EKS-POA-00426

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00426

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	259.4	4.0E-77	95	267	173

Status

Unreviewed

Ensembl Protein

ENSPPYP00000009920

UniProt Accession

H2NVC0;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK2

Gene Synonyms/Alias

ULK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000008842	ENSPPYP00000009920	ENSPPYT00000010319

Organism

Pongo abelii

Functional Description

Protein Length

1028

Protein Sequence
(FASTA)

MSIANQSNVR SSQVCPGGAA MEVVGDFEYS KRDLVGHGAF AVVFRGRHRQ KTDWEVAIKS 60

INKKNLSKSQ ILLGKEIKIL KELQHENIVA LYDVQKGTLS EDTIRVFLHQ IAAAMRILHS 120

KGIIHRDLKP QNILLSYANR RKSSVSGIRI KIADFGFARY LHSNMMAATL CGSPMYMAPE 180

VIMSQHYDAK ADLWSIGTVI YQCLVGKPPF QANSPQDLRM FYEKNRSLMP SIPRETSPYL 240

ANLLLGLLQR NQKDRMDFEA FFSHPFLEQV PVKKSCPVPV PMYSGSVSGS SCGSSPSCRF 300

ASPPSLPDMQ HIQEENLSSP PLGPPNYLQV SKDSASTSSK NSSCDTDDFV LVPHNISSDH 360

SNDMPMGTAG RRASNEFLVC GGQCQPTVSP HSETAPIPVP TQIRNYQRIE QNLTSTASSG 420

TNVHGSPRSA VVRRSNTSPM GFLRLGSCSP VPADTAQTVG RRLSTGSSRP YSPSPLVGTI 480

PEQFSQCCCG HPQGHDSRSR NSSGSPVPQA QSPQSLLSGA RLQSAPTLTD IYQNKQKLRK 540

QHSDPVCPSH TGAGYSYSPQ PSRPGSLGTS PTKHLGSSPR SSDWFFKTPL PTIIGSPTKT 600

TAPFKIPKTQ ASSNLLALVT RHGPAEEQSK DGNEPRECVH CLLVQGSERQ RAEQQSKAVF 660

GRSSTGKSDH QGKTPICRHQ GSTDSLNTER PMDIAPAGAC GGVLAPPAGT AASSRAVLFT 720

VGSPPHSAAA PTCTHMFLRT RTTSVGPSNS GGSLCAMSGR VCVGSPPGPG FGSSPPGAEA 780

APSLRKVPYG ASPPSLEGLI TFEAPELPDT LMEREHTDTL RYLNVMLMFT ECVLDTAMRG 840

GNLELCTSAV SLYQIQESVV VDQISQLSKD WGRVEQLVLY MKAAQLLAAS LHLAKAQIKS 900

GKLSPSTAVK QVVKNLNERY KFCITMCKKL TEKLNRFFSD KQRFIDEINS VTAEKLIYNC 960

AVEMVQSAAL DEMFQQTEDI VYRYHKAALL LEGLSKILQD PADIENVHKY KCSIERRLSA 1020

LCHSTATM 1028

Nucleotide Sequence
(FASTA)

