EKS-POA-00403
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00403
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Trk534.25.7E-161538823286
StatusUnreviewed
Ensembl ProteinENSPPYP00000007657
UniProt AccessionH2NP37;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameNTRK3
Gene Synonyms/Alias NTRK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000006749ENSPPYP00000024228ENSPPYT00000033490
ENSPPYG00000006749ENSPPYP00000007657ENSPPYT00000007969
OrganismPongo abelii
Functional Description
Protein Length839
Protein Sequence
(FASTA)
MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ 60
DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRSIQP 120
RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELQLEQN FFNCSCDIRW MQLWQEQGEA 180
KLNSQNLYCI NADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD 240
VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT 300
VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV EYYQEGEISE 360
GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF PESTDNFILF DEVSPTPPIT 420
VTHKPEEDTF GVSIAVGLAA FACVLLVVLF IMINKYGRRS KFGMKGPVAV ISGEEDSASP 480
LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTYV QHIKRRDIVL 540
KRELGEGAFG KVFLAECYNL SPTKDKMLVA VKALKDPTLA ARKDFQREAE LLTNLQHEHI 600
VKFYGVCGDG DPLIMVFEYM KHGDLNKFLR AHGPDAMILV DGQPRQAKGE LGLSQMLHIA 660
SQIASGMVYL ASQHFVHRDL ATRNCLVGAN LLVKIGDFGM SRDVYSTDYY RLFNPSGNDF 720
CIWCEVGGHT MLPIRWMPPE SIMYRKFTTE SDVWSFGVIL WEIFTYGKQP WFQLSNTEVI 780
ECITQGRVLE RPRVCPKEVY DVMLGCWQRE PQQRLNIKEI YKILHALGKA TPIYLDILG 839
Nucleotide Sequence
(FASTA)
ATGGATGTCT CTCTTTGCCC AGCCAAGTGT AGTTTCTGGC GGATTTTCTT GCTGGGAAGC 60
GTCTGGCTGG ACTATGTGGG CTCCGTGCTG GCTTGCCCTG CAAATTGTGT CTGCAGCAAG 120
ACTGAGATCA ATTGCCGGCG GCCGGACGAT GGGAACCTCT TCCCCCTCCT GGAAGGGCAG 180
GATTCAGGGA ACAGCAATGG GAACGCCAGC ATCAACATCA CGGACATCTC AAGGAATATC 240
ACTTCCATAC ACATAGAGAA CTGGCGCAGT CTTCACACGC TCAACGCCGT GGACATGGAA 300
CTCTACACCG GACTTCAAAA GCTGACCATC AAGAACTCAG GACTTCGGAG CATTCAGCCC 360
AGAGCCTTTG CCAAGAACCC CCATTTGCGT TATATAAACC TGTCAAGCAA CCGGCTCACC 420
ACACTCTCGT GGCAGCTCTT CCAGACGCTG AGTCTTCGGG AATTGCAGTT GGAGCAGAAC 480
TTTTTCAACT GCAGCTGTGA CATCCGCTGG ATGCAGCTCT GGCAGGAGCA GGGGGAGGCC 540
AAGCTCAACA GCCAGAACCT CTACTGCATC AACGCTGATG GCTCCCAGCT TCCTCTCTTC 600
CGCATGAACA TCAGTCAGTG TGACCTTCCT GAGATCAGCG TGAGCCACGT CAACCTGACT 660
GTACGAGAGG GTGACAATGC TGTCATCACT TGCAATGGCT CTGGATCACC CCTTCCTGAT 720
GTGGACTGGA TAGTCACTGG GCTGCAGTCC ATCAACACTC ACCAGACCAA TCTGAACTGG 780
ACTAATGTTC ATGCCATCAA CTTGACGCTG GTGAATGTGA CAAGTGAGGA CAATGGCTTC 840
ACCCTGACGT GCATTGCAGA GAACGTGGTG GGCATGAGCA ATGCCAGTGT TGCCCTCACT 900
GTCTACTATC CCCCACGTGT GGTGAGCCTG GAGGAGCCTG AGCTGCGCCT GGAGCACTGC 960
ATCGAGTTTG TGGTGCGTGG CAACCCCCCA CCAACGCTGC ACTGGCTGCA CAATGGGCAG 1020
CCTCTGCGGG AGTCCAAGAT CATCCATGTG GAATACTACC AGGAGGGAGA GATTTCTGAG 1080
GGCTGCCTGC TCTTCAACAA GCCCACCCAC TACAACAATG GCAACTATAC CCTCATTGCC 1140
AAAAACCCAC TGGGCACAGC CAACCAGACC ATCAATGGCC ACTTCCTCAA GGAGCCTTTT 1200
CCAGAGAGCA CGGATAACTT TATCTTGTTT GACGAAGTGA GTCCCACACC TCCTATCACT 1260
GTGACCCACA AACCAGAAGA AGACACTTTT GGGGTATCCA TAGCAGTTGG ACTTGCTGCT 1320
TTTGCCTGTG TCCTGTTGGT GGTTCTCTTC ATCATGATCA ACAAATATGG TCGACGGTCC 1380
AAATTTGGAA TGAAGGGTCC CGTGGCTGTC ATCAGTGGTG AGGAAGACTC AGCTAGCCCA 1440
CTGCACCACA TCAACCACGG CATCACCACG CCCTCGTCGC TGGACGCCGG GCCCGACACT 1500
GTGGTCATCG GCATGACCCG CATCCCTGTT ATTGAGAACC CCCAGTACTT CCGTCAGGGA 1560
CACAACTGCC ACAAGCCGGA CACGTATGTG CAGCACATTA AGAGGAGAGA CATCGTGTTG 1620
AAGCGAGAAC TGGGTGAGGG AGCCTTTGGA AAGGTCTTCC TGGCCGAGTG CTACAACCTC 1680
AGCCCGACCA AGGACAAGAT GCTTGTGGCT GTGAAGGCCC TGAAGGATCC CACCCTGGCT 1740
GCCCGGAAGG ATTTCCAGAG GGAGGCCGAG CTGCTCACCA ACCTACAGCA TGAGCACATT 1800
GTCAAGTTCT ATGGAGTGTG TGGCGATGGG GACCCCCTCA TCATGGTCTT TGAATACATG 1860
AAGCATGGAG ACCTGAATAA GTTCCTCAGG GCCCATGGGC CAGATGCAAT GATCCTTGTG 1920
GATGGACAGC CACGCCAGGC CAAGGGTGAG CTGGGGCTCT CCCAAATGCT CCACATTGCC 1980
