EKS-POA-00296

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00296

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/Alpha	286.0	2.0E-85	121	318	198

Status

Unreviewed

Ensembl Protein

ENSPPYP00000008119

UniProt Accession

H2NQD5;

Protein Name

Protein Synonyms/Alias

Gene Name

EEF2K

Gene Synonyms/Alias

EEF2K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000007179	ENSPPYP00000008119	ENSPPYT00000008454

Organism

Pongo abelii

Functional Description

Protein Length

725

Protein Sequence
(FASTA)

MADEDLIFRL EGVDGGQSPR AGHDGDFDGD SDDEEGYFIC PITDDPRSNQ NVSSKVNKYY 60

SNLTKSEQYS SSGSPANSFH FKEAWKHAIQ KAKHMPDPWA EFHLEDIATE RATRHRYNAV 120

TGEWLDDEVL IKMASQPFGR GAMRECFRTK KLSNFLHAQQ WKGASNYVAK RYIEPVDRDV 180

YFEDVRLQME AKLWGEEYNR HKPPKQVDIM QMCIIELKDR PGKPLFHLEH YIEGKYIKYN 240

SNSGFVRDDN IRLTPQAFSH FTFERSGHQL IVVDIQGVGD LYTDPQIHTE TGTDFGDGNL 300

GVRGMALFFY SHACNRICES MGLAPFDLSP RERDAVNQNT KLLQSAKTIL RGTEEKCGSP 360

RVRTLSGSRP PLLRPLSENS GDENMSDVTF DSLPSSPSSA TPHSQKLDHL HWPVFSDLDN 420

MASRDHDHLD NHRDSENSGD SGYPSEKRGE LDDPEPREHG HSYGNRKYES DEDSLGSSGR 480

VCVEKWNLLN SSRLHLPRAS AVALEVQRLN ALDLEKKIGK SILGKVHLAM VRYHEGGRFC 540

EKGEEWDRES AVFHLEHAAN LGELEAIVGL GLMYSQLPHH ILADVSLKET EENKTKGFDY 600

LLKAAEAGDR QSMILVARAF DTGQNLSPDR CQDWLEALHW YNTALEMTDC DEGGEYDGMQ 660

DEPRYAMLAR EAEMLFTGGY GLEKDPQRSG DLYTQAAEAA MEAMKGRLAN QYYQKAEEAW 720

AQMEE 725

Nucleotide Sequence
(FASTA)

