EPS-POA-00028

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-POA-00028

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	267.6	1.4E-79	61	373	313

Status

Unreviewed

Ensembl Protein

ENSPPYP00000009568

UniProt Accession

H2NUD3;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1D

Gene Synonyms/Alias

PPM1D;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000008517	ENSPPYP00000009568	ENSPPYT00000009950

Organism

Pongo abelii

Functional Description

Protein Length

605

Protein Sequence
(FASTA)

MAGLYSLVVS VFSDQGGRKY MEDVTQIVVE PEPTAEEKPS PRRSLSQPLP PRPSPAALPG 60

GEVSGKGPTV AAREARDPLP DAGASPAPSR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL 120

WGFIKKQKGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII 180

RGMKMYVAHV GDSGVVLGIQ DDPKDDFVRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG 240

VNRVVWKRPR LTHNGPVRRS TVIDQIPFLA VARALGDLWS YDFFSGEFVV SPEPDTSVHT 300

LFFHKHKYII LGSDGLWNMI PPQDAISMCQ DQEEKKYLMG EHGQSCAKML VNRALGRWRQ 360

RMLRADNTSA IVICISPEVD NQGNFTNEDE LYLNLTDSPS YNSQETCVMT PSPCSTPPVK 420

SLEEDPWPRL NSKDHIPALV RSNAFSENFL EVSAEIAREN VQGVVISSKD PEPLEENCAK 480

ALTLRIHDSL NNSLPVGLVP TNSTNTVMDQ KNLKMSTPGQ MKAQEIERTP PTNFKRTLEE 540

SNSGPLMKKH RRNGLSRSSG AQPASLPTTS QRKNSVKLTM RRRLRGQKKI GNPLLHQHRK 600

TVCVC 605

Nucleotide Sequence
(FASTA)

