EKS-POA-00279

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00279

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	483.8	1.4E-145	453	714	262

Status

Unreviewed

Ensembl Protein

ENSPPYP00000023705

UniProt Accession

H2NUF8;

Protein Name

Protein Synonyms/Alias

Gene Name

ERN1

Gene Synonyms/Alias

ERN1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000008539	ENSPPYP00000023705	ENSPPYT00000032972
ENSPPYG00000008539	ENSPPYP00000009594	ENSPPYT00000009977

Organism

Pongo abelii

Functional Description

Protein Length

859

Protein Sequence
(FASTA)

MGKKQDIWYV IDLLTGEKQQ TLSSAFADSL CPSTSLLYLG RTEYTITMYD TKTRELRWNA 60

TYFDYAASLP EDDVDYKMSH FVSNGDGLVV TVDSESGDVL WIQNYASPVV AFYVWQREGL 120

RKVMHINVAV ETLRYLTFMS GEVGRITKWK YPFPKETEAK SKLTPTLYVG KYSTSLYASP 180

SMVHEGVAVV PRGSTLPLLE GPQTDGVTIG DKGECVITPS TDVKFDPGLK SKNKLNYLRN 240

YWLLIGHHET PLSASTKMLE RFPNNLPKHR ENVIPADSEK KSFEEVINLV DQTSENAPTT 300

VSRDVEEKPA HAPARPEAPV DSMLKDMATI ILSTFLLIGW VAFIITYPLS MHQQQQLQHQ 360

QFQKELEKIQ LLQQQQQLPF HPPGDTAQDG ELLDTSGPYS ESSGTSSPST SPRASNHSLC 420

SGSFASKAGS SPSLEQDDGD EETSMVIVGK ISFCPKDVLG HGAEGTIVYR GMFDNRDVAV 480

KRILPECFSF ADREVQLLRE SDEHPNVIRY FCTEKDRQFQ YIAIELCAAT LQEYVEQKDF 540

AHLGLEPITL LQQTTSGLAH LHSLNIVHRD LKPHNILISM PNAHGKIKAM ISDFGLCKKL 600

AVGRHSFSRR SGVPGTEGWI APEMLSEDCK ENPTYTVDIF SAGCVFYYVI SEGSHPFGKS 660

LQRQANILLG ASSLDCLHPE KHEDVIAREL IEKMIAMDPQ KRPSAKHVLK HPFFWSLEKQ 720

LQFFQDVSDR IEKESLDGPI VKQLERGGRA VVKMDWRENI TVPLQTDLRK FRTYKGGSVR 780

DLLRAMRNKK HHYRELPAEV RETLGSLPDD FVCYFTSRFP HLLAHTYQAM ELCSHERLFQ 840

PYYFHEPPEP QPPVTPDAL 859

Nucleotide Sequence
(FASTA)

