EKS-POA-00050

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00050

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	404.3	2.9E-121	534	795	262

Status

Unreviewed

Ensembl Protein

ENSPPYP00000005708

UniProt Accession

H2NIT5;

Protein Name

Protein Synonyms/Alias

Gene Name

KSR2

Gene Synonyms/Alias

KSR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000005006	ENSPPYP00000005708	ENSPPYT00000005926

Organism

Pongo abelii

Functional Description

Protein Length

817

Protein Sequence
(FASTA)

MTDEQVCETV EKYGANREEC ARLNASLSCL RNVHMSGGNL SKQDWTIQWP TTETGKENNP 60

VCPPEPTPWI RTHLSQSPRV PSKCVQHYCH TSPTPGAPVY THVDRLTVDA YPGLCPPPPL 120

ESGHRSLPPS PRQRHAVRTP PRTPNIVTTV TPPGTPPMRK KNKLKPPGTP PPSSRKLIHL 180

IPGFTALHRS KSHEFQLGHR VDEAHTPKAK KKSKPLNLKI HSSVGSCENI PSQQRSPLLS 240

ERSLRSFFVG HAPFLPSTPP VHTEANFSAN TLSVPRWSPQ IPRRDLGNSI KHTVCGKGML 300

FGLKCKNCKL KCHNKCTKEA PPCHLLIIHR GDPARLVRTE SVPCDINNPL RKPPRYSDLH 360

ISQTLPKTNK INKDHIPVPY QPDSSSNPSY TTSFTPSSPA PPLPPSATPP SPLHPSPQCT 420

RQQKNFNLPA SHYYKYKQQF IFPDVVPVPE TPTRAPQVIL HPVTSNPILE GNPLLQIEVE 480

PTSENEEVHD EAEESEDDFE EMNLSLLSAR SFPRKASQTS IFLQEWDIPF EQLEIGELIG 540

KGRFGQVYHG RWHGEVAIRL IDIERDNEDQ LKAFKREVMA YRQTRHENVV LFMGACMSPP 600

HLAIITSLCK GRTLYSVVRD AKIVLDVNKT RQIAQEIVKG MGYLHAKGIL HKDLKSKNVF 660

YDNGKVVITD FGLFSISGVL QAGRREDKLR IQNGWLCHLA PEIIRQLSPD TEEDKLPFSK 720

HSDVFALGTI WYELHAREWP FKTQPAEAII WQMGTGMKPN LSQIGMGKEI SDILLFCWAF 780

EQEERPTFTK LMDMLEKLPK RNRRLSHPGH FWKSADL 817

Nucleotide Sequence
(FASTA)

