EKS-POA-00090

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00090

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	418.5	2.2E-125	2643	2961	319

Status

Unreviewed

Ensembl Protein

ENSPPYP00000004403

UniProt Accession

H2NF74;

Protein Name

Protein Synonyms/Alias

Gene Name

ATM

Gene Synonyms/Alias

ATM;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000003845	ENSPPYP00000004403	ENSPPYT00000004578

Organism

Pongo abelii

Functional Description

Protein Length

3003

Protein Sequence
(FASTA)

MSLVLNDLLI CCRQLEHDRA TERKKEVEKF KRLIRDPETI KHLDRHSDSK QGKYLNWDAV 60

FRFLQKYIQK ETECLRIAKP NVSASTQASR QKKMQEISSL VKYFIKCANR RAPRLKCQEL 120

LNYIMDTVKD SSNGAIYGAD YSNILLKDIL SVRKYWCEIS QQQWLELFSV YFRLYLKPSQ 180

DVHRVLVARI IHAVTKGCCS QTDGLNSKFL DFFSKAIQCA RQEKSSSGLN HILAALTIFL 240

KTLAVNFRIR VCELGDEILP TLLYIWTQHR LNDSLKEVII ELFQLQIYIH HPKGAKTQEK 300

GAYESTKWKS ILYNLYDLLV NEISHIGSRG KYSSGFRNIA VKENLIELMA DICHQVFNED 360

TRSLEISQSY TTTQRESSDY SVPCKRKKIE LGWEVIKDHL QKSQNDFDLV PWLQIATQLI 420

SKYPASLPNC ELSPLLMILS QLLPQQRHGE RTPYVLRCLT EVALCQDKRS NLESSQKSDL 480

LKLWNKIWCI TFRGISSEQI QAENFGLLGA IIQGSLVEVD REFWKLFTGS ACRPSCPAVC 540

CLTLALTTSI VPGTVKMGIE QNMCEVNRSF SLKESIMKWL LFYQLEGDLE NSTEVPPILH 600

SNFPHLVLEK ILVSLTMKNC KAAMNFFQSV PECEHHQKYK EELSFSEVEE LFLQTTFDKM 660

DFLTIVRECG IEKHQSSIGF SVHQNLKESL DRYLLGLSEQ LLNNYSSEIT NSETLVRCSR 720

LLVGVLGCYC YMGVVAEEEA YKSELFQKAK SLMQCAGESI TLFKNKTNEE FRIGSLRNMM 780

HLCTRCLSNC TKKSPNKIAS GFFLRLLTSK LMNDIADICK SLASLIKKPF DRGEVESMEV 840

DTNGNLMEVE DQSSMNLFND YPDSSVSDAN EPGESQSTIG AINPLAEEYL SKQDLLFLDM 900

LKFLCLCVTT AQTNTVSFRA ADIRRKLLML IDSSTLDPTK SLHLHMYLML LKELPGEEYP 960

LPVEDVVELL KPLSNVCSLY RRDQDVCKTI LNYVLHIVKN LGQSNMDSEN TRDAQGQFLT 1020

VIGAFWHLTK ERKYIFSVRM ALVNCLKTLL EVDPYSKWAI LNVMGEDFPV NEVFTQFLAD 1080

NHHQVRMLAA ESINRLFQDT KGDSSRLLKA LPLKLQQTAF ENAYLKAQEG MREMSHSAEN 1140

PEPLDEIYNR KSVLLTLIAV VLSCSPICEK QALFALCKSV KENGLEPHLV KKVLKKVSET 1200

FGYRRLEDFM ASHLDYLVLE WLNLQDTEYN LSSFPFILLN YANIEDFYRS CYKVLIPHLV 1260

IRSHFDEVKS IANQIQEDWK SLLTDCFPKV LVNILPYFAY EGIGDSGMAQ RRETATKVYD 1320