ATGGGTAAAA AGCAGGACAT CTGGTATGTT ATTGACCTCC TGACCGGGGA GAAGCAGCAG 60

ACTTTGTCAT CGGCCTTTGC AGATAGTCTC TGCCCATCAA CCTCTCTTCT GTATCTTGGG 120

CGAACAGAAT ACACCATCAC CATGTATGAC ACCAAAACCC GAGAGCTCCG GTGGAATGCC 180

ACCTACTTTG ACTATGCGGC CTCGCTGCCT GAGGACGACG TGGACTACAA GATGTCCCAC 240

TTTGTGTCCA ATGGTGACGG ACTGGTGGTG ACTGTGGACA GTGAATCTGG GGATGTCCTG 300

TGGATCCAAA ACTACGCCTC CCCTGTGGTG GCCTTTTATG TCTGGCAGCG GGAGGGTCTG 360

AGGAAGGTGA TGCACATCAA TGTCGCTGTG GAGACCCTGC GCTATCTGAC CTTCATGTCT 420

GGGGAGGTGG GGCGCATCAC CAAGTGGAAG TACCCGTTCC CCAAAGAGAC AGAGGCCAAG 480

AGCAAGCTGA CGCCCACTCT GTATGTTGGG AAATACTCTA CCAGCCTCTA TGCCTCTCCC 540

TCAATGGTAC ACGAGGGGGT TGCTGTCGTG CCCCGCGGCA GCACACTTCC TTTGCTGGAA 600

GGGCCCCAGA CTGATGGCGT CACCATTGGG GACAAGGGGG AGTGTGTGAT CACGCCCAGC 660

ACAGACGTCA AGTTTGACCC CGGACTCAAA AGCAAGAACA AGCTCAACTA CTTGAGGAAT 720

TACTGGCTTC TGATAGGACA CCATGAAACC CCACTGTCTG CGTCTACTAA GATGCTGGAG 780

AGATTTCCTA ACAATCTACC CAAACATCGG GAAAATGTGA TTCCTGCTGA TTCAGAGAAA 840

AAGAGCTTTG AGGAAGTTAT CAACCTGGTT GACCAGACTT CAGAAAACGC ACCTACCACC 900

GTGTCTCGGG ATGTGGAGGA GAAGCCTGCC CATGCCCCTG CCCGGCCCGA GGCCCCCGTG 960

GACTCCATGC TCAAGGACAT GGCTACCATC ATCCTGAGCA CCTTCCTGCT GATTGGCTGG 1020

GTGGCCTTCA TCATCACCTA TCCCCTGAGC ATGCATCAGC AGCAGCAGCT CCAGCACCAG 1080

CAGTTCCAGA AGGAACTGGA GAAGATACAG CTCCTGCAGC AGCAGCAGCA GCTGCCCTTC 1140

CACCCACCGG GAGACACGGC TCAGGACGGC GAGCTCCTGG ACACGTCTGG CCCATACTCA 1200

GAGAGCTCGG GCACCAGCAG CCCCAGCACG TCCCCCAGGG CCTCCAACCA CTCGCTCTGC 1260

TCCGGCAGCT TTGCCTCTAA GGCTGGCAGC AGCCCCTCCC TGGAACAAGA CGATGGAGAT 1320

GAGGAAACCA GCATGGTGAT AGTTGGGAAA ATTTCCTTCT GTCCCAAGGA TGTCCTGGGC 1380

CATGGAGCTG AGGGCACAAT TGTGTACCGG GGCATGTTTG ACAACCGGGA CGTGGCCGTG 1440

AAGAGGATCC TACCGGAGTG TTTTAGCTTT GCAGACCGTG AGGTCCAGCT GTTGCGAGAA 1500

TCGGATGAGC ACCCGAACGT GATCCGCTAC TTCTGCACGG AGAAGGACCG GCAATTCCAG 1560

TACATTGCCA TTGAGCTGTG TGCAGCCACC CTGCAAGAGT ATGTGGAGCA GAAGGACTTT 1620

GCGCATCTCG GCCTGGAGCC CATCACCTTG CTGCAGCAGA CCACCTCGGG CCTGGCCCAC 1680

CTCCACTCCC TCAACATCGT TCACAGAGAC CTAAAGCCGC ATAACATTCT CATATCCATG 1740

CCCAATGCAC ACGGCAAGAT CAAGGCCATG ATCTCTGACT TTGGCCTCTG CAAGAAGCTG 1800

GCAGTGGGCA GACACAGTTT CAGCCGCCGA TCTGGGGTGC CTGGCACAGA AGGCTGGATC 1860

GCTCCGGAGA TGCTGAGCGA AGACTGTAAG GAGAACCCTA CCTACACGGT GGACATATTT 1920

TCTGCAGGCT GCGTCTTTTA CTACGTGATC TCTGAGGGCA GCCACCCTTT TGGCAAGTCC 1980

CTACAGCGGC AGGCCAACAT CCTCCTGGGT GCCTCCAGCC TTGACTGCTT GCACCCAGAG 2040

AAGCACGAAG ACGTCATTGC ACGTGAATTG ATAGAGAAGA TGATTGCAAT GGATCCTCAG 2100

AAACGCCCCT CAGCGAAGCA CGTGCTCAAA CACCCATTCT TCTGGAGCCT AGAGAAGCAG 2160

CTCCAGTTCT TCCAGGACGT GAGCGACAGA ATAGAAAAGG AATCCCTGGA TGGCCCGATC 2220

GTGAAGCAGT TAGAGAGAGG CGGGAGAGCC GTGGTGAAGA TGGACTGGCG GGAGAACATC 2280

