EKS-POA-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/Alpha	320.2	6.5E-96	1598	1816	219

Status

Unreviewed

Ensembl Protein

ENSPPYP00000007334

UniProt Accession

H2NN79;

Protein Name

Protein Synonyms/Alias

Gene Name

TRPM7

Gene Synonyms/Alias

TRPM7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000006471	ENSPPYP00000007334	ENSPPYT00000007636

Organism

Pongo abelii

Functional Description

Protein Length

1865

Protein Sequence
(FASTA)

MSQKSWIEST LTKRECVYII PSSKDPHRCL PGCQICQQLV RCFCGRLVKQ HACFTASLAM 60

KYSDVKLGDH FNQAIEEWSV EKHTEQSPTD AYGVINFQGG SHSYRAKYVR LSYDTKPEVI 120

LQLLLKEWQM ELPKLVISVH GGMQKFELHP RIKQLLGKGL IKAAVTTGAW ILTGGVNTGV 180

AKHVGDALKE HASRSSRKIC TIGIAPWGVI ENRNDLVGRD VVAPYQTLLN PLSKLNVLNN 240

LHSHFILVDD GTVGKYGAEV RLRRELEKTI NQQRIHARIG QGVPVVALIF EGGPNVILTV 300

LEYLQESPPV PVVVCEGTGR AADLLAYIHK QTEEGGNLPD AAEPDIISTI KKTFNFGQNE 360

AVHLFQTLME CMKRKELITV FHIGSDEHQD IDVAILTALL KGTNASAFDQ LILTLAWDRV 420

DIAKNHVFVY GQQWLVGSLE QAMLDALVMD RVAFVKLLIE NGVSMHKFLT IPRLEELYNT 480

KQGPTNPMLF HLVRDVKQGN LPPGYKITLI DIGLVIEYLM GGTYRCTYTR KRFRLIYNSL 540

GGNNRRSGRN TSSSTPQLRK SHESFGNRAD KKEKMRHNHF IKTAQPYRPK IDTVMEEGRK 600

KRTKDEIVDI DDPETKRFPY PLNELLIWAC LMKRQVMARF LWQHGEESMA KALVACKIYR 660

SMAYEAKQSD LVDDTSEELK QYSNDFGQLA VELLEQSFRQ DETMAMKLLT YELKNWSNST 720

CLKLAVSSRL RPFVAHTCTQ MLLSDMWMGR LNMRKNSWYK VILSILVPPA ILLLEYKTKA 780

EMSHIPQSQD AHQMTMDDSE NNFQNITEEI PMEVFKEVRI LDSNEGKNEM EIQMKSKKLP 840

ITRKFYAFYH APIVKFWFNT LAYLGFLMLY TFVVLVQMEQ LPSVQEWIVI AYIFTYAIEK 900

VREIFMSEAG KVNQKIKVWF SDYFNISDTI AIISFFIGFG LRFGAKWNFA NAYDNHVFVA 960

GRLIYCLNII FWYVRLLDFL AVNQQAGPYV MMIGKMVANM FYIVVIMALV LLSFGVPRKA 1020

ILYPHEAPSW TLAKDIVFHP YWMIFGEVYA YEIDVCANDS VIPQICGPGT WLTPFLQAVY 1080

LFVQYIIMVN LLIAFFNNVY LQVKAISNIV WKYQRYHFIM AYHEKPVLPP PLIILSHIVS 1140

LFCCICKRRK KDKTSDGPKL FLTEEDQKKL HDFEEQCVEM YFNEKDDKFH SGSEERIRVT 1200

FERVEQMCIQ IKEVGDRVNY IKRSLQSLDS QIGHLQDLSA LTVDTLKTLT AQKASEASKV 1260

HNEITRELSI SKHLAQNLID DGPVRPSVWK KHSVVNTLSS SLPQGDLESN NPFHCNILMK 1320

DDKDPQCNIF GQDLPAIPQR KEFNFPEAGS SSGALFPSAV SPPELRQRLH GVELLKIFNK 1380

NQKLGSSSTS IPHLSSPPTK FFVSTPSQPS CKSHLETGTK DQETVCSKAA EGDNIEFGAF 1440

VGHRDSMDLQ RFKETSNKIK EILSNNNTSE NTLKRVSSLA GFTDCHRTSI PLHSKQEKIS 1500

RRPSTEDTHE VDSKAALIPD WLQDRPSNRE MPSEEGTLNG LTSPFKPAMD TNYYYSAVER 1560

NNLMRLSQSI PFTPVPPRGE PVTVYRLEES SPNILNNSMS SWSQLGLCAK IEFLSKEEMG 1620

GGLRRAVKVQ CTWSEHDILK SGHLYIIKSF LPEVINTWSS IYKEDTVLHL CLREIQQQRA 1680

AQKLTFAFNQ MKPKSIPYSP RFLEVFLLYC HSAGQWFAVE ECMTGEFRKY NNNNGDEIIP 1740

TNTLEEIMLA FSHWTYEYTR GELLVLDLQG VGENLTDPSV IKAEEKRSCD MVFGPANLGE 1800

DAIKNFRAKH HCNSCCRKLK LPDLKRNDYT PDKIIFPQEE PSDLNLQPGN STKESESTNS 1860

VRLML 1865

Nucleotide Sequence
(FASTA)

