EKS-POA-00208

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00208

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NKF3	569.7	2.1E-171	1330	1664	335

Status

Unreviewed

Ensembl Protein

ENSPPYP00000007580

UniProt Accession

H2NNW6;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK269

Gene Synonyms/Alias

SGK269;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000006681	ENSPPYP00000007580	ENSPPYT00000007888

Organism

Pongo abelii

Functional Description

Protein Length

1747

Protein Sequence
(FASTA)

MSACNTFTEH VWKPGECKNC FKPKSLHQLP PDPEKAPITH GNVKTNANHS NNHRIRNTGN 60

FRPPVAKKPT IAVKPTMIVA DGQSICGELS IQEHCENKPV IIGWNRNRAA LSQKPLNNNN 120

EDDEGISHVP KPYGNNDSAK KMSNNNNGLT EVLKEIAGLD TAPQIRGNET NSRETFLGRI 180

NDCYKRSLER KLPPSCMIGG IKETQGKHVI LSGSTEVISN EGGRFCYPEF SSGEESEEDV 240

LFSNMEEEHE SWDESDEELL AMEIRMRGQP RFANFRANTL SPVRFFVDKK WNTIPLRNKS 300

LQRICAVDYD DSYDEILNGY EENSVVSYGQ GSIQSMVSSD STSPDSSLTE ESRSETASSL 360

SQKICNGGIS PGNPGDSNDM KEIEPNYESP SSNNQDKDSS QASKSSVKVP ETHKAVLALR 420

LEEKDGKIAV QTEKEESKAS TDVAGQAVTI NLVPTEEQAK PYRVVNLEQP LCKPYTIVDV 480

SAAMASEHLE GPVNSPKTKS SSSTPNSPVT SSSLTPGQIS AHFQKSSAIR YQEVWTSSTS 540

PRQKIPKVEL ITSGTGPNVP PRKNCHKSAP TSPTATNISS KTIPVKSPNL SEIKFNSYNN 600

AGMPPFPIII HDEPTYARSS KNAIKVPIVI NPNAYDNLAI YKSFLGTSGE LPVKEKTTSV 660

ISHTYEEIET ESKVPDNTTS KTTDCLQTKG FSNSTEHKRG SVAQKVQEFN NCLNRGQSSP 720

QRSYSSSHSS PAKIQRTTQE PVAKIEGTQE SQMVGSSSTR EKASTVLSQI VASIQPPQSP 780

PETPQSGPKT CSVEELYAIP PDADVAKCTP KSTPVRPKSL FTSQPSGEAE APQTTDSPTT 840

KVQKDPSIKP VTPSPSKLVT SPQSEPPPPF PPPRSTSSPY HAGNLLQRHF TNWTKPTSPT 900

RSTEAESVLH SEGSRRAADA KPKRWISFKS FFRRRKTDEE DDKEKEREKG KLVGLDGTVI 960

HMLPPPPVQR HHWFTEAKGE SSEKPAIVFM YRCDPAQGQL SVDQSKARTD QAAVMEKGRA 1020

ENALLQDSEK KKRSHSSPSQ IPKNILSHMT HEVTEDFSPR DPRTVVGKQD GGGCTSVTTA 1080

LSLPELERED GKEDISDPMD PNPCSATYSN LGQSRAAMIP PKQPRQPKGA VDDAIAFGGK 1140

TDQEAPNASQ PTPPPLPKKM IIRANTEPIS KDLQKSMESS LCVMANPTYD IDPNWDASSA 1200

GSSISYELKG LDIESYDSLE RPLRKERPVP SAANSISSLT TLSIKDRFSN SMESLSSRRG 1260

PSCRQDRGIQ KPQRQALYRG LENREEVVGK IRSLHTDALK KLAVKCEDLF MAGQKDQLRF 1320

GVDSWSDFRL TSDKPCCEAG DAVYYTASYA KDPLNNYAVK ICKSKAKESQ HYYHSLAVRQ 1380

SLAVHFNIQQ DCGHFLAEVP NRLLPWEDPD DPEKDEDDME ETEEEAKGET DGKNPKPCSE 1440

AASSQKENQG VMSKKQRSHV VVITREVPCL TVADFVRDSL AQHGKSPDLY ERQVCLLLLQ 1500

LCSGLEHLKP YHVTHCDLRL ENLLLVHYQP GGTAQGFGPA EPSPTSSYPT RLIVSNFSQA 1560

KQKSHLVDPE ILRDQSRLAP EIITATQYKK CDEFQTGILI YEMLHLPNPF DENPELKERE 1620

YTRADLPRIP FRSPYSRGLQ QLASCLLNPN PSERILISDA KGILQCLLWG PREDLFQTFT 1680

ACPSLVQRNT LLQNWLDIKR TLLMIKFAEK SLDREGGINL EDWLCAQYLA FATTDSLSCI 1740

VKILQHR 1747

Nucleotide Sequence
(FASTA)