MLKSENLLGK QIDHLFISNL PEIVVELLMT LHEPANSSAS QSTDLCDFSG DLDPAPNPPH 1380

FPSHVIKATF AYISNCHKTK LKSILEILSK SPDSYQKILL AICEQAAETN NVYKKHRILK 1440

IYHLFVSLLL KDIKSGLGGA WAFVLRDVIY TLIHYINQRP SCIMDVSLRS FSLCCDLLSQ 1500

VCQTAVTYCK DALENHLHVI VGTLIPLVDE QVEVQKQVLD LLKYLVIDNK DNENLYLTIK 1560

LLDPFPDHVV FKDLRITQQK IKYSRGPFSL LEEINHFLSV SVYDALPLTR LEGLKDLRRQ 1620

LELHKDQMMD IMRASQDNPQ DGIMVKLVVN LLQLSKMAIN HTGEKEVLEA VGSCLGEVGP 1680

IDFSTIAIQH SKDASYTKAL KLFEDKELQW TFIMLTYLNN TLVEDCVKVR SAAVTCLKNI 1740

LATKTGHSFW EIYKMTTDPM LAYLQPFRTS RKKFLEVPRF DKENPFEGLD DINLWIPLSE 1800

NHDIWIKTLT CAFLDSGGTK CEILQLLKPM CEVKTDFCQT VLPYLIHDIL LQDKNESWRN 1860

LLSSHVQGFF TSCLRHFSQT SRSTTPANLD SESEHFFRCC LDKKSQRTML AVVDYMRRQK 1920

RPSSGTIFND AFWLDLNYLE VAKVAQSCAA HFTALLYAEI YADKKSMDDQ EKRSLAFEEG 1980

SQSTTISSLS EKSKEETGIS LQDLLLEIYR SIGEPDSLYG CGGGKMLQPI TRLRTYEHEA 2040

MWGKALVTYD LETAIPSSTR QAGIIQALQN LGLCHILSMY LKGLDYENKD WCPELEELHY 2100

QAAWRNMQWD HCTSVSKEIE GTSYHESLYN ALQSLRDREF STFYESLKYA RVKEVEELCK 2160

RSLESVYSLY PTLSRLQAIG ELESIGELFS RSVTHGQLCE VYIKWQKHSQ LLKDSDFSFQ 2220

EPIMALRTVI LEILMEKEMD NSQRECIKDI LTKHLVELSI LARTFKNTQL PERAIFQIKQ 2280

YNSVSCGVSE WQLEEAQVFW AKKEQSLALS ILKQMIKKLD ASCAANNPSL KLIYTECLRV 2340

CGNWLAETCL ENPAVIMQTY LEKAVEVAGN YDGESGDELR NGKMKAFLSL ARFSDTQYQR 2400

IENYMKSSEF ENKQALLKRA KEEVGLLREH KIQTNRYTVK VQRELELDEL ALRALKEDRK 2460

RFLCKAVENY INCLLSGEEH DMWVFRLCSL WLENSGVSEV NGMMKRDGMK IPTYKFLPLM 2520

YQLAARMGTK MMGGLGFHEV LNNDRTEAAN RIICTIRSRR PQMVRSVEAL CDAYIILANL 2580

DATQWKTQRK GINIPADQPI TKLKNLEDVV VPTMEIKVDH TGEYGNLVTI QSFKAEFRLA 2640

GGVNLPKIID CVGSDGKERR QLVKGRDDLR QDAVMQQVFQ MCNTLLQRNT ETRKRKLTIC 2700

TYKVVPLSQR SGVLEWCTGT VPIGEFLVNN EDGAHKRYRP NDFSAFQCQK KMMEVQKKSF 2760

EEKYEVFMDV CQNFQPVFRY FCMEKFLDPA IWFEKRLAYT RSVATSSIVG YILGLGDRHV 2820

QNILINEQSA ELVHIDLGVA FEQGKILPTP ETVPFRLTRD IVDGMGITGV EGVFRRCCEK 2880

TMEVMRNSQE TLLTIVEVLL YDPLFDWTMN PLKALYLQQR PEDETELHPT LNADDQECKR 2940

NLSDIDQSFN KVAERVLMRL QEKLKGVEEG TVLSVGGQVN LLIQQAIDPK NLSRLFPGWK 3000

AWV 3003

Nucleotide Sequence
(FASTA)