ATGTCCCAGA AATCCTGGAT AGAAAGCACT TTGACCAAGA GGGAATGTGT ATATATTATA 60

CCAAGTTCCA AGGACCCTCA CAGATGCCTT CCAGGATGTC AAATTTGTCA ACAACTCGTC 120

AGGTGTTTTT GTGGTCGCTT GGTCAAGCAA CATGCTTGTT TTACTGCAAG TCTTGCCATG 180

AAATACTCAG ATGTGAAATT GGGTGACCAT TTTAATCAGG CAATAGAAGA ATGGTCTGTG 240

GAAAAGCATA CAGAACAGAG CCCAACGGAT GCTTATGGAG TCATAAATTT TCAAGGGGGT 300

TCTCATTCCT ACAGAGCTAA GTATGTGAGG CTATCATATG ACACCAAACC TGAAGTCATT 360

CTGCAACTTC TGCTTAAAGA ATGGCAAATG GAATTACCCA AACTTGTTAT CTCTGTACAT 420

GGGGGCATGC AGAAATTTGA GCTTCATCCA CGAATCAAGC AGTTGCTTGG AAAAGGTCTT 480

ATTAAAGCTG CAGTTACAAC CGGAGCCTGG ATTTTAACTG GAGGAGTAAA CACAGGTGTG 540

GCAAAACATG TTGGAGATGC CCTCAAAGAA CATGCTTCCA GATCATCTCG AAAGATTTGC 600

ACTATCGGAA TAGCTCCATG GGGAGTGATT GAAAACAGAA ATGATCTTGT TGGGAGAGAT 660

GTGGTTGCTC CTTATCAAAC CTTATTGAAC CCCCTGAGCA AATTGAATGT TTTGAATAAT 720

CTGCATTCCC ATTTCATATT GGTGGATGAT GGCACTGTTG GAAAGTATGG GGCAGAAGTC 780

AGACTGAGAA GAGAACTCGA AAAAACTATT AATCAGCAAA GAATTCATGC TAGGATTGGC 840

CAGGGTGTCC CTGTGGTGGC ACTTATATTT GAGGGTGGGC CAAATGTTAT CCTCACAGTT 900

CTTGAATACC TTCAGGAAAG CCCCCCTGTT CCAGTAGTTG TATGTGAAGG AACAGGCAGA 960

GCTGCAGATC TGCTAGCATA TATTCATAAA CAAACAGAAG AAGGAGGGAA TCTTCCTGAT 1020

GCAGCAGAAC CCGATATTAT TTCCACTATC AAAAAAACAT TTAACTTTGG CCAGAATGAA 1080

GCAGTTCATT TATTTCAAAC ACTGATGGAG TGCATGAAAA GAAAGGAGCT TATCACTGTT 1140

TTCCATATTG GGTCAGATGA ACATCAAGAT ATAGATGTAG CAATACTTAC TGCACTGCTA 1200

AAAGGTACTA ATGCATCTGC ATTTGACCAG CTTATCCTTA CATTGGCATG GGATAGAGTT 1260

GACATTGCCA AAAATCATGT ATTTGTTTAT GGACAGCAGT GGCTGGTTGG ATCCTTGGAA 1320

CAAGCTATGC TTGATGCTCT TGTAATGGAT AGAGTTGCAT TTGTAAAACT TCTTATTGAA 1380

AATGGAGTAA GCATGCATAA ATTCCTTACC ATTCCGAGAC TGGAAGAACT TTACAACACT 1440

AAACAAGGTC CAACTAATCC AATGCTGTTT CATCTTGTTC GAGACGTCAA ACAGGGAAAT 1500

CTTCCTCCAG GATATAAGAT CACTCTAATT GATATAGGAC TTGTTATTGA ATATCTCATG 1560

GGAGGAACCT ACAGATGCAC CTATACTAGG AAACGTTTTC GATTAATATA TAATAGTCTT 1620

GGTGGAAATA ATCGGAGGTC TGGCCGAAAT ACCTCCAGCA GCACTCCTCA GTTGCGAAAG 1680

AGTCATGAAT CTTTTGGCAA TAGGGCAGAT AAAAAGGAAA AAATGAGGCA TAACCATTTC 1740

ATTAAGACAG CACAGCCCTA CCGACCAAAG ATTGATACAG TTATGGAAGA AGGAAGGAAG 1800

AAAAGAACCA AAGATGAAAT TGTAGACATT GATGATCCAG AAACCAAGCG CTTTCCTTAT 1860

