EKS-POA-00143
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00143
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR559.31.2E-168316592277
StatusUnreviewed
Ensembl ProteinENSPPYP00000003165
UniProt AccessionH2NBT5;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR2
Gene Synonyms/Alias FGFR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000002710ENSPPYP00000003165ENSPPYT00000003272
OrganismPongo abelii
Functional Description
Protein Length656
Protein Sequence
(FASTA)
MLCLQPTLSS FAAQPGGTPI TDHAVAEKRE RSLSRSIALE ATRYETSTGA SLWKAWSHAD 60
KGNYTCVVEN EYGSINHTYH LDVVERSPHR PILQAGLPAN ASTVVGGDVE FVCKVYSDAQ 120
PHIQWIKHVE KNGSKYGPDG LPYLKVLKAA GVNTTDKEIE VLYIRNVTFE DAGEYTCLAG 180
NSIGISFHSA WLTVLPAPGR EKEITASPDY LEIAIYCIGV FLIACMVVTV ILCRMKNTTK 240
KPDFSSQPAV HKLTKRIPLR RQVTVSAESS SSMNSNTPLV RITTRLSSTA DTPMLAGVSE 300
YELPEDPKWE FPRDKLTLGK PLGEGCFGQV VMAEAVGIDK DKPKEAVTVA VKMLKDDATE 360
KDLSDLVSEM EMMKMIGKHK NIINLLGACT QDGPLYVIVE YASKGNLREY LRARRPPGME 420
YSYDINRVPE EQMTFKDLVS CTYQLARGME YLASQKCIHR DLAARNVLVT ENNVMKIADF 480
GLARDINNID YYKKTTNGRL PVKWMAPEAL FDRVYTHQSD VWSFGVLMWE IFTLGGSPYP 540
GIPVEELFKL LKEGHRMDKP ANCTNELYMM MRDCWHAVPS QRPTFKQLVE DLDRILTLTT 600
NEEYLDLSQP LEQYSPSYPD TRSSCSSGDD SVFSPDPMPY EPCLPQYPHI NGSVKT 656
Nucleotide Sequence
(FASTA)
ATGCTGTGCC TGCAGCCAAC ACTGTCAAGT TTCGCTGCCC AGCCGGGGGG AACCCCAATC 60
ACCGACCATG CGGTGGCTGA AAAACGGGAA AGGAGTTTAA GCAGGAGCAT CGCATTGGAG 120
GCTACAAGGT ACGAAACCAG CACTGGAGCC TCATTATGGA AAGCGTGGTC CCATGCTGAC 180
AAGGGAAATT ATACCTGTGT GGTGGAGAAT GAATACGGGT CCATCAATCA CACGTACCAC 240
CTGGATGTTG TGGAGCGATC GCCTCACCGG CCCATCCTTC AAGCCGGACT GCCGGCAAAT 300
GCCTCCACAG TGGTCGGAGG AGACGTAGAG TTTGTCTGCA AGGTTTACAG TGATGCCCAG 360
CCCCACATCC AGTGGATCAA GCACGTGGAA AAGAACGGCA GTAAATACGG GCCTGACGGG 420
CTGCCCTACC TCAAGGTTCT CAAGGCCGCC GGTGTTAACA CCACGGACAA AGAGATTGAG 480
GTTCTCTATA TTCGGAATGT AACTTTTGAG GACGCTGGGG AATATACGTG CTTGGCGGGT 540
AATTCTATTG GGATATCCTT TCACTCTGCA TGGTTGACAG TTCTGCCAGC TCCTGGAAGA 600
GAAAAGGAGA TCACAGCTTC CCCAGACTAC CTGGAGATAG CCATTTACTG CATAGGGGTC 660
TTCTTAATCG CCTGTATGGT GGTAACAGTC ATCCTGTGCC GAATGAAGAA CACGACCAAG 720
AAGCCAGACT TCAGCAGCCA GCCGGCTGTG CACAAGCTGA CCAAGCGCAT CCCCCTGCGG 780
AGACAGGTAA CAGTTTCGGC TGAGTCCAGC TCCTCCATGA ACTCCAATAC CCCGCTGGTG 840
AGGATAACAA CACGCCTCTC TTCAACGGCA GACACCCCCA TGCTGGCAGG GGTCTCCGAG 900
TATGAACTTC CAGAGGACCC AAAATGGGAG TTTCCAAGAG ATAAGCTGAC ACTGGGCAAG 960
CCCCTGGGAG AAGGTTGCTT TGGGCAAGTG GTCATGGCGG AAGCAGTGGG AATTGACAAA 1020
GACAAGCCCA AGGAGGCGGT CACCGTGGCC GTGAAGATGT TGAAAGATGA TGCCACAGAG 1080
AAAGACCTTT CTGATCTGGT GTCAGAGATG GAGATGATGA AGATGATTGG GAAACACAAG 1140
AATATCATAA ATCTTCTTGG AGCCTGCACA CAGGATGGGC CTCTCTATGT CATAGTTGAG 1200
TATGCCTCTA AAGGCAACCT CCGAGAATAC CTCCGAGCCC GGAGGCCACC CGGGATGGAG 1260
TACTCCTATG ACATTAACCG TGTTCCTGAG GAGCAGATGA CCTTCAAGGA CTTGGTGTCA 1320
TGCACCTACC AGCTGGCCAG AGGCATGGAA TACTTGGCTT CCCAAAAATG TATTCATCGA 1380
GATTTAGCAG CCAGAAATGT TTTGGTAACA GAAAACAATG TGATGAAAAT AGCAGACTTT 1440
GGACTTGCCA GAGATATCAA CAATATAGAC TATTACAAAA AGACCACCAA TGGGCGACTT 1500
CCAGTCAAGT GGATGGCTCC AGAAGCCCTG TTTGATAGAG TATACACTCA TCAGAGTGAT 1560
GTCTGGTCCT TCGGGGTGTT AATGTGGGAG ATCTTCACTT TAGGGGGCTC GCCCTACCCA 1620
GGGATTCCCG TGGAGGAACT TTTTAAGCTG CTGAAGGAAG GACACAGAAT GGATAAACCA 1680
GCCAACTGCA CCAACGAACT GTACATGATG ATGAGGGACT GTTGGCATGC AGTGCCCTCC 1740
CAGAGACCAA CGTTCAAGCA GTTGGTAGAA GACTTGGATC GAATTCTCAC TCTCACAACC 1800
AATGAGGAAT ACTTGGACCT CAGCCAACCT CTCGAACAGT ATTCACCTAG TTACCCTGAC 1860
ACAAGAAGTT CTTGTTCTTC AGGAGATGAT TCTGTTTTTT CTCCAGACCC CATGCCTTAC 1920
GAACCATGCC TTCCTCAGTA TCCACACATA AACGGCAGTG TTAAAACATG A 1971
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 316   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  375
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+t+
Q: 376   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF  435
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt
Q: 436   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  495
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 496   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  555
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl
Q: 556   RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  592
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSYDI NRVPEEQMTF 120
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00139
EKS-BOT-00148
EKS-CAE-00120
EKS-CAJ-00155
EKS-CAF-00154
EKS-CAP-00147
EKS-DAR-00432
EKS-FEC-00140
EKS-GOG-00147
EKS-HOS-00152
EKS-ICT-00144
EKS-LOA-00149
EKS-MAM-00147
EKS-MOD-00147
EKS-MUM-00151
EKS-MUP-00151
EKS-OTG-00152
EKS-PAT-00137
EKS-PTV-00139
EKS-RAN-00145
EKS-SAH-00142
EKS-TAG-00176
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013