EKS-POA-00260
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00260
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK446.27.3E-134197525329
StatusUnreviewed
Ensembl ProteinENSPPYP00000003875
UniProt AccessionH2NDR6;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK3
Gene Synonyms/Alias HIPK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000003374ENSPPYP00000003875ENSPPYT00000004023
OrganismPongo abelii
Functional Description
Protein Length1214
Protein Sequence
(FASTA)
MASQVLVYPP YVYQTQSSAF CSVKKLKVEP SSCVFQERNY PRTYVNGRNF GNSHPPTKGS 60
AFQTKIPFNR PRGHNFSLQT SAVVLKNTAG ATKVIAAQAQ QAHVQASHIG AWRNRLHFLE 120
GPQRCGLKRK SEELDNHSSA MQIVDELSIL PAMLQTNMGN PVTVVTATTG SKQNCTTGEG 180
DYQLVQHEVL CSMKNTYEVL DFLGRGTFGQ VVKCWKRGTN EIVAIKILKN HPSYARQGQI 240
EVSILARLST ENADEYNFVR AYECFQHRNH TCLVFEMLEQ NLYDFLKQNK FSPLPLKVIR 300
PILQQVATAL KKLKSLGLIH ADLKPENIML VDPVRQPYRV KVIDFGSASH VSKTVCSTYL 360
QSRYYRAPEI ILGLPFCEAI DMWSLGCVIA ELFLGWPLYP GALEYDQIRY ISQTQGLPGE 420
QLLNVGTKST RFFCKETDMS HSGWRLKTLE EHEAETGMKS KEARKYIFNS LDDIAHVNTV 480
MDLEGSDLLA EKADRREFVS LLKKMLLIDA DLRITPAETL NHPFVNMKHL LDFPHSNHVK 540
SCFHIMDICK SHLNSCDTNN HNKTSLLRPV ASSSTATLTA NFTKIGTLRS QALTTSAHSV 600
VHHGIPLQAG TAQFGCGDAF QQTLIICPPA IQGIPATHGK PTGYSIRLDN TVPLVTQAPA 660
VQPLQIRPGV LSQTWSGRTQ QMLVPAWQQV TPLAPATTTL TSESVAGSHR LGDWGKMISC 720
SNHYNSVMPQ PLLTNQITLS APQPVSVGIA HVVWPQPATT KKNKQCQNRG ILVKLMGWEP 780
GREEINAFSW SNSLQNTNIP HSAFISSKII NGKDVEEVSC IETQDNQNSE GEARNCCETS 840
IRQDSDSSVS DKQRQTIIIA DSPSPAVSVI TISSDTDEEE TSKHSLRECK GSLDCEACQS 900
TLNIDRMCSL SSPDSTLSTS SSGQSSPSPC KRPNSMSDEE QESGCDTVDG SPTSDSSGRD 960
SPFAESTFVE DTHENTELVS SADTETKPAA CSVVVPPVEL ENGLNADEHM ANTDSICQPL 1020
IKGRSAPGRL NQPSAVGTRQ QKLTSAFQQQ HLNFSQVQHF GSGHQEWNGN FGHRRQQAYI 1080
PTSVTSNPFT LSHGSPNHTA VHAHLAGNTH LGGQPTLLPY PSSATLSSAA PVAHLLASPC 1140
TSRPMLQHPT YNISHPSGIV HQVPVGLNPR LLPSPTIHQT QYKPIFPPHS YIAASPAYTG 1200
FPLSPTKLSQ YPYM 1214
Nucleotide Sequence
(FASTA)
ATGGCCTCAC AAGTCTTGGT CTACCCACCA TATGTTTATC AAACTCAGTC AAGTGCCTTT 60
TGTAGTGTGA AGAAACTCAA AGTAGAGCCA AGCAGTTGTG TATTCCAGGA AAGAAACTAT 120
CCACGGACCT ATGTGAATGG TAGAAACTTT GGAAATTCTC ATCCTCCCAC TAAGGGTAGT 180
GCTTTTCAGA CAAAGATACC ATTTAATAGA CCTCGAGGAC ACAACTTTTC ATTGCAGACA 240
AGTGCTGTTG TTTTGAAAAA CACTGCAGGT GCTACAAAGG TCATAGCAGC TCAGGCGCAG 300
CAAGCTCACG TGCAGGCATC TCACATTGGG GCGTGGCGAA ACAGATTGCA TTTCCTAGAA 360
GGTCCCCAGC GATGTGGATT AAAGCGCAAG AGTGAGGAGT TGGATAATCA TAGCAGCGCA 420
ATGCAGATTG TCGATGAATT GTCCATACTT CCTGCAATGT TGCAAACCAA CATGGGAAAT 480
CCAGTGACAG TTGTGACAGC TACCACAGGT TCAAAACAGA ATTGTACCAC TGGAGAAGGT 540
GACTATCAGT TAGTACAGCA TGAAGTCTTA TGCTCCATGA AAAATACTTA TGAAGTCCTT 600
GATTTTCTTG GTCGAGGCAC GTTTGGCCAG GTAGTTAAAT GCTGGAAAAG AGGGACAAAT 660
GAAATTGTAG CAATCAAAAT TTTGAAGAAT CATCCTTCTT ATGCACGTCA AGGTCAAATA 720
GAAGTGAGCA TATTAGCAAG GCTCAGTACT GAAAATGCTG ATGAATATAA CTTTGTACGA 780
GCTTATGAAT GCTTTCAGCA CCGTAACCAT ACTTGTTTAG TCTTTGAGAT GCTGGAACAA 840
