EKS-POA-00015

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00015

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	541.1	4.0E-163	999	1266	268

Status

Unreviewed

Ensembl Protein

ENSPPYP00000007720

UniProt Accession

H2NP98;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

IGF1R

Gene Synonyms/Alias

IGF1R;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000006808	ENSPPYP00000007720	ENSPPYT00000008036

Organism

Pongo abelii

Functional Description

Protein Length

1367

Protein Sequence
(FASTA)

MKSGSGGGSP TSLWGLLFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE NCTVIEGYLH 60

ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF 120

EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTVDWSLI LDAVSNNYIV GNKPPKECGD 180

LCPGTMEEKP MCEKTTINNE YNYRCWTTNR CQKMCPSACG KRACTENNEC CHPECLGSCS 240

APDNDTACVA CRHYYYAGVC VPACPPNTYR FEGWRCVDRD FCANILSAES SDSEGFVIHD 300

GECMQECPSG FIRNGSQSMY CIPCEGPCPK VCEEEKKTKT IDSVTSAQML QGCTIFKGNL 360

LINIRRGNNI ASELENFMGL IEVVTGYVKI RHSHALVSLS FLKNLRLILG EEQLEGNYSF 420

YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF NPKLCVSEIY RMEEVTGTKG RQSKGDINTR 480

NNGERASCES DVLHFTSTTT SKNRIIITWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG 540

QDACGSNSWN MVDVDLPPNK DVEPGILLHG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE 600

ILYIRTNASV PSIPLDVLSA SNSSSQLIVK WNPPSLPNGN LSYYIVRWQR QPQDGYLYRH 660

NYCSKDKIPI RKYADGTIDI EEVTENPKTE VCGGEKGPCC ACPKTEAEKQ AEKEEAEYRK 720

VFENFLHNSI FVPRPERKRR DVMQVANTTM SSRSRNTTAA DTYNITDPEE LETEYPFFES 780

RVDNKERTVI SNLRPFTLYR IDIHSCNHEA EKLGCSASKF VFARTMPAEG ADDIPGPVTW 840

EPRPENSIFL KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN 900

YTARIQATSL SGNGSWTDPV FFYVQAKTGY ENFIHLIIAL PVAVLLIVGG LVIMLYVFHR 960

KRNNSRLGNG VLYASVNPEY FSAADVYVPD EWEVAREKIT MSRELGQGSF GMVYEGVAKG 1020

VVKDEPETRV AIKTVNEAAS MRERIEFLNE ASVMKEFNCH HVVRLLGVVS QGQPTLVIME 1080

LMTRGDLKSY LRSLRPEMEN NPVLAPPSLS KMIQMAGEIA DGMAYLNANK FVHRDLAARN 1140

CMVAEDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT TYSDVWSFGV 1200

VLWEIATLAE QPYQGLSNEQ VLRFVMEGGL LDKPDNCPDM LFELMRMCWQ YNPKMRPAFL 1260

EIISSIKDEM EPGFREVSFY YSEENKLPEP EELDLEPENM ESVPLDPSAS SSSLPLPDRH 1320

SGHKAENGPG PGVLVLRASF DERQPYAHMN GGRKNERALP LPQSSTC 1367

Nucleotide Sequence
(FASTA)

