EKS-POA-00479
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00479
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RIPK345.42.2E-10321283263
StatusUnreviewed
Ensembl ProteinENSPPYP00000006485
UniProt AccessionH2NKX0;
Protein Name
Protein Synonyms/Alias
Gene NameRIPK3
Gene Synonyms/Alias RIPK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000005703ENSPPYP00000006485ENSPPYT00000006741
OrganismPongo abelii
Functional Description
Protein Length518
Protein Sequence
(FASTA)
MSCVKLWPSG APAPLVSIEE LENQELVGKG GFGTVFRAQH RKWGYDVAVK IVNSKAISRE 60
VKAMASLDNE FVLRLEGVIE KVNWDQDPKP ALVTKFMENG SLSGLLQSQC PRPWPLLCRL 120
LKEVVLGMFY LHDQNPVLLH RDLKPSNVLL DPELHVKLAD FGLSTFQGGS QSGTGSGEPG 180
GTLGYLAPEL FVNINRKAST ASDVYSFGIL MWAVLAGREV ELPTEPSLVY GAVCKRQTRP 240
SLAELPQAGP ETPGLEGLKE LMQLCWSSEP EDRPSFQECL PKTDEAFRMV ENHMNAAVST 300
VKNFLSELRS SNRRFSTPES GQGGTEMDGF RRTTENQHSR NDVMVSEWLN KLNLEGPPSS 360
VPKKCPSLTK RSRAQEEQVP QARTAGTSSD SMAQPPQTPE TSTFRNQMPS PTSTGTPSPG 420
PRGNQGAERQ GMNWSCRTPE PNPVTGRPLV NIYNCSGVQV GDNNYLTMQQ TTALPTWGLA 480
PSGKGRGLQH PPPVGSQESP KDPEAWSRPQ GWYNHSGK 518
Nucleotide Sequence
(FASTA)
ATGTCGTGCG TCAAGTTATG GCCCAGCGGT GCCCCCGCCC CCTTGGTGTC CATCGAGGAA 60
CTGGAGAACC AGGAGCTCGT CGGCAAAGGC GGGTTCGGCA CAGTGTTCCG GGCGCAACAT 120
AGGAAGTGGG GCTACGATGT GGCGGTCAAG ATCGTAAACT CGAAGGCGAT ATCCAGGGAG 180
GTCAAGGCCA TGGCAAGTCT GGATAACGAA TTCGTGCTGC GCCTAGAAGG GGTTATCGAG 240
AAGGTGAACT GGGACCAAGA TCCCAAGCCG GCTCTGGTGA CTAAATTCAT GGAGAACGGC 300
TCCCTGTCGG GGCTGCTGCA GTCCCAGTGC CCTCGGCCCT GGCCGCTCCT TTGCCGCCTG 360
CTGAAAGAAG TGGTGCTTGG AATGTTTTAC CTGCACGACC AGAACCCGGT GCTCCTGCAC 420
CGGGACCTCA AGCCGTCCAA CGTCCTGCTG GACCCAGAGC TGCACGTCAA GCTGGCAGAT 480
TTTGGCCTGT CCACATTTCA GGGAGGCTCA CAGTCAGGGA CAGGGTCCGG GGAGCCAGGG 540
GGCACCCTGG GCTACTTGGC CCCAGAACTG TTTGTTAACA TAAACCGGAA GGCCTCCACA 600
GCCAGTGATG TCTACAGCTT CGGGATCCTA ATGTGGGCAG TGCTTGCTGG AAGAGAAGTT 660
GAGTTGCCAA CCGAACCATC ACTGGTATAT GGAGCAGTGT GCAAGAGGCA GACCCGGCCC 720
TCATTGGCTG AGCTTCCCCA AGCCGGGCCT GAGACTCCCG GCTTAGAAGG ACTGAAGGAG 780
CTAATGCAGC TCTGCTGGAG CAGTGAGCCC GAGGACAGAC CCTCCTTCCA GGAATGCCTA 840
CCAAAAACTG ATGAAGCCTT CCGGATGGTG GAGAACCATA TGAATGCTGC TGTCTCCACA 900
GTAAAGAATT TCCTGTCTGA ACTCAGGAGC AGCAATAGGA GATTTTCTAC CCCAGAGTCA 960
GGCCAAGGAG GGACAGAAAT GGATGGCTTT AGGAGAACCA CAGAAAACCA GCACTCTCGT 1020
AATGATGTCA TGGTTTCTGA GTGGCTAAAC AAACTGAATC TAGAGGGGCC TCCCAGCTCT 1080
GTTCCTAAAA AATGCCCGAG CCTTACCAAG AGGAGCAGGG CACAAGAGGA GCAGGTTCCA 1140
CAAGCCAGAA CAGCAGGCAC ATCTTCAGAT TCAATGGCCC AACCTCCCCA GACTCCAGAG 1200
ACCTCAACTT TCAGAAACCA GATGCCCAGC CCCACCTCAA CTGGAACACC AAGTCCTGGA 1260
CCCCGAGGGA ATCAGGGGGC TGAGAGACAA GGCATGAACT GGTCCTGCAG GACCCCGGAG 1320
CCAAATCCAG TAACAGGGCG ACCACTCGTT AACATATACA ACTGCTCTGG GGTGCAAGTT 1380