ATGTCTGCTT GTAACACCTT TACTGAACAT GTTTGGAAAC CTGGTGAATG CAAGAATTGC 60

TTTAAACCTA AAAGTTTGCA CCAGCTTCCC CCAGACCCTG AGAAGGCACC CATCACCCAT 120

GGCAATGTGA AAACTAATGC CAATCACAGT AACAACCACC GCATCAGGAA CACCGGCAAT 180

TTCCGGCCTC CTGTGGCTAA AAAACCCACT ATAGCTGTGA AGCCCACTAT GATAGTGGCA 240

GATGGGCAAA GTATATGTGG TGAGCTTAGC ATCCAAGAAC ACTGTGAGAA CAAACCTGTC 300

ATCATAGGGT GGAACCGAAA CAGAGCTGCC TTGAGTCAGA AACCACTTAA CAATAATAAT 360

GAAGACGATG AAGGAATTAG CCATGTTCCT AAGCCTTATG GCAATAATGA TAGTGCAAAG 420

AAGATGTCAA ATAACAATAA TGGACTAACT GAAGTGTTAA AGGAGATAGC AGGCTTGGAT 480

ACTGCCCCTC AGATAAGAGG AAATGAAACA AACTCCAGAG AAACATTCTT GGGAAGAATA 540

AATGATTGCT ATAAACGATC ATTGGAAAGA AAGCTTCCAC CAAGTTGCAT GATAGGTGGG 600

ATAAAGGAAA CTCAGGGCAA GCATGTTATT CTGAGTGGGA GCACAGAAGT GATTAGTAAC 660

GAAGGGGGCC GGTTCTGTTA CCCAGAGTTT TCCAGTGGCG AGGAGAGTGA AGAGGATGTA 720

CTTTTCAGTA ACATGGAGGA GGAGCACGAG AGTTGGGATG AGAGTGATGA AGAGCTGTTG 780

GCCATGGAGA TTCGCATGAG AGGGCAACCT CGCTTTGCCA ACTTCAGAGC AAACACTTTG 840

TCTCCTGTTC GATTCTTTGT GGACAAAAAA TGGAATACTA TCCCCCTGCG AAACAAGTCT 900

CTGCAGAGAA TCTGTGCTGT GGACTATGAT GACAGCTATG ATGAAATCCT GAACGGTTAT 960

GAGGAAAATT CTGTGGTCTC TTATGGACAA GGAAGCATTC AGAGCATGGT GTCATCTGAC 1020

TCCACATCAC CAGATTCTTC TTTAACAGAA GAATCACGTT CTGAGACAGC CAGTAGTTTA 1080

TCCCAGAAGA TTTGTAATGG GGGAATATCT CCTGGTAACC CAGGAGATTC TAACGACATG 1140

AAGGAAATTG AGCCCAATTA TGAAAGTCCC TCTAGTAATA ATCAGGATAA AGATTCATCA 1200

CAAGCTTCCA AAAGCTCAGT AAAAGTTCCA GAGACCCACA AAGCAGTCCT TGCTCTCCGA 1260

TTAGAAGAGA AAGATGGCAA GATTGCTGTA CAGACTGAGA AGGAAGAAAG TAAAGCCTCT 1320

ACAGATGTTG CTGGGCAAGC AGTAACCATA AACCTTGTCC CCACAGAAGA GCAAGCAAAA 1380

CCTTACCGAG TTGTGAATCT GGAACAGCCA TTGTGCAAGC CATATACTAT CGTGGATGTG 1440

TCAGCAGCCA TGGCCAGTGA GCACCTCGAG GGCCCTGTTA ACAGCCCCAA GACAAAAAGC 1500

TCATCTTCTA CTCCAAACTC TCCAGTTACA TCATCTTCAT TGACACCAGG ACAAATAAGT 1560

GCCCATTTCC AAAAATCCAG TGCAATTCGA TACCAAGAAG TGTGGACTTC TAGCACCAGT 1620

CCACGACAAA AGATACCTAA AGTAGAACTA ATTACTAGTG GAACTGGACC AAATGTTCCT 1680

CCGAGGAAAA ACTGTCACAA ATCAGCACCT ACATCACCCA CAGCTACAAA CATTTCCTCC 1740

AAAACCATCC CTGTTAAGTC ACCTAATTTG TCTGAAATAA AATTTAATAG TTATAACAAT 1800

GCTGGTATGC CACCTTTTCC AATTATCATT CATGACGAGC CAACTTATGC TCGGAGTTCC 1860