CCACTTAACG AACTTTTAAT TTGGGCTTGC CTTATGAAGA GGCAGGTCAT GGCCCGTTTT 1920

TTATGGCAAC ATGGTGAAGA ATCAATGGCT AAAGCATTAG TTGCCTGTAA GATCTATCGT 1980

TCAATGGCAT ATGAAGCAAA GCAGAGTGAC CTGGTAGATG ATACTTCAGA AGAACTGAAA 2040

CAGTATTCCA ATGATTTTGG TCAGTTGGCC GTTGAATTAT TAGAACAGTC CTTCAGACAA 2100

GATGAAACCA TGGCTATGAA ATTGCTCACT TATGAACTGA AGAACTGGAG TAATTCAACC 2160

TGCCTTAAGT TAGCAGTTTC TTCAAGACTT AGACCTTTTG TAGCCCACAC CTGTACACAA 2220

ATGTTGTTAT CCGATATGTG GATGGGAAGG CTGAATATGA GGAAAAATTC CTGGTACAAG 2280

GTCATACTAA GCATTTTAGT TCCACCTGCC ATATTACTGT TAGAATATAA AACTAAGGCT 2340

GAAATGTCCC ATATCCCACA ATCTCAAGAT GCTCATCAGA TGACAATGGA TGACAGCGAA 2400

AACAACTTTC AGAACATAAC AGAAGAGATC CCCATGGAAG TGTTTAAAGA AGTACGAATT 2460

TTGGATAGTA ATGAAGGAAA GAATGAGATG GAGATACAAA TGAAATCAAA AAAGCTTCCA 2520

ATCACGCGAA AGTTTTATGC CTTTTATCAT GCACCAATTG TAAAATTCTG GTTTAACACG 2580

TTGGCATATT TAGGATTTCT GATGCTTTAT ACATTTGTGG TTCTTGTACA AATGGAACAA 2640

TTACCTTCAG TTCAAGAATG GATTGTTATT GCTTATATTT TTACTTATGC CATTGAGAAA 2700

GTCCGTGAGA TCTTTATGTC TGAAGCTGGG AAAGTAAACC AGAAGATTAA AGTATGGTTT 2760

AGTGATTACT TCAACATCAG TGATACAATT GCCATAATTT CTTTCTTCAT TGGATTTGGA 2820

CTAAGATTTG GAGCAAAATG GAACTTTGCA AATGCATATG ATAATCATGT TTTTGTGGCT 2880

GGAAGATTAA TTTACTGTCT TAACATAATA TTTTGGTATG TGCGTTTGCT AGATTTTCTA 2940

GCTGTAAATC AACAGGCAGG ACCTTATGTA ATGATGATTG GAAAAATGGT GGCCAATATG 3000

TTCTACATTG TAGTGATTAT GGCTCTTGTA TTACTTAGTT TTGGTGTTCC CAGAAAGGCA 3060

ATACTTTATC CTCATGAAGC ACCATCTTGG ACTCTTGCTA AAGATATAGT TTTTCACCCA 3120

TACTGGATGA TTTTTGGTGA AGTTTATGCA TACGAAATTG ATGTGTGTGC AAATGATTCT 3180

GTTATCCCTC AAATCTGTGG TCCTGGGACG TGGTTGACTC CATTTCTTCA AGCAGTCTAC 3240

CTCTTTGTAC AGTATATCAT TATGGTTAAT CTTCTTATTG CATTTTTCAA CAATGTGTAT 3300

TTACAAGTGA AGGCAATTTC CAATATTGTA TGGAAGTACC AGCGTTATCA TTTTATTATG 3360

GCTTATCATG AGAAACCAGT TCTGCCTCCT CCACTTATCA TTCTTAGCCA TATAGTTTCT 3420

CTCTTTTGCT GCATATGTAA GAGAAGAAAG AAAGATAAGA CTTCCGATGG ACCAAAACTT 3480

TTCTTAACAG AAGAAGATCA AAAGAAACTT CATGATTTTG AAGAGCAGTG TGTTGAGATG 3540

TATTTCAATG AAAAAGATGA CAAATTTCAT TCTGGGAGTG AAGAGAGAAT TCGTGTCACT 3600

TTTGAAAGAG TGGAACAGAT GTGCATTCAG ATTAAGGAAG TTGGAGATCG TGTCAACTAC 3660

ATAAAAAGAT CATTACAATC ATTAGATTCT CAAATTGGCC ATTTGCAAGA TCTTTCAGCC 3720

