EKS-POA-00391

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00391

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	408.8	1.0E-122	478	720	243

Status

Unreviewed

Ensembl Protein

ENSPPYP00000007573

UniProt Accession

H2NNW0;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100458080

Gene Synonyms/Alias

LOC100458080;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000006675	ENSPPYP00000007573	ENSPPYT00000007881

Organism

Pongo abelii

Functional Description

Protein Length

745

Protein Sequence
(FASTA)

LMGAPAKLTV SQGQPVKLNC SVEGMEELDI QWVKDGAVVQ NLDQLYIPVS EQHWIGFLSL 60

KSVERSDMGY WCQVDGGKTK ISQPVWLTVV GVPLFTVEPK DLAVPPNAPF QLSCKAVGPP 120

EPVTIVWWRG TTKIRGPAPS LSVLNVTGVT QSTFSWEAHS LKCLASSHIA TVLLQALPAV 180

PFNITVTKLC SGNTSVAWMP GADGRVLLQS YTVQVTQAPG GEVLAVVVLV PPFTCLLRDL 240

VPATSYSLRV CCANALGPSP YADWVPFQTK GLAPASTPQN LHAIHTDSGL ILEWEEVIPE 300

GPLEGPLGPY KLSWVQDSGT QDELTMEGTR ANLTGWDPQK GLIVCVCVSS AVGCGPWSQP 360

LVVSSHDHAG QKGCPHSHTS WVPVVLGVLT ALVTAAALAL ILLRKRRKET WFGQGFDSVM 420

ALGEPAIHFR AARSFNRERP KRIEATLDSL GINSKLKEKL EDVLIPEQQF TLARYWAKAQ 480

LKQEDGSFVK VAVKMLKADI IASSDIEEFL REAACMKEFD HPHVAKLVGS LWSRAKGCHP 540

IPMVILPFMK HGDLHAFLLT SRLGENPFTL IRFMVDNACG MEYLSSRNFI HRDLAARNCV 600

LAEDMTVCVA DFGLSWKIYS GTGCASKLPV KWLALESLAD NLYTVHSDVW AFGVTVWEIM 660

TCGQTPYAGN NTEIYNYLIG GNRLKQLPEY MEPSDDLLYD LMYQCWSADP KQRPSFTCLR 720

MELENILGQL SVLSASQDPL YINIE 745

Nucleotide Sequence
(FASTA)