ATGAAGTCTG GCTCCGGAGG AGGGTCCCCG ACCTCGCTGT GGGGGCTCCT GTTTCTCTCC 60

GCCGCGCTCT CGCTCTGGCC GACGAGTGGA GAAATCTGTG GGCCAGGCAT CGACATCCGC 120

AACGACTATC AGCAGCTGAA GCGCCTGGAG AACTGCACGG TGATCGAGGG CTACCTCCAC 180

ATCCTGCTCA TCTCCAAGGC CGAGGACTAC CGCAGCTACC GCTTCCCCAA GCTCACGGTC 240

ATTACCGAGT ACTTGCTGCT GTTCCGAGTG GCTGGCCTCG AGAGCCTCGG AGACCTCTTC 300

CCCAACCTCA CGGTCATCCG TGGCTGGAAA CTCTTCTACA ACTACGCCCT GGTCATCTTC 360

GAGATGACCA ATCTCAAGGA TATTGGGCTT TACAACCTGA GGAACATTAC TCGGGGGGCC 420

ATCAGGATTG AGAAAAATGC TGACCTCTGT TACCTCTCCA CTGTGGACTG GTCCCTGATC 480

CTGGATGCAG TGTCCAATAA CTACATTGTG GGGAATAAGC CCCCAAAAGA ATGTGGGGAC 540

CTGTGTCCAG GGACCATGGA GGAGAAGCCG ATGTGTGAGA AGACCACCAT CAACAATGAG 600

TACAACTACC GCTGCTGGAC CACAAACCGC TGCCAGAAAA TGTGCCCGAG CGCATGTGGG 660

AAGCGAGCGT GCACCGAGAA CAACGAGTGC TGTCACCCCG AGTGCCTGGG CAGCTGCAGC 720

GCGCCTGACA ACGACACGGC CTGCGTAGCT TGCCGCCACT ACTACTACGC CGGTGTCTGC 780

GTGCCTGCCT GCCCGCCCAA CACCTACAGG TTTGAGGGCT GGCGCTGTGT GGACCGTGAC 840

TTCTGCGCCA ACATCCTCAG CGCCGAGAGC AGCGACTCCG AGGGGTTTGT GATCCACGAC 900

GGCGAGTGCA TGCAGGAGTG CCCCTCGGGC TTCATCCGCA ACGGCAGCCA GAGCATGTAC 960

TGCATCCCAT GTGAAGGTCC TTGCCCCAAG GTCTGTGAGG AAGAAAAGAA AACAAAGACC 1020

ATTGATTCTG TTACTTCTGC TCAGATGCTC CAAGGATGCA CCATCTTCAA GGGCAATTTG 1080

CTCATTAACA TCCGACGGGG GAATAACATT GCTTCAGAAC TGGAGAACTT CATGGGGCTC 1140

ATCGAGGTGG TGACGGGCTA CGTGAAGATC CGCCATTCTC ATGCCTTGGT CTCCTTGTCC 1200

TTCCTAAAAA ACCTTCGCCT CATCTTAGGA GAGGAGCAGC TAGAAGGGAA TTACTCCTTC 1260

TACGTCCTCG ACAACCAGAA CTTGCAGCAA CTATGGGACT GGGACCACCG CAACCTGACC 1320

ATCAAAGCAG GGAAAATGTA CTTTGCTTTC AATCCCAAAT TATGTGTTTC TGAAATTTAC 1380

CGCATGGAGG AAGTGACGGG GACTAAAGGA CGCCAAAGCA AAGGGGACAT AAACACCAGG 1440

AACAACGGGG AGAGAGCCTC CTGTGAAAGT GATGTCCTGC ATTTCACCTC CACCACCACG 1500

TCGAAGAATC GCATCATCAT AACCTGGCAC CGGTACCGGC CCCCTGACTA CAGGGATCTC 1560

ATCAGCTTCA CCGTTTACTA CAAGGAAGCA CCCTTTAAGA ATGTCACGGA GTATGATGGG 1620

CAGGACGCCT GCGGCTCCAA CAGCTGGAAC ATGGTTGACG TGGACCTCCC ACCCAATAAG 1680

GACGTGGAGC CCGGCATCTT ACTGCATGGG CTGAAGCCCT GGACTCAGTA CGCCGTTTAC 1740

GTCAAGGCTG TGACCCTCAC CATGGTGGAG AACGACCATA TCCGTGGAGC CAAGAGTGAG 1800

ATCTTGTACA TTCGCACCAA TGCTTCAGTT CCTTCCATTC CCTTGGACGT TCTTTCAGCA 1860

TCGAACTCCT CTTCTCAGTT AATCGTGAAG TGGAACCCTC CCTCTCTGCC CAACGGCAAC 1920

CTGAGTTACT ACATTGTGCG CTGGCAGCGG CAGCCTCAGG ACGGCTACCT TTACCGGCAC 1980

