EKS-POA-00171
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00171
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC322.32.7E-96339508170
StatusUnreviewed
Ensembl ProteinENSPPYP00000009612
UniProt AccessionH2NUH6;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCA
Gene Synonyms/Alias PRKCA;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000008557ENSPPYP00000009612ENSPPYT00000009995
OrganismPongo abelii
Functional Description
Protein Length645
Protein Sequence
(FASTA)
MADVFPGNDS TASQDVANRF ARKGALRQKN VHEVKDHKFI ARFFKQPTFC SHCTDFIWGF 60
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 120
LLYGLIHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVAD EKLHVTVRDA 180
KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTIRSTLN PQWNESFTFK LKPSDKDRRL 240
SVEIWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PEGDEEGNME 300
LRQKFEKAKL GPAGNKVISP SEDRKQPSNN LDRVKLTDFN FLMVLGKGSF GKVMLADRKG 360
TEELYAIKIL KKDVVIQDDD VECTMVEKRV LALLDKPPFL TQLHSCFQTV DRLYFVMEYV 420
NGGDLMYHIQ QVGKFKEPQA VFYAAEISIG LFFLHKRGII YRDLKLDNVM LDSEGHIKIA 480
DFGMCKEHMM DGVTTRTFCG TPDYIAPEPP FDGEDEDELF QSIMEHNVSY PKSLSKEAVS 540
ICKGLMTKHP AKRLGCGPEG ERDVREHAFF RRIDWEKLEN REIQPPFKPR VCGKGAENFD 600
KFFTRGQPVL TPPDQLVIAN IDQSDFEGFS YVNPQFVHPI LQSAV 645
Nucleotide Sequence
(FASTA)
ATGGCTGACG TTTTCCCGGG CAACGACTCC ACGGCGTCTC AGGACGTGGC CAACCGCTTC 60
GCCCGCAAAG GGGCGCTGAG GCAGAAGAAC GTGCACGAGG TGAAGGACCA CAAATTCATC 120
GCGCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGGTTT 180
GGGAAACAAG GCTTCCAGTG CCAAGTTTGC TGTTTTGTGG TCCACAAGAG GTGCCATGAA 240
TTTGTTACTT TTTCTTGTCC GGGTGCGGAT AAGGGACCCG ACACTGATGA CCCCAGAAGC 300
AAGCACAAGT TCAAAATCCA CACTTACGGA AGCCCCACCT TCTGTGATCA CTGTGGGTCA 360
CTGCTCTATG GACTTATCCA TCAAGGGATG AAATGTGACA CCTGCGATAT GAACGTTCAC 420
AAGCAATGCG TCATCAATGT CCCCAGCCTC TGCGGAATGG ATCACACTGA GAAGAGGGGG 480
CGGATTTACC TAAAGGCTGA GGTTGCTGAC GAAAAGCTCC ATGTCACAGT ACGAGATGCA 540
AAAAATCTAA TCCCTATGGA TCCAAACGGG CTTTCAGATC CTTATGTGAA GCTGAAACTT 600
ATTCCTGATC CCAAGAATGA AAGCAAGCAA AAAACCAAAA CCATCCGCTC CACACTAAAT 660
CCCCAGTGGA ATGAGTCCTT TACATTCAAA TTGAAACCTT CAGACAAAGA CCGACGACTG 720
TCTGTAGAAA TCTGGGACTG GGATCGAACA ACAAGGAATG ACTTCATGGG ATCCCTTTCC 780
TTTGGAGTTT CGGAGCTGAT GAAGATGCCG GCCAGTGGAT GGTACAAGTT GCTTAACCAA 840
GAAGAAGGTG AGTACTACAA CGTACCCATT CCGGAAGGGG ACGAAGAAGG AAACATGGAA 900
CTCAGGCAGA AATTCGAGAA AGCCAAACTT GGCCCTGCTG GCAACAAAGT CATCAGTCCC 960
TCCGAAGACA GGAAACAACC TTCCAACAAC CTTGACCGAG TGAAACTCAC GGACTTCAAT 1020
TTCCTCATGG TGTTGGGGAA GGGGAGTTTT GGAAAGGTGA TGCTTGCCGA CAGGAAGGGC 1080
ACAGAGGAAC TCTATGCAAT CAAAATCCTG AAGAAGGATG TGGTGATTCA GGATGATGAT 1140
GTGGAGTGCA CCATGGTAGA AAAGCGAGTC TTGGCCCTGC TTGATAAACC CCCGTTCTTG 1200
ACGCAGCTGC ACTCCTGCTT CCAGACAGTG GATCGGCTGT ACTTCGTCAT GGAGTATGTC 1260
AACGGTGGGG ACCTCATGTA CCACATTCAG CAAGTAGGAA AATTTAAGGA ACCACAAGCA 1320
GTATTCTATG CGGCAGAGAT TTCCATCGGA TTGTTCTTCC TTCATAAAAG AGGAATCATT 1380
TATAGGGATC TGAAGTTAGA TAATGTCATG TTGGATTCAG AAGGACATAT CAAAATTGCT 1440
GACTTTGGAA TGTGCAAGGA ACACATGATG GATGGAGTCA CGACCAGGAC CTTCTGTGGG 1500
ACTCCAGATT ACATTGCCCC AGAGCCTCCA TTTGATGGTG AAGATGAAGA CGAGCTATTT 1560
CAGTCTATCA TGGAGCACAA CGTTTCCTAT CCAAAGTCCT TGTCCAAGGA GGCTGTTTCC 1620
ATCTGCAAAG GACTGATGAC CAAACACCCA GCCAAGCGGC TGGGCTGTGG GCCTGAGGGG 1680
GAGAGGGACG TGAGAGAACA TGCCTTCTTC CGGAGGATCG ACTGGGAAAA ACTGGAGAAC 1740