AGTCAGATCG CCTCAGGTAT GGTGTACCTG GCCTCCCAGC ACTTTGTGCA CCGAGACCTG 2040
GCCACCAGGA ACTGCCTGGT TGGAGCGAAT CTGCTAGTGA AGATTGGGGA CTTCGGCATG 2100
TCCAGAGATG TCTACAGCAC GGATTATTAC AGGCTCTTTA ATCCATCTGG AAATGATTTT 2160
TGTATATGGT GTGAGGTGGG AGGACACACC ATGCTCCCCA TTCGCTGGAT GCCCCCTGAA 2220
AGCATCATGT ACCGGAAGTT CACTACAGAG AGCGATGTGT GGAGCTTCGG GGTGATCCTC 2280
TGGGAGATCT TCACCTATGG AAAGCAGCCA TGGTTCCAAC TCTCAAACAC GGAGGTCATT 2340
GAGTGCATTA CCCAAGGTCG TGTTTTGGAG CGGCCCCGAG TCTGCCCCAA AGAGGTGTAC 2400
GATGTCATGC TGGGGTGCTG GCAGAGGGAA CCACAGCAGC GGCTGAACAT CAAGGAGATC 2460
TACAAAATCC TCCATGCTTT GGGGAAGGCC ACCCCAATCT ACCTGGACAT TCTCGGCTAG 2520
Domain Profile
S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60
         ivlkrelgegafgkvflaecynl+p+kdk+lvavkalkd++ aarkdf+reaelltnlqh
Q: 538   IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQH  597
         89**********************************************************
S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep...kgelglsqll  117
         ehivk+yGvc +gdpl++vfeymkhGdlnkflrahgpda++lv+g+p   kgelglsq+l
Q: 598   EHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPrqaKGELGLSQML  657
         ***********************************************9999*********
S: 118   aiakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyr......  171
         +ia+qia+G+vylasqhfvhrdlatrnclvg++llvkigdfgmsrdvystdyyr      
Q: 658   HIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRlfnpsg  717
         *****************************************************8655655
S: 172   ........vggrtmlpirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnt  223
                 vgg+tmlpirw+ppesi+yrkfttesdvws+Gv+lwei+tyGkqp++qlsnt
Q: 718   ndfciwceVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNT  777
         5655555579**************************************************
S: 224   eviecitqGrvlerpracpkevydlmlgcwqrepqkrlnikeiyal  269
         eviecitqGrvlerpr+cpkevyd+mlgcwqrepq+rlnikeiy++
Q: 778   EVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKI  823
         *******************************************985
Domain Sequence
(FASTA)
IVLKRELGEG AFGKVFLAEC YNLSPTKDKM LVAVKALKDP TLAARKDFQR EAELLTNLQH 60
EHIVKFYGVC GDGDPLIMVF EYMKHGDLNK FLRAHGPDAM ILVDGQPRQA KGELGLSQML 120
HIASQIASGM VYLASQHFVH RDLATRNCLV GANLLVKIGD FGMSRDVYST DYYRLFNPSG 180
NDFCIWCEVG GHTMLPIRWM PPESIMYRKF TTESDVWSFG VILWEIFTYG KQPWFQLSNT 240
EVIECITQGR VLERPRVCPK EVYDVMLGCW QREPQQRLNI KEIYKI 286
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Leucine-rich repeat; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-CAJ-00415
EKS-CAF-00412
EKS-CAP-00438
EKS-DAR-00796
EKS-EQC-00403
EKS-GAG-00347
EKS-GAA-00497
EKS-GOG-00402
EKS-HOS-00417
EKS-ICT-00390
EKS-LOA-00419
EKS-MAM-00409
EKS-MEG-00340
EKS-MIM-00063
EKS-MOD-00388
EKS-MUM-00443
EKS-MUP-00405
EKS-MYL-00406
EKS-NOL-00374
EKS-ORN-00522
EKS-ORA-00358
EKS-OTG-00413
EKS-RAN-00425
EKS-SAH-00380
EKS-SUS-00363
EKS-TAG-00481
EKS-TUT-00124
EKS-XIM-00513
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005030; F:neurotrophin receptor activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0042490; P:mechanoreceptor differentiation
GO:0048691; P:positive regulation of axon extension involved in regeneration
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
pon:100458353;
InterPros
IPR000483; Cys-rich_flank_reg_C.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR001611; Leu-rich_rpt.
IPR000372; LRR-contain_N.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020446; Tyr_kin_neurotrophic_rcpt_3.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR020777; Tyr_kinase_NGF_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07679; I-set; 2.
PF01462; LRRNT; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00082; LRRCT; 1.
SM00013; LRRNT; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS51450; LRR; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR01939; NTKRECEPTOR.
PR01942; NTKRECEPTOR3.
PR00109; TYRKINASE.
Created Date20-Feb-2013