EKS-POA-00432

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00432

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	458.6	6.5E-138	1	248	248

Status

Unreviewed

Ensembl Protein

ENSPPYP00000007005

UniProt Accession

H2NMB5;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000006164	ENSPPYP00000007005	ENSPPYT00000007284

Organism

Pongo abelii

Functional Description

Protein Length

1617

Protein Sequence
(FASTA)

MKNTERIYAM KILNKWEMLK RAETACFREE RDVLVNGDCQ WITALHYAFQ DENHLYLVMD 60

YYVGGDLLTL LSKFEDKLPE DMARFYIGEM VLAIDSIHQL HYVHRDIKPD NVLLDVNGHI 120

RLADFGSCLK MNDDGTVQSS VAVGTPDYIS PEILQAMEDG MGKYGPECDW WSLGVCMYEM 180

LYGETPFYAE SLVETYGKIM NHEERFQFPS HVTDVSEEAK DLIQRLICSR ERRLGQNGIE 240

DFKKHAFFEG LNWENIRNLE APYIPDVSSP SDTSNFDVDD DVLRNTEILP PGSHTGFSGL 300

HLPFIGFTFT TESCFSDRGS LKSIMQSNTL TKDEDVQRDL EHSLQMEAYE RRIRRLEQEK 360

LELSRKLQES TQTVQSLHGS SRALSNSNRD KEIKKLNEEI ERLKNKIADS NRLERQLEDT 420

VALRQEREDS TQRLRGLEKQ HRVVRQEKEE LHKQLVEASE RLKSQAKELK DAHQQRKLAL 480

QEFSELNERM AELRAQKQKV SRQLRDKEEE MEVATQKVDA MRQEMRRAEK LRKELEAQLD 540

DAVAEASKER KLREHSENFC KQMESELEAL KVKQGGRGAG ATLEHQQEIS KIKSELEKKV 600

LFYEEELVRR EASHVLEVKN VKKEVHDSES HQLALQKEIL MLKDKLEKSK RERHNEMEEA 660

VGTIKDKYER ERAMLFDENK KLTAENEKLC SFVDKLTAQN RQLEDELQDL AAKKESVAHW 720

EAQIAEIIQW VSDEKDARGY LQALASKMTE ELEALRSSSL GSRTLDPLWK VRRSQKLDMS 780

ARLELQSALE AEIRAKQLVQ EELRKVKDSN LTLESKLKDS EAKNRELLEE MEILKKKMEE 840

KFRADTGLKL PDFQDSIFEY FNTAPLAHDL TFRTNSASEQ ETQAPKPEAS PSMSVAASEQ 900

QEDMARPPQR PSAVPLPATQ ALALAGPKPK AHQFSIKSFS SPTQCSHCTS LMVGLIRQGY 960

ACEVCSFACH VSCKDSAPQV CPIPPEQSKR PLGVDVQRGI GTAYKGHVKV PKPTGVKKGW 1020

QRAYAVVCDC KLFLYDLPEG KSTQPGVIAS QVLDLRDDEF SVSSVLASDV IHATRRDIPC 1080

IFRVTASLLG APSKTSSLLI LTENENEKRK WVGILEGLQS ILHKNRLRNQ VVHVPLEAYD 1140

SSLPLIKAVL TAAIVDADRI AVGLEEGLYV IEVTRDVIVR AADSKKVHQI ELAPREKIVI 1200

LLCGRNHHVH LYPWSSLDGA EGSFDIKLPE TKGCQLMATA ILKRNSGTCL FVAVKRLILC 1260

YEIQRTKPFH RKFNEIVAPG SVQCLAVLRD RLCVGYPSGF CLLSIQGDGQ PLNLVNPNDP 1320

SLAFLSQQSF DALCAVELES EEYLLCFSHM GLYVDPQGRR ARAQELMWPA APVACSCSPT 1380

HVTVYSEYGV DVFDVRTMEW VQTIGLRRIR PLNSEGTLNL LNCEPPRLIY FKSKFSGAVL 1440

NVPDTSDNSK KQMLRTRSKR RFVFKVPEEE RLQQRREMLR DPELRSKMIS NPTNFNHVAH 1500

MGPGDGMQVL MDLPLSAAPP SQEERPGPAP SNLARQPPSR NKPYISWPSS GGSEPGVTVP 1560

LRSMSDPDQD FDKEPDSDST KHSTPSNSSN PSGPPSPNSP HRSQLPLEGL EQPACDT 1617

Nucleotide Sequence
(FASTA)