ATGAGTCTAG TACTTAATGA TCTGCTTATC TGCTGCCGTC AACTAGAACA TGATAGAGCT 60

ACAGAACGAA AGAAAGAAGT TGAGAAATTT AAGCGCCTGA TTCGAGATCC TGAAACAATT 120

AAACATCTAG ATCGGCATTC AGATTCCAAA CAAGGAAAAT ATTTGAATTG GGATGCTGTT 180

TTTAGATTTT TACAGAAATA TATTCAAAAA GAAACAGAAT GTCTGAGAAT AGCAAAACCA 240

AACGTATCAG CCTCAACACA AGCCTCCAGG CAGAAAAAGA TGCAGGAAAT CAGTAGTTTG 300

GTCAAATACT TCATCAAATG TGCAAATAGA AGAGCACCTA GGCTAAAATG TCAAGAACTC 360

TTAAATTATA TCATGGATAC AGTGAAAGAT TCATCTAATG GTGCTATTTA CGGAGCTGAT 420

TATAGCAACA TACTACTCAA AGACATTCTT TCTGTGAGAA AATACTGGTG TGAAATATCT 480

CAGCAACAGT GGTTAGAATT GTTCTCTGTG TACTTCAGGC TCTATCTGAA ACCTTCACAA 540

GATGTTCATA GAGTTTTAGT GGCTAGAATA ATTCATGCTG TTACCAAAGG ATGCTGTTCT 600

CAGACTGACG GATTAAATTC CAAATTTTTG GACTTTTTTT CCAAGGCTAT TCAGTGTGCA 660

AGACAAGAAA AGAGCTCTTC AGGTCTAAAT CATATCTTAG CAGCTCTTAC TATCTTCCTC 720

AAGACTTTGG CTGTCAACTT TCGAATTCGA GTGTGTGAAT TAGGAGATGA AATTCTTCCC 780

ACTTTGCTTT ATATTTGGAC TCAACATAGA CTTAATGATT CTTTAAAAGA AGTCATTATT 840

GAATTATTTC AACTGCAAAT TTATATCCAT CATCCAAAAG GAGCCAAAAC CCAAGAAAAA 900

GGTGCTTATG AATCAACAAA ATGGAAAAGT ATTTTATACA ACTTATATGA TCTGCTAGTG 960

AATGAGATAA GTCATATAGG AAGTAGAGGA AAGTATTCTT CAGGATTTCG TAATATTGCC 1020

GTCAAAGAAA ATTTGATTGA ATTGATGGCA GATATTTGTC ACCAGGTTTT TAATGAAGAT 1080

ACCAGATCCT TGGAGATTTC TCAATCTTAT ACTACTACAC AAAGAGAATC TAGTGATTAC 1140

AGTGTACCTT GCAAAAGGAA GAAAATAGAA CTAGGCTGGG AAGTAATAAA AGATCACCTT 1200

CAGAAGTCAC AGAATGATTT TGATCTTGTG CCTTGGCTAC AGATTGCAAC CCAATTAATA 1260

TCAAAGTATC CTGCAAGTTT ACCTAACTGT GAGCTGTCTC CATTACTGAT GATACTATCT 1320

CAGCTTCTAC CCCAACAGCG ACATGGGGAA CGTACACCAT ATGTGTTACG ATGCCTTACG 1380

GAAGTTGCAT TGTGTCAAGA CAAGAGGTCA AACCTAGAAA GCTCACAAAA GTCAGATTTA 1440

TTAAAACTCT GGAATAAAAT TTGGTGTATT ACCTTTCGTG GTATAAGTTC TGAGCAAATA 1500

CAAGCTGAAA ACTTTGGCTT ACTTGGAGCC ATAATTCAGG GTAGTTTAGT TGAGGTTGAC 1560

AGAGAATTCT GGAAGTTATT TACTGGGTCA GCCTGCAGAC CTTCATGTCC TGCAGTATGC 1620

TGTTTGACTT TGGCACTGAC CACCAGTATA GTTCCAGGAA CAGTAAAAAT GGGAATAGAG 1680

CAAAATATGT GTGAAGTAAA TAGAAGCTTT TCTTTAAAGG AATCAATAAT GAAATGGCTC 1740

TTATTCTATC AGCTAGAGGG TGACTTAGAA AATAGCACAG AAGTGCCTCC AATTCTTCAC 1800

AGTAATTTTC CTCATCTTGT ACTGGAGAAA ATTCTTGTGA GTCTCACTAT GAAAAACTGT 1860

