EKS-POA-00336

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00336

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	358.4	2.1E-107	68	306	239

Status

Unreviewed

Ensembl Protein

ENSPPYP00000008900

UniProt Accession

H2NSI9;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK1

Gene Synonyms/Alias

TNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000007913	ENSPPYP00000008900	ENSPPYT00000009265

Organism

Pongo abelii

Functional Description

Protein Length

596

Protein Sequence
(FASTA)

MLPEAGSLWL LKLLRDIQLA QFYWPILEEL NVTRPEHFDF VKPEDLDGIG MGRPAQRRLS 60

EALKRLRSGP KSVPVAVKSL RVGPEGPMGT ELGDFLREVS VMMNLEHPHV LRLHGLVLGQ 120

PLQMVMELAP LGSLHARLTA PAPTPPLLVA LLCLFLRQLA GAMAYLGARG LVHRDLATRN 180

LLLASPRTIK VADFGLVRPL GGARGRYVMG GPRPIPYAWC APESLRHGAF SSASDVWMFG 240

VTLWEMFSGG EEPWAGVPPY LILQRLEDRA RLPRPPLCSR ALYSLALRCW APHPADRPSF 300

SHLEGLLQEA WPSEGCCVRD VTEPGALRME TGDPITVIEG SSSFHSPDST IWKGQNGRTF 360

KVGSFPASAV TLADAGGLPA TRPVHRGTPA RGDQHPGSID GDRKKADLWD APPARGQRRN 420

VPLERMKGIS RSLESVLSLG PRPTGGGSSP PEIRQARAVP QGPPGLPPRP PLSSSSPQPS 480

QPPRERLPWP KRKPPHNHPM GTPGASKAAA LSGGLLPDPE LQRKIMEVEL SVHGVTHQEC 540

QTALGATGGD VVSAIRNLKV DQLFHLSSRS RADCRRILEH YQWDLSAASR YVLARP 596

Nucleotide Sequence
(FASTA)

