EKS-POA-00160
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00160
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb448.38.0E-135521781261
StatusUnreviewed
Ensembl ProteinENSPPYP00000006894
UniProt AccessionH2NM09;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA5
Gene Synonyms/Alias RPS6KA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000006063ENSPPYP00000006894ENSPPYT00000007168
OrganismPongo abelii
Functional Description
Protein Length896
Protein Sequence
(FASTA)
MAPLPCWLWA ERPEEAAVEQ GAVWLRGTSG ARRRGRRRGA SRAARAGKRL VFASEFWSRR 60
TPAPGAAAAA ARGRASAVSW VPLVATRGIG KKEKMEEEGG SSGGAAGTSA DGGDGGEQLL 120
TVKHELRTAN LTGHAEKVGI ENFELLKVLG TGAYGKVFLV RKISGHDTGK LYAMKVLKKA 180
TIVQKAKTTE HTRTERQVLE HIRQSPFLVT LHYAFQTETK LHLILDYING GELFTHLSQR 240
ERFTEHEVQI YVGEIVLALE HLHKLGIIYR DIKLENILLD SNGHVMLTDF GLSKEFVADE 300
TERAYSFCGT IEYMAPDIVR GGDSGHDKAV DWWSLGVLMY ELLTGASPFT VDGEKNSQAE 360
ISRRILKSEP PYPQEMSALA KDLIQHLLMK DPKKRLGCGP RDADEIKEHL FFQKINWDDL 420
AAKKVPAPFK PVIRDELDVS NFAEEFTEMD PTYSPAALPQ SSEKLFQGYS FVAPSILFKR 480
NAAVIDPLQF HMEVERPGVT NVARSAMMKD SPFYQHYDLD LKDKPLGEGS FSICRKCVHK 540
KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE VFHDQLHTFL VMELLNGGEL 600
FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK PENLLFTDEN DNLEIKIIDF 660
GFARLKPPDN QPLKTPCFTL HYAAPELLNQ NGYDESCDLW SLGVILYTML SGQVPFQSHD 720
RSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG LLTVDPNKRL KMSGLRYNEW 780
LQDGSQLSSN PLMTPDILGS SGAAVHTCVK ATFHAFNKYK REGFCLQNVD KAPLAKRRKM 840
KKTSTSTETR SSSSESSHSS SSHSHGKTTP TKTLQPSNPA DSNNPETLFQ FSDSVA 896
Nucleotide Sequence
(FASTA)
ATGGCTCCCT TACCTTGCTG GCTGTGGGCG GAGCGGCCTG AGGAGGCGGC GGTGGAGCAG 60
GGGGCGGTTT GGTTGCGCGG TACTAGCGGT GCCCGCCGAA GGGGGAGGAG GCGAGGAGCG 120
AGCCGTGCGG CCAGAGCGGG AAAGAGACTC GTCTTTGCGT CCGAGTTCTG GAGCCGCCGC 180
ACCCCGGCTC CTGGGGCCGC GGCAGCGGCT GCGAGGGGAC GGGCGTCCGC TGTCTCCTGG 240
GTTCCCCTCG TAGCGACCCG AGGGATCGGA AAAAAGGAGA AGATGGAGGA GGAGGGTGGC 300
AGCAGCGGTG GCGCCGCGGG GACCAGCGCG GACGGCGGCG ACGGAGGAGA GCAGCTCCTC 360
ACTGTCAAGC ACGAGCTGCG GACTGCTAAT TTGACAGGAC ATGCTGAGAA GGTGGGAATA 420
GAAAATTTTG AGCTCCTGAA GGTCCTAGGA ACTGGAGCTT ATGGAAAAGT ATTTCTAGTT 480
CGTAAAATAA GTGGCCATGA TACTGGAAAG CTGTATGCCA TGAAAGTTTT GAAAAAGGCA 540
ACAATAGTTC AAAAGGCCAA AACCACAGAG CATACAAGGA CAGAACGACA AGTCCTGGAG 600
CACATTAGGC AGTCGCCATT TTTGGTGACA TTACATTATG CTTTCCAGAC AGAAACCAAA 660