AAAGCTGCAA TGAATTTTTT CCAAAGTGTG CCAGAATGTG AACACCACCA AAAATATAAA 1920

GAAGAACTTT CATTCTCAGA AGTAGAAGAA CTATTTCTTC AGACAACTTT TGACAAGATG 1980

GACTTTTTAA CCATTGTGAG AGAATGTGGT ATAGAAAAGC ACCAGTCCAG TATTGGCTTC 2040

TCTGTCCACC AGAATCTCAA GGAATCACTG GATCGCTATC TTCTGGGATT ATCAGAACAG 2100

CTTCTGAATA ATTACTCATC TGAGATTACA AATTCAGAAA CTCTTGTCCG GTGTTCACGT 2160

CTTTTGGTGG GTGTCCTTGG CTGCTACTGT TATATGGGTG TAGTAGCTGA AGAGGAAGCA 2220

TATAAGTCAG AATTATTCCA GAAAGCCAAG TCTCTAATGC AATGTGCAGG AGAAAGTATC 2280

ACTCTGTTTA AAAATAAGAC AAATGAGGAA TTCAGAATTG GTTCCTTGAG AAATATGATG 2340

CATCTATGTA CACGTTGCTT AAGCAACTGT ACCAAGAAGA GTCCAAATAA GATTGCATCT 2400

GGCTTTTTCC TGCGATTGTT AACATCAAAG CTAATGAATG ACATTGCAGA TATTTGTAAA 2460

AGTTTAGCAT CCTTAATCAA AAAGCCATTT GACCGTGGAG AAGTAGAATC AATGGAAGTT 2520

GATACTAATG GAAATCTAAT GGAGGTGGAG GATCAGTCAT CCATGAATCT ATTTAACGAT 2580

TACCCTGATA GTAGTGTTAG TGATGCAAAC GAACCTGGAG AGAGCCAAAG TACCATAGGT 2640

GCCATTAATC CTTTAGCTGA AGAATATCTG TCAAAGCAAG ATCTACTTTT CTTAGACATG 2700

CTCAAGTTCT TGTGTTTGTG TGTAACTACT GCTCAGACCA ATACTGTGTC CTTTAGGGCA 2760

GCTGATATTC GGAGGAAATT GTTAATGTTA ATTGATTCTA GCACGCTAGA CCCTACCAAA 2820

TCCCTCCACC TGCATATGTA TCTAATGCTT TTAAAGGAGC TTCCTGGAGA AGAGTACCCC 2880

TTGCCAGTGG AAGATGTTGT TGAACTTCTG AAACCACTAT CTAATGTGTG TTCTTTGTAT 2940

CGTCGTGACC AAGATGTTTG TAAAACTATT TTAAACTATG TCCTTCATAT AGTGAAAAAC 3000

CTAGGTCAAA GCAATATGGA CTCTGAGAAC ACAAGGGATG CTCAAGGACA GTTTCTTACA 3060

GTAATTGGAG CATTTTGGCA TCTAACAAAG GAGAGGAAAT ATATATTCTC TGTAAGAATG 3120

GCCCTAGTAA ATTGCCTTAA AACTTTGCTT GAGGTCGATC CTTATTCAAA ATGGGCCATT 3180

CTTAATGTAA TGGGAGAAGA CTTTCCTGTA AATGAAGTAT TTACACAATT TCTTGCTGAT 3240

AATCATCACC AAGTTCGCAT GTTGGCTGCA GAGTCAATCA ATAGATTGTT CCAGGACACG 3300

AAGGGAGATT CTTCCAGGTT ACTGAAAGCA CTTCCTTTGA AGCTTCAGCA AACAGCTTTT 3360

GAAAATGCAT ACTTGAAAGC TCAGGAAGGA ATGAGAGAAA TGTCCCATAG TGCTGAGAAC 3420

CCTGAACCTT TGGATGAAAT TTATAATAGA AAATCTGTTT TACTGACGTT GATAGCCGTG 3480

GTTTTATCCT GTAGCCCTAT CTGCGAAAAA CAGGCTTTGT TTGCCCTATG TAAATCTGTG 3540

AAAGAGAATG GATTAGAACC TCACCTTGTG AAAAAGGTTT TAAAGAAAGT TTCTGAAACT 3600

TTTGGATATA GACGTTTAGA AGACTTTATG GCATCTCATT TAGATTACCT GGTTTTGGAA 3660