ATGCTTCCTG AGGCCGGCTC CCTGTGGCTA CTGAAGCTGC TCCGGGACAT CCAGTTGGCC 60

CAGTTTTACT GGCCCATCCT TGAGGAGCTT AATGTCACTC GGCCAGAGCA CTTCGACTTT 120

GTAAAGCCCG AGGACCTGGA CGGCATTGGC ATGGGCCGGC CTGCTCAGCG CAGACTGTCC 180

GAAGCTCTGA AAAGGCTACG TTCCGGGCCT AAGTCTGTCC CAGTGGCTGT CAAGTCTCTC 240

CGGGTAGGTC CCGAAGGTCC GATGGGCACA GAACTGGGGG ACTTCCTGCG AGAGGTATCG 300

GTCATGATGA ACTTGGAGCA CCCACACGTG CTGCGCCTGC ACGGCCTTGT ACTGGGCCAG 360

CCTCTGCAGA TGGTGATGGA GCTGGCGCCA CTGGGCTCCC TGCACGCGCG CCTAACGGCC 420

CCGGCCCCGA CACCCCCGCT GCTCGTGGCC CTGCTCTGCC TCTTCCTGCG GCAGCTGGCG 480

GGAGCCATGG CGTACCTGGG GGCCCGCGGG CTGGTGCACC GAGACCTCGC TACGCGCAAC 540

CTGCTGCTGG CGTCGCCGCG CACCATCAAG GTGGCTGACT TCGGGCTGGT GCGGCCTCTG 600

GGCGGTGCCC GGGGCCGCTA CGTCATGGGC GGGCCCCGCC CCATCCCCTA CGCCTGGTGT 660

GCCCCAGAGA GCCTGCGCCA CGGAGCCTTC TCGTCTGCCT CGGACGTGTG GATGTTTGGG 720

GTGACGCTGT GGGAGATGTT CTCGGGGGGC GAGGAACCCT GGGCCGGGGT CCCACCGTAC 780

CTCATCCTGC AGCGGCTGGA GGACAGAGCC CGGCTACCTA GGCCTCCCCT CTGCTCCAGG 840

GCCCTCTACT CCCTCGCCTT GCGCTGCTGG GCCCCCCACC CTGCCGACCG GCCTAGCTTT 900

TCCCACCTGG AGGGGCTGCT GCAAGAGGCC TGGCCTTCGG AAGGATGCTG TGTGAGGGAT 960

GTCACAGAGC CAGGCGCCCT GAGGATGGAG ACTGGTGACC CCATCACAGT CATCGAGGGC 1020

AGCTCCTCTT TCCACAGCCC CGACTCCACA ATCTGGAAGG GCCAGAATGG TCGCACCTTC 1080

AAAGTGGGCA GCTTCCCAGC CTCGGCGGTG ACGCTGGCAG ATGCGGGGGG CTTGCCAGCC 1140

ACCCGTCCAG TCCACAGAGG CACCCCTGCC CGGGGAGATC AACACCCAGG AAGCATAGAT 1200

GGAGACAGAA AGAAGGCAGA TCTTTGGGAT GCGCCCCCAG CACGGGGCCA GAGGAGGAAC 1260

GTGCCCCTGG AGAGGATGAA AGGCATTTCC AGGAGTCTGG AGTCAGTTCT GTCCCTGGGT 1320

CCTCGTCCCA CAGGGGGTGG TTCAAGCCCC CCTGAAATTC GACAAGCCAG AGCTGTGCCC 1380

CAGGGACCCC CAGGCCTGCC TCCACGCCCA CCTTTATCCT CTAGCTCTCC TCAGCCCAGC 1440

CAGCCCCCTA GGGAGAGGCT TCCCTGGCCC AAAAGAAAAC CCCCACACAA TCACCCCATG 1500

GGAACGCCTG GAGCCAGTAA AGCCGCTGCC CTCTCTGGAG GCCTCTTGCC CGATCCTGAG 1560

TTGCAGAGGA AGATTATGGA GGTGGAGCTG AGTGTCCATG GGGTCACCCA CCAGGAGTGC 1620

CAGACAGCAC TAGGAGCCAC TGGGGGAGAT GTGGTTTCTG CCATCCGGAA CCTCAAGGTA 1680

GACCAGCTCT TCCACCTGAG TAGCCGGTCC AGAGCTGACT GCCGGCGCAT CCTGGAGCAT 1740

TACCAGTGGG ACCTCTCAGC TGCCAGCCGC TATGTCCTAG CCAGGCCCTG A 1791

Domain Profile

S: 23    psgksvqvavkvlk..sdkllstelddflrevsvllklehenlvrlyGvvltqplklvte  80

         ++ ksv+vavk+l+  ++  ++tel+dflrevsv+++leh++++rl+G+vl+qpl++v+e

Q: 68    SGPKSVPVAVKSLRvgPEGPMGTELGDFLREVSVMMNLEHPHVLRLHGLVLGQPLQMVME  127

         56799********9999*******************************************

S: 81    laelgslldrlrkeakrdsllvallleyavqiaeglayleskrlvhrdlaarnlllaskk  140

         la+lgsl++rl+++a +++llvall+ +++q+a ++ayl+++ lvhrdla+rnlllas++

Q: 128   LAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLASPR  187

         ************************************************************

S: 141   lvkisdfGlvralgeeedlyvlaenkkvPfaWcaPeslrtrkfssasdvWafGvtlWemf  200

         ++k++dfGlvr+lg ++++yv+  ++++P+aWcaPeslr+ +fssasdvW+fGvtlWemf

Q: 188   TIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMF  247

         ************************************************************

S: 201   syGeePWvglsglqilkkidkekerlekPeacpediyslllkcWakkpadrpkfsalkek  260

         s GeePW+g++++ il++++ +++rl++P++c++++ysl+l+cWa +padrp+fs+l++

Q: 248   SGGEEPWAGVPPYLILQRLE-DRARLPRPPLCSRALYSLALRCWAPHPADRPSFSHLEGL  306

         ********************.9***********************************976

Domain Sequence
(FASTA)

SGPKSVPVAV KSLRVGPEGP MGTELGDFLR EVSVMMNLEH PHVLRLHGLV LGQPLQMVME 60

LAPLGSLHAR LTAPAPTPPL LVALLCLFLR QLAGAMAYLG ARGLVHRDLA TRNLLLASPR 120

TIKVADFGLV RPLGGARGRY VMGGPRPIPY AWCAPESLRH GAFSSASDVW MFGVTLWEMF 180

SGGEEPWAGV PPYLILQRLE DRARLPRPPL CSRALYSLAL RCWAPHPADR PSFSHLEGL 239

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0030308	; P:negative regulation of cell growth
GO:0046580	; P:negative regulation of Ras protein signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013