EKS-POA-00268

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00268

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.9	2.8E-137	155	442	288

Status

Unreviewed

Ensembl Protein

ENSPPYP00000005175

UniProt Accession

H2NHC3;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000004535	ENSPPYP00000005175	ENSPPYT00000005377

Organism

Pongo abelii

Functional Description

Protein Length

453

Protein Sequence
(FASTA)

MVSIFNLDGM EHHVRTCIPK VELVPAGKPF YCLSSEDLRN THCCYTDYCN RIDLRVPSGH 60

LKEPEHPSMW GPVELVGIIA GPVFLLFLII IIVFLVINYH QRVYHNRQRL DMEDPSCEMC 120

LSKDKTLQDL VYDLSTSGSG SGLPLFVQRT VARTIVLQEI IGKGRFGEVW RGRWRGGDVA 180

VKIFSSREER SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD 240

YLNRYTVTIE GMIKLALSAA SGLAHLHMEI VGTQGKPGIA HRDLKSKNIL VKKNGMCAIA 300

DLGLAVRHDA VTDTIDIAPN QRVGTKRYMA PEVLDETINM KHFDSFKCAD IYALGLVYWE 360

IARRCNSGGV HEEYQLPYYD LVPSDPSIEE MRKVVCDQKL RPNIPNWWQS YEALRVMGKM 420

MRECWYANGA ARLTALRIKK TLSQLSVQED VKI 453

Nucleotide Sequence
(FASTA)

ATGGTTTCCA TTTTCAATCT GGATGGGATG GAGCACCATG TGCGCACCTG CATCCCCAAA 60

GTGGAGCTGG TCCCTGCCGG GAAGCCCTTC TACTGCCTGA GCTCGGAGGA CCTGCGCAAC 120

ACCCACTGCT GCTACACTGA CTACTGCAAC AGGATCGACT TGAGGGTGCC CAGTGGTCAC 180

CTCAAGGAGC CTGAGCACCC GTCCATGTGG GGCCCGGTGG AGCTGGTAGG CATCATCGCC 240

GGCCCGGTGT TCCTCCTGTT CCTCATCATC ATCATTGTTT TCCTTGTCAT TAACTATCAT 300

CAGCGTGTCT ATCACAACCG CCAGAGACTG GACATGGAAG ATCCCTCATG TGAGATGTGT 360

CTCTCCAAAG ACAAGACGCT CCAGGATCTT GTCTACGATC TCTCCACCTC AGGGTCTGGC 420

TCAGGGTTAC CCCTCTTTGT CCAGCGCACA GTGGCCCGAA CCATCGTTTT ACAAGAGATT 480

ATTGGCAAGG GTCGGTTTGG GGAAGTATGG CGGGGCCGCT GGAGGGGTGG TGATGTGGCT 540

GTGAAAATAT TCTCTTCTCG TGAAGAACGG TCTTGGTTCA GGGAAGCAGA GATATACCAG 600

ACAGTCATGC TGCGCCATGA AAACATCCTT GGATTTATTG CCGCTGACAA TAAAGATAAT 660

GGCACCTGGA CACAGCTGTG GCTTGTTTCT GACTATCATG AGCATGGGTC CCTGTTTGAT 720

TATCTGAACC GGTACACAGT GACAATTGAG GGGATGATTA AGCTGGCCTT GTCTGCTGCT 780

AGTGGGCTGG CACACCTGCA CATGGAGATC GTGGGCACCC AAGGGAAGCC TGGAATTGCT 840

CATCGAGACT TAAAGTCAAA GAACATTCTG GTGAAGAAAA ATGGCATGTG TGCCATAGCA 900

GACCTGGGCC TGGCTGTCCG TCACGATGCA GTCACTGACA CCATCGACAT TGCCCCGAAT 960

CAGAGGGTGG GGACCAAACG ATACATGGCC CCTGAAGTAC TTGATGAAAC CATTAATATG 1020

AAACACTTTG ACTCCTTTAA ATGTGCTGAT ATTTATGCCC TCGGGCTTGT ATATTGGGAG 1080

ATTGCTCGAA GATGCAATTC TGGAGGAGTC CATGAAGAAT ATCAGCTGCC ATATTACGAC 1140

TTAGTGCCCT CTGACCCTTC CATTGAGGAA ATGCGAAAGG TTGTATGTGA TCAGAAGCTG 1200

CGTCCTAACA TCCCCAACTG GTGGCAGAGT TATGAGGCGC TGCGGGTGAT GGGGAAGATG 1260

ATGCGAGAGT GTTGGTATGC CAACGGCGCG GCCCGCCTGA CGGCCCTGCG CATCAAGAAG 1320

ACCCTCTCCC AGCTCAGCGT GCAGGAAGAC GTGAAGATCT AA 1362

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 155   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  214

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 215   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  274

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 275   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  332

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 333   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  391

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 392   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  442

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001942	; P:hair follicle development
GO:0001701	; P:in utero embryonic development
GO:0006917	; P:induction of apoptosis
GO:0030308	; P:negative regulation of cell growth
GO:0038092	; P:nodal signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013