVDQ GSLCTSFVGT LQYLAPELFE 180

NKPYTATVDY WSFGTMVFEC IAGYRPFLHH LQPFTWHEKI KKKDPKCIFA CEEMSGEVRF 240

SSHLPQPNSL CSLIVEPMEN WLQLMLNWDP QQRG 274

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0008384	; F:IkappaB kinase activity
GO:0007252	; P:I-kappaB phosphorylation
GO:0007595	; P:lactation
GO:0060749	; P:mammary gland alveolus development
GO:0033598	; P:mammary gland epithelial cell proliferation
GO:0002011	; P:morphogenesis of an epithelial sheet
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0030316	; P:osteoclast differentiation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade

KEGG

InterPros

IPR022007	; IKKbetaNEMObind.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12179	; IKKbetaNEMObind; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013