EKS-POA-00106
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00106
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/MLCK410.82.1E-123517770254
StatusUnreviewed
Ensembl ProteinENSPPYP00000008714
UniProt AccessionH2NS07;
Protein Name
Protein Synonyms/Alias Myosin light chain kinase 3;
Gene NameMYLK3
Gene Synonyms/Alias MYLK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000007730ENSPPYP00000008714ENSPPYT00000009069
OrganismPongo abelii
Functional Description
Protein Length819
Protein Sequence
(FASTA)
MSGTSKESLG HGGLPGLGKA CLTTMDKKLN MLNEKVDQLL HFQEDVTEKL QSMCRDMGHL 60
ERGLHRLEAS RAPGPGGTDG VLRVDTQAGW PEVLELVRAM QQDAAQHGAR LEALFRMVAA 120
VDRAIALVGA TFQKSKVADF LMQGRVPWRR GSPGDSPEEN KERVEEEGAK PKHVLSASGV 180
QSDAREPGEE SQKADVLEGT VERLPPIRAS GLGADPAQAV VSPGQGDGVP GPAQAFPGHL 240
PLPTKGEAKA PETPSENLRT GLELAPAPGR VNVVSPSLEV APGAGQGASS SRPDPEPLEE 300
GTRLTPGPGP QCPGPPGLPA QARAAHSGGE TPPRISIHIQ EMGTPGEMLV TGRGSLGPTL 360
TTDAPAAAQP GKQGPPGTGR CLQAPGTEPG EQTPEGAREL SLLQESSSPG GVKAEEEQRA 420
GAEPGTRPSL ARSDDNDHKV GALGLQQGKS PGVGNPEPEQ DCAARAPVRA EAVRRTPPGA 480
QAGSMVLDDS PAPPAPFEHR LVSVKETSIS AGYEVCQHEV LGGGRFGQVH RCTEKSTGLP 540
LAAKIIKVKS AKDREDVKNE INIMNQLSHV NLIQLYDAFE SKHSCTLVME YVDGGELFDR 600
ITDEKYHLTE LDVVLFTRQI CEGVHYLHQH YILHLDLKPE NILCVNQTGH QIKIIDFGLA 660
RRYKPREKLK VNFGTPEFLA PEVVNYEFVS FPTDMWSVGV ITYMLLSGLS PFLGETDAET 720
MNFIVNCSWD FDADTFEGLS EEAKDFVSRL LVKEKSCRMS ATQCLKHEWL NNLPAKALRS 780
KTRLKSQLLL QKYIAQRKWK KHFYVVTAAN RLRKFPTCP 819
Nucleotide Sequence
(FASTA)
ATGTCAGGAA CCTCCAAGGA GAGTCTGGGG CACGGGGGGC TGCCAGGGTT GGGCAAGGCC 60
TGCTTAACCA CCATGGACAA AAAGCTGAAC ATGCTGAATG AGAAGGTGGA CCAGCTCCTG 120
CACTTCCAAG AAGATGTCAC AGAGAAGTTG CAGAGCATGT GCCGAGACAT GGGCCACCTG 180
GAGCGGGGCC TGCACAGGCT GGAGGCCTCC CGGGCACCGG GCCCGGGCGG GACTGACGGG 240
GTTCTCCGCG TTGACACCCA GGCCGGGTGG CCCGAGGTCC TGGAGCTGGT GAGGGCCATG 300
CAGCAGGATG CGGCCCAGCA TGGTGCCAGG CTGGAGGCCC TCTTCAGGAT GGTGGCTGCG 360
GTGGACAGGG CCATCGCTTT GGTGGGGGCC ACGTTCCAGA AATCGAAGGT GGCGGATTTC 420
CTCATGCAGG GGCGTGTCCC CTGGAGGAGA GGCAGCCCAG GTGACAGCCC TGAGGAGAAC 480
AAAGAGCGAG TAGAAGAAGA GGGAGCAAAA CCAAAGCATG TGCTGAGCGC CAGTGGGGTG 540
CAGTCTGATG CCAGGGAGCC TGGGGAAGAG AGCCAGAAGG CGGACGTGCT GGAGGGGACA 600
GTGGAGAGGC TGCCCCCCAT CAGAGCGTCA GGGCTGGGAG CTGACCCCGC CCAGGCAGTG 660
GTCTCACCAG GCCAGGGAGA TGGTGTTCCT GGCCCAGCTC AGGCATTCCC CGGCCACCTG 720