ATGAAGAATA CTGAACGAAT TTATGCAATG AAAATCCTCA ACAAGTGGGA GATGCTGAAA 60

AGAGCAGAGA CCGCGTGCTT CCGAGAGGAG CGCGATGTGC TGGTGAACGG CGACTGCCAA 120

TGGATCACTG CGCTGCACTA CGCCTTTCAG GACGAGAACC ACCTGTACTT AGTCATGGAT 180

TACTATGTGG GTGGTGATTT ACTGACCCTG CTCAGCAAAT TTGAAGACAA GCTTCCAGAA 240

GATATGGCGA GGTTCTACAT TGGTGAAATG GTGCTGGCCA TTGACTCCAT CCATCAGCTT 300

CATTACGTGC ACAGAGACAT TAAACCTGAC AATGTCCTTT TGGATGTGAA TGGTCATATC 360

CGCCTGGCTG ACTTTGGATC ATGTTTGAAG ATGAATGATG ATGGAACTGT GCAGTCCTCC 420

GTGGCCGTGG GCACACCTGA CTACATCTCA CCGGAGATCC TGCAGGCGAT GGAGGATGGC 480

ATGGGCAAAT ACGGGCCTGA GTGTGACTGG TGGTCTCTGG GTGTCTGCAT GTATGAGATG 540

CTCTATGGAG AAACTCCGTT TTATGCAGAG TCACTCGTGG AGACCTACGG GAAGATCATG 600

AACCATGAAG AGCGATTCCA GTTCCCATCC CATGTCACGG ATGTATCTGA AGAAGCGAAG 660

GACCTCATCC AGAGACTGAT CTGCAGTAGA GAGCGCAGGC TGGGGCAGAA TGGAATAGAG 720

GATTTCAAAA AGCATGCGTT TTTTGAAGGT CTAAATTGGG AAAATATACG AAACCTAGAA 780

GCACCTTATA TTCCCGACGT GAGCAGTCCC TCTGACACAT CCAACTTCGA CGTGGATGAC 840

GACGTGCTGA GAAACACGGA AATATTACCT CCTGGTTCTC ACACAGGCTT TTCTGGATTA 900

CATTTGCCAT TCATTGGTTT TACATTCACA ACGGAAAGCT GTTTTTCTGA TCGAGGCTCT 960

CTGAAGAGCA TAATGCAGTC CAATACATTA ACCAAAGATG AGGATGTGCA GCGGGACCTG 1020

GAGCACAGCC TGCAGATGGA AGCTTACGAG AGGAGGATTC GGAGGCTGGA ACAGGAGAAG 1080

CTGGAGCTGA GCAGGAAGCT GCAAGAGTCC ACCCAGACTG TGCAGTCCCT CCATGGCTCA 1140

TCTCGGGCCC TCAGCAATTC AAACCGAGAT AAAGAAATCA AAAAGCTAAA TGAAGAAATC 1200

GAACGCTTGA AGAATAAAAT AGCAGATTCA AACAGGCTCG AGCGACAGCT TGAGGACACA 1260

GTGGCGCTTC GCCAAGAGCG TGAGGACTCC ACACAGCGGC TGCGGGGGTT GGAGAAGCAG 1320

CACCGCGTGG TCCGGCAGGA GAAGGAGGAG CTGCACAAGC AACTGGTTGA AGCCTCAGAG 1380

CGGTTGAAAT CCCAGGCCAA AGAACTCAAA GATGCCCATC AGCAGCGAAA GCTGGCCCTA 1440

CAGGAGTTCT CAGAGCTGAA CGAGCGCATG GCAGAGCTCC GCGCCCAGAA GCAGAAGGTG 1500

TCCCGGCAAC TGCGAGACAA GGAGGAGGAG ATGGAGGTGG CCACGCAGAA GGTGGACGCC 1560

ATGCGGCAGG AAATGCGGAG AGCTGAGAAG CTCAGGAAAG AGCTGGAAGC TCAGCTTGAT 1620

GATGCTGTTG CTGAGGCCTC CAAGGAGCGC AAGCTTCGTG AGCACAGCGA GAACTTCTGC 1680

AAGCAGATGG AAAGCGAGCT GGAGGCCCTC AAGGTGAAGC AAGGAGGCCG GGGAGCGGGT 1740

GCCACCTTAG AGCACCAGCA AGAGATTTCC AAAATCAAAT CCGAGCTGGA GAAGAAAGTC 1800

TTATTTTATG AAGAGGAGTT GGTCAGACGT GAGGCCTCCC ATGTGCTAGA AGTGAAAAAT 1860

GTGAAGAAGG AGGTGCATGA TTCGGAAAGC CACCAGCTGG CCCTGCAGAA AGAAATCTTG 1920

ATGTTAAAAG ATAAGTTAGA AAAGTCAAAG CGAGAACGGC ATAATGAGAT GGAGGAGGCA 1980

GTGGGTACAA TAAAAGATAA ATACGAACGA GAAAGAGCGA TGCTGTTTGA TGAAAACAAG 2040

AAGCTAACCG CTGAAAATGA AAAGCTCTGT TCCTTTGTGG ATAAACTCAC AGCTCAAAAT 2100

AGACAGCTGG AGGATGAGCT GCAGGACCTG GCAGCCAAGA AGGAGTCGGT GGCCCACTGG 2160