CTCATGGGAG CCCCGGCAAA GCTGACAGTG TCTCAGGGGC AGCCGGTGAA GCTCAACTGC 60

AGCGTGGAGG GGATGGAGGA GCTTGACATC CAGTGGGTGA AGGATGGGGC TGTGGTCCAG 120

AACTTGGACC AGTTGTACAT CCCAGTCAGC GAGCAGCACT GGATCGGCTT CCTCAGCCTG 180

AAGTCAGTGG AGCGCTCTGA CATGGGCTAC TGGTGCCAGG TGGATGGGGG CAAAACCAAG 240

ATCTCACAGC CAGTGTGGCT CACGGTAGTA GGTGTGCCAC TTTTCACAGT GGAGCCAAAA 300

GATCTGGCAG TGCCACCCAA TGCCCCTTTC CAACTGTCTT GCAAGGCTGT GGGTCCCCCT 360

GAACCTGTTA CCATTGTCTG GTGGAGAGGA ACTACGAAGA TCAGGGGACC TGCTCCCTCT 420

CTATCTGTTT TAAATGTAAC AGGGGTGACC CAGAGCACCT TTTCCTGGGA AGCTCACAGC 480

CTAAAATGCC TGGCCTCTTC TCACATAGCC ACTGTTCTCC TTCAAGCACT GCCTGCAGTC 540

CCCTTCAACA TCACCGTGAC AAAGCTTTGC AGTGGCAACA CTAGTGTGGC CTGGATGCCA 600

GGTGCTGATG GCCGAGTCCT GCTACAGTCC TATACAGTTC AGGTGACACA GGCCCCAGGA 660

GGCGAAGTCC TGGCTGTTGT GGTCCTTGTG CCCCCCTTTA CCTGCCTGCT CCGGGACCTG 720

GTGCCTGCCA CCAGCTACAG CCTCAGGGTG TGTTGTGCCA ATGCCTTGGG GCCCTCTCCT 780

TATGCTGACT GGGTACCCTT TCAGACCAAG GGTCTAGCCC CAGCCAGCAC TCCCCAAAAC 840

CTCCATGCCA TCCACACAGA TTCAGGCCTC ATCTTGGAGT GGGAAGAAGT GATCCCCGAG 900

GGCCCTTTGG AAGGCCCCCT GGGACCCTAT AAACTGTCCT GGGTTCAAGA CAGTGGAACC 960

CAGGATGAGC TGACAATGGA GGGGACCAGG GCCAATTTGA CAGGCTGGGA TCCCCAAAAG 1020

GGCCTGATCG TATGTGTGTG TGTCTCCAGT GCAGTTGGCT GTGGACCCTG GAGTCAGCCA 1080

CTGGTGGTCT CTTCTCATGA CCATGCAGGC CAGAAGGGCT GTCCTCACAG CCACACATCC 1140

TGGGTACCTG TGGTCCTTGG TGTGCTAACG GCCCTGGTGA CGGCTGCTGC CCTGGCCCTC 1200

ATCTTGCTTC GAAAGAGACG GAAAGAGACG TGGTTTGGGC AAGGCTTTGA CAGTGTCATG 1260

GCCCTGGGAG AGCCAGCCAT TCACTTCCGG GCAGCCAGGT CCTTCAATCG AGAAAGGCCC 1320

AAGCGCATCG AGGCCACATT GGACAGCTTG GGCATCAACA GCAAACTAAA GGAAAAACTG 1380

GAGGATGTGC TCATCCCAGA GCAGCAGTTC ACCCTGGCCA GATATTGGGC AAAGGCCCAG 1440

CTGAAGCAGG AGGATGGCTC CTTTGTGAAA GTGGCTGTGA AGATGCTGAA AGCTGATATC 1500

ATTGCCTCAA GCGACATTGA AGAGTTCCTC AGGGAAGCAG CTTGCATGAA GGAGTTTGAT 1560

CATCCACATG TGGCCAAACT TGTTGGGAGC CTCTGGAGCA GGGCTAAAGG CTGTCACCCC 1620

ATCCCCATGG TCATCTTGCC CTTCATGAAG CATGGTGACC TGCACGCCTT CCTGCTCACC 1680

TCCCGGCTTG GGGAGAACCC CTTTACCCTG ATCCGGTTCA TGGTGGACAA TGCCTGTGGC 1740

ATGGAGTACC TGAGCTCTCG GAACTTCATC CACCGAGACC TGGCCGCTCG GAACTGTGTG 1800

CTGGCAGAGG ACATGACAGT GTGTGTGGCT GACTTCGGAC TCTCCTGGAA GATCTACAGT 1860

GGGACTGGCT GTGCCTCCAA ATTGCCTGTC AAGTGGCTGG CCCTGGAGAG CCTGGCTGAC 1920

AACCTGTATA CTGTGCACAG TGACGTGTGG GCCTTCGGGG TGACCGTGTG GGAGATCATG 1980

ACATGTGGGC AGACGCCATA CGCTGGCAAC AACACTGAGA TTTACAACTA CCTCATTGGC 2040

GGGAATCGCC TGAAACAGCT TCCAGAGTAT ATGGAGCCTT CAGACGACCT TTTATATGAT 2100

CTCATGTACC AGTGCTGGAG TGCTGACCCC AAGCAGCGCC CAAGCTTTAC TTGCCTGCGA 2160

ATGGAACTGG AGAACATCCT GGGCCAGCTG TCTGTGCTAT CTGCCAGCCA GGACCCCTTA 2220

TACATCAACA TCGAG 2235

Domain Profile

S: 17    egqlkqedgsilkvavktlkldiiarseieeflseaacmkefdhpnvirlvgvslessek  76

         ++qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdhp+v++lvg sl s++k

Q: 478   KAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVG-SLWSRAK  536

         69**************************************************.7899***

S: 77    grlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmvdiasgmeylssrnfih  136

         g  p+p+vilpfmk+gdlhafll srlgenp+     tl++fmvd a+gmeylssrnfih

Q: 537   GCHPIPMVILPFMKHGDLHAFLLTSRLGENPF-----TLIRFMVDNACGMEYLSSRNFIH  591

         *******************************8.....68*********************

S: 137   rdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvkwiaiesladrvytsks  196

         rdlaarnc+laedmtvcvadfgls kiysg     g+++klpvkw+a+eslad++yt++s

Q: 592   RDLAARNCVLAEDMTVCVADFGLSWKIYSG----TGCASKLPVKWLALESLADNLYTVHS  647

         *****************************9....5*************************

S: 197   dvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedcl....delydlmyrcw  252

         dvwafgvt+wei+t gqtpyag +n+eiy+yl++gnrlkq ++ +    d lydlmy+cw

Q: 648   DVWAFGVTVWEIMTCGQTPYAG-NNTEIYNYLIGGNRLKQLPEYMepsdDLLYDLMYQCW  706

         **********************.89***************999993332348********

S: 253   eadpkdrpsfsvlr  266

         +adpk+rpsf+ lr

Q: 707   SADPKQRPSFTCLR  720

         ***********998

Domain Sequence
(FASTA)

KAQLKQEDGS FVKVAVKMLK ADIIASSDIE EFLREAACMK EFDHPHVAKL VGSLWSRAKG 60

CHPIPMVILP FMKHGDLHAF LLTSRLGENP FTLIRFMVDN ACGMEYLSSR NFIHRDLAAR 120

NCVLAEDMTV CVADFGLSWK IYSGTGCASK LPVKWLALES LADNLYTVHS DVWAFGVTVW 180

EIMTCGQTPY AGNNTEIYNY LIGGNRLKQL PEYMEPSDDL LYDLMYQCWS ADPKQRPSFT 240

CLR 243

Keyword

Complete proteome; Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013