EKS-POA-00310

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00310

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	333.9	7.0E-100	34	292	259

Status

Unreviewed

Ensembl Protein

ENSPPYP00000003059

UniProt Accession

H2NBI4;

Protein Name

Protein Synonyms/Alias

Gene Name

SLK

Gene Synonyms/Alias

SLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000002629	ENSPPYP00000003059	ENSPPYT00000003163

Organism

Pongo abelii

Functional Description

Protein Length

1236

Protein Sequence
(FASTA)

MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EDFWEIIGEL GDGAFGKVYK AQNKETSVLA 60

AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120

LELERPLTES QIQVVCKQTL DALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 180

TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP 240

MRVLLKIAKS EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPI 300

RELIAEAKAE VTEEVEDGKE EDEEEETENS LPIPASKRAS SDLSIASSEE DKLSQNACIL 360

ESVSEKTERS NSEDKLNSKI LNEKPITDEP EKAVEDINEH ITDAQLEAMT ELHDRTAVIK 420

ENEREEKRPK LENLPDTEDQ ETVDINSVSE GKENNIMITL ETNIEHNLKS EEEKDQEKQQ 480

MFENKLIKSE EIKDTILQTV NLVSQETGEK EANIQAVDSE VGLTKEDTQE KLGEEDKTQK 540

DVISNTSDVT GTYEAADVAQ KADEDSAEDT QSNDGKEVVE VGQKLINKPM VGPEAGGTKE 600

VPIKEIVEMN EIEEGKNKEQ VINSSENIMD INEEPGTTEV EEITESSSTE EMEVRSVVAD 660

TDQKALGSEV QDASKVTTQI DKEKKEIPMS IKKEPQVTAV SQPTEPQPVL IPSININSDS 720

GENKEAIGSL SKTETILPPE SENPKENDND SGTGSAADTS SIDLNLSISS FLSKTKDSGS 780

ISLQETRRQK KTLKKTRKFI VDGVEVSVTT SKIVTDSDSK TEELRFLRRQ ELRELRFLQK 840

EEQRAQQQLN SKLQQQREQI FRRFEQEMMS KKRQYDQEIE NLEKQQKQTI ERLEQEHTNR 900

LRDEAKRIKG EQEKELSKFQ NMLKNRKKEV INEVEKAPKE LRKELMKRRK EELAQSQHAQ 960

EQEFVQKQQQ ELDGSLKKII QQQKAELANI ERECLNNKQQ LMRAREAAIW ELEERHLQEK 1020

HQLLKQQLKD QYFMQRHQLL KRHEKETEQM QRYNQRLIEE LKNRQTQERA RLPKIQRSEA 1080

KTRMAMFKKS LRINSTATPD QDRDKIKQFA AQEEKRQKNE RMAQHQKHEN QMRDLQLQCE 1140

ANVRELHQLQ NEKCHLLVEH ETQKLKELDE EHSQELKEWR EKLRPRKKTL EEEFARKLQE 1200

QEVFFKMTGE SECLNPSTQS RISKFYPIPS LHSTGS 1236

Nucleotide Sequence
(FASTA)