TGGCTAAATC TTCAAGATAC TGAATACAAC TTATCTTCTT TTCCTTTTAT TTTATTAAAC 3720

TACGCAAATA TTGAGGATTT CTATAGATCT TGTTATAAGG TTTTGATTCC ACATCTGGTG 3780

ATTAGAAGTC ATTTTGATGA GGTGAAGTCC ATTGCTAATC AGATTCAAGA GGACTGGAAA 3840

AGTCTTCTAA CAGACTGCTT TCCAAAGGTT CTTGTAAATA TTCTTCCTTA TTTTGCCTAT 3900

GAGGGTATAG GAGACAGTGG AATGGCACAG CGAAGAGAGA CTGCTACGAA GGTCTATGAT 3960

ATGCTTAAAA GTGAAAACTT ATTGGGAAAA CAGATTGATC ACTTATTCAT TAGTAATTTA 4020

CCAGAGATTG TGGTGGAGTT ACTGATGACG TTACATGAGC CAGCAAATTC TAGTGCCAGT 4080

CAGAGCACTG ACCTCTGTGA CTTTTCAGGG GATTTGGATC CTGCTCCTAA TCCACCTCAT 4140

TTTCCATCGC ATGTGATTAA AGCAACATTT GCCTATATCA GCAATTGTCA TAAAACCAAG 4200

TTAAAAAGCA TTTTAGAAAT TCTTTCCAAA AGCCCTGATT CCTATCAGAA AATTCTTCTT 4260

GCCATATGTG AGCAAGCGGC TGAAACAAAT AATGTTTATA AGAAGCACAG AATTCTTAAA 4320

ATATACCACC TGTTTGTTAG TTTATTACTG AAAGATATAA AAAGTGGCTT AGGAGGAGCT 4380

TGGGCCTTTG TTCTTCGAGA TGTTATTTAT ACTTTGATTC ACTATATCAA CCAAAGGCCT 4440

TCTTGTATCA TGGATGTGTC ATTACGTAGC TTCTCCCTTT GTTGTGACTT GTTAAGTCAG 4500

GTTTGCCAGA CAGCCGTGAC TTACTGTAAG GATGCTCTAG AAAACCATCT TCATGTTATT 4560

GTTGGTACAC TTATACCCCT TGTGGATGAG CAGGTGGAGG TTCAGAAACA GGTATTGGAC 4620

TTGTTGAAAT ACTTAGTGAT AGATAACAAG GATAATGAAA ACCTCTATCT CACGATTAAG 4680

CTTTTAGATC CTTTTCCTGA CCATGTTGTT TTTAAGGATT TGCGTATTAC TCAGCAAAAA 4740

ATCAAATACA GTAGAGGACC CTTTTCACTC TTGGAGGAAA TTAACCATTT TCTCTCAGTA 4800

AGTGTTTATG ATGCACTTCC ATTGACAAGA CTTGAAGGAC TAAAGGATCT TCGAAGACAA 4860

CTGGAACTAC ATAAAGATCA GATGATGGAC ATTATGAGAG CATCTCAGGA TAATCCACAA 4920

GATGGGATTA TGGTGAAGCT AGTTGTCAAT TTGTTGCAGT TATCCAAGAT GGCAATAAAC 4980

CACACTGGTG AAAAAGAAGT TCTAGAGGCT GTTGGAAGCT GCTTGGGAGA AGTGGGTCCT 5040

ATAGATTTCT CTACCATAGC TATACAACAT AGTAAAGATG CATCTTATAC CAAGGCCCTT 5100

AAGTTATTTG AAGATAAAGA ACTTCAGTGG ACCTTCATAA TGTTGACCTA CCTGAATAAC 5160

ACACTGGTAG AAGATTGTGT CAAAGTTCGA TCAGCAGCTG TTACCTGTTT GAAAAACATT 5220

TTAGCCACAA AGACTGGACA TAGTTTCTGG GAGATTTATA AGATGACAAC AGATCCAATG 5280

CTGGCCTATC TACAGCCTTT TAGAACATCG AGAAAAAAGT TTTTAGAAGT ACCCAGATTT 5340

GACAAAGAAA ACCCTTTTGA AGGCCTGGAT GATATAAATC TGTGGATTCC TCTCAGTGAA 5400

AATCATGACA TTTGGATAAA GACACTGACT TGTGCTTTTT TGGACAGTGG AGGCACAAAA 5460