ATGACGGATG AACAGGTGTG CGAGACCGTG GAGAAATATG GAGCCAACCG GGAGGAGTGT 60

GCCCGCCTCA ACGCCTCCCT CTCCTGCCTC AGAAATGTCC ACATGTCAGG AGGCAACCTT 120

TCCAAACAAG ACTGGACCAT CCAGTGGCCC ACCACAGAGA CGGGGAAGGA GAACAATCCC 180

GTGTGCCCCC CGGAGCCCAC TCCGTGGATC CGCACCCATC TCTCCCAGAG CCCCAGGGTC 240

CCGTCCAAGT GCGTCCAGCA CTATTGTCAC ACTAGCCCCA CTCCCGGGGC CCCTGTGTAC 300

ACCCACGTGG ACAGGCTTAC CGTGGACGCC TACCCGGGCT TGTGCCCGCC CCCGCCACTG 360

GAGTCGGGCC ACCGTTCCCT GCCCCCATCG CCCAGGCAGC GGCACGCGGT CCGCACCCCG 420

CCGCGCACCC CCAACATCGT CACCACCGTG ACCCCGCCGG GCACGCCGCC CATGAGGAAG 480

AAGAACAAGC TGAAGCCCCC GGGGACTCCA CCGCCCTCCT CCCGAAAACT GATACACTTG 540

ATCCCGGGAT TCACCGCGCT GCATCGGAGC AAATCCCACG AGTTCCAGCT GGGGCACCGC 600

GTGGACGAGG CCCACACGCC CAAAGCCAAG AAGAAGAGCA AACCCTTGAA CCTCAAGATC 660

CACAGCAGCG TAGGCAGCTG CGAGAACATC CCCTCTCAGC AGCGCTCCCC GCTGCTGTCT 720

GAGCGCTCCC TCCGCTCCTT CTTTGTGGGA CATGCACCTT TCCTGCCTTC CACCCCTCCT 780

GTTCACACTG AGGCCAACTT CTCTGCAAAC ACACTGTCAG TGCCACGCTG GTCTCCGCAG 840

ATCCCTCGCA GAGATCTCGG CAACTCCATC AAGCACACAG TCTGTGGGAA AGGGATGCTT 900

TTTGGCCTCA AGTGTAAAAA CTGCAAGTTA AAGTGCCACA ACAAATGCAC CAAAGAAGCC 960

CCACCCTGTC ATCTTCTGAT CATCCACCGA GGAGATCCAG CAAGGTTAGT CCGGACAGAG 1020

TCCGTTCCAT GTGACATCAA CAACCCTCTA CGGAAGCCAC CTCGGTATTC AGACCTGCAC 1080

ATCAGTCAGA CGCTCCCCAA AACCAACAAA ATCAACAAGG ACCACATCCC TGTCCCTTAC 1140

CAGCCAGACT CCAGCAGCAA CCCCTCCTAC ACGACGTCCT TCACGCCCTC CTCGCCAGCA 1200

CCCCCCCTCC CTCCTAGTGC CACGCCGCCT TCTCCCCTAC ACCCTTCCCC GCAGTGCACA 1260

CGGCAGCAGA AGAACTTCAA CCTGCCAGCA TCCCACTACT ACAAATACAA GCAGCAGTTC 1320

ATCTTCCCAG ATGTGGTGCC GGTGCCGGAG ACGCCGACCC GGGCGCCCCA GGTCATCCTG 1380

CATCCGGTGA CCTCGAATCC AATCTTGGAA GGAAATCCAT TACTTCAAAT TGAAGTGGAG 1440

CCAACGTCGG AGAATGAAGA GGTCCATGAT GAGGCCGAGG AGTCAGAGGA TGACTTCGAG 1500

GAGATGAACC TGTCCCTCCT CTCGGCCCGG AGCTTCCCAC GCAAGGCCAG CCAGACCAGC 1560

ATCTTCCTTC AGGAGTGGGA CATCCCCTTT GAGCAGCTGG AGATCGGCGA GCTCATTGGA 1620

AAGGGCCGCT TTGGGCAAGT GTACCACGGC CGCTGGCACG GTGAGGTGGC CATCCGGCTG 1680

ATTGACATTG AGAGGGACAA CGAGGACCAG CTCAAGGCCT TCAAGCGGGA GGTGATGGCC 1740

TACAGGCAGA CGCGGCATGA GAACGTGGTG CTTTTCATGG GCGCCTGCAT GAGCCCGCCT 1800

CACCTGGCCA TCATCACCAG CCTCTGTAAG GGACGGACGC TCTATTCCGT TGTGAGGGAT 1860

GCCAAAATCG TCTTGGATGT CAACAAAACC AGACAGATTG CTCAAGAAAT TGTGAAGGGC 1920

ATGGGCTACC TCCACGCCAA GGGAATCCTA CACAAGGACC TCAAGTCAAA GAACGTCTTC 1980

TACGACAATG GCAAAGTGGT CATCACGGAC TTTGGACTCT TCAGCATTTC TGGGGTGCTG 2040

CAGGCTGGCA GGCGGGAGGA CAAACTGCGC ATCCAGAATG GCTGGCTATG CCACCTGGCA 2100

CCAGAGATCA TCCGCCAGCT GTCCCCCGAC ACAGAGGAGG ATAAGCTCCC CTTCTCCAAG 2160

CACTCTGACG TCTTTGCCCT TGGCACAATC TGGTATGAAC TCCACGCCAG GGAATGGCCT 2220

TTCAAGACCC AACCAGCAGA GGCAATAATC TGGCAAATGG GCACAGGCAT GAAACCCAAC 2280

CTCAGCCAGA TTGGCATGGG AAAAGAAATC TCGGACATTC TTCTCTTCTG CTGGGCCTTT 2340

GAACAAGAAG AGAGACCTAC CTTCACCAAG CTCATGGACA TGCTGGAGAA ACTGCCAAAG 2400

CGAAACCGCC GCCTGTCTCA CCCTGGACAT TTCTGGAAGT CTGCAGACCT G 2451

Domain Profile

S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFm  61

         e++e iG+GrfG+vy+g+whG+va++l+++e+++e+ql+aFk+ev+ay++tRhen+vLFm

Q: 534   EIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFM  593

         7899********************************************************

S: 62    G.yvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120

         G ++s+p+lai+tslckg++Ly+++++++  ld++k+++ia++i++gm+YLhak+ilhkD

Q: 594   GaCMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKD  653

         ************************************************************

S: 121   lksknilleeglkvvitDFgllsvkrllsg.rrekqleipkgwilylapeviralsidle  179

         lkskn+++++g kvvitDFgl+s++ +l++ rre++l+i++gw+++lape+ir+ls+d+e

Q: 654   LKSKNVFYDNG-KVVITDFGLFSISGVLQAgRREDKLRIQNGWLCHLAPEIIRQLSPDTE  712

         ***********.***************9977*****************************

S: 180   qdelpfskesDvyafGivlyellarelpykeesadqilfavgrGlkpdlskvksklpkel  239

         +d+lpfsk+sDv+a+G+++yel+are+p+k+++a++i++++g+G+kp+ls++   ++ke+

Q: 713   EDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQI--GMGKEI  770

         ****************************************************..******

S: 240   kellleClkfekeeRPlftqilkkl  264

         +++ll C++fe+eeRP+ft+++++l

Q: 771   SDILLFCWAFEQEERPTFTKLMDML  795

         **********************986

Domain Sequence
(FASTA)

EIGELIGKGR FGQVYHGRWH GEVAIRLIDI ERDNEDQLKA FKREVMAYRQ TRHENVVLFM 60

GACMSPPHLA IITSLCKGRT LYSVVRDAKI VLDVNKTRQI AQEIVKGMGY LHAKGILHKD 120

LKSKNVFYDN GKVVITDFGL FSISGVLQAG RREDKLRIQN GWLCHLAPEI IRQLSPDTEE 180

DKLPFSKHSD VFALGTIWYE LHAREWPFKT QPAEAIIWQM GTGMKPNLSQ IGMGKEISDI 240

LLFCWAFEQE ERPTFTKLMD ML 262

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00109

; C1; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013