ACCGTCCCCC TCCAGACAGA CCTGCGTAAA TTCAGGACCT ATAAAGGTGG TTCTGTCAGA 2340

GATCTCCTCC GAGCCATGAG AAACAAGAAG CACCACTACC GGGAGCTGCC TGCGGAGGTG 2400

CGGGAGACAC TGGGGTCCCT CCCCGACGAC TTCGTGTGCT ACTTCACATC TCGCTTCCCC 2460

CACCTCCTCG CACACACCTA CCAGGCCATG GAGCTGTGCA GCCACGAGAG ACTCTTCCAG 2520

CCCTACTACT TCCACGAGCC CCCAGAGCCG CAGCCCCCAG TGACTCCAGA CGCCCTCTGA 2580

Domain Profile

S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60

         f+pkdvlG+GaeGt+v+rG+f++r+vavkr+l+e++++a+rev+llresdehpnviryfc

Q: 453   FCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFC  512

         79**********************************************************

S: 61    tekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivhrdl  120

         tekdrqf+yia+elcaa+lq+yve+kd++ + +lepi+ll+q++sGlahlhsl+ivhrdl

Q: 513   TEKDRQFQYIAIELCAATLQEYVEQKDFA-HLGLEPITLLQQTTSGLAHLHSLNIVHRDL  571

         *****************************.******************************

S: 121   kpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltke  180

         kp+nilis+p+a+gk++++isdfGlckkl+vG++sfsrrsgv+GteGwiape+l+e++ke

Q: 572   KPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKE  631

         ************************************************************

S: 181   rltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviaedli  240

         ++t++vdifs+Gcvfyyv+s+G+hpfG+sl+rqanil g+ sld+l++ek+e+via++li

Q: 632   NPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGASSLDCLHPEKHEDVIARELI  691

         ************************************************************

S: 241   skmidkdplkrpsakkvlkhplf  263

         +kmi++dp+krpsak+vlkhp+f

Q: 692   EKMIAMDPQKRPSAKHVLKHPFF  714

         **********************9

Domain Sequence
(FASTA)

FCPKDVLGHG AEGTIVYRGM FDNRDVAVKR ILPECFSFAD REVQLLRESD EHPNVIRYFC 60

TEKDRQFQYI AIELCAATLQ EYVEQKDFAH LGLEPITLLQ QTTSGLAHLH SLNIVHRDLK 120

PHNILISMPN AHGKIKAMIS DFGLCKKLAV GRHSFSRRSG VPGTEGWIAP EMLSEDCKEN 180

PTYTVDIFSA GCVFYYVISE GSHPFGKSLQ RQANILLGAS SLDCLHPEKH EDVIARELIE 240

KMIAMDPQKR PSAKHVLKHP FF 262

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0030176	; C:integral to endoplasmic reticulum membrane
GO:0005637	; C:nuclear inner membrane
GO:0005524	; F:ATP binding
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006987	; P:activation of signaling protein activity involved in unfolded protein response
GO:0007050	; P:cell cycle arrest
GO:0006917	; P:induction of apoptosis
GO:0006397	; P:mRNA processing
GO:1900103	; P:positive regulation of endoplasmic reticulum unfolded protein response
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR018391	; PQQ_beta_propeller_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00564	; PQQ; 5.
SM00580	; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013