AAAAATGCTA TCAAAGTTCC CATTGTTATC AATCCAAATG CATATGACAA TCTAGCTATC 1920

TACAAAAGTT TTCTGGGAAC AAGTGGAGAA CTCCCAGTGA AGGAAAAAAC CACAAGTGTA 1980

ATAAGCCATA CTTATGAAGA AATAGAAACT GAAAGCAAAG TGCCTGATAA CACCACTAGC 2040

AAAACCACTG ACTGTCTTCA AACTAAAGGG TTTTCAAACA GCACAGAGCA TAAAAGGGGC 2100

TCAGTGGCTC AGAAGGTTCA AGAGTTTAAC AACTGTCTCA ACAGAGGTCA GTCTTCACCA 2160

CAGAGAAGCT ATAGTTCCAG CCACAGCTCC CCAGCAAAGA TCCAGAGAAC CACTCAAGAG 2220

CCTGTGGCCA AAATAGAAGG CACTCAGGAG TCTCAGATGG TGGGCAGCAG CAGCACCAGA 2280

GAGAAAGCAA GCACAGTGCT TTCTCAGATT GTGGCTTCAA TCCAACCCCC ACAGTCTCCT 2340

CCAGAAACAC CTCAATCTGG CCCTAAAACT TGCAGTGTGG AAGAACTTTA TGCCATTCCT 2400

CCAGATGCTG ATGTTGCTAA GTGTACACCT AAGAGTACGC CAGTCCGGCC CAAATCTCTC 2460

TTTACATCTC AGCCTAGTGG TGAGGCTGAA GCACCTCAGA CCACAGACAG TCCTACCACC 2520

AAAGTACAGA AAGACCCATC CATAAAGCCA GTCACTCCCT CTCCCTCCAA ATTAGTGACT 2580

AGCCCCCAGA GTGAGCCACC ACCTCCCTTT CCCCCGCCAC GCTCTACTTC TTCTCCTTAC 2640

CATGCAGGTA ACCTTTTGCA GAGGCATTTC ACCAACTGGA CCAAGCCAAC CAGCCCTACC 2700

AGGTCAACAG AAGCTGAATC AGTTTTGCAC TCTGAAGGCA GCAGGCGGGC AGCTGATGCA 2760

AAACCTAAGC GCTGGATATC ATTTAAAAGC TTCTTCCGCC GTCGGAAAAC AGATGAGGAG 2820

GATGACAAAG AGAAAGAGCG AGAGAAAGGG AAACTGGTGG GCCTGGATGG CACAGTCATT 2880

CACATGCTGC CTCCTCCTCC AGTTCAGCGC CATCACTGGT TCACAGAGGC AAAAGGAGAG 2940

TCCAGTGAGA AACCAGCCAT TGTCTTCATG TATAGGTGCG ACCCTGCTCA AGGCCAGCTC 3000

AGTGTGGATC AGAGCAAGGC TAGGACAGAC CAGGCAGCAG TCATGGAGAA GGGTAGAGCA 3060

GAGAATGCAT TACTACAGGA CTCAGAGAAG AAGAAGAGGA GTCATTCTTC TCCATCACAG 3120

ATTCCTAAAA ATATTCTCAG TCACATGACC CATGAAGTAA CAGAGGATTT TTCTCCTCGG 3180

GATCCAAGAA CTGTTGTTGG GAAGCAAGAT GGCGGGGGCT GCACTTCAGT CACAACAGCA 3240

TTGTCCCTAC CTGAACTGGA AAGGGAAGAT GGAAAAGAAG ACATTTCAGA TCCTATGGAC 3300

CCGAACCCTT GTAGTGCAAC ATACAGCAAC TTAGGGCAAT CTAGAGCAGC CATGATACCT 3360

CCCAAGCAGC CACGACAGCC CAAGGGAGCT GTGGACGATG CCATCGCCTT TGGAGGGAAA 3420

ACAGACCAAG AAGCACCCAA TGCTTCCCAG CCTACACCAC CCCCACTGCC AAAGAAGATG 3480

ATCATAAGAG CCAATACAGA GCCAATCTCC AAGGACCTCC AAAAATCCAT GGAAAGTAGT 3540

CTCTGTGTCA TGGCTAATCC CACCTATGAT ATCGACCCCA ACTGGGATGC CAGCAGTGCT 3600

GGTTCTTCCA TCAGCTATGA ACTCAAAGGA CTGGACATTG AGTCTTACGA CTCCTTGGAA 3660