ATGGCGGGGC TGTACTCGCT GGTAGTGAGC GTCTTCTCCG ACCAGGGCGG GAGGAAGTAC 60

ATGGAGGACG TTACTCAAAT CGTTGTGGAG CCCGAACCGA CCGCTGAAGA AAAGCCCTCG 120

CCGCGGCGGT CGCTGTCTCA ACCGTTGCCT CCGCGGCCGT CGCCGGCCGC CCTTCCCGGC 180

GGCGAAGTCT CGGGGAAAGG CCCAACGGTG GCAGCCCGAG AGGCTCGCGA CCCTCTCCCG 240

GACGCCGGGG CCTCGCCGGC ACCCAGCCGC TGCTGCCGCC GCCGTTCCTC CGTGGCCTTT 300

TTCGCCGTGT GCGACGGGCA CGGCGGGCGG GAGGCGGCAC AGTTTGCCCG GGAGCACTTG 360

TGGGGTTTCA TCAAGAAGCA GAAGGGTTTC ACCTCGTCCG AGCCGGCTAA GGTTTGCGCT 420

GCCATCCGCA AAGGCTTTCT CGCTTGTCAC CTCGCCATGT GGAAGAAACT GGCGGAATGG 480

CCAAAGACTA TGACAGGTCT TCCCAGCACA TCAGGGACAA CTGCCAGTGT GGTCATCATA 540

CGGGGCATGA AGATGTATGT AGCTCACGTA GGTGACTCAG GGGTGGTTCT TGGAATTCAG 600

GATGACCCGA AGGATGACTT TGTCAGAGCT GTGGAGGTGA CACAGGACCA TAAGCCAGAA 660

CTTCCCAAGG AAAGAGAACG AATCGAAGGA CTTGGTGGGA GTGTAATGAA CAAGTCTGGG 720

GTGAATCGTG TAGTTTGGAA ACGACCTCGG CTCACTCACA ATGGACCTGT TAGGAGGAGC 780

ACAGTTATTG ACCAGATTCC TTTTCTGGCA GTAGCAAGAG CACTTGGTGA TTTGTGGAGC 840

TATGATTTCT TCAGTGGTGA ATTTGTGGTG TCACCTGAAC CAGACACAAG TGTCCACACT 900

CTTTTTTTTC ACAAGCACAA GTATATTATA TTGGGAAGTG ATGGACTTTG GAATATGATT 960

CCACCACAAG ATGCCATCTC AATGTGCCAG GACCAAGAGG AGAAAAAATA CCTGATGGGT 1020

GAGCATGGAC AATCTTGTGC CAAAATGCTT GTGAATCGAG CATTGGGCCG CTGGAGGCAG 1080

CGTATGCTCC GAGCAGATAA CACTAGTGCC ATAGTAATCT GCATCTCTCC AGAAGTGGAC 1140

AATCAGGGAA ACTTTACCAA TGAAGATGAG TTATACCTGA ACCTGACTGA CAGCCCTTCC 1200

TATAATAGTC AAGAAACCTG TGTGATGACT CCTTCCCCAT GTTCTACACC ACCAGTCAAG 1260

TCACTGGAGG AGGATCCATG GCCAAGGCTG AACTCTAAGG ACCATATACC TGCCCTGGTT 1320

CGTAGCAATG CCTTCTCAGA GAATTTTTTA GAGGTTTCAG CTGAGATAGC TCGAGAGAAT 1380

GTCCAGGGTG TAGTCATATC CTCAAAAGAT CCAGAACCAC TTGAAGAAAA TTGCGCTAAA 1440

GCCCTGACTT TAAGGATACA TGATTCTTTG AATAATAGCC TTCCAGTTGG CCTTGTGCCT 1500

ACTAATTCAA CAAACACTGT CATGGACCAA AAAAATTTGA AGATGTCAAC TCCTGGCCAA 1560

ATGAAAGCCC AAGAAATTGA AAGAACCCCT CCAACAAACT TTAAAAGGAC ATTAGAAGAG 1620

TCCAATTCTG GCCCCCTGAT GAAGAAGCAT AGACGAAATG GCTTAAGTCG AAGTAGTGGT 1680

GCTCAGCCTG CAAGTCTCCC CACAACCTCA CAGCGAAAGA ACTCTGTTAA ACTCACCATG 1740

CGACGCAGAC TTAGGGGCCA GAAGAAAATT GGAAATCCTT TACTTCATCA ACACAGGAAA 1800

ACTGTTTGTG TTTGCTGA 1818

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr......laffgvyDGhggsevakfcsekl  57

         g vs++g++   ++a+++ p++++sp+ +++      +aff+v+DGhgg+e+a+f++e+l

Q: 61    GEVSGKGPTVAAREARDPLPDAGASPAPSRCcrrrssVAFFAVCDGHGGREAAQFAREHL  120

         67999************************99*****************************

S: 58    heilaeelesseseerkvkkalakaFlstdeel.....kvleeksldidksGstavvali  112

         + ++++++ +++se +kv++a++k+Fl+++ ++     +++++++  +++sG+ta+v++i

Q: 121   WGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMwkklaEWPKTMTGLPSTSGTTASVVII  180

         ************************************************************

S: 113   kdsklyvanvGdSravLcrngk.......avelssdHkpsredEleRieeaggsvilkdg  165

         +++k+yva+vGdS++vL+ +++       ave+++dHkp+ ++E+eRie  ggsv++k+g

Q: 181   RGMKMYVAHVGDSGVVLGIQDDpkddfvrAVEVTQDHKPELPKERERIEGLGGSVMNKSG  240

         *******************77656999999******************************

S: 166   a.Rv.....................lGvLavsRalGdlylk......pyvtpePevtshr  197

         + Rv                     +++Lav+RalGdl+++      ++v+peP++++h+

Q: 241   VnRVvwkrprlthngpvrrstvidqIPFLAVARALGDLWSYdffsgeFVVSPEPDTSVHT  300

         ************************************************************

S: 198   ltsede.fliLasDGlwdvvsneeavslvrdvle....kkeaeqeaakkLvklalargsk  252

         l   ++ ++iL+sDGlw+++++++a+s+++d++e    ++e+ q++ak+Lv++al r+++

Q: 301   LFFHKHkYIILGSDGLWNMIPPQDAISMCQDQEEkkylMGEHGQSCAKMLVNRALGRWRQ  360

         *665555*****************************************************

S: 253   .....dnvsaivv  260

              dn+saiv+

Q: 361   rmlraDNTSAIVI  373

         ***********97

Domain Sequence
(FASTA)

GEVSGKGPTV AAREARDPLP DAGASPAPSR CCRRRSSVAF FAVCDGHGGR EAAQFAREHL 60

WGFIKKQKGF TSSEPAKVCA AIRKGFLACH LAMWKKLAEW PKTMTGLPST SGTTASVVII 120

RGMKMYVAHV GDSGVVLGIQ DDPKDDFVRA VEVTQDHKPE LPKERERIEG LGGSVMNKSG 180

VNRVVWKRPR LTHNGPVRRS TVIDQIPFLA VARALGDLWS YDFFSGEFVV SPEPDTSVHT 240

LFFHKHKYII LGSDGLWNMI PPQDAISMCQ DQEEKKYLMG EHGQSCAKML VNRALGRWRQ 300

RMLRADNTSA IVI 313

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0009617	; P:response to bacterium

KEGG

pon:100438569

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013