ATGTCCTTCT TCAATTTCCG TAAGATCTTC AAGTTGGGGA GCGAGAAGAA GAAGAAACAG 60

TACGAACACG TGAAGAGGGA CCTGAACCCC GAAGACTTTT GGGAGATTAT AGGCGAACTG 120

GGCGACGGAG CCTTTGGGAA AGTGTACAAG GCCCAGAATA AAGAGACCAG TGTTTTAGCT 180

GCTGCAAAAG TGATTGACAC TAAATCTGAA GAAGAACTTG AAGATTACAT GGTAGAGATT 240

GATATATTAG CATCTTGTGA TCACCCAAAT ATAGTCAAGC TTCTAGATGC CTTCTATTAT 300

GAGAACAATC TTTGGATCCT CATTGAATTT TGTGCAGGTG GAGCAGTAGA TGCTGTGATG 360

CTTGAACTTG AGAGACCATT AACTGAGTCC CAAATACAAG TAGTTTGCAA GCAGACTTTA 420

GATGCATTGA ACTACTTACA TGATAATAAG ATCATCCACA GAGATCTAAA GGCTGGCAAC 480

ATTCTCTTTA CCTTAGATGG AGATATCAAA TTGGCGGATT TTGGAGTATC AGCTAAAAAC 540

ACGAGGACAA TTCAAAGAAG AGATTCCTTT ATTGGTACAC CATATTGGAT GGCTCCTGAA 600

GTAGTCATGT GTGAAACATC TAAGGACAGA CCCTATGACT ACAAAGCTGA TGTTTGGTCC 660

CTGGGTATCA CTTTAATAGA AATGGCTGAG ATAGAACCAC CTCATCATGA ATTAAATCCA 720

ATGCGAGTGC TGCTAAAAAT AGCAAAATCT GAGCCACCTA CATTAGCACA GCCATCAAGA 780

TGGTCTTCAA ATTTTAAGGA CTTTCTAAAG AAATGCTTAG AAAAGAATGT GGATGCCAGG 840

TGGACTACAT CTCAGCTGCT GCAGCATCCC TTTGTTACTG TTGATTCCAA CAAACCCATC 900

CGAGAATTGA TTGCAGAGGC AAAGGCTGAA GTAACAGAAG AAGTTGAAGA TGGCAAAGAG 960

GAAGATGAAG AGGAGGAAAC AGAAAATTCT CTGCCAATAC CTGCAAGTAA GCGTGCGTCT 1020

TCTGACCTTA GTATCGCCAG CTCTGAAGAA GATAAACTTT CACAAAATGC TTGTATTTTG 1080

GAATCTGTCT CAGAAAAAAC AGAACGTAGT AACTCTGAAG ATAAACTCAA CAGCAAAATT 1140

CTTAATGAAA AACCTATCAC TGATGAACCT GAAAAGGCTG TGGAGGATAT TAATGAACAT 1200

ATTACCGATG CTCAGTTAGA AGCAATGACT GAACTCCATG ACAGAACAGC AGTAATCAAG 1260

GAGAATGAGA GAGAGGAGAA GAGGCCCAAG CTTGAAAATC TGCCTGACAC AGAAGACCAA 1320

GAAACTGTGG ACATTAATTC AGTCAGTGAA GGAAAAGAGA ATAATATAAT GATAACCTTA 1380

GAAACAAATA TTGAACATAA TCTAAAGTCT GAGGAAGAAA AGGATCAGGA AAAGCAACAG 1440

ATGTTTGAAA ATAAGCTTAT AAAATCTGAA GAAATTAAAG ATACTATTTT GCAAACAGTA 1500

AATTTAGTTT CTCAAGAGAC TGGAGAAAAA GAGGCAAATA TTCAGGCAGT TGATAGTGAA 1560

GTTGGGCTTA CAAAGGAAGA CACCCAAGAG AAACTGGGGG AAGAAGACAA AACTCAAAAA 1620

GATGTGATCA GCAATACAAG TGATGTGACA GGAACGTATG AGGCAGCAGA TGTGGCTCAG 1680

AAAGCGGATG AAGACAGCGC TGAGGATACG CAGAGTAATG ATGGGAAAGA AGTGGTCGAA 1740

GTAGGCCAGA AGTTAATTAA TAAGCCCATG GTGGGTCCTG AGGCTGGTGG TACTAAGGAA 1800

GTTCCTATTA AAGAAATAGT TGAAATGAAT GAAATAGAAG AAGGTAAAAA TAAGGAACAA 1860

GTAATAAACA GTTCAGAGAA CATAATGGAC ATCAATGAGG AACCAGGAAC AACTGAAGTT 1920

GAAGAAATCA CTGAGTCAAG TAGCACTGAA GAAATGGAGG TCAGAAGTGT GGTGGCTGAT 1980

ACTGACCAAA AGGCTTTAGG AAGTGAAGTT CAGGATGCTT CTAAAGTCAC TACTCAGATA 2040

GATAAAGAGA AAAAAGAAAT TCCAATGTCA ATTAAAAAAG AGCCTCAAGT TACTGCAGTT 2100

TCACAGCCCA CTGAACCTCA GCCTGTTCTA ATACCCAGTA TTAATATCAA CTCTGACAGT 2160

GGAGAAAATA AAGAAGCAAT AGGTTCTTTA TCAAAAACTG AAACTATTCT GCCACCAGAA 2220

TCTGAGAATC CAAAGGAAAA TGATAATGAT TCAGGCACTG GTTCCGCTGC TGATACTAGC 2280

AGTATTGACT TGAATTTATC CATCTCTAGC TTTCTAAGTA AAACTAAAGA CAGTGGATCG 2340

ATATCTTTAC AAGAAACAAG AAGACAAAAG AAAACATTGA AGAAAACACG CAAATTTATT 2400

GTTGATGGTG TAGAAGTGAG TGTAACAACA TCAAAGATAG TTACAGATAG TGATTCCAAA 2460