AATTACTGCT CCAAAGACAA AATCCCCATC AGGAAGTATG CCGACGGCAC CATCGACATT 2040

GAGGAAGTCA CAGAGAACCC CAAGACTGAG GTGTGTGGTG GTGAGAAAGG GCCTTGCTGC 2100

GCCTGCCCCA AAACTGAAGC CGAGAAGCAG GCTGAGAAGG AGGAGGCTGA GTACCGCAAA 2160

GTCTTTGAGA ATTTCCTGCA CAACTCCATC TTCGTGCCCA GACCTGAAAG GAAGCGGAGA 2220

GATGTCATGC AAGTGGCCAA CACCACCATG TCCAGCCGAA GCAGGAACAC CACGGCCGCA 2280

GACACGTACA ACATCACCGA CCCAGAAGAG CTGGAGACAG AGTACCCTTT CTTTGAGAGC 2340

AGAGTGGATA ACAAGGAGAG AACTGTCATT TCTAACCTTC GGCCTTTCAC ATTGTACCGC 2400

ATCGATATCC ACAGCTGCAA CCATGAGGCT GAGAAGCTGG GCTGCAGCGC CTCCAAATTC 2460

GTCTTTGCAA GGACTATGCC CGCAGAAGGA GCAGATGACA TTCCTGGGCC AGTGACCTGG 2520

GAGCCAAGGC CTGAAAACTC CATCTTTTTA AAGTGGCCAG AACCTGAGAA TCCCAATGGA 2580

TTGATTCTAA TGTATGAAAT AAAATACGGA TCACAAGTTG AGGATCAGCG AGAATGTGTG 2640

TCCAGACAGG AATACAGGAA GTATGGAGGG GCCAAGCTAA ACCGGCTAAA CCCGGGGAAC 2700

TACACAGCCC GGATTCAGGC CACATCTCTC TCTGGGAATG GGTCGTGGAC AGATCCTGTG 2760

TTCTTCTATG TCCAGGCCAA AACAGGATAT GAAAACTTCA TCCATCTGAT CATCGCTCTG 2820

CCCGTCGCTG TCCTGTTGAT TGTGGGAGGG TTGGTGATTA TGCTGTACGT CTTCCATAGA 2880

AAGAGAAATA ACAGCAGGCT GGGGAATGGA GTGCTGTATG CCTCTGTGAA CCCGGAGTAC 2940

TTCAGCGCTG CGGATGTGTA CGTTCCTGAT GAGTGGGAGG TGGCTCGGGA GAAGATCACC 3000

ATGAGCCGGG AACTTGGGCA GGGGTCGTTT GGGATGGTCT ATGAAGGAGT TGCCAAGGGT 3060

GTGGTGAAAG ATGAACCTGA AACCAGAGTG GCCATTAAAA CAGTGAACGA GGCCGCAAGC 3120

ATGCGTGAAA GGATCGAGTT TCTCAACGAA GCTTCTGTGA TGAAGGAGTT CAATTGTCAC 3180

CATGTGGTGC GATTGCTGGG TGTGGTGTCC CAAGGCCAGC CAACACTGGT CATCATGGAA 3240

CTGATGACAC GGGGCGATCT CAAAAGTTAT CTCCGGTCTC TGAGGCCAGA AATGGAGAAT 3300

AATCCAGTCC TAGCACCTCC AAGCCTAAGC AAGATGATTC AGATGGCCGG AGAGATTGCA 3360

GACGGCATGG CATACCTCAA CGCCAACAAG TTCGTCCACA GAGACCTTGC TGCCCGGAAT 3420

TGCATGGTAG CCGAAGATTT CACAGTCAAA ATCGGAGATT TTGGTATGAC GCGAGATATC 3480

TATGAGACAG ACTATTACCG GAAAGGAGGG AAAGGGCTGC TGCCCGTGCG CTGGATGTCT 3540

CCCGAGTCCC TCAAGGATGG AGTCTTCACC ACTTACTCGG ACGTCTGGTC CTTCGGGGTC 3600

GTCCTCTGGG AGATTGCCAC ACTGGCCGAG CAGCCCTACC AGGGCTTGTC CAACGAGCAA 3660

GTCCTTCGCT TCGTCATGGA GGGCGGCCTT CTGGACAAGC CAGACAACTG TCCTGACATG 3720

CTGTTTGAAC TGATGCGCAT GTGCTGGCAG TATAACCCCA AGATGAGGCC TGCCTTCCTG 3780

GAGATCATCA GCAGCATCAA AGACGAGATG GAGCCTGGCT TCCGGGAGGT CTCCTTCTAC 3840

TACAGCGAGG AGAACAAGCT GCCCGAGCCG GAGGAACTGG ACCTCGAGCC AGAGAACATG 3900

GAGAGCGTCC CCCTGGACCC CTCGGCCTCC TCGTCCTCCC TGCCACTGCC CGACAGACAC 3960

