EKS-POA-00449
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00449
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK432.09.8E-13044332289
StatusUnreviewed
Ensembl ProteinENSPPYP00000008184
UniProt AccessionH2NQJ9;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK3
Gene Synonyms/Alias MAPK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000007239ENSPPYP00000008184ENSPPYT00000008521
OrganismPongo abelii
Functional Description
Protein Length381
Protein Sequence
(FASTA)
MAAAAAAAQG GGGGEPRRTE GVGPGVPGEV EMVKGQPFDV GPRYTQLQYI GEGAYGMVSS 60
AYDHVRKTRV AIKKISPFEH QTYCQRTLRE IQILLRFRHE NVIGIRDILR ASTLEAMRDV 120
YIVQDLMETD LYKLLKSQQL SNDHICYFLY QILRGLKYIH SANVLHRDLK PSNLLINTTC 180
DLKICDFGLA RIADPEHDHT GFLTEYVATR WYRAPEIMLN SKGYTKSIDI WSVGCILAEM 240
LSNRPIFPGK HYLDQLNHIL GILGSPSQED LNCIINMKAR NYLQSLPSKT KVAWAKLFPK 300
SDSKALDLLD RMLTFNPNKR ITVEEALAHP YLEQYYDPTD EPVAEEPFTF AMELDDLPKE 360
RLKELIFQET ARFQPGVLEA P 381
Nucleotide Sequence
(FASTA)
ATGGCGGCGG CGGCGGCGGC GGCTCAGGGG GGCGGGGGCG GGGAGCCCCG TAGAACCGAG 60
GGGGTCGGCC CGGGGGTCCC GGGGGAGGTG GAGATGGTGA AGGGGCAGCC GTTCGACGTG 120
GGCCCGCGCT ACACGCAGTT GCAGTACATC GGCGAGGGCG CGTACGGCAT GGTCAGCTCG 180
GCCTATGACC ACGTGCGCAA GACTCGCGTG GCCATCAAGA AGATCAGCCC CTTCGAGCAT 240
CAGACCTACT GCCAGCGCAC GCTCCGGGAG ATCCAGATCC TGCTGCGCTT CCGCCATGAG 300
AATGTCATCG GCATCCGAGA CATTCTGCGG GCGTCCACCC TGGAAGCCAT GAGGGATGTC 360
TACATTGTGC AGGACCTGAT GGAGACTGAC CTGTACAAGT TGCTGAAAAG CCAGCAGCTG 420
AGCAATGACC ATATCTGCTA CTTCCTCTAC CAGATCCTGC GGGGCCTCAA ATACATCCAC 480
TCCGCCAACG TGCTCCACCG AGATCTAAAG CCCTCCAACC TGCTCATCAA CACCACCTGC 540
GACCTTAAGA TTTGCGATTT CGGCCTGGCC CGGATTGCCG ATCCTGAGCA TGACCACACC 600
GGCTTCCTGA CGGAGTATGT GGCTACGCGC TGGTACCGGG CCCCAGAGAT CATGCTGAAC 660
TCCAAGGGCT ATACCAAGTC CATCGACATC TGGTCTGTGG GCTGCATTCT GGCTGAGATG 720
CTCTCTAACC GGCCCATCTT CCCCGGCAAG CACTACCTGG ATCAGCTCAA CCACATTCTG 780
GGCATCCTGG GCTCCCCATC CCAGGAGGAC CTGAATTGTA TCATCAACAT GAAGGCCCGA 840
AACTACCTAC AGTCTCTGCC CTCCAAGACC AAGGTGGCTT GGGCCAAGCT TTTTCCCAAG 900
TCAGACTCCA AAGCCCTTGA CCTGCTGGAC CGGATGTTAA CCTTTAACCC CAATAAACGG 960
ATCACAGTGG AGGAAGCGCT GGCTCACCCC TACCTGGAGC AGTACTATGA CCCGACGGAT 1020
GAGCCAGTGG CCGAGGAGCC CTTCACCTTC GCCATGGAGC TGGACGACCT ACCTAAGGAG 1080
CGGCTGAAGG AGCTCATCTT CCAGGAGACA GCACGCTTCC AGCCCGGAGT GCTGGAGGCC 1140
CCCTAG 1146
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++l+++geGayg+v sa+d+ +++rvaikk+s pf+++t ++rtlRE+++l +++heN+
Q: 44    YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV  102
         7899****************************9.**************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i + d++++++ le+++dvY+v++lmetdL+k++ksq+ls++hi ++lyqilrglky+Hs
Q: 103   IGIRDILRAST-LEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHS  161
         *********99.************************************************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178