CCCCTGCCCA CAAAGGGGGA AGCCAAGGCT CCTGAGACAC CCAGCGAGAA CCTCAGGACT 780
GGCCTGGAAT TGGCTCCAGC ACCCGGCAGG GTCAATGTGG TCTCCCCGAG CCTGGAGGTT 840
GCACCAGGTG CAGGACAAGG AGCATCGTCC AGCAGGCCTG ACCCTGAGCC CTTAGAGGAA 900
GGCACGAGGC TGACTCCAGG GCCTGGCCCC CAGTGCCCAG GGCCTCCAGG GCTGCCAGCC 960
CAGGCCAGGG CAGCCCACAG TGGTGGAGAA ACACCTCCAA GGATCTCCAT CCACATACAA 1020
GAGATGGGTA CTCCTGGGGA GATGCTGGTG ACAGGCAGGG GCAGCCTTGG ACCCACCCTC 1080
ACCACAGACG CTCCAGCAGC TGCCCAGCCA GGCAAGCAGG GCCCACCTGG GACCGGGCGC 1140
TGCCTCCAAG CCCCTGGGAC TGAGCCCGGA GAACAGACCC CTGAAGGAGC CAGAGAGCTC 1200
TCCCTGCTGC AGGAGAGCAG CAGCCCCGGG GGAGTGAAGG CAGAGGAGGA GCAAAGGGCT 1260
GGGGCCGAGC CTGGCACGAG ACCAAGTTTG GCCAGGAGCG ATGACAATGA CCACAAGGTT 1320
GGGGCCCTGG GCCTGCAGCA GGGCAAAAGC CCAGGGGTGG GAAACCCTGA GCCTGAGCAG 1380
GACTGTGCAG CCAGGGCTCC GGTGAGAGCC GAAGCAGTAA GGAGGACGCC CCCAGGCGCC 1440
CAGGCTGGCA GCATGGTTCT GGATGACAGT CCGGCCCCGC CAGCTCCTTT TGAACACCGG 1500
TTAGTGAGCG TCAAGGAGAC CTCCATCTCT GCGGGTTACG AGGTGTGCCA GCACGAAGTC 1560
TTGGGAGGGG GCCGGTTTGG CCAGGTCCAC AGGTGCACAG AGAAGTCCAC AGGCCTCCCG 1620
CTGGCCGCCA AGATCATCAA AGTGAAGAGC GCCAAGGACC GGGAGGACGT GAAGAACGAG 1680
ATCAACATCA TGAACCAGCT CAGCCACGTG AACCTGATCC AGCTCTATGA CGCCTTCGAG 1740
AGCAAGCACA GCTGCACCCT TGTCATGGAG TATGTGGACG GGGGTGAGCT CTTCGACCGG 1800
ATCACAGACG AGAAGTACCA CCTGACTGAG CTGGATGTGG TCCTGTTCAC CAGGCAGATC 1860
TGCGAGGGCG TGCATTACCT GCACCAGCAC TACATCCTGC ACCTGGACCT CAAGCCGGAG 1920
AACATATTGT GTGTCAATCA GACAGGACAT CAAATTAAGA TCATTGACTT TGGGCTGGCC 1980
AGAAGGTACA AGCCTCGAGA GAAGCTGAAG GTGAACTTCG GCACTCCTGA GTTCCTGGCC 2040
CCAGAAGTTG TCAACTATGA GTTTGTCTCA TTCCCCACGG ACATGTGGAG TGTGGGAGTC 2100
ATCACCTACA TGCTACTCAG TGGCTTGTCC CCATTTCTAG GGGAAACAGA TGCGGAGACC 2160
ATGAATTTCA TTGTAAACTG TAGCTGGGAT TTTGATGCTG ACACCTTTGA AGGGCTCTCG 2220
GAGGAGGCCA AGGACTTTGT TTCCCGGTTG CTGGTCAAAG AGAAGAGCTG CAGAATGAGT 2280
GCCACACAGT GCCTGAAACA TGAGTGGCTG AATAATTTGC CTGCCAAAGC TTTAAGATCC 2340
AAAACTCGTC TCAAATCCCA ACTACTGCTG CAGAAATACA TAGCTCAAAG AAAATGGAAG 2400
AAACATTTCT ATGTGGTGAC TGCTGCCAAC AGGTTAAGGA AATTTCCAAC TTGTCCCTAA 2460
Domain Profile
S: 3     ikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliqly  62
         ++e lg G+fg+v++++ekstg  laaki+kv+++kd+e+vk+Ei+i+nql+H +liqly
Q: 517   QHEVLGGGRFGQVHRCTEKSTGLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLY  576