AGGCCTTTGC GCAAGGAGAG ACCTGTCCCC TCAGCAGCAA ACAGCATTTC CAGCTTAACC 3720

ACTCTCAGTA TTAAGGATAG ATTTTCCAAC AGCATGGAAT CCCTCTCCAG CCGGCGTGGG 3780

CCCTCTTGCA GACAGGACCG AGGCATCCAG AAGCCGCAGA GACAAGCACT TTATCGAGGA 3840

CTTGAGAATC GGGAGGAAGT AGTGGGTAAA ATCCGAAGCC TTCATACAGA TGCCTTGAAG 3900

AAACTGGCTG TTAAATGCGA AGACCTTTTC ATGGCTGGGC AGAAGGACCA GCTCCGTTTT 3960

GGAGTGGACA GCTGGTCAGA CTTCAGGCTA ACCAGTGACA AACCATGTTG TGAGGCAGGT 4020

GATGCTGTTT ACTATACTGC TTCATATGCA AAAGATCCAC TTAATAACTA TGCAGTCAAG 4080

ATCTGTAAGA GCAAAGCTAA AGAATCTCAG CACTATTATC ACAGCTTGGC TGTCCGGCAG 4140

AGTCTGGCTG TCCATTTTAA CATTCAGCAG GACTGTGGTC ATTTCCTTGC TGAAGTCCCT 4200

AACCGTCTGC TTCCCTGGGA GGATCCAGAT GACCCTGAAA AGGATGAGGA TGACATGGAA 4260

GAGACTGAAG AAGAAGCCAA AGGAGAAACG GATGGGAAAA ACCCAAAGCC CTGTTCTGAA 4320

GCAGCATCAT CCCAGAAAGA GAATCAGGGA GTCATGAGCA AGAAGCAGAG GAGCCATGTT 4380

GTGGTCATCA CCAGGGAGGT TCCATGTCTT ACTGTGGCTG ATTTTGTGCG AGACTCTCTG 4440

GCCCAGCATG GGAAAAGCCC TGATTTGTAT GAGAGGCAGG TATGTCTGCT GCTCTTACAG 4500

CTATGCTCTG GTCTTGAGCA CCTCAAACCC TACCATGTCA CTCACTGCGA TCTACGCCTA 4560

GAGAACCTGC TACTTGTCCA CTACCAGCCT GGGGGGACTG CCCAAGGCTT TGGGCCTGCA 4620

GAGCCCAGCC CCACCTCATC TTATCCCACT AGGCTTATAG TGAGCAACTT CTCTCAGGCC 4680

AAGCAGAAGA GCCATCTGGT GGACCCTGAG ATCCTCCGGG ACCAGTCTCG CCTTGCTCCA 4740

GAGATCATAA CAGCTACCCA GTATAAAAAG TGTGATGAGT TCCAGACAGG CATCCTCATC 4800

TATGAGATGC TGCACCTACC CAACCCCTTT GATGAGAACC CAGAGCTGAA GGAGAGGGAA 4860

TACACACGAG CAGACCTGCC TCGCATCCCA TTCCGCTCCC CCTACTCCCG GGGTCTGCAG 4920

CAGCTGGCCA GCTGCCTCCT GAATCCCAAC CCTTCTGAGC GGATCCTCAT TTCAGACGCC 4980

AAAGGCATCC TCCAGTGTCT GCTCTGGGGC CCCCGCGAAG ATCTCTTCCA GACTTTCACC 5040

GCCTGCCCTA GCCTAGTACA GAGGAATACC CTGCTCCAAA ACTGGCTAGA CATCAAGCGA 5100

ACACTGCTCA TGATCAAGTT TGCTGAGAAG TCCCTGGACA GGGAAGGTGG GATCAACCTT 5160

GAGGACTGGC TTTGTGCTCA GTATTTGGCT TTTGCCACTA CAGACTCCCT CAGTTGTATT 5220

GTGAAAATTC TGCAGCACCG TTAA 5244

Domain Profile

S: 1     ltsdkpcceagdavyytasyakdplsnyavkickskekksqsy.....vrqslpvhfniq  55

         ltsdkpcceagdavyytasyakdpl+nyavkicksk+k+sq+y     vrqsl+vhfniq

Q: 1330  LTSDKPCCEAGDAVYYTASYAKDPLNNYAVKICKSKAKESQHYyhslaVRQSLAVHFNIQ  1389

         79**********************************************************