AACTTATATG ACTTTCTGAA ACAAAATAAA TTTAGTCCCC TCCCACTAAA AGTGATTCGG 900
CCCATTCTTC AACAAGTGGC CACTGCACTG AAAAAATTGA AAAGTCTTGG TTTAATTCAT 960
GCTGATCTCA AGCCAGAGAA TATTATGTTG GTGGATCCTG TTCGGCAACC TTACAGGGTT 1020
AAAGTAATAG ACTTTGGGTC GGCCAGTCAT GTATCAAAGA CTGTTTGTTC AACATATCTA 1080
CAATCTCGGT ACTACAGAGC TCCAGAAATT ATATTGGGGT TGCCATTTTG TGAAGCCATA 1140
GACATGTGGT CATTGGGATG TGTGATTGCA GAATTATTTC TTGGATGGCC GCTCTACCCA 1200
GGAGCCTTGG AGTATGATCA GATTCGATAC ATTTCTCAGA CTCAAGGTTT GCCAGGAGAA 1260
CAGTTGTTAA ATGTGGGTAC TAAATCCACA AGATTTTTTT GCAAAGAAAC AGATATGTCT 1320
CATTCTGGTT GGAGATTAAA GACATTGGAA GAGCATGAGG CAGAGACAGG AATGAAGTCT 1380
AAAGAAGCCA GAAAATATAT TTTCAACAGT CTGGATGATA TAGCGCATGT GAACACAGTG 1440
ATGGATTTGG AAGGAAGTGA TCTTTTGGCT GAGAAAGCTG ATAGAAGAGA ATTTGTTAGT 1500
CTGTTGAAGA AAATGTTGCT GATTGATGCA GATTTAAGAA TTACTCCAGC TGAGACCCTG 1560
AACCATCCTT TTGTTAATAT GAAACATCTT CTAGATTTCC CTCATAGCAA CCATGTAAAG 1620
TCCTGTTTTC ATATTATGGA TATTTGTAAG TCCCACCTAA ATTCATGTGA CACAAATAAT 1680
CACAACAAAA CTTCACTTTT AAGACCAGTT GCTTCAAGCA GTACTGCTAC ACTGACTGCA 1740
AATTTTACTA AAATTGGAAC ATTAAGAAGT CAGGCATTGA CCACATCTGC TCATTCAGTT 1800
GTGCACCATG GAATACCTCT GCAGGCAGGA ACTGCTCAGT TTGGTTGTGG TGATGCTTTT 1860
CAGCAGACAT TGATTATCTG TCCCCCAGCT ATTCAAGGTA TTCCTGCAAC ACATGGTAAA 1920
CCCACCGGTT ATTCAATAAG GTTAGATAAT ACAGTTCCAC TTGTAACTCA GGCCCCAGCT 1980
GTGCAGCCAC TACAGATCCG ACCAGGAGTT CTTTCTCAGA CGTGGTCTGG TAGAACACAA 2040
CAGATGCTGG TGCCTGCCTG GCAACAGGTG ACACCCCTGG CTCCTGCTAC TACTACACTA 2100
ACTTCTGAAA GTGTGGCTGG TTCACACAGG CTTGGAGACT GGGGGAAGAT GATTTCATGC 2160
AGCAATCATT ATAACTCAGT GATGCCGCAG CCTCTCCTGA CCAATCAGAT AACTTTATCT 2220
GCCCCTCAGC CAGTTAGTGT GGGGATTGCA CATGTTGTCT GGCCTCAGCC TGCCACTACC 2280
AAGAAAAATA AACAGTGCCA GAACAGAGGT ATTTTGGTAA AACTAATGGG ATGGGAGCCA 2340
GGAAGAGAGG AAATAAATGC TTTCAGTTGG AGTAATTCAT TACAGAATAC CAATATCCCA 2400
CATTCAGCAT TTATTTCTTC AAAGATAATT AATGGGAAAG ATGTCGAGGA AGTAAGTTGT 2460
ATAGAAACAC AGGACAATCA GAACTCAGAA GGAGAGGCAA GAAATTGCTG TGAAACATCT 2520
ATCAGACAGG ACTCTGATTC ATCAGTTTCA GACAAACAGC GGCAAACCAT CATTATTGCT 2580
GACTCCCCGA GTCCTGCAGT GAGTGTCATC ACTATCAGCA GTGACACTGA TGAGGAAGAG 2640
ACTTCCAAAC ATTCACTCAG AGAATGTAAA GGTAGTCTAG ATTGTGAAGC TTGCCAGAGC 2700
ACTTTGAATA TTGATCGGAT GTGTTCATTA AGTAGTCCTG ATAGTACTCT GAGTACCAGC 2760
TCCTCAGGGC AGTCCAGCCC ATCCCCCTGC AAGAGACCGA ATAGTATGTC AGATGAAGAG 2820
CAAGAAAGTG GTTGTGATAC GGTGGATGGC TCTCCGACAT CCGACTCTTC CGGGCGTGAC 2880
AGTCCATTTG CAGAGAGCAC TTTTGTGGAG GACACTCATG AAAACACAGA ATTGGTATCC 2940
TCTGCCGACA CAGAAACCAA GCCAGCTGCC TGTTCTGTTG TGGTGCCACC AGTAGAACTA 3000
GAAAATGGCT TAAATGCCGA TGAGCATATG GCAAACACAG ATTCTATATG CCAGCCATTA 3060
ATAAAAGGAC GATCTGCCCC TGGAAGATTA AACCAGCCTT CTGCAGTGGG TACTCGTCAG 3120
CAAAAATTGA CATCAGCATT CCAGCAGCAG CATTTGAACT TCAGTCAGGT TCAGCACTTT 3180
GGATCTGGGC ATCAAGAGTG GAATGGAAAC TTTGGGCATA GAAGACAGCA AGCTTATATT 3240
