EKS-POA-00371

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00371

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	316.2	1.7E-94	128	363	236

Status

Unreviewed

Ensembl Protein

ENSPPYP00000005225

UniProt Accession

H2NHH3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K12

Gene Synonyms/Alias

MAP3K12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000004582	ENSPPYP00000005225	ENSPPYT00000005429

Organism

Pongo abelii

Functional Description

Protein Length

859

Protein Sequence
(FASTA)

MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTHVLQL HEQDAGGPGG 60

AAGSPESRAS RVRADEVRLQ CQSGSGFLEG LFGCLRPVWT MIGKAYSTEH KQQQEDLWEV 120

PFEEILDLQW VGSGAQGAVF LGRFHGEEVA VKKVRDLKET DIKHLRKLKH PNIITFKGVC 180

TQAPCYCILM EFCAQGQLYE VLRAGRPVTP SLLVDWSMGI AGGMNYLHLH KIIHRDLKSP 240

NMLITYDDVV KISDFGTSKE LSDKSTKMSF AGTVAWMAPE VIRNEPVSEK VDIWSFGVVL 300

WELLTGEIPY KDVDSSAIIW GVGSNSLHLP VPSSCPDGFK ILLRQCWNSK PRNRPSFRQI 360

LLHLDIASAD VLSTPQETYF KSQAEWREEV KLHFEKIKSE GTCLHRLEEE LVMRRREELR 420

HALDIREHYE RKLERANNLY MELNALMLQL ELKERELLRR EQALERRCPG LLKPHPSRGL 480

LHGNTMEKLI KKRNVPQKLS PHSKRPDILK TESLLPKLDA ALSGVGLPGC PKGPPSPGRS 540

RRGKTRHRKA SAKGSCGDLP GLRTAVPPHE PGGPGSPGGL GGGPSAWEAC PPALRGLHHD 600

LLLRKMSSSS PDLLSAALGS RGRGATGGAG DPGSPPPARG DTPPSEGSAP GSTSPDSPGG 660

AKGEPPPPVG PGEGVGLLGT GREGTSGRGG SRAGSQHLTP AALLYRAAVT RSQKRGISSE 720

EEEGEVDSEV ELTSSQRWPQ SLNMRQSLST FSSENPSDGE EGTASEPSPS GTPEVGSTNT 780

DERPDERSDD MCSQGSEIPL DPPPSEVIPG PEASSLPIPH QELFRERGPP NSEDSDCDST 840

ELDNSNSVDA LRPPASLPP 859

Nucleotide Sequence
(FASTA)