CTTCATCTCA TTTTAGATTA TATAAACGGT GGTGAACTTT TTACTCATCT TTCTCAAAGA 720
GAGCGTTTCA CAGAGCACGA GGTGCAGATT TATGTTGGAG AGATTGTGCT TGCCCTTGAA 780
CATCTCCACA AGTTGGGGAT TATATATCGT GATATTAAGC TTGAGAATAT TCTACTTGAT 840
TCTAATGGCC ATGTGATGCT GACAGATTTT GGTCTGAGTA AGGAGTTTGT GGCTGATGAA 900
ACTGAAAGAG CATATTCCTT TTGTGGAACT ATTGAATACA TGGCACCAGA TATTGTCAGA 960
GGGGGAGATT CAGGACATGA CAAGGCAGTT GACTGGTGGA GTTTAGGTGT TCTAATGTAT 1020
GAATTACTAA CTGGAGCATC TCCTTTCACT GTTGATGGAG AAAAAAATTC CCAAGCTGAG 1080
ATATCTAGGA GAATATTAAA AAGTGAGCCT CCATATCCCC AAGAAATGAG TGCTTTAGCT 1140
AAAGACCTAA TTCAGCATCT TTTGATGAAA GATCCCAAGA AGAGATTGGG ATGTGGTCCA 1200
CGTGATGCAG ATGAAATCAA AGAACATCTC TTCTTTCAGA AAATAAATTG GGATGATTTA 1260
GCCGCCAAAA AAGTGCCTGC ACCATTTAAG CCAGTCATTC GAGATGAATT AGATGTGAGT 1320
AACTTTGCAG AAGAGTTCAC AGAAATGGAT CCCACTTATT CTCCCGCAGC CCTGCCCCAG 1380
AGCTCTGAGA AGCTGTTTCA GGGCTATTCC TTTGTTGCTC CTTCCATCCT GTTCAAGCGT 1440
AATGCAGCTG TCATAGACCC TCTTCAGTTT CACATGGAAG TTGAACGTCC TGGAGTGACA 1500
AATGTTGCCA GGAGTGCAAT GATGAAGGAC TCTCCGTTCT ATCAACACTA TGACCTAGAT 1560
TTGAAGGACA AACCCCTGGG AGAAGGTAGT TTTTCCATTT GTCGAAAGTG CGTGCATAAA 1620
AAAAGTAACC AAGCTTTTGC AGTCAAAATA ATCAGCAAAA GGATGGAAGC CAATACTCAG 1680
AAGGAAATAA CAGCTCTAAA ACTCTGTGAA GGACACCCCA ATATTGTGAA GTTGCATGAA 1740
GTTTTTCATG ATCAGCTTCA CACATTTCTA GTGATGGAAC TTCTGAATGG AGGAGAACTG 1800
TTTGAACGCA TTAAGAAAAA GAAGCACTTC AGTGAGACGG AAGCCAGCTA CATCATGAGG 1860
AAGCTTGTTT CAGCTGTAAG CCACATGCAT GATGTTGGAG TGGTGCACAG GGATCTGAAA 1920
CCTGAGAATT TATTGTTCAC CGATGAAAAT GACAATTTGG AAATTAAAAT AATTGATTTT 1980
GGATTTGCAC GGCTAAAGCC ACCGGATAAT CAGCCCCTGA AGACTCCATG CTTCACCCTT 2040
CATTATGCGG CCCCAGAGCT CTTGAATCAG AATGGCTACG ATGAGTCCTG TGACCTGTGG 2100
AGCTTGGGCG TCATTTTGTA CACAATGTTG TCAGGACAGG TTCCCTTCCA ATCTCATGAC 2160
CGAAGTTTGA CGTGTACCAG CGCAGTGGAA ATCATGAAGA AAATTAAAAA GGGAGATTTC 2220
TCCTTTGAAG GAGAAGCCTG GAAGAATGTA TCCCAAGAGG CTAAAGATTT GATCCAAGGA 2280
CTTCTCACAG TAGATCCAAA CAAAAGGCTT AAAATGTCTG GCTTGAGGTA CAATGAATGG 2340
CTTCAAGATG GCAGTCAGCT GTCCTCCAAT CCTCTGATGA CTCCGGATAT TCTAGGATCT 2400
TCCGGAGCTG CCGTGCATAC CTGTGTGAAA GCAACCTTCC ACGCCTTTAA CAAATACAAG 2460
AGAGAGGGGT TTTGCCTTCA GAATGTCGAT AAGGCCCCTT TGGCTAAGAG AAGAAAAATG 2520
AAAAAGACTA GCACCAGTAC CGAGACGCGC AGCAGTTCCA GTGAGAGTTC CCATTCTTCT 2580
TCCTCTCATT CTCACGGTAA AACTACACCC ACCAAGACAC TGCAGCCCAG CAATCCTGCC 2640
GACAGCAATA ACCCGGAGAC CCTCTTCCAG TTCTCGGACT CAGTAGCTTA G 2691