CTGACGGTAG ATACATTAAA AACACTCACT GCCCAGAAAG CGTCGGAAGC TAGCAAAGTT 3780

CATAATGAAA TCACACGAGA ACTGAGCATT TCCAAACACT TGGCTCAAAA CCTTATTGAT 3840

GATGGTCCTG TAAGACCTTC TGTATGGAAA AAGCATAGTG TTGTAAATAC GCTTAGCTCC 3900

TCTCTTCCTC AAGGTGATCT TGAAAGTAAC AATCCTTTTC ATTGTAATAT TTTAATGAAA 3960

GATGACAAAG ATCCCCAATG TAATATATTT GGTCAAGACT TACCTGCAAT ACCCCAGAGA 4020

AAAGAATTTA ATTTTCCAGA GGCTGGTTCC TCTTCTGGTG CCTTATTCCC AAGTGCTGTT 4080

TCCCCTCCAG AACTGCGACA GAGACTACAT GGGGTAGAAC TCTTAAAAAT ATTTAATAAA 4140

AATCAAAAAT TAGGCAGTTC ATCTACTAGC ATACCACATC TGTCATCCCC ACCAACCAAA 4200

TTTTTTGTTA GTACACCATC TCAGCCAAGT TGCAAAAGCC ACTTGGAAAC TGGAACCAAA 4260

GATCAAGAAA CTGTTTGCTC TAAAGCTGCA GAAGGAGATA ATATAGAATT TGGAGCATTT 4320

GTAGGACACA GAGATAGCAT GGATTTACAG AGGTTTAAAG AAACATCAAA CAAGATAAAA 4380

GAAATACTAT CCAATAACAA CACTTCTGAA AACACTTTGA AACGAGTGAG TTCTCTTGCT 4440

GGATTTACTG ACTGCCACAG AACTTCCATT CCTCTTCATT CAAAACAAGA AAAAATCAGT 4500

AGAAGGCCAT CTACCGAAGA CACTCATGAA GTAGATTCCA AAGCAGCTTT AATACCGGAT 4560

TGGTTACAAG ATAGACCATC AAACAGAGAA ATGCCATCTG AAGAAGGAAC ATTAAATGGT 4620

CTCACTTCTC CATTTAAGCC AGCTATGGAT ACAAATTACT ATTATTCAGC TGTGGAAAGA 4680

AATAACTTGA TGAGGTTATC ACAGAGCATT CCATTTACAC CTGTGCCTCC AAGAGGGGAG 4740

CCTGTCACAG TGTATCGTTT GGAAGAGAGT TCACCCAACA TACTAAATAA CAGCATGTCT 4800

TCTTGGTCAC AACTAGGCCT CTGTGCCAAA ATAGAGTTTT TAAGCAAAGA GGAGATGGGC 4860

GGAGGTTTAC GAAGAGCTGT CAAAGTACAG TGTACCTGGT CAGAACATGA TATCCTCAAA 4920

TCAGGGCATC TTTATATTAT CAAATCTTTT CTTCCAGAGG TGATTAATAC ATGGTCAAGT 4980

ATTTATAAAG AAGATACAGT TCTGCATCTC TGTCTGAGAG AAATTCAACA ACAGAGAGCA 5040

GCACAAAAGC TTACATTTGC CTTTAATCAA ATGAAACCCA AATCCATACC ATATTCTCCA 5100

AGGTTCCTTG AAGTTTTCCT GCTGTATTGC CATTCAGCAG GACAGTGGTT TGCTGTGGAA 5160

GAATGTATGA CTGGAGAATT TAGAAAATAC AACAATAATA ATGGAGATGA GATTATTCCA 5220

ACTAATACTC TGGAAGAGAT CATGCTAGCC TTTAGCCACT GGACTTACGA ATATACAAGA 5280

GGGGAGTTAC TGGTACTTGA TTTGCAAGGT GTTGGTGAAA ATTTGACTGA CCCATCTGTG 5340

ATAAAAGCAG AAGAAAAGAG ATCCTGTGAT ATGGTTTTTG GCCCAGCAAA TCTAGGAGAA 5400

GATGCAATTA AAAACTTCAG AGCAAAACAT CACTGTAATT CTTGCTGTAG AAAGCTTAAA 5460

CTTCCAGATC TGAAGAGGAA TGATTATACG CCTGATAAAA TTATATTTCC TCAGGAGGAG 5520