ATGGCTTGCC TCCATGAGAC CCGAACACCC TCTCCTTCCT TTGGGGGCTT CGTGTCTACC 60

CTAAGTGAGG CATCCATGCG CAAGCTGGAC CCAGACACTT CTGACTGCAC TCCCGAGAAG 120

GACCTGACGC CTACCCATGT CCTGCAGCTA CATGAGCAGG ATGCAGGGGG CCCAGGGGGA 180

GCAGCTGGGT CACCTGAGAG TCGGGCATCC AGAGTTCGAG CTGACGAGGT GCGACTGCAG 240

TGCCAGAGTG GCAGTGGCTT CCTTGAGGGC CTCTTTGGCT GCCTGCGCCC TGTCTGGACC 300

ATGATTGGCA AAGCCTACTC CACTGAGCAC AAGCAGCAGC AGGAAGACCT TTGGGAGGTC 360

CCCTTTGAGG AAATCCTGGA CCTGCAGTGG GTGGGCTCAG GGGCCCAGGG TGCTGTCTTC 420

CTGGGGCGCT TCCACGGGGA GGAGGTGGCT GTGAAGAAGG TGCGAGACCT CAAAGAAACC 480

GACATCAAGC ACTTGCGAAA GCTGAAGCAC CCCAACATCA TCACCTTCAA GGGTGTGTGC 540

ACCCAGGCTC CCTGCTACTG CATCCTCATG GAGTTCTGCG CCCAGGGCCA GCTGTATGAG 600

GTACTGCGGG CTGGCCGCCC TGTCACCCCC TCCTTACTGG TTGACTGGTC CATGGGCATC 660

GCCGGTGGCA TGAACTACCT GCACCTGCAC AAGATTATCC ACAGGGATCT CAAGTCACCC 720

AACATGTTAA TCACCTACGA CGATGTGGTG AAGATCTCAG ATTTTGGCAC TTCCAAGGAG 780

CTGAGTGACA AGAGCACCAA GATGTCCTTT GCAGGGACAG TAGCCTGGAT GGCCCCTGAG 840

GTGATCCGCA ATGAGCCTGT GTCTGAGAAG GTCGACATCT GGTCCTTTGG TGTGGTGCTG 900

TGGGAACTGC TGACTGGTGA GATCCCCTAC AAAGACGTAG ATTCCTCAGC CATTATCTGG 960

GGTGTGGGAA GCAACAGTCT CCATCTGCCC GTGCCCTCCA GTTGCCCAGA TGGTTTCAAG 1020

ATCCTGCTTC GCCAGTGCTG GAATAGCAAA CCACGAAATC GCCCATCATT CCGACAGATC 1080

CTGCTGCATC TGGACATTGC CTCAGCTGAT GTACTCTCCA CACCCCAGGA GACTTACTTT 1140

AAGTCCCAGG CAGAGTGGCG GGAAGAAGTA AAACTGCACT TTGAAAAGAT TAAGTCAGAA 1200

GGGACCTGTC TGCACCGCCT AGAAGAGGAA CTGGTGATGA GGAGGAGGGA GGAGCTCAGA 1260

CACGCCCTGG ACATCAGGGA GCACTATGAA AGGAAGCTGG AGAGAGCCAA CAACCTGTAT 1320

ATGGAACTTA ATGCCCTCAT GTTGCAGCTG GAACTCAAGG AGAGGGAGCT GCTCAGGCGA 1380

GAGCAAGCTT TAGAGCGGAG GTGCCCAGGC CTGCTGAAGC CACACCCTTC CCGGGGCCTC 1440

CTGCACGGAA ACACAATGGA GAAGCTTATC AAGAAGAGGA ATGTGCCACA GAAGCTGTCA 1500

CCCCATAGCA AAAGGCCAGA TATCCTCAAG ACGGAGTCTT TGCTCCCTAA ACTAGATGCA 1560

GCCCTAAGTG GGGTTGGGCT TCCTGGGTGT CCTAAGGGCC CCCCCTCACC AGGACGGAGT 1620

CGCCGTGGCA AGACCCGTCA CCGCAAGGCC AGCGCCAAGG GGAGCTGTGG GGACCTGCCT 1680

GGGCTTCGTA CAGCTGTGCC ACCCCATGAA CCTGGAGGAC CAGGAAGCCC AGGGGGCCTA 1740

GGAGGGGGAC CCTCAGCCTG GGAGGCCTGC CCCCCCGCCC TCCGTGGGCT TCATCATGAC 1800

CTCCTGCTCC GCAAAATGTC TTCATCATCC CCAGACCTGC TGTCAGCAGC ACTAGGGTCC 1860

CGGGGCCGGG GGGCCACAGG CGGAGCTGGG GATCCTGGCT CACCACCTCC AGCCCGGGGT 1920

GACACCCCAC CAAGTGAGGG CTCAGCCCCT GGCTCCACCA GCCCAGATTC ACCTGGGGGA 1980

GCCAAAGGGG AGCCACCTCC TCCAGTAGGG CCTGGTGAAG GTGTGGGGCT TCTGGGAACT 2040

GGAAGGGAAG GGACCTCAGG CCGGGGAGGA AGCCGGGCTG GGTCCCAGCA CTTGACCCCA 2100

GCTGCACTGC TGTACAGGGC TGCCGTCACC CGAAGTCAGA AACGTGGCAT CTCATCAGAA 2160

GAGGAGGAAG GAGAGGTAGA CAGTGAAGTA GAGCTGACAT CAAGCCAGAG GTGGCCTCAG 2220

AGCCTGAACA TGCGCCAGTC ACTATCTACC TTCAGCTCAG AGAATCCATC AGATGGAGAG 2280

GAAGGCACAG CTAGTGAACC TTCCCCCAGT GGCACACCTG AAGTTGGCAG CACCAACACT 2340

GATGAGCGGC CAGATGAGCG GTCTGATGAC ATGTGCTCCC AGGGCTCAGA AATCCCACTG 2400

GACCCACCTC CTTCAGAGGT CATCCCCGGC CCTGAAGCCA GCTCCCTGCC CATTCCACAC 2460

CAGGAACTTT TCAGAGAGCG GGGCCCTCCC AATTCTGAGG ACTCAGACTG TGACAGCACT 2520

GAATTGGACA ACTCCAACAG CGTTGATGCC TTGCGGCCCC CAGCTTCCCT CCCTCCATGA 2580

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G

Q: 128   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  178

         689**************************9999.........******************

S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii

Q: 179   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  233

         **************************..99************************...9**

S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182

         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D

Q: 234   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  292

         ***********.99****************99****************************

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+psscp+ +k L+++cwn++p+

Q: 293   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPR  352

         ************************************************************

S: 243   kRpsfseivks  253

         +Rpsf++i+ +

Q: 353   NRPSFRQILLH  363

         ********876

Domain Sequence
(FASTA)

LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60

ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120

DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180

IPYKDVDSSA IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 236

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0033267	; C:axon part
GO:0005829	; C:cytosol
GO:0030426	; C:growth cone
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0016572	; P:histone phosphorylation
GO:0000165	; P:MAPK cascade
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013