ATGAGTATTG CAAATCAGAG TAACGTCCGC TCTTCCCAGG TGTGCCCCGG GGGCGCGGCC 60

ATGGAGGTGG TGGGCGACTT CGAGTACAGC AAGAGGGATC TCGTGGGACA CGGGGCCTTC 120

GCCGTGGTCT TCCGGGGGCG GCACCGCCAG AAAACTGATT GGGAGGTAGC TATTAAAAGT 180

ATTAATAAAA AGAACTTGTC AAAATCACAA ATACTGCTTG GAAAGGAAAT TAAAATCTTA 240

AAGGAACTTC AGCATGAAAA TATTGTAGCA CTCTATGATG TTCAGAAAGG GACTCTCAGT 300

GAAGACACTA TCAGAGTCTT TCTGCATCAG ATTGCTGCTG CCATGCGAAT CCTGCACAGC 360

AAAGGAATCA TCCACAGAGA TCTCAAACCA CAGAACATCT TGCTGTCCTA TGCCAATCGC 420

AGAAAATCAA GTGTCAGTGG TATTCGCATC AAAATAGCGG ATTTTGGTTT TGCTCGTTAC 480

CTACATAGTA ACATGATGGC TGCAACACTA TGTGGATCCC CGATGTACAT GGCTCCTGAG 540

GTTATTATGT CTCAACATTA TGATGCTAAG GCTGACTTGT GGAGCATAGG AACGGTGATA 600

TACCAATGCC TAGTTGGAAA ACCACCTTTT CAGGCCAATA GTCCTCAAGA CTTAAGGATG 660

TTTTATGAAA AAAATAGGAG CTTAATGCCT AGTATTCCCA GAGAAACATC ACCTTATTTG 720

GCTAATCTCC TTTTGGGTTT GCTTCAGAGA AACCAAAAAG ATAGAATGGA CTTTGAAGCA 780

TTTTTTAGCC ATCCTTTTCT TGAGCAAGTT CCAGTAAAAA AATCTTGCCC AGTTCCAGTG 840

CCCATGTATT CTGGTTCTGT CTCTGGAAGC TCCTGTGGCA GCTCTCCATC TTGTCGTTTT 900

GCTTCTCCAC CATCCCTTCC AGATATGCAG CATATTCAGG AAGAAAACTT ATCTTCCCCA 960

CCATTGGGTC CTCCCAACTA TCTACAAGTT TCCAAAGATT CTGCCAGTAC TAGTAGCAAG 1020

AACTCTTCTT GTGACACGGA TGACTTTGTT TTGGTGCCAC ACAACATCTC GTCAGACCAC 1080

TCAAATGATA TGCCAATGGG GACTGCTGGC AGACGTGCTT CAAATGAGTT CTTGGTGTGT 1140

GGAGGGCAGT GTCAGCCTAC TGTGTCACCT CACAGCGAAA CAGCACCAAT TCCAGTTCCT 1200

ACTCAAATAA GGAATTATCA GCGCATAGAG CAGAATCTTA CATCTACTGC CAGCTCAGGC 1260

ACAAATGTAC ATGGATCTCC AAGATCTGCA GTGGTACGAA GGTCCAACAC CAGCCCCATG 1320

GGCTTCCTCC GGCTGGGATC ATGCTCCCCA GTGCCAGCAG ACACAGCACA GACAGTTGGA 1380

CGAAGGCTCT CCACTGGGTC TTCTAGGCCT TACTCACCTT CCCCTTTGGT TGGTACCATT 1440

CCCGAGCAAT TCAGTCAGTG CTGCTGTGGG CATCCTCAGG GCCATGACTC CAGGAGTAGA 1500

AACTCCTCAG GTTCTCCAGT GCCACAAGCT CAGTCACCAC AGTCTCTCTT ATCGGGTGCT 1560

AGACTGCAGA GCGCCCCCAC TCTCACTGAC ATCTATCAGA ACAAGCAGAA GCTCAGAAAA 1620

CAGCACTCTG ACCCCGTGTG CCCATCCCAT ACTGGGGCTG GGTACAGCTA CTCGCCTCAG 1680

CCCAGTCGGC CTGGCAGCCT TGGAACTTCT CCCACCAAGC ACTTGGGGTC CTCTCCACGG 1740

AGTTCTGACT GGTTCTTTAA AACTCCTTTG CCAACAATCA TTGGCTCTCC TACTAAGACC 1800

ACAGCTCCTT TCAAAATCCC TAAAACGCAA GCATCTTCCA ACCTGTTAGC CTTGGTTACT 1860

CGTCATGGGC CTGCTGAAGA ACAGTCCAAA GATGGGAACG AGCCACGGGA ATGTGTCCAT 1920

TGCCTCTTAG TGCAAGGAAG TGAGAGGCAG CGGGCCGAGC AGCAGAGCAA GGCAGTGTTT 1980

GGCAGATCTA GTACTGGGAA GTCAGATCAT CAAGGAAAGA CTCCTATATG TCGACATCAG 2040

GGCAGCACAG ACAGTTTAAA TACAGAACGA CCAATGGATA TAGCTCCAGC AGGAGCCTGT 2100

GGTGGTGTTC TGGCACCTCC TGCAGGTACA GCAGCAAGTT CCAGGGCTGT CCTCTTCACT 2160