         6899********************************************************
S: 63    dafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHld  122
         dafesk++++lv+E+v+ggelf+ri++e+y+ltE +vvlf+rq++e+++ylH+++i+Hld
Q: 577   DAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQICEGVHYLHQHYILHLD  636
         ************************************************************
S: 123   lkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDmW  182
         lkpenil+++++++qiK+idFGlar++k++eklkv+fgtpef+aPEvvn+e+vs+ tDmW
Q: 637   LKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMW  696
         ************************************************************
S: 183   svGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkekk  242
         svGvity+LlsGlsPFlg++d+et++ + ++++dfd+++f+ +seeakdF+s+llvkek+
Q: 697   SVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKS  756
         ************************************************************
S: 243   kRmsaeeaLkhkwl  256
         +Rmsa+++Lkh+wl
Q: 757   CRMSATQCLKHEWL  770
         *************8
Domain Sequence
(FASTA)
QHEVLGGGRF GQVHRCTEKS TGLPLAAKII KVKSAKDRED VKNEINIMNQ LSHVNLIQLY 60
DAFESKHSCT LVMEYVDGGE LFDRITDEKY HLTELDVVLF TRQICEGVHY LHQHYILHLD 120
LKPENILCVN QTGHQIKIID FGLARRYKPR EKLKVNFGTP EFLAPEVVNY EFVSFPTDMW 180
SVGVITYMLL SGLSPFLGET DAETMNFIVN CSWDFDADTF EGLSEEAKDF VSRLLVKEKS 240
CRMSATQCLK HEWL 254
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00108
EKS-ANC-00104
EKS-BOT-00113
EKS-CAJ-00115
EKS-CAF-00115
EKS-CAP-00109
EKS-CIS-00129
EKS-DAR-00366
EKS-EQC-00109
EKS-ERE-00057
EKS-FEC-00106
EKS-GAM-00054
EKS-GAG-00093
EKS-GOG-00112
EKS-HOS-00114
EKS-ICT-00106
EKS-LAC-00117
EKS-LOA-00109
EKS-MAM-00109
EKS-MEG-00088
EKS-MOD-00110
EKS-MUM-00114
EKS-MUP-00114
EKS-NOL-00107
EKS-OCP-00074
EKS-ORA-00093
EKS-ORC-00104
EKS-OTG-00119
EKS-PAT-00102
EKS-PES-00097
EKS-PEM-00056
EKS-RAN-00111
EKS-SAH-00106
EKS-SUS-00101
EKS-TAG-00142
EKS-TUT-00102
EKS-XET-00093
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004683; F:calmodulin-dependent protein kinase activity
GO:0004687; F:myosin light chain kinase activity
GO:0071347; P:cellular response to interleukin-1
GO:0002528; P:regulation of vascular permeability involved in acute inflammatory response
GO:0045214; P:sarcomere organization
KEGG
InterPros
IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013