AGGGAGATCC AGCCACCATT CAAGCCCAGA GTGTGTGGCA AAGGAGCAGA AAACTTTGAC 1800
AAGTTCTTCA CACGAGGACA GCCCGTCTTA ACACCGCCTG ATCAGCTGGT TATTGCTAAC 1860
ATAGACCAGT CTGATTTTGA AGGGTTCTCG TATGTCAACC CCCAGTTTGT GCACCCCATC 1920
TTACAGAGTG CAGTATGA 1938
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal +k+p
Q: 339   FNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPP  398
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g
Q: 399   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRG  458
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPe  170
         iiyrdlkldnv+ld+eGhik+adfG+cke++++g tt+tfcGtPdyiaPe
Q: 459   IIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPE  508
         *************************************************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLADR KGTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALLDKPP 60
FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS IGLFFLHKRG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEH MMDGVTTRTF CGTPDYIAPE 170
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00161
EKS-ANC-00165
EKS-BOT-00169
EKS-CAJ-00173
EKS-CAF-00176
EKS-CAP-00169
EKS-DAR-00460
EKS-EQC-00167
EKS-FEC-00159
EKS-GAM-00089
EKS-GAG-00145
EKS-GAA-00203
EKS-GOG-00167
EKS-HOS-00175
EKS-ICT-00164
EKS-LAC-00179
EKS-LOA-00168
EKS-MAM-00167
EKS-MEG-00134
EKS-MOD-00168
EKS-MUM-00174
EKS-MUP-00173
EKS-MYL-00178
EKS-NOL-00162
EKS-ORA-00149
EKS-ORC-00155
EKS-ORL-00198
EKS-OTG-00175
EKS-PAT-00160
EKS-PES-00149
EKS-PEM-00092
EKS-PRC-00045
EKS-RAN-00168
EKS-SAH-00163
EKS-TAG-00197
EKS-TAR-00221
EKS-XIM-00207
Gene Ontology
GO:0005829; C:cytosol
GO:0030425; C:dendrite
GO:0005783; C:endoplasmic reticulum
GO:0005739; C:mitochondrion
GO:0043025; C:neuronal cell body
GO:0005634; C:nucleus
GO:0001750; C:photoreceptor outer segment
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004698; F:calcium-dependent protein kinase C activity
GO:0035403; F:histone kinase activity (H3-T6 specific)
GO:0008270; F:zinc ion binding
GO:0006874; P:cellular calcium ion homeostasis
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0002062; P:chondrocyte differentiation
GO:0000188; P:inactivation of MAPK activity
GO:0050930; P:induction of positive chemotaxis
GO:0035556; P:intracellular signal transduction
GO:0008285; P:negative regulation of cell proliferation
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0046325; P:negative regulation of glucose import
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0030593; P:neutrophil chemotaxis
GO:0045766; P:positive regulation of angiogenesis
GO:0043536; P:positive regulation of blood vessel endothelial cell migration
GO:0045785; P:positive regulation of cell adhesion
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0050729; P:positive regulation of inflammatory response
GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045931; P:positive regulation of mitotic cell cycle
GO:0001934; P:positive regulation of protein phosphorylation
GO:0006937; P:regulation of muscle contraction
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0090330; P:regulation of platelet aggregation
GO:0002026; P:regulation of the force of heart contraction
GO:0070555; P:response to interleukin-1
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013