TGTGAAATTC TTCAATTATT AAAGCCAATG TGTGAAGTGA AAACTGACTT TTGTCAGACT 5520

GTACTTCCAT ACTTGATTCA TGATATTTTA CTCCAAGATA AAAATGAATC ATGGAGAAAT 5580

CTGCTTTCTT CACATGTTCA GGGATTTTTC ACCAGCTGTC TTCGACACTT CTCGCAAACG 5640

AGCCGATCCA CAACCCCTGC AAACTTGGAT TCAGAGTCAG AGCACTTTTT CCGATGCTGT 5700

TTGGATAAAA AATCACAAAG AACAATGCTT GCTGTTGTGG ACTACATGAG AAGACAAAAG 5760

AGACCTTCTT CAGGAACAAT TTTTAATGAT GCTTTCTGGC TGGATTTAAA TTATCTAGAA 5820

GTTGCCAAGG TAGCTCAGTC TTGTGCTGCT CACTTTACAG CTTTACTCTA TGCAGAAATC 5880

TATGCAGATA AGAAAAGCAT GGATGATCAA GAGAAAAGAA GTCTTGCATT TGAAGAAGGA 5940

AGCCAAAGTA CAACTATTTC TAGCTTGAGT GAAAAAAGTA AAGAAGAAAC TGGAATAAGT 6000

TTACAGGATC TTCTCTTAGA AATCTACAGA AGTATAGGAG AGCCAGATAG TTTGTATGGC 6060

TGTGGTGGAG GGAAGATGTT ACAACCCATT ACTAGACTAC GAACATATGA ACACGAAGCA 6120

ATGTGGGGCA AAGCCCTAGT AACATACGAC CTTGAAACAG CAATCCCCTC ATCAACCCGC 6180

CAGGCAGGAA TCATTCAGGC CTTGCAGAAT TTGGGACTCT GCCATATTCT TTCCATGTAT 6240

TTAAAAGGAT TGGATTATGA AAATAAAGAC TGGTGTCCTG AACTAGAGGA ACTTCATTAC 6300

CAAGCAGCAT GGAGGAATAT GCAGTGGGAC CATTGCACTT CTGTCAGCAA AGAAATAGAA 6360

GGAACCAGTT ACCATGAATC ATTGTACAAT GCTCTACAGT CTCTAAGAGA CAGAGAATTC 6420

TCTACATTTT ATGAAAGTCT CAAATATGCC AGAGTAAAAG AAGTGGAAGA GTTGTGTAAG 6480

CGCAGCCTTG AGTCTGTATA TTCGCTCTAC CCCACACTTA GCAGGTTGCA GGCCATTGGA 6540

GAGCTGGAAA GCATTGGGGA GCTTTTCTCA AGATCAGTCA CACATGGACA ACTCTGTGAA 6600

GTATATATTA AGTGGCAGAA ACACTCCCAG CTTCTCAAGG ACAGTGATTT TAGTTTTCAG 6660

GAGCCTATCA TGGCTCTACG CACAGTCATT TTGGAGATCC TGATGGAAAA GGAAATGGAC 6720

AACTCACAGA GAGAATGTAT TAAGGACATT CTCACCAAAC ACCTTGTAGA ACTCTCTATA 6780

CTGGCCAGAA CTTTCAAGAA CACTCAGCTC CCTGAAAGGG CAATATTTCA AATTAAACAG 6840

TACAATTCAG TTAGCTGTGG AGTCTCTGAG TGGCAGCTGG AAGAAGCACA AGTATTCTGG 6900

GCAAAAAAGG AGCAGAGTCT TGCCCTGAGT ATTCTCAAGC AAATGATCAA GAAGTTAGAT 6960

GCCAGCTGTG CAGCGAACAA TCCCAGCCTA AAACTTATAT ACACAGAATG TCTGAGGGTT 7020

TGTGGCAACT GGTTAGCAGA AACTTGCTTA GAAAATCCTG CGGTCATCAT GCAGACCTAT 7080

CTAGAAAAGG CAGTAGAAGT TGCTGGAAAT TATGATGGAG AAAGTGGTGA TGAGCTAAGA 7140

AATGGAAAAA TGAAGGCATT TCTCTCATTA GCCCGGTTTT CAGATACTCA ATACCAAAGA 7200

ATTGAAAACT ACATGAAATC ATCGGAATTT GAAAACAAGC AAGCTCTCCT GAAAAGAGCC 7260