S: 56    qdcGhflaevpsrlla..dpdapekd...................pkpasetepsake..  92

         qdcGhflaevp+rll+  dpd+pekd                   pkp+se+++s+ke

Q: 1390  QDCGHFLAEVPNRLLPweDPDDPEKDeddmeeteeeakgetdgknPKPCSEAASSQKEnq  1449

         ************************************************************

S: 93    .......rdhvvvitrevphltvadfvrdslashraepelyerrvcllllqlcsGlehlk  145

                r+hvvvitrevp+ltvadfvrdsla+h+++p+lyer+vcllllqlcsGlehlk

Q: 1450  gvmskkqRSHVVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLK  1509

         ************************************************************

S: 146   eygvihrdlrlenlllvhlqpqagaaqaaapaepaptsaapsaapaattasqegprekql  205

         +y+v+h+dlrlenlllvh+qp +g+aq+++paep+pts++p

Q: 1510  PYHVTHCDLRLENLLLVHYQP-GGTAQGFGPAEPSPTSSYP-------------------  1549

         *********************.*******************...................

S: 206   trlivsnflkakqksgglvdlqikkdqarlapeivsasqykkfdefqtGiliyellhlpn  265

         trlivsnf++akqks +lvd++i++dq+rlapei++a+qykk+defqtGiliye+lhlpn

Q: 1550  TRLIVSNFSQAKQKS-HLVDPEILRDQSRLAPEIITATQYKKCDEFQTGILIYEMLHLPN  1608

         9**************.********************************************

S: 266   pfevraelkereyrredlprlpllslysrGlqqlasllleadpikriliseakrvl  321

         pf++++elkerey+r+dlpr+p++s+ysrGlqqlas+ll+++p++rilis+ak++l

Q: 1609  PFDENPELKEREYTRADLPRIPFRSPYSRGLQQLASCLLNPNPSERILISDAKGIL  1664

         ******************************************************98

Domain Sequence
(FASTA)

LTSDKPCCEA GDAVYYTASY AKDPLNNYAV KICKSKAKES QHYYHSLAVR QSLAVHFNIQ 60

QDCGHFLAEV PNRLLPWEDP DDPEKDEDDM EETEEEAKGE TDGKNPKPCS EAASSQKENQ 120

GVMSKKQRSH VVVITREVPC LTVADFVRDS LAQHGKSPDL YERQVCLLLL QLCSGLEHLK 180

PYHVTHCDLR LENLLLVHYQ PGGTAQGFGP AEPSPTSSYP TRLIVSNFSQ AKQKSHLVDP 240

EILRDQSRLA PEIITATQYK KCDEFQTGIL IYEMLHLPNP FDENPELKER EYTRADLPRI 300

PFRSPYSRGL QQLASCLLNP NPSERILISD AKGIL 335

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005925	; C:focal adhesion
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0016477	; P:cell migration
GO:0046777	; P:protein autophosphorylation
GO:0034446	; P:substrate adhesion-dependent cell spreading

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013