Domain Profile
S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60
         +++++lG+Gs+s+c++cvhk++nq+favkii+k+ +++t++ei++l+++e+hpniv+l++
Q: 521   LKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRmEANTQKEITALKLCEGHPNIVKLHE  580
         5789******************************9*************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         v++d+++++lv+ell+GGel++rikkkk+fse+eas+i+r+lv+av+++h++Gvvhrdlk
Q: 581   VFHDQLHTFLVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLK  640
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         pen+l++de+dn+e ikiidfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl
Q: 641   PENLLFTDENDNLE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDL  699
         **************.*********************************************
S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236
         wslGv+lytml+G+vpf    +++++++a+ei++kik+G+fs++Geaw++vs+eakdl++
Q: 700   WSLGVILYTMLSGQVPFqshdRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQ  759
         *****************9998899************************************
S: 237   klltvdpakrlkleqllkhswl  258
         +lltvdp+krlk+++l++++wl
Q: 760   GLLTVDPNKRLKMSGLRYNEWL  781
         *********************7
Domain Sequence
(FASTA)
LKDKPLGEGS FSICRKCVHK KSNQAFAVKI ISKRMEANTQ KEITALKLCE GHPNIVKLHE 60
VFHDQLHTFL VMELLNGGEL FERIKKKKHF SETEASYIMR KLVSAVSHMH DVGVVHRDLK 120
PENLLFTDEN DNLEIKIIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNQ NGYDESCDLW 180
SLGVILYTML SGQVPFQSHD RSLTCTSAVE IMKKIKKGDF SFEGEAWKNV SQEAKDLIQG 240
LLTVDPNKRL KMSGLRYNEW L 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00163
EKS-CAE-00125
EKS-CAJ-00167
EKS-CAF-00170
EKS-CAP-00162
EKS-CII-00093
EKS-CIS-00194
EKS-DAR-00452
EKS-DIO-00087
EKS-DRM-00077
EKS-EQC-00162
EKS-FEC-00153
EKS-GAG-00140
EKS-GAA-00192
EKS-GOG-00163
EKS-HOS-00169
EKS-ICT-00158
EKS-LAC-00173
EKS-LOA-00162
EKS-MAM-00160
EKS-MAE-00060
EKS-MEG-00130
EKS-MOD-00162
EKS-MUM-00169
EKS-MUP-00167
EKS-MYL-00173
EKS-NOL-00156
EKS-ORN-00202
EKS-ORA-00141
EKS-ORC-00151
EKS-ORL-00189
EKS-OTG-00170
EKS-PAT-00153
EKS-PES-00139
EKS-PEM-00087
EKS-RAN-00161
EKS-SAH-00157
EKS-SUS-00141
EKS-TAG-00191
EKS-TAR-00209
EKS-TEN-00202
EKS-XET-00152
EKS-XIM-00197
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043990; P:histone H2A-S1 phosphorylation
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013