AAAGAGGAAG TAGGTCTCCT TAGGGAACAT AAAATTCAGA CAAACAGATA CACAGTAAAG 7320

GTTCAGCGAG AGCTGGAGTT GGATGAATTA GCCCTGCGTG CACTGAAAGA GGATCGTAAA 7380

CGCTTCTTAT GTAAAGCAGT TGAAAATTAC ATCAACTGCT TATTAAGTGG AGAAGAACAT 7440

GATATGTGGG TATTCCGACT TTGTTCCCTC TGGCTTGAAA ATTCTGGAGT TTCTGAAGTC 7500

AATGGCATGA TGAAGAGAGA CGGAATGAAG ATTCCAACAT ACAAATTTTT GCCTCTTATG 7560

TACCAGTTGG CTGCTAGAAT GGGGACCAAG ATGATGGGAG GCCTAGGATT TCATGAAGTC 7620

CTCAATAATG ATCGAACAGA GGCTGCAAAC AGAATAATAT GTACTATCAG AAGTAGGAGA 7680

CCTCAGATGG TCAGAAGTGT TGAGGCACTT TGTGATGCTT ATATTATATT AGCAAACTTA 7740

GATGCCACTC AGTGGAAGAC TCAGAGAAAA GGCATAAATA TTCCAGCAGA CCAGCCAATT 7800

ACTAAACTTA AGAATTTAGA AGATGTTGTT GTCCCTACTA TGGAAATTAA GGTGGACCAC 7860

ACAGGAGAAT ATGGAAATCT GGTGACTATA CAGTCATTTA AAGCAGAATT TCGCTTAGCA 7920

GGAGGTGTAA ATTTACCAAA AATAATAGAT TGTGTAGGTT CTGACGGCAA GGAGAGGAGA 7980

CAGCTTGTTA AGGGCCGTGA TGACCTGAGA CAAGATGCTG TCATGCAACA GGTCTTCCAG 8040

ATGTGTAATA CATTACTGCA GAGAAACACG GAAACTAGGA AGAGGAAATT AACTATCTGT 8100

ACTTATAAGG TCGTTCCCCT CTCTCAGCGA AGTGGTGTTC TTGAATGGTG CACAGGAACT 8160

GTCCCCATTG GTGAATTTCT TGTTAACAAT GAAGATGGTG CTCATAAAAG ATACAGGCCA 8220

AATGATTTCA GTGCCTTTCA GTGCCAAAAG AAAATGATGG AGGTGCAAAA AAAGTCTTTT 8280

GAAGAGAAAT ATGAAGTCTT CATGGATGTT TGCCAAAATT TTCAACCAGT TTTCCGTTAC 8340

TTCTGCATGG AAAAATTCTT GGATCCAGCT ATTTGGTTTG AGAAGCGATT GGCTTATACG 8400

CGCAGTGTAG CCACTTCTTC TATTGTTGGT TACATACTTG GACTTGGTGA TAGACATGTA 8460

CAGAATATCT TGATAAATGA GCAGTCAGCA GAACTTGTAC ATATAGATTT AGGTGTTGCT 8520

TTTGAACAGG GCAAAATCCT TCCTACTCCT GAGACAGTTC CTTTTAGACT CACCAGAGAT 8580

ATTGTGGATG GCATGGGCAT TACTGGTGTT GAAGGTGTCT TCAGAAGATG CTGTGAGAAA 8640

ACCATGGAAG TGATGAGAAA CTCTCAGGAA ACTTTGTTAA CCATTGTAGA GGTCCTTCTG 8700

TATGATCCAC TCTTTGACTG GACCATGAAT CCTTTGAAAG CTTTGTATTT ACAGCAGAGG 8760

CCGGAAGACG AAACTGAGCT TCACCCTACT CTGAATGCAG ATGACCAAGA ATGCAAACGA 8820

AATCTCAGTG ATATTGACCA GAGTTTCAAC AAAGTAGCTG AACGTGTCTT AATGAGACTA 8880

CAAGAGAAAC TGAAAGGAGT GGAAGAAGGC ACTGTGCTCA GTGTTGGTGG ACAAGTGAAT 8940

TTGCTCATAC AGCAGGCCAT AGACCCCAAA AATCTCAGCC GACTTTTCCC AGGATGGAAA 9000

GCTTGGGTGT GA 9012

Domain Profile

S: 14    kqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdketsrrkLkirty  73

