EKS-POA-00261

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00261

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	436.6	5.9E-131	104	400	297

Status

Unreviewed

Ensembl Protein

ENSPPYP00000004751

UniProt Accession

H2NG62;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK4

Gene Synonyms/Alias

DYRK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000004169	ENSPPYP00000004751	ENSPPYT00000004939

Organism

Pongo abelii

Functional Description

Protein Length

520

Protein Sequence
(FASTA)

MPASELKASE IPFHPSIKTQ DPKAEEKSPK KHKVPLTAAE ALKLFKNQLS LYEQSEILGY 60

AELWFLGLEA KKLDMAPEKL SKTSFDDEHG SYLKVLHDHI AYRYEVLEMI GKGSFGQVAK 120

CLDHKNNELV ALKIIRNKKR FHQQALMELK ILEALRKKDK DNTYNVVHMK DFFYFRNHFC 180

ITFELLGINL YELMKNNNFQ GFSLSIVRRF TLSVLKCLQM LSVEKIIHCD LKPENIVLYQ 240

KGQVSVKVID FGSSCYEHQK VYTYIQSRFY RSPEVILGHP YDMAIDMWSL GCIMAELYTG 300

YPLFPGENEV EQLACIMEVL GLPPAGFIQM ASRRQTFFDS KGFPKNITNN RGNKRYPDSK 360

DLTMVLKTYD SSFLDFLRRC LVWEPSLRMT PDQALKHAWI HQSQNLKPQP RPQTLRKSNS 420

FFSSETRKNK VQGCHHSRKK ADEITKETTE KTKDGPMKHV QHSGDQQDSL QLGADTVQLP 480

QLVEAPKKSE AAVGAEVSVT SPGQSKNFSL KNTNILPPIV 520

Nucleotide Sequence
(FASTA)

ATGCCGGCCT CAGAGCTCAA GGCTTCAGAA ATACCTTTCC ACCCTAGCAT TAAAACCCAG 60

GATCCCAAGG CAGAGGAGAA GTCACCAAAG AAGCACAAGG TGCCTCTGAC AGCCGCAGAG 120

GCCCTAAAGC TTTTTAAGAA CCAGCTGTCT CTATACGAGC AAAGTGAAAT CCTGGGCTAC 180

GCGGAGCTGT GGTTCCTGGG GCTTGAAGCC AAGAAGCTCG ACATGGCTCC TGAGAAATTG 240

AGCAAGACGA GTTTTGATGA TGAGCATGGC TCCTATCTGA AGGTCCTGCA TGATCACATT 300

GCCTACCGCT ATGAAGTTCT GGAGATGATC GGGAAGGGGT CCTTTGGACA GGTGGCCAAG 360

TGCTTGGATC ACAAAAACAA TGAGCTGGTG GCCCTGAAAA TCATCAGGAA CAAGAAGAGA 420

TTTCACCAGC AGGCCCTGAT GGAGCTGAAG ATCCTGGAAG CTCTCAGAAA GAAGGACAAA 480

GACAACACCT ACAATGTGGT GCATATGAAG GACTTTTTCT ACTTTCGCAA TCACTTCTGC 540

ATCACCTTTG AGCTCCTGGG AATCAACTTG TATGAGTTGA TGAAGAATAA CAACTTTCAA 600

GGCTTCAGTC TGTCGATAGT TCGGCGCTTC ACTCTCTCTG TTTTGAAGTG CTTGCAAATG 660

CTTTCTGTAG AGAAAATCAT CCACTGCGAT CTCAAGCCCG AAAATATAGT GCTATACCAA 720

AAGGGCCAAG TCTCTGTTAA AGTCATTGAC TTTGGATCAA GCTGTTATGA ACACCAGAAA 780

GTATACACGT ACATCCAAAG CCGGTTCTAC CGATCCCCAG AAGTGATCCT GGGCCACCCC 840

TACGACATGG CCATTGACAT GTGGAGCCTG GGGTGCATCA TGGCAGAGTT GTACACGGGC 900

TACCCCCTGT TTCCTGGGGA GAATGAGGTG GAGCAGCTGG CCTGCATCAT GGAGGTGCTG 960

GGTCTGCCAC CAGCTGGCTT CATTCAGATG GCCTCCAGGA GACAGACATT CTTTGATTCC 1020

AAAGGTTTTC CTAAAAATAT AACCAACAAC AGGGGGAACA AAAGATACCC AGATTCCAAG 1080

GACCTCACGA TGGTGCTGAA AACCTATGAC AGCAGCTTCC TGGACTTTCT CAGAAGGTGT 1140

TTGGTATGGG AACCTTCTCT TCGCATGACC CCGGACCAGG CCCTCAAGCA TGCTTGGATT 1200

CATCAGTCTC AGAACCTCAA GCCACAGCCC AGGCCCCAGA CCCTAAGGAA ATCCAATTCC 1260

TTTTTCTCCT CTGAGACAAG GAAGAACAAG GTTCAAGGCT GTCATCACTC GAGGAAAAAA 1320

GCAGATGAGA TCACCAAAGA GACTACAGAG AAAACAAAAG ATGGCCCCAT GAAGCATGTT 1380

CAGCATTCAG GTGATCAGCA GGACTCTCTC CAGCTCGGAG CTGACACTGT TCAGCTGCCT 1440

CAACTGGTAG AAGCTCCCAA GAAGTCAGAG GCAGCTGTTG GGGCGGAGGT GTCCGTGACC 1500

TCCCCAGGAC AAAGCAAAAA CTTCTCCCTC AAGAACACAA ACATTTTACC CCCTATTGTA 1560

TGA 1563

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevle+igkGsfgqV+k+ld+k++e va+kii+nkkrf++qa +E++iLe+l+kkdk+++

Q: 104   YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNT  163

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         ynvv+++++f+frnh+c++fell +nLyel+k+n+f+g+sl++vr+++ ++lk+L++L+

Q: 164   YNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSV  223

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNi+l++k++ +vkviDFGss++++qk +ytyiqsrfYr+PE+ilg++yd

Q: 224   EKIIHCDLKPENIVLYQKGQVSVKVIDFGSSCYEHQK-VYTYIQSRFYRSPEVILGHPYD  282

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         +aiDmWSlGc++aEl+tG+pLfpGenev+qla+i+evlglpp+ +++ a+++++ff++k+

Q: 283   MAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQMASRRQTFFDSKG  342

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +pk i+                ++  ++++p sk+l+++lk+++++ f d+l+r+l ++p

Q: 343   FPKNIT----------------NNRGNKRYPDSKDLTMVLKTYDSS-FLDFLRRCLVWEP  385

         *99766................34456789999***9999998877.*************

S: 301   akRitpkealkhpfv  315

         + R+tp++alkh ++

Q: 386   SLRMTPDQALKHAWI  400

         *************97

Domain Sequence
(FASTA)

YEVLEMIGKG SFGQVAKCLD HKNNELVALK IIRNKKRFHQ QALMELKILE ALRKKDKDNT 60

YNVVHMKDFF YFRNHFCITF ELLGINLYEL MKNNNFQGFS LSIVRRFTLS VLKCLQMLSV 120

EKIIHCDLKP ENIVLYQKGQ VSVKVIDFGS SCYEHQKVYT YIQSRFYRSP EVILGHPYDM 180

AIDMWSLGCI MAELYTGYPL FPGENEVEQL ACIMEVLGLP PAGFIQMASR RQTFFDSKGF 240

PKNITNNRGN KRYPDSKDLT MVLKTYDSSF LDFLRRCLVW EPSLRMTPDQ ALKHAWI 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013