TCAGGACACA AGGCCGAGAA CGGCCCCGGC CCTGGAGTGC TGGTCCTCCG CGCCAGCTTC 4020

GACGAGAGAC AGCCTTACGC ACACATGAAC GGGGGCCGCA AGAACGAGCG GGCCTTGCCA 4080

CTGCCCCAGT CTTCGACCTG CTGA 4104

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeGvak+vvk+e etrvaiktvneaas+reriefl+easvmkef+

Q: 999   ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFN  1058

         799*********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrpe+en+++lapp+l+k+iqma+e

Q: 1059  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGE  1118

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1119  IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1178

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft+ sdvwsfGvvlwei+tlaeqpyqGlsneqvl+fv++gg+l+kp+ncp

Q: 1179  MSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP  1238

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l+elmr+cwqynpk+rp+flei++++

Q: 1239  DMLFELMRMCWQYNPKMRPAFLEIISSI  1266

         *************************976

Domain Sequence
(FASTA)

ITMSRELGQG SFGMVYEGVA KGVVKDEPET RVAIKTVNEA ASMRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPEM ENNPVLAPPS LSKMIQMAGE 120

IADGMAYLNA NKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180

MSPESLKDGV FTTYSDVWSF GVVLWEIATL AEQPYQGLSN EQVLRFVMEG GLLDKPDNCP 240

DMLFELMRMC WQYNPKMRPA FLEIISSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0043559	; F:insulin binding
GO:0005010	; F:insulin-like growth factor-activated receptor activity
GO:0007420	; P:brain development
GO:0031017	; P:exocrine pancreas development
GO:0006955	; P:immune response
GO:0051389	; P:inactivation of MAPKK activity
GO:0048009	; P:insulin-like growth factor receptor signaling pathway
GO:0030238	; P:male sex determination
GO:0030879	; P:mammary gland development
GO:0043066	; P:negative regulation of apoptotic process
GO:0051898	; P:negative regulation of protein kinase B signaling cascade
GO:0048015	; P:phosphatidylinositol-mediated signaling
GO:0030335	; P:positive regulation of cell migration
GO:0045740	; P:positive regulation of DNA replication
GO:0043410	; P:positive regulation of MAPK cascade
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060740	; P:prostate gland epithelium morphogenesis
GO:0046777	; P:protein autophosphorylation
GO:0051262	; P:protein tetramerization
GO:0046328	; P:regulation of JNK cascade

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013