          + pk +   Gsdgke+++Lvkg++Dlrqd++++q+f+++NtlL++++et++rkL+i+ty

Q: 2643  VNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTY  2702

         567999999***************************************************

S: 74    kVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdlstvqarkpklkhl  133

         kVvpls+rsg++ew+++tv+++e+l   v++++++++   +yr++d+s++q++k++++++

Q: 2703  KVVPLSQRSGVLEWCTGTVPIGEFL---VNNEDGAHK---RYRPNDFSAFQCQKKMMEVQ  2756

         *************************...799*****9...********************

S: 134   kls....levfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvislvgyiLg  189

         k+s    +evf++v++n++p  +++++++ekf++p+ wfe+r aytrs+A++s+vgyiLg

Q: 2757  KKSfeekYEVFMDVCQNFQP--VFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILG  2814

         ********************..9*************************************

S: 190   LgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnalgvtgveGv  249

         Lgdrh++n+li+++++e+vhid+gvafe++k+ l++pe+vPFRLTr+iv+++g+tgveGv

Q: 2815  LGDRHVQNILINEQSAELVHIDLGVAFEQGKI-LPTPETVPFRLTRDIVDGMGITGVEGV  2873

         ********************************.***************************

S: 250   frasceavlrvlreskeklltiLevflydplvdwkk......kkktsketeeelaekaka  303

         fr++ce++++v+r+s+e+llti+ev+lydpl+dw++      + ++++e+e+el+++ +a

Q: 2874  FRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMnplkalYLQQRPEDETELHPTLNA  2933

         ******************************************9*****************

S: 304   ealkikkllskvekaenavatrdlllle  331

         +++++k++ls++++++n+va+r+l++l+

Q: 2934  DDQECKRNLSDIDQSFNKVAERVLMRLQ  2961

         ***********************99987

Domain Sequence
(FASTA)

VNLPKIIDCV GSDGKERRQL VKGRDDLRQD AVMQQVFQMC NTLLQRNTET RKRKLTICTY 60

KVVPLSQRSG VLEWCTGTVP IGEFLVNNED GAHKRYRPND FSAFQCQKKM MEVQKKSFEE 120

KYEVFMDVCQ NFQPVFRYFC MEKFLDPAIW FEKRLAYTRS VATSSIVGYI LGLGDRHVQN 180

ILINEQSAEL VHIDLGVAFE QGKILPTPET VPFRLTRDIV DGMGITGVEG VFRRCCEKTM 240

EVMRNSQETL LTIVEVLLYD PLFDWTMNPL KALYLQQRPE DETELHPTLN ADDQECKRNL 300

SDIDQSFNKV AERVLMRLQ 319

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000781	; C:chromosome, telomeric region
GO:0005819	; C:spindle
GO:0016303	; F:1-phosphatidylinositol-3-kinase activity
GO:0005524	; F:ATP binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0007420	; P:brain development
GO:0007050	; P:cell cycle arrest
GO:0071480	; P:cellular response to gamma radiation
GO:0006975	; P:DNA damage induced protein phosphorylation
GO:0006281	; P:DNA repair
GO:0007292	; P:female gamete generation
GO:0031572	; P:G2/M transition DNA damage checkpoint
GO:0007507	; P:heart development
GO:0071044	; P:histone mRNA catabolic process
GO:0016572	; P:histone phosphorylation
GO:0008630	; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0042159	; P:lipoprotein catabolic process
GO:0007094	; P:mitotic cell cycle spindle assembly checkpoint
GO:0043066	; P:negative regulation of apoptotic process
GO:0030889	; P:negative regulation of B cell proliferation
GO:0051402	; P:neuron apoptotic process
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525	; P:positive regulation of neuron apoptotic process
GO:0002331	; P:pre-B cell allelic exclusion
GO:0090399	; P:replicative senescence
GO:0001756	; P:somitogenesis
GO:0000723	; P:telomere maintenance

KEGG

pon:100451505

;

InterPros

IPR016024	; ARM-type_fold.
IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR021668	; TAN.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF11640	; TAN; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013