CCTACTAGTG TTACCAGTAA TCCATTCACT CTTTCTCATG GAAGTCCCAA TCACACAGCA 3300
GTGCATGCCC ACCTGGCTGG AAATACACAC CTCGGAGGAC AGCCTACTCT ACTTCCATAC 3360
CCATCATCAG CCACCCTCAG TAGTGCTGCA CCAGTGGCCC ACCTGTTAGC CTCTCCATGT 3420
ACCTCAAGAC CTATGTTACA GCATCCAACT TATAATATCT CCCATCCCAG TGGCATAGTT 3480
CACCAAGTCC CAGTGGGCTT AAATCCCCGT CTGTTACCGT CCCCAACCAT TCATCAGACT 3540
CAGTACAAAC CAATCTTCCC ACCACATTCT TACATTGCAG CATCACCTGC ATATACTGGA 3600
TTTCCACTGA GTCCAACAAA ACTCAGCCAG TATCCATATA TGTGA 3645
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevl+++g+G+fgqVvk++++ t+eivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 197   YEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLST-ENADE  255
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr++e+f++rnh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aLk+Lk+
Q: 256   YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKS  315
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 316   LGLIHADLKPENIMLVDPVRQPyrVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLP  375
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG+ e+dq+++i++++glp e+ll+ ++k+++ff  
Q: 376   FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFck  435
         **********************************************************99
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
          t+++++ ++lkt          ks++++k+++n  ++++++++ ++ e ++ l+ek+d+
Q: 436   eTDMSHSGWRLKTLeeheaetgmKSKEARKYIFNSLDDIAHVNTVMDLEGSDLLAEKADR  495
         8889999999999999*******************************************9
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + f++llk+ml +d++ Ritp+e+l+hpfv
Q: 496   ReFVSLLKKMLLIDADLRITPAETLNHPFV  525
         99***************************7
Domain Sequence
(FASTA)
YEVLDFLGRG TFGQVVKCWK RGTNEIVAIK ILKNHPSYAR QGQIEVSILA RLSTENADEY 60
NFVRAYECFQ HRNHTCLVFE MLEQNLYDFL KQNKFSPLPL KVIRPILQQV ATALKKLKSL 120
GLIHADLKPE NIMLVDPVRQ PYRVKVIDFG SASHVSKTVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGALEYD QIRYISQTQG LPGEQLLNVG TKSTRFFCKE 240
TDMSHSGWRL KTLEEHEAET GMKSKEARKY IFNSLDDIAH VNTVMDLEGS DLLAEKADRR 300
EFVSLLKKML LIDADLRITP AETLNHPFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00252
EKS-ANC-00259
EKS-BOT-00270
EKS-CAJ-00276
EKS-CAF-00277
EKS-CAP-00305
EKS-DAR-00610
EKS-DIO-00021
EKS-EQC-00262
EKS-FEC-00256
EKS-GAG-00227
EKS-GAA-00333
EKS-GOG-00269
EKS-HOS-00276
EKS-ICT-00259
EKS-LAC-00281
EKS-LOA-00280
EKS-MAM-00272
EKS-MEG-00215
EKS-MOD-00267
EKS-MUM-00301
EKS-MUP-00267
EKS-MYL-00272
EKS-NOL-00247
EKS-ORN-00349
EKS-ORA-00234
EKS-ORC-00255
EKS-ORL-00325
EKS-OTG-00276
EKS-PAT-00255
EKS-PES-00240
EKS-RAN-00285
EKS-SAH-00254
EKS-SUS-00232
EKS-TAG-00285
EKS-TAR-00346
EKS-VIP-00012
EKS-XET-00344
EKS-XIM-00341
EKS-SAC-00053
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0009299; P:mRNA transcription
GO:0043508; P:negative regulation of JUN kinase activity
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013