GTAGGGTCTC CTCCACACAG TGCAGCGGCC CCCACTTGTA CCCACATGTT CCTTCGAACA 2220

AGAACAACCT CAGTGGGGCC CAGCAACTCC GGGGGCTCTC TGTGTGCCAT GAGTGGCCGC 2280

GTGTGTGTGG GGTCCCCGCC TGGCCCAGGC TTCGGCTCTT CCCCTCCAGG AGCAGAGGCA 2340

GCTCCCAGCC TAAGAAAGGT GCCTTACGGT GCTTCACCCC CCAGCCTAGA GGGGCTCATC 2400

ACCTTTGAAG CCCCTGAACT GCCGGACACA CTGATGGAGC GAGAACACAC AGACACTTTA 2460

CGCTATCTGA ATGTGATGCT GATGTTCACT GAGTGTGTGC TGGATACAGC CATGAGGGGA 2520

GGAAACCTTG AGCTGTGCAC ATCTGCTGTG TCCTTGTACC AGATCCAGGA GAGTGTGGTG 2580

GTGGACCAGA TCAGTCAGCT GAGCAAAGAC TGGGGGCGGG TGGAGCAGCT GGTGTTGTAC 2640

ATGAAAGCAG CACAGCTGCT TGCGGCTTCT CTGCATCTTG CCAAAGCCCA GATCAAGTCC 2700

GGGAAATTGA GCCCATCCAC AGCTGTGAAA CAAGTTGTCA AGAATCTGAA CGAACGATAT 2760

AAATTCTGCA TCACCATGTG CAAGAAACTT ACAGAAAAGC TGAATCGATT CTTCTCTGAC 2820

AAACAGAGGT TTATTGATGA AATCAACAGT GTGACTGCAG AGAAACTCAT CTATAATTGT 2880

GCTGTAGAAA TGGTTCAGTC TGCAGCCCTG GATGAGATGT TTCAGCAGAC CGAAGATATT 2940

GTTTATCGCT ACCATAAGGC AGCCCTTCTT TTGGAAGGCC TAAGTAAGAT TCTACAGGAT 3000

CCTGCAGATA TTGAAAATGT ACATAAATAT AAATGTAGTA TTGAGAGAAG ACTGTCGGCG 3060

CTCTGCCATA GCACCGCAAC CATGTGA 3087

Domain Profile

S: 91    qkkeLsedtvreflqqlasalkaLhskkivhrDlkPqniLlsyadakk.elkkvtlklad  149

         qk++Lsedt+r+fl+q+a+a+++Lhsk+i+hrDlkPqniLlsya+++k +++ +++k+ad

Q: 95    QKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKsSVSGIRIKIAD  154

         689******************************************99989**********

S: 150   FglarvlkeesmaatlkGsplYmaPEvvkeqqydakaDlWSiGtilyellvGkpPfaaes  209

         Fg+ar+l++++maatl+Gsp+YmaPEv+++q+ydakaDlWSiGt++y++lvGkpPf+a+s

Q: 155   FGFARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANS  214

         ************************************************************

S: 210   iseLvekiekndvleppipkeisselkdllqsLLqrdpkkRisfeelfahpfl  262

         +++L++++ekn++l+p+ip+e+s+ l++ll +LLqr++k+R++fe +f+hpfl

Q: 215   PQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFL  267

         ***************************************************96

Domain Sequence
(FASTA)

QKGTLSEDTI RVFLHQIAAA MRILHSKGII HRDLKPQNIL LSYANRRKSS VSGIRIKIAD 60

FGFARYLHSN MMAATLCGSP MYMAPEVIMS QHYDAKADLW SIGTVIYQCL VGKPPFQANS 120

PQDLRMFYEK NRSLMPSIPR ETSPYLANLL LGLLQRNQKD RMDFEAFFSH PFL 173

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0034045	; C:pre-autophagosomal structure membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0048675	; P:axon extension
GO:0048671	; P:negative regulation of collateral sprouting
GO:0046777	; P:protein autophosphorylation
GO:0010506	; P:regulation of autophagy
GO:0042594	; P:response to starvation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013