EKS-POA-00165
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00165
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC479.52.9E-144342600259
StatusUnreviewed
Ensembl ProteinENSPPYP00000008139
UniProt AccessionH2NQF5;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCB
Gene Synonyms/Alias PRKCB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000007198ENSPPYP00000008139ENSPPYT00000008474
OrganismPongo abelii
Functional Description
Protein Length673
Protein Sequence
(FASTA)
MADPAAGPPP SEGEESTVRF ARKGALRQKN VHEVKNHKFT ARFFNQPTFC SHCTDFIWGF 60
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPASDDPRS KHKFKIHTYS SPTFCDHCGS 120
LLYGLIHQGM KCDTCMMNVH KRCVMNVPSL CGTDHTERRG RIYIQAHIDR DVLIVLVRDA 180
KNLVPMDPNG LSDPYVKLKL IPDPKSESKQ KTKTIKCSLN PEWNETFRFQ LKESDKDRRL 240
SVEIWDWDLT SRNDFMGSLS FGISELQKAS VDGWFKLLSQ EEGEYFNVPV PPEGSEANEE 300
LRQKFERAKI SQGTKVPEEK TTNTVSKFDN NGNRDRMKLT DFNFLMVLGK GSFGKVMLSE 360
RKGTDELYAV KILKKDVVIQ DDDVECTMVE KRVLALPGKP PFLTQLHSCF QTMDRLYFVM 420
EYVNGGDLMY HIQQVGRFKE PHAVFYAAEI AIGLFFLQSK GIIYRDLKLD NVMLDSEGHI 480
KIADFGMCKE NIWDGVTTKT FCGTPDYIAP EIIAYQPYGK SVDWWAFGVL LYEMLAGQAP 540
FEGEDEDELF QSIMEHNVAY PKSMSKEAVA ICKGLMTKHP GKRLGCGPEG ERDIKEHAFF 600
RYIDWEKLER KEIQPPYKPK ACGRNAENFD RFFTRHPPVL TPPDQEVIRN IDQSEFEGFS 660
FVNSEFLKPE VKS 673
Nucleotide Sequence
(FASTA)
ATGGCTGACC CGGCTGCGGG GCCGCCGCCG AGCGAGGGCG AGGAGAGCAC CGTGCGCTTC 60
GCCCGCAAAG GCGCCCTCCG GCAGAAGAAC GTGCATGAGG TCAAGAACCA CAAATTCACC 120
GCCCGCTTCT TCAATCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGCTTC 180
GGGAAACAGG GATTCCAGTG CCAAGTTTGC TGCTTTGTGG TGCACAAGCG GTGCCATGAA 240
TTTGTCACAT TCTCCTGCCC TGGCGCTGAC AAGGGTCCAG CCTCTGATGA CCCCCGGAGC 300
AAACACAAGT TTAAGATCCA CACGTACTCC AGCCCCACGT TTTGTGACCA CTGTGGGTCA 360
CTGCTGTATG GACTCATCCA CCAGGGGATG AAATGTGACA CCTGCATGAT GAATGTGCAC 420
AAGCGCTGCG TGATGAACGT TCCCAGCCTG TGTGGCACGG ACCACACGGA GCGCCGCGGC 480
CGCATCTACA TCCAGGCCCA CATCGACAGG GACGTCCTCA TTGTCCTCGT AAGAGATGCT 540
AAAAACCTTG TACCTATGGA CCCCAATGGC CTGTCAGATC CCTACGTAAA ACTGAAACTG 600
ATTCCCGATC CCAAAAGTGA GAGCAAACAG AAGACCAAAA CCATCAAATG CTCCCTCAAC 660
CCCGAGTGGA ACGAGACATT TAGATTTCAG CTGAAAGAAT CGGACAAAGA CAGAAGACTG 720
TCAGTAGAGA TTTGGGATTG GGATTTGACC AGCAGGAATG ACTTCATGGG ATCTTTGTCC 780
TTTGGGATTT CTGAACTGCA AAAAGCCAGT GTTGATGGCT GGTTTAAGTT ACTGAGCCAG 840
GAGGAAGGCG AGTACTTCAA TGTGCCTGTG CCACCAGAAG GAAGTGAGGC CAATGAAGAA 900
CTGCGGCAGA AATTTGAGAG GGCCAAGATC AGTCAGGGGA CCAAGGTCCC AGAAGAAAAG 960
ACGACCAACA CTGTCTCCAA ATTTGACAAC AATGGCAACA GAGACCGGAT GAAACTGACC 1020
GATTTTAACT TCCTAATGGT GCTGGGGAAA GGCAGCTTTG GCAAGGTCAT GCTTTCAGAA 1080
CGAAAAGGCA CAGATGAGCT CTATGCTGTG AAGATCCTGA AGAAGGACGT TGTGATCCAA 1140
GATGATGACG TGGAGTGCAC TATGGTGGAG AAGCGGGTGC TGGCCCTGCC CGGGAAGCCA 1200
CCCTTCCTGA CCCAGCTCCA CTCCTGCTTC CAGACCATGG ACCGCCTGTA CTTTGTGATG 1260
GAGTACGTGA ATGGGGGCGA CCTCATGTAT CACATCCAGC AAGTCGGCCG GTTCAAGGAG 1320
CCCCATGCTG TATTTTACGC TGCAGAAATT GCCATCGGTC TGTTCTTCTT ACAGAGTAAG 1380