CCTTCAGATT TGAATCTTCA GCCTGGAAAT TCCACCAAAG AATCAGAATC AACTAATTCT 5580

GTTCGTCTGA TGTTATAA 5598

Domain Profile

S: 1     ssesWsqqetivlikvlskeekkGalRkalrv..........kkgslflvkeelkevvry  50

         s++sWsq +++++i++lskee+ G+lR+a++v          k+g+l+++k++l+ev+++

Q: 1598  SMSSWSQLGLCAKIEFLSKEEMGGGLRRAVKVqctwsehdilKSGHLYIIKSFLPEVINT  1657

         699*********************************************************

S: 51    vakiykeqkvlhlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqll  110

         +++iyke++vlhl+lr++++qraaqkl+++fnq+kPk+i+y+pr++evfL +++s++q++

Q: 1658  WSSIYKEDTVLHLCLREIQQQRAAQKLTFAFNQMKPKSIPYSPRFLEVFLLYCHSAGQWF  1717

         ************************************************************

S: 111   tvEeyllGefvKynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTD  170

         +vEe+++Gef+Kynnnngdei+++n+lee+mlafsH+tyeyt+gellV+DlqGvge+lTD

Q: 1718  AVEECMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTD  1777

         ************************************************************

S: 171   pqiat....ksrgtkfgkanlgeraiknFfakhhCNeiC  205

         p++++    +s++++fg+anlge+aiknF+akhhCN++C

Q: 1778  PSVIKaeekRSCDMVFGPANLGEDAIKNFRAKHHCNSCC  1816

         *****99999*****************************

Domain Sequence
(FASTA)

SMSSWSQLGL CAKIEFLSKE EMGGGLRRAV KVQCTWSEHD ILKSGHLYII KSFLPEVINT 60

WSSIYKEDTV LHLCLREIQQ QRAAQKLTFA FNQMKPKSIP YSPRFLEVFL LYCHSAGQWF 120

AVEECMTGEF RKYNNNNGDE IIPTNTLEEI MLAFSHWTYE YTRGELLVLD LQGVGENLTD 180

PSVIKAEEKR SCDMVFGPAN LGEDAIKNFR AKHHCNSCC 219

Keyword

Complete proteome; Ion transport; Ionic channel; Membrane; Reference proteome; Transmembrane; Transport.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0001726	; C:ruffle
GO:0005524	; F:ATP binding
GO:0005262	; F:calcium channel activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0031032	; P:actomyosin structure organization
GO:0016340	; P:calcium-dependent cell-matrix adhesion
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR005821	; Ion_trans_dom.
IPR011009	; Kinase-like_dom.
IPR004166	; MHCK_EF2_kinase.

Pfam

PF02816	; Alpha_kinase; 1.
PF00520	; Ion_trans; 1.

SMARTs

SM00811

; Alpha_kinase; 1.

Prosites

PS51158

; ALPHA_KINASE; 1.

Prints

Created Date

20-Feb-2013