GGAGACAACA ACTACTTGAC TATGCAACAG ACAACTGCCT TGCCCACATG GGGCCTGGCA 1440
CCTTCGGGCA AGGGGAGGGG CTTGCAGCAC CCCCCACCAG TAGGTTCGCA AGAAAGCCCT 1500
AAAGATCCTG AAGCCTGGAG CAGGCCACAG GGTTGGTATA ATCATAGCGG GAAATAA 1557
Domain Profile
S: 1     leelelvgsGgfgkvfkarhrkwrvevavkslvlktdaldserkelleeakkmeklrfsy  60
         le++elvg+Ggfg+vf+a+hrkw+++vavk         ++++k++++e+k+m++l++++
Q: 21    LENQELVGKGGFGTVFRAQHRKWGYDVAVK---------IVNSKAISREVKAMASLDNEF  71
         6899**************************.........999******************
S: 61    vlkllGvikeeek.....lglvmeymenGsLeklLkseielpwplkfRilkevvlgmnyL  115
         vl+l+Gvi+++++      +lv+++menGsL++lL+s++++pwpl +R+lkevvlgm+yL
Q: 72    VLRLEGVIEKVNWdqdpkPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYL  131
         *************999999*****************************************
S: 116   hslkPpllhkDLkpeniLlDnelhvkiaDfGlskfmeessqskevsssaegGtlaYlaPe  175
         h+++P+llh+DLkp+n+LlD+elhvk+aDfGls+f ++ sqs + s+++ gGtl YlaPe
Q: 132   HDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF-QGGSQSGTGSGEP-GGTLGYLAPE  189
         ***********************************.*************.**********
S: 176   lleevnkkaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPeleevseel  235
         l++++n+kas++sDvYsf+i++Wavla++e++  ++ sl++ +v+k+++RP+l+e++++ 
Q: 190   LFVNINRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYGAVCKRQTRPSLAELPQAG  249
         ************************************************************
S: 236   Prevpq...lieLmkrcWeadpeeRPsFleieekt  267
         P e+p+   l+eLm+ cW+++pe+RPsF+e+ +kt
Q: 250   P-ETPGlegLKELMQLCWSSEPEDRPSFQECLPKT  283
         *.7787788**********************9986
Domain Sequence
(FASTA)
LENQELVGKG GFGTVFRAQH RKWGYDVAVK IVNSKAISRE VKAMASLDNE FVLRLEGVIE 60
KVNWDQDPKP ALVTKFMENG SLSGLLQSQC PRPWPLLCRL LKEVVLGMFY LHDQNPVLLH 120
RDLKPSNVLL DPELHVKLAD FGLSTFQGGS QSGTGSGEPG GTLGYLAPEL FVNINRKAST 180
ASDVYSFGIL MWAVLAGREV ELPTEPSLVY GAVCKRQTRP SLAELPQAGP ETPGLEGLKE 240
LMQLCWSSEP EDRPSFQECL PKT 263
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00461
EKS-ANC-00483
EKS-BOT-00493
EKS-CAJ-00503
EKS-CAF-00493
EKS-CAP-00525
EKS-DAR-00919
EKS-ECT-00078
EKS-EQC-00480
EKS-ERE-00060
EKS-FEC-00472
EKS-GOG-00484
EKS-HOS-00502
EKS-ICT-00470
EKS-MAM-00490
EKS-MIM-00096
EKS-MUM-00525
EKS-MYL-00484
EKS-NOL-00448
EKS-ORN-00627
EKS-OTG-00501
EKS-PAT-00464
EKS-PTV-00183
EKS-RAN-00508
EKS-SOA-00064
EKS-SUS-00435
EKS-TUT-00197
EKS-XIM-00617
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004704; F:NF-kappaB-inducing kinase activity
GO:0007249; P:I-kappaB kinase/NF-kappaB cascade
GO:0006917; P:induction of apoptosis
KEGG
pon:100461174;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR025735; RHIM_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF12721; RHIM; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013