ACTGAAGAAT TGCGGTTTCT TAGACGTCAG GAACTTCGAG AATTAAGATT TCTTCAGAAA 2520

GAAGAGCAAA GAGCCCAACA ACAGCTCAAT AGCAAACTAC AGCAACAACG AGAACAAATT 2580

TTCCGGCGCT TTGAGCAGGA AATGATGAGT AAAAAGCGAC AATATGACCA GGAAATTGAG 2640

AATCTAGAAA AACAGCAGAA ACAGACTATC GAACGCCTGG AACAAGAGCA CACAAATCGC 2700

TTGCGAGATG AAGCCAAACG CATTAAAGGA GAACAAGAGA AAGAGTTGTC CAAATTTCAG 2760

AATATGCTGA AGAACCGAAA GAAGGAGGTT ATAAATGAAG TGGAGAAAGC ACCCAAAGAG 2820

CTGAGAAAAG AGCTCATGAA ACGCAGGAAA GAGGAGCTTG CACAAAGCCA GCATGCTCAG 2880

GAACAAGAGT TTGTTCAGAA ACAACAGCAA GAATTAGATG GCTCTCTGAA AAAGATCATC 2940

CAGCAGCAGA AGGCAGAGTT AGCTAATATT GAGAGAGAGT GCCTGAATAA CAAGCAACAG 3000

CTCATGAGAG CTCGAGAAGC TGCAATTTGG GAGCTCGAAG AACGACACTT ACAAGAAAAA 3060

CACCAGCTGC TCAAACAGCA GCTTAAAGAT CAGTATTTCA TGCAAAGACA TCAGCTACTT 3120

AAGCGCCACG AGAAGGAAAC AGAGCAAATG CAGCGTTACA ATCAAAGACT TATTGAGGAA 3180

TTGAAAAACA GACAGACTCA AGAAAGAGCA AGACTGCCCA AGATTCAGCG CAGTGAAGCC 3240

AAGACTCGAA TGGCCATGTT TAAGAAAAGT TTGAGAATTA ACTCAACAGC CACACCAGAT 3300

CAGGACCGTG ATAAAATTAA ACAGTTTGCT GCACAAGAAG AAAAGAGGCA GAAAAATGAG 3360

AGAATGGCTC AGCATCAGAA ACATGAGAAT CAAATGCGGG ATCTTCAGTT GCAGTGTGAA 3420

GCCAATGTCC GCGAACTGCA TCAGCTGCAG AATGAAAAAT GCCACTTGTT GGTTGAGCAT 3480

GAGACTCAGA AACTGAAGGA GTTAGATGAG GAACATAGCC AAGAATTAAA GGAGTGGAGA 3540

GAGAAATTGA GACCTAGGAA AAAGACACTG GAAGAAGAGT TTGCCAGGAA ACTACAGGAA 3600

CAGGAAGTAT TCTTTAAAAT GACTGGGGAG TCTGAATGCC TTAACCCATC AACACAGAGC 3660

CGGATTTCCA AATTTTATCC TATTCCCAGC TTGCATTCCA CCGGATCATA A 3711

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkvy+a++k+t+ l+a k+i+++++e+le+++ ei +l +++hpniv+

Q: 34    WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVK  93

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f++e++lw+++e++agG+++ ++  el+++l+E+qi+++++++l+aL+ylH++k+i

Q: 94    LLDAFYYENNLWILIEFCAGGAVDAVML-ELERPLTESQIQVVCKQTLDALNYLHDNKII  152

         **************************99.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+niL+t +g++kL+dfgv+a+ ++t ++r++++gtpywmAPEv+ +e   ++ Y

Q: 153   HRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCEtskDRPY  212

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaD+wslGIt+ie+ae epP+++l+p+++llki+k+epp+l +++++s++fk+f++kc

Q: 213   DYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKC  272

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+kn+++R+++s+ll+h+F+

Q: 273   LEKNVDARWTTSQLLQHPFV  292

         *******************7

Domain Sequence
(FASTA)

WEIIGELGDG AFGKVYKAQN KETSVLAAAK VIDTKSEEEL EDYMVEIDIL ASCDHPNIVK 60

LLDAFYYENN LWILIEFCAG GAVDAVMLEL ERPLTESQIQ VVCKQTLDAL NYLHDNKIIH 120

RDLKAGNILF TLDGDIKLAD FGVSAKNTRT IQRRDSFIGT PYWMAPEVVM CETSKDRPYD 180

YKADVWSLGI TLIEMAEIEP PHHELNPMRV LLKIAKSEPP TLAQPSRWSS NFKDFLKKCL 240

EKNVDARWTT SQLLQHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

pon:100446498

;

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001943	; UVR_dom.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50151	; UVR; 1.

Prints

Created Date

20-Feb-2013