EKS-POA-00141

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00141

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	472.5	2.3E-142	182	427	246

Status

Unreviewed

Ensembl Protein

ENSPPYP00000007539

UniProt Accession

H2NNS6;

Protein Name

Protein Synonyms/Alias

Gene Name

CSK

Gene Synonyms/Alias

CSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000006646	ENSPPYP00000007539	ENSPPYT00000007846

Organism

Pongo abelii

Functional Description

Protein Length

437

Protein Sequence
(FASTA)

MYCQYNFHGT AEQDLPFCKG DVLTIVDITK DPNWYKAKNK VGREGIIPAN YVQKREGVKA 60

GTKLSLMPWF HGKITREQAE RLLYPPETGL FLVRESTNYP GDYTLCVSCD GKVEHYRIMY 120

HASKLSIDEE VYFENLMQLV EHYTSDADGL CTRLIKPKVM EGTVAAQDEF YRSGWALNMK 180

ELKLLQTIGK GEFGDVMLGD YRGNKVAVKC IKNDATAQAF LAEASVMTQL RHSNLVQLLG 240

VIVEEKGGLY IVTEYMAKGS LVDYLRSRGR SVLGGDCLLK FSLDVCEAME YLEGNNFVHR 300

DLAARNVLVS EDNVAKVSDF GLTKEASSTQ DTGKLPVKWT APEALREKKF STKSDVWSFG 360

ILLWEIYSFG RVPYPRIPLK DVVPRVEKGY KMDAPDGCPP AVYEVMKNCW HLDAAMRPSF 420

LQLREQLEHI KTHELHL 437

Nucleotide Sequence
(FASTA)

ATGTATTGCC AGTACAACTT CCACGGCACT GCCGAGCAGG ACCTGCCCTT CTGCAAAGGA 60

GACGTGCTCA CCATTGTGGA CATCACCAAG GACCCCAACT GGTACAAAGC CAAAAACAAG 120

GTGGGCCGTG AGGGCATCAT CCCAGCCAAC TACGTCCAGA AGCGGGAGGG CGTGAAGGCG 180

GGTACCAAAC TCAGCCTCAT GCCTTGGTTC CACGGCAAGA TCACACGGGA GCAGGCTGAG 240

CGGCTTCTGT ACCCGCCGGA GACAGGCCTG TTCCTGGTGC GGGAGAGCAC CAACTACCCT 300

GGAGACTACA CGCTGTGCGT GAGCTGCGAC GGCAAGGTGG AGCACTACCG CATCATGTAC 360

CATGCCAGCA AGCTCAGCAT CGACGAGGAG GTGTACTTTG AGAACCTCAT GCAGCTGGTG 420

GAGCACTACA CCTCAGACGC AGATGGGCTC TGTACGCGCC TCATTAAACC AAAGGTCATG 480

GAGGGCACGG TGGCGGCCCA GGATGAGTTC TACCGCAGCG GCTGGGCCCT GAACATGAAG 540

GAGCTGAAGC TGCTGCAGAC CATCGGCAAG GGGGAGTTTG GAGACGTGAT GCTGGGCGAT 600

TACCGAGGGA ACAAAGTCGC TGTCAAGTGC ATTAAGAACG ACGCCACTGC CCAGGCCTTC 660

CTGGCTGAAG CCTCAGTCAT GACGCAACTG CGGCATAGCA ACCTGGTGCA GCTCCTGGGC 720

GTGATCGTGG AGGAGAAGGG CGGGCTCTAC ATCGTCACTG AGTACATGGC CAAGGGGAGC 780

CTCGTGGACT ACTTGCGGTC TCGGGGTCGG TCAGTGCTGG GCGGAGACTG TCTCCTCAAG 840

TTCTCGCTAG ATGTCTGTGA GGCCATGGAG TACCTGGAGG GCAACAACTT CGTGCATCGA 900

GACCTGGCTG CCCGCAATGT GCTGGTGTCT GAGGACAACG TGGCCAAGGT CAGCGACTTT 960

GGTCTCACCA AGGAGGCGTC CAGCACCCAG GACACGGGCA AGCTGCCAGT CAAGTGGACA 1020

GCCCCTGAGG CCCTGAGAGA GAAGAAATTC TCCACTAAGT CTGACGTGTG GAGTTTCGGA 1080

ATCCTTCTCT GGGAAATCTA CTCCTTTGGG CGAGTGCCTT ATCCAAGAAT TCCCCTGAAG 1140

GACGTCGTCC CTCGGGTGGA GAAGGGCTAC AAGATGGATG CCCCCGACGG CTGCCCGCCC 1200

GCAGTCTATG AGGTCATGAA GAACTGCTGG CACCTGGACG CCGCCATGCG GCCCTCCTTC 1260

CTACAGCTCC GAGAGCAGCT TGAGCACATC AAAACCCACG AGCTGCACCT GTGA 1314

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv

Q: 182   LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV  241

         6899********************************************************

S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119

         i+eek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd

Q: 242   IVEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD  301

         *****99*****************************************************

S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179

         laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi

Q: 302   LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI  361

         ************************************************************

S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239

         llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vye+mk++w+l+aa+rpsf

Q: 362   LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFL  421

         ************************************************************

S: 240   klkekl  245

         +l+e+l

Q: 422   QLREQL  427

         ***997

Domain Sequence
(FASTA)

LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60

IVEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120

LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180

LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYEVMKNCWH LDAAMRPSFL 240

QLREQL 246

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013