         anv+HrDlKPsNll+n++c+lki+dFGlar+ad+e++++  lteyvatrwYraPei+l++
Q: 162   ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTgfLTEYVATRWYRAPEIMLNS  221
         ***********************************99999********************
S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238
         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arn
Q: 222   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN  281
         ************************************************************
S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
         y++slp+k+k  +++lfpk++++aldLl+++L+++p+kRi+veeaL+hpYl
Q: 282   YLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL  332
         **************************************************7
Domain Sequence
(FASTA)
YTQLQYIGEG AYGMVSSAYD HVRKTRVAIK KISPFEHQTY CQRTLREIQI LLRFRHENVI 60
GIRDILRAST LEAMRDVYIV QDLMETDLYK LLKSQQLSND HICYFLYQIL RGLKYIHSAN 120
VLHRDLKPSN LLINTTCDLK ICDFGLARIA DPEHDHTGFL TEYVATRWYR APEIMLNSKG 180
YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGIL GSPSQEDLNC IINMKARNYL 240
QSLPSKTKVA WAKLFPKSDS KALDLLDRML TFNPNKRITV EEALAHPYL 289
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00436
EKS-ANC-00449
EKS-BOT-00462
EKS-CAE-00385
EKS-CAJ-00472
EKS-CAF-00465
EKS-CAP-00493
EKS-CII-00260
EKS-CIS-00220
EKS-DAR-00867
EKS-DAN-00034
EKS-DIO-00097
EKS-DRM-00222
EKS-ECT-00060
EKS-EQC-00449
EKS-ERE-00049
EKS-FEC-00445
EKS-GAM-00267
EKS-GAG-00389
EKS-GAA-00558
EKS-GOG-00456
EKS-HOS-00468
EKS-ICT-00441
EKS-LAC-00473
EKS-LOA-00471
EKS-MAM-00463
EKS-MAE-00072
EKS-MEG-00382
EKS-MIM-00088
EKS-MOD-00453
EKS-MUM-00493
EKS-MUP-00452
EKS-MYL-00457
EKS-NOL-00423
EKS-OCP-00120
EKS-ORN-00584
EKS-ORA-00408
EKS-ORC-00440
EKS-ORL-00529
EKS-OTG-00478
EKS-PAT-00435
EKS-PES-00410
EKS-PEM-00252
EKS-PTV-00167
EKS-RAN-00475
EKS-SAH-00430
EKS-SUS-00410
EKS-TAG-00529
EKS-TAR-00571
EKS-TAS-00069
EKS-TEN-00572
EKS-TUT-00168
EKS-XET-00610
EKS-XIM-00573
EKS-SAC-00101
EKS-SCP-00101
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0031143; C:pseudopodium
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0051216; P:cartilage development
GO:0071260; P:cellular response to mechanical stimulus
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0000165; P:MAPK cascade
GO:2000657; P:negative regulation of apolipoprotein binding
GO:0009887; P:organ morphogenesis
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
GO:0006974; P:response to DNA damage stimulus
GO:0043330; P:response to exogenous dsRNA
GO:0019233; P:sensory perception of pain
GO:0006351; P:transcription, DNA-dependent
KEGG
pon:100431824;
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008349; MAPK_ERK1/2.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01770; ERK1ERK2MAPK.
Created Date20-Feb-2013