GAAGCTCAGA TTGCGGAAAT CATTCAGTGG GTCAGTGACG AGAAAGATGC CCGGGGTTAC 2220

CTTCAAGCTC TTGCTTCCAA GATGACCGAA GAGCTTGAGG CTTTGAGGAG TTCTAGTCTG 2280

GGGTCAAGAA CACTGGATCC ACTGTGGAAG GTGCGCCGCA GCCAGAAGCT GGACATGTCC 2340

GCGCGGCTAG AGCTGCAGTC GGCCCTGGAG GCAGAGATCC GGGCCAAGCA GCTTGTCCAG 2400

GAGGAGCTGA GGAAGGTCAA GGACTCCAAC CTCACCTTGG AAAGCAAACT AAAGGATTCC 2460

GAAGCCAAAA ACAGAGAATT ATTAGAAGAA ATGGAAATTT TGAAGAAAAA GATGGAAGAA 2520

AAATTCAGAG CAGATACTGG GCTCAAACTT CCAGATTTTC AGGATTCCAT TTTTGAGTAT 2580

TTCAACACTG CTCCTCTTGC ACATGACCTG ACATTTAGAA CCAACTCAGC TAGTGAGCAA 2640

GAAACACAAG CTCCGAAGCC AGAAGCATCC CCATCGATGT CTGTGGCTGC ATCAGAGCAA 2700

CAGGAGGACA TGGCTCGGCC CCCGCAGAGG CCATCCGCTG TGCCGTTGCC CGCCACGCAG 2760

GCCCTGGCTC TGGCTGGACC GAAGCCAAAA GCTCACCAGT TCAGCATCAA GTCCTTCTCC 2820

AGCCCTACTC AGTGCAGCCA CTGCACCTCC CTGATGGTTG GGCTGATCCG GCAGGGCTAC 2880

GCCTGCGAGG TGTGTTCCTT TGCTTGCCAT GTGTCCTGCA AAGACAGTGC CCCCCAGGTG 2940

TGCCCAATAC CTCCCGAGCA GTCCAAGAGG CCTCTGGGCG TGGATGTGCA GCGAGGCATC 3000

GGAACAGCCT ACAAAGGCCA TGTCAAGGTC CCAAAGCCCA CGGGGGTGAA GAAGGGATGG 3060

CAGCGCGCAT ATGCGGTCGT TTGTGACTGC AAGCTCTTCC TGTATGATCT GCCTGAAGGA 3120

AAATCCACCC AGCCTGGTGT CATTGCGAGC CAAGTCTTGG ATCTCAGAGA TGACGAGTTT 3180

TCCGTGAGCT CAGTCCTGGC CTCAGATGTC ATTCATGCTA CACGCCGAGA TATTCCATGT 3240

ATATTCAGGG TGACAGCCTC TCTCTTAGGT GCACCTTCTA AGACCAGCTC GCTGCTCATT 3300

CTGACAGAAA ATGAGAATGA AAAGAGGAAG TGGGTTGGGA TTCTAGAAGG ACTCCAGTCC 3360

ATCCTTCATA AAAACCGGCT GAGGAATCAG GTCGTGCATG TTCCCTTGGA AGCCTACGAC 3420

AGCTCGCTGC CTCTCATCAA GGCCGTCCTG ACAGCTGCCA TCGTGGATGC AGACAGGATT 3480

GCAGTCGGCC TAGAAGAAGG GCTGTATGTC ATAGAGGTCA CCCGAGATGT GATCGTCCGT 3540

GCCGCTGACT CTAAGAAGGT GCACCAGATC GAGCTTGCGC CCAGGGAGAA GATCGTAATC 3600

CTCCTGTGTG GCCGGAACCA CCATGTGCAC CTCTATCCAT GGTCGTCCCT TGATGGAGCG 3660

GAAGGCAGTT TTGACATCAA ACTTCCGGAA ACCAAAGGCT GCCAGCTCAT GGCCACGGCC 3720

ATACTCAAGA GGAACTCTGG CACCTGCCTG TTTGTGGCCG TGAAACGGCT GATCCTTTGC 3780

TATGAGATCC AGAGAACGAA GCCATTCCAC AGAAAGTTCA ATGAGATTGT GGCTCCCGGC 3840

AGCGTGCAGT GCCTGGCGGT GCTCAGGGAC AGGCTCTGTG TGGGCTACCC TTCTGGGTTC 3900

TGCCTGCTGA GCATCCAGGG GGACGGGCAG CCTCTAAACC TGGTAAATCC CAATGACCCC 3960

TCGCTTGCGT TCCTCTCACA ACAGTCTTTT GATGCCCTTT GTGCTGTGGA GCTCGAAAGC 4020

GAGGAGTACC TGCTTTGCTT CAGCCACATG GGACTGTACG TGGACCCGCA AGGCCGGAGG 4080

GCACGCGCGC AGGAGCTCAT GTGGCCTGCG GCTCCTGTCG CCTGTAGTTG CAGCCCCACC 4140

CACGTCACGG TGTACAGCGA GTATGGCGTG GACGTCTTTG ATGTGCGCAC CATGGAGTGG 4200

GTGCAGACCA TCGGCCTGCG GAGGATAAGG CCCCTGAACT CTGAAGGCAC CCTCAACCTC 4260