GGCATCATTT ACCGTGACCT AAAACTTGAC AACGTGATGC TCGATTCTGA GGGGCACATC 1440
AAGATTGCTG ATTTTGGCAT GTGTAAGGAA AACATCTGGG ATGGGGTGAC AACCAAGACA 1500
TTCTGTGGCA CTCCAGACTA CATCGCCCCC GAGATAATTG CTTATCAGCC CTATGGGAAG 1560
TCCGTGGATT GGTGGGCATT TGGAGTCCTG CTGTATGAAA TGTTGGCTGG GCAGGCACCC 1620
TTTGAAGGGG AGGATGAAGA TGAACTCTTC CAATCCATCA TGGAACACAA CGTAGCCTAT 1680
CCCAAGTCTA TGTCCAAGGA AGCTGTGGCC ATCTGCAAAG GGCTGATGAC CAAACACCCA 1740
GGCAAACGTC TGGGTTGTGG ACCTGAAGGC GAACGTGATA TCAAAGAGCA TGCATTTTTC 1800
CGGTATATTG ATTGGGAGAA ACTTGAACGC AAAGAGATCC AGCCCCCATA TAAGCCAAAA 1860
GCTTGTGGGC GAAATGCTGA AAACTTCGAC CGATTTTTCA CCCGCCATCC ACCAGTCCTA 1920
ACACCTCCCG ACCAGGAAGT CATCAGGAAT ATTGACCAAT CAGAATTCGA AGGATTTTCC 1980
TTTGTTAACT CTGAATTTTT AAAACCCGAA GTCAAGAGCT AA 2022
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+l+e+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal  k+p
Q: 342   FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPP  401
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt+drl+fv+eyvnGGdlm+hiq+++++ke++a+fyaaei+++l+fl++kg
Q: 402   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG  461
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks
Q: 462   IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  521
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p 
Q: 522   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPG  581
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+dikehaff
Q: 582   KRLGCGPEGERDIKEHAFF  600
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLSER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALPGKPP 60
FLTQLHSCFQ TMDRLYFVME YVNGGDLMYH IQQVGRFKEP HAVFYAAEIA IGLFFLQSKG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPG 240
KRLGCGPEGE RDIKEHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00168
EKS-CAE-00131
EKS-CAJ-00172
EKS-CAF-00175
EKS-CAP-00168
EKS-CII-00114
EKS-CIS-00205
EKS-DAR-00459
EKS-DRM-00084
EKS-EQC-00173
EKS-FEC-00158
EKS-GAM-00088
EKS-GAG-00144
EKS-GAA-00202
EKS-GOG-00171
EKS-HOS-00174
EKS-ICT-00163
EKS-LAC-00180
EKS-MAM-00166
EKS-MOD-00167
EKS-MUM-00173
EKS-MUP-00172
EKS-MYL-00177
EKS-NOL-00161
EKS-OCP-00107
EKS-ORN-00212
EKS-ORC-00156
EKS-OTG-00174
EKS-PAT-00159
EKS-PES-00148
EKS-RAN-00164
EKS-SAH-00162
EKS-TEN-00211
EKS-XET-00157
EKS-XIM-00206
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005246; F:calcium channel regulator activity
GO:0003682; F:chromatin binding
GO:0035403; F:histone kinase activity (H3-T6 specific)
GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0042113; P:B cell activation
GO:0050853; P:B cell receptor signaling pathway
GO:0006816; P:calcium ion transport
GO:0006874; P:cellular calcium ion homeostasis
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0035556; P:intracellular signal transduction
GO:0010829; P:negative regulation of glucose transport
GO:0045766; P:positive regulation of angiogenesis
GO:0050861; P:positive regulation of B cell receptor signaling pathway
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013