ATGGCAGACG AAGATCTCAT CTTCCGCCTG GAAGGTGTTG ATGGCGGCCA GTCCCCCCGA 60

GCTGGCCATG ATGGTGATTT TGATGGGGAC AGCGACGATG AGGAAGGTTA CTTCATCTGC 120

CCCATCACGG ATGACCCAAG GTCAAACCAG AATGTCAGTT CCAAGGTTAA TAAGTACTAC 180

AGCAACCTAA CAAAAAGTGA GCAGTATAGC TCCAGCGGGT CCCCGGCAAA CTCCTTCCAC 240

TTCAAGGAAG CCTGGAAGCA CGCAATCCAG AAGGCTAAGC ACATGCCCGA CCCCTGGGCT 300

GAGTTCCACC TGGAAGACAT TGCCACCGAA CGTGCTACTC GACACAGGTA CAACGCTGTC 360

ACCGGGGAAT GGCTGGATGA TGAAGTTCTG ATCAAGATGG CGTCTCAGCC CTTCGGCCGA 420

GGAGCAATGA GGGAGTGCTT CCGGACGAAG AAGCTCTCCA ACTTCTTGCA TGCCCAGCAG 480

TGGAAGGGAG CCTCCAACTA TGTGGCGAAG CGCTACATCG AGCCCGTAGA CCGGGATGTG 540

TACTTTGAGG ACGTGCGTCT ACAGATGGAG GCCAAGCTCT GGGGGGAGGA GTATAATCGG 600

CACAAGCCCC CCAAGCAGGT GGACATCATG CAGATGTGCA TCATCGAGCT GAAGGACAGA 660

CCGGGCAAGC CCCTCTTCCA CCTGGAGCAC TACATCGAGG GCAAGTACAT CAAGTACAAC 720

TCCAACTCTG GCTTTGTCCG TGATGACAAC ATCCGCCTGA CGCCGCAGGC CTTCAGCCAC 780

TTCACGTTTG AGCGTTCCGG CCATCAGCTG ATAGTGGTGG ACATCCAGGG AGTTGGGGAT 840

CTCTACACCG ACCCACAGAT CCACACGGAG ACGGGCACTG ACTTTGGAGA CGGCAACCTA 900

GGTGTCCGCG GGATGGCGCT CTTCTTCTAC TCTCATGCCT GCAACCGGAT TTGCGAGAGC 960

ATGGGCCTTG CTCCCTTTGA CCTCTCGCCC CGGGAGAGGG ATGCGGTGAA TCAGAACACC 1020

AAGCTGCTGC AATCAGCCAA GACCATCTTG AGAGGAACAG AGGAAAAATG TGGGAGCCCC 1080

CGAGTAAGGA CCCTCTCTGG GAGCCGGCCA CCCCTGCTCC GTCCCCTTTC AGAGAACTCT 1140

GGAGACGAGA ACATGAGCGA CGTGACCTTC GACTCTCTCC CTTCTTCCCC ATCTTCGGCC 1200

ACACCACACA GCCAGAAGCT AGACCACCTC CATTGGCCAG TGTTCAGTGA CCTCGATAAC 1260

ATGGCATCCA GAGACCATGA TCATCTAGAC AACCACCGGG ACTCTGAGAA TAGTGGGGAC 1320

AGCGGATACC CCAGTGAGAA GCGGGGTGAG CTGGATGACC CTGAGCCCCG AGAACATGGT 1380

CACTCATACG GTAATCGGAA GTACGAGTCC GACGAAGACA GCCTGGGCAG CTCCGGACGG 1440

GTATGTGTAG AGAAGTGGAA TCTCCTCAAC TCCTCCCGCC TCCACCTGCC GAGGGCTTCG 1500

GCCGTGGCCC TGGAAGTGCA AAGGCTTAAT GCTCTGGACC TCGAAAAGAA AATCGGGAAG 1560

TCCATTTTGG GGAAGGTCCA TCTGGCCATG GTGCGCTACC ACGAGGGTGG GCGCTTCTGC 1620

GAGAAGGGCG AGGAGTGGGA CCGGGAGTCG GCTGTCTTCC ACCTGGAGCA CGCAGCCAAC 1680

CTGGGCGAGC TGGAGGCCAT CGTGGGCCTG GGACTCATGT ACTCGCAGTT GCCCCATCAC 1740

ATCCTAGCTG ATGTCTCTCT CAAGGAGACA GAAGAGAACA AAACCAAAGG ATTTGATTAC 1800

TTACTGAAGG CCGCTGAAGC TGGCGACAGG CAGTCCATGA TCCTAGTGGC GCGAGCTTTT 1860

GACACTGGCC AGAACCTCAG CCCAGACAGG TGCCAAGACT GGCTAGAGGC CCTGCACTGG 1920

TACAACACTG CCCTGGAGAT GACGGACTGT GATGAAGGCG GTGAGTACGA TGGAATGCAG 1980

GACGAGCCCC GGTACGCAAT GCTGGCCAGG GAGGCCGAGA TGCTGTTCAC AGGAGGCTAC 2040

GGGCTGGAGA AGGACCCGCA GAGATCAGGG GACTTGTATA CCCAGGCAGC AGAGGCAGCG 2100

ATGGAAGCCA TGAAGGGCCG GCTGGCCAAT CAGTACTACC AAAAGGCTGA AGAGGCCTGG 2160

GCCCAGATGG AGGAGTAA 2178

Domain Profile

S: 2     sesWsqqetivlikvlskeekkGalRkalrvkkgslflvkeelkevvryvakiykeqkvl  61

         +++W+++e  vlik++s+++++Ga+R+++r+kk+s+fl+++++k++++yvak+y+e++++

Q: 121   TGEWLDDE--VLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDR  178

         789*****..**************************************************

S: 62    hlylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqlltvEeyllGefv  121

         ++y++dv+ q++a+ +++e+n++kP+k+v+i+++++++Lkdr++k +l+++E+y++G+++

Q: 179   DVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGK-PLFHLEHYIEGKYI  237

         *********************************************.**************

S: 122   KynnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTDpqiatksrgtk  181

         Kyn+n+g  ++r+++++ +++afsHft+e+++++l+VvD+qGvg+ +TDpqi+t ++gt+

Q: 238   KYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHT-ETGTD  294

         *******..*********************************************.*****

S: 182   fgkanlgeraiknFfakhhCNeiC  205

         fg++nlg+r+++ Ff++h+CN+iC

Q: 295   FGDGNLGVRGMALFFYSHACNRIC  318

         ************************

Domain Sequence
(FASTA)

TGEWLDDEVL IKMASQPFGR GAMRECFRTK KLSNFLHAQQ WKGASNYVAK RYIEPVDRDV 60

YFEDVRLQME AKLWGEEYNR HKPPKQVDIM QMCIIELKDR PGKPLFHLEH YIEGKYIKYN 120

SNSGFVRDDN IRLTPQAFSH FTFERSGHQL IVVDIQGVGD LYTDPQIHTE TGTDFGDGNL 180

GVRGMALFFY SHACNRIC 198

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005509	; F:calcium ion binding
GO:0004686	; F:elongation factor-2 kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0031952	; P:regulation of protein autophosphorylation

KEGG

pon:100457763

;

InterPros

IPR017400	; Elongation_factor_2_kinase.
IPR011009	; Kinase-like_dom.
IPR004166	; MHCK_EF2_kinase.
IPR006597	; Sel1-like.
IPR011990	; TPR-like_helical.

Pfam

PF02816	; Alpha_kinase; 1.
PF08238	; Sel1; 4.

SMARTs

SM00811

; Alpha_kinase; 1.

Prosites

PS51158

; ALPHA_KINASE; 1.

Prints

Created Date

20-Feb-2013