CTCAACTGCG AGCCTCCACG CTTGATCTAC TTCAAGAGCA AGTTCTCGGG AGCGGTTCTC 4320

AACGTGCCGG ACACCTCCGA CAACAGCAAG AAGCAGATGC TGCGCACCAG GAGCAAGAGG 4380

CGGTTCGTCT TCAAGGTCCC AGAGGAAGAG AGGCTGCAGC AGAGGCGAGA GATGCTTAGA 4440

GACCCAGAAT TGAGATCCAA AATGATATCC AACCCAACCA ACTTCAACCA CGTGGCTCAC 4500

ATGGGCCCAG GCGACGGCAT GCAGGTGCTC ATGGACCTGC CTCTGAGTGC TGCGCCCCCC 4560

TCCCAGGAGG AAAGGCCGGG CCCCGCTCCC AGCAACCTGG CTCGCCAGCC TCCATCCAGG 4620

AACAAGCCCT ACATCTCGTG GCCCTCATCA GGTGGATCGG AGCCTGGCGT GACCGTGCCT 4680

CTGAGAAGTA TGTCCGATCC AGACCAGGAC TTTGACAAAG AGCCTGATTC GGACTCCACC 4740

AAACACTCAA CTCCATCGAA TAGCTCCAAC CCCAGCGGCC CACCGAGCCC CAACTCCCCC 4800

CACAGGAGCC AGCTCCCCCT CGAAGGCCTG GAGCAGCCGG CCTGTGACAC CTGA 4854

Domain Profile

S: 20    ekatekvyamkilkklellkraesaffreerdvlvkadsewivqlqyafqdekylylvme  79

         +k+te++yamkil+k+e+lkrae+a+freerdvlv++d++wi++l+yafqde++lylvm+

Q: 1     MKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMD  60

         689*********************************************************

S: 80    ylvGGdlltllskyedklpeelarfylaelvlaldsvhelgyvhrdikpdnilldksGhi  139

         y+vGGdlltllsk+edklpe++arfy+ e+vla+ds+h+l+yvhrdikpdn+lld++Ghi

Q: 61    YYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHI  120

         ************************************************************

S: 140   kladfGsclklnedgtvkssvavGtpdyispevlkaleegkgeygkecdwwslGvilyel  199

         +ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+g+g+yg+ecdwwslGv++ye+

Q: 121   RLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEM  180

         ************************************************************

S: 200   lvgetpfyaeslvetyskilnhkeslkfpede.kvseeakdlikklltsreerlgregie  258

         l+getpfyaeslvety+ki+nh+e+++fp+++ +vseeakdli++l++sre+rlg++gie

Q: 181   LYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEAKDLIQRLICSRERRLGQNGIE  240

         *******************************99***************************

S: 259   dlkkhpff  266

         d+kkh+ff

Q: 241   DFKKHAFF  248

         *******9

Domain Sequence
(FASTA)

MKNTERIYAM KILNKWEMLK RAETACFREE RDVLVNGDCQ WITALHYAFQ DENHLYLVMD 60

YYVGGDLLTL LSKFEDKLPE DMARFYIGEM VLAIDSIHQL HYVHRDIKPD NVLLDVNGHI 120

RLADFGSCLK MNDDGTVQSS VAVGTPDYIS PEILQAMEDG MGKYGPECDW WSLGVCMYEM 180

LYGETPFYAE SLVETYGKIM NHEERFQFPS HVTDVSEEAK DLIQRLICSR ERRLGQNGIE 240

DFKKHAFF 248

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0042641	; C:actomyosin
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0031032	; P:actomyosin structure organization
GO:0016477	; P:cell migration
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013