EKS-POA-00233

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00233

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.5	2.4E-116	20	271	252

Status

Unreviewed

Ensembl Protein

ENSPPYP00000003610

UniProt Accession

H2ND17;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK2

Gene Synonyms/Alias

MARK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000003125	ENSPPYP00000003610	ENSPPYT00000003739

Organism

Pongo abelii

Functional Description

Protein Length

640

Protein Sequence
(FASTA)

MIRGRNSATS ADEQPHIGNY RLLKTIGKGN FAKVKLARHI LTGKEVAVKI IDKTQLNSSS 60

LQKLFREVRI MKVLNHPNIV KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR 120

AKFRQIVSAV QYCHQKFIVH RDLKAENLLL DADMNIKIAD FGFSNEFTFG NKLDTFCGSP 180

PYAAPELFQG KKYDGPEVDV WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM 240

STDCENLLKK FLILNPSKRG TLEQIMKDRW MNVGHEDDEL KPYVEPLPDY KDPRRTELMV 300

SMGYTREEIQ DSLVGQRYNE VMATYLLLGY KSSELEGDTI TLKPRPSADL TNSSAPSPSH 360

KVQRSVSANP KQRRFSDQAG PAIPTSNSYS KKTQSNNAEN KRPEEDRESG RKASSTAKVP 420

ASPLPGLERK KTTPTPSTNS VLSTSTNRSR NSPLLERASL GQASIQNGKD STAPQRVPVA 480

SPSAHNISSS GGAPDRTNFP RGVSSRSTFH AGQLRQVRDQ QNLPYGVTPA SPSGHSQGRR 540

GASGSIFSKF TSKFVRRNLS FRFARRNLNE PESKDRVETL RPHVVGSGGN DKEKEEFREA 600

KPRSLRFTWS MKTTSSMEPN EMMREIPQGA GPEQLPERAA 640

Nucleotide Sequence
(FASTA)

ATGATTCGGG GCCGCAACTC AGCCACCTCT GCTGATGAGC AGCCCCACAT TGGAAACTAC 60

CGGCTCCTCA AGACCATTGG CAAGGGTAAC TTTGCCAAGG TGAAGTTGGC CCGACACATC 120

CTGACTGGGA AAGAGGTAGC TGTGAAGATC ATTGACAAGA CTCAACTGAA CTCCTCCAGC 180

CTCCAGAAAC TATTCCGCGA AGTAAGAATA ATGAAGGTTT TGAATCATCC CAACATAGTT 240

AAATTATTTG AAGTGATTGA GACTGAGAAA ACGCTCTACC TTGTCATGGA GTACGCTAGT 300

GGCGGAGAGG TATTTGATTA CCTAGTGGCT CATGGCAGGA TGAAAGAAAA AGAGGCTCGA 360

GCCAAATTCC GCCAGATAGT GTCTGCTGTG CAGTACTGTC ACCAGAAGTT TATTGTCCAT 420

AGAGACTTAA AGGCAGAAAA CCTGCTCTTG GATGCTGATA TGAACATCAA GATTGCAGAC 480

TTTGGCTTCA GCAATGAATT CACCTTTGGG AACAAGCTGG ACACCTTCTG TGGCAGTCCC 540

CCTTATGCTG CCCCAGAACT CTTCCAGGGC AAAAAATATG ATGGACCCGA GGTGGATGTG 600

TGGAGCCTAG GAGTTATCCT CTATACACTG GTCAGCGGAT CCCTGCCTTT TGATGGACAG 660

AACCTCAAGG AGCTGCGGGA ACGGGTACTG AGGGGAAAAT ACCGTATTCC GTTCTACATG 720

TCCACGGACT GTGAAAACCT GCTTAAGAAA TTTCTCATTC TTAATCCCAG CAAGAGAGGC 780

ACTTTAGAGC AAATCATGAA AGATCGATGG ATGAATGTGG GTCACGAAGA TGATGAACTA 840

AAGCCTTACG TGGAGCCACT CCCTGACTAC AAGGACCCCC GGCGGACAGA GCTGATGGTG 900

TCCATGGGGT ATACACGGGA AGAGATCCAG GACTCGCTGG TGGGCCAGAG ATACAACGAG 960

GTGATGGCCA CCTATCTGCT CCTGGGCTAC AAGAGCTCCG AGCTGGAAGG CGACACCATC 1020

ACCCTGAAAC CCCGGCCTTC AGCTGATCTG ACCAATAGCA GCGCCCCATC CCCATCCCAC 1080

AAGGTACAGC GCAGCGTGTC GGCCAATCCC AAGCAGCGGC GCTTCAGCGA CCAGGCTGGT 1140

CCTGCCATTC CCACCTCTAA TTCTTACTCT AAGAAGACTC AGAGTAACAA CGCAGAAAAT 1200

AAGCGGCCTG AGGAGGACCG GGAGTCAGGG CGGAAAGCCA GCAGCACAGC CAAGGTGCCT 1260

GCCAGCCCCC TGCCCGGTCT GGAGAGGAAG AAGACCACCC CAACGCCCTC CACGAACAGC 1320

GTCCTCTCCA CCAGCACAAA TCGAAGCAGG AATTCCCCAC TTTTGGAGCG GGCCAGCCTC 1380

GGCCAGGCCT CCATCCAGAA TGGCAAAGAC AGCACAGCCC CCCAGCGTGT CCCTGTTGCC 1440

TCCCCATCCG CCCACAACAT CAGCAGCAGT GGTGGAGCCC CAGACCGAAC TAATTTCCCC 1500

CGGGGTGTGT CCAGCCGAAG CACCTTCCAT GCTGGGCAGC TCCGACAGGT GCGGGACCAG 1560

CAGAATTTGC CCTACGGTGT GACCCCAGCC TCTCCCTCTG GCCACAGCCA GGGCCGGCGG 1620

GGGGCCTCTG GGAGCATCTT CAGCAAGTTC ACCTCCAAGT TTGTACGCAG AAATCTGTCT 1680

TTCAGGTTTG CCAGAAGGAA CCTGAATGAA CCTGAAAGCA AAGACCGAGT GGAGACGCTC 1740

AGACCTCACG TGGTGGGCAG TGGCGGCAAC GACAAAGAAA AGGAAGAATT TCGGGAGGCC 1800

AAGCCCCGCT CCCTCCGCTT CACGTGGAGT ATGAAGACCA CGAGCTCCAT GGAGCCCAAC 1860

GAGATGATGC GGGAGATCCC GCAAGGTGCT GGACCCGAAC AGCTGCCAGA GCGAGCTGCA 1920

TGA 1923

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 20    YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI  79

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 80    VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV  139

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 140   HRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  199

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 200   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKR  259

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 260   GTLEQIMKDRWM  271

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKVLNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKFIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTF GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 240

GTLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013