EKS-POA-00457

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00457

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	334.2	6.4E-100	22	312	291

Status

Unreviewed

Ensembl Protein

ENSPPYP00000010293

UniProt Accession

H2NWD0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK4

Gene Synonyms/Alias

MAPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000009161	ENSPPYP00000010293	ENSPPYT00000010699

Organism

Pongo abelii

Functional Description

Protein Length

587

Protein Sequence
(FASTA)

MAEKGDCIAS AYGYDLGGRF VDFQPLGFGV NGLVLSAMDS RACRKVAVKK IALSDARSMK 60

HALREIKIIR RLDHDNIVKV YEVLGPKGTD LQGELFKFSV AYIVQEYMET DLARLLEQGT 120

LAEEHAKLFM YQLLRGLKYI HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIVDQHYS 180

HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GAHELEQMQL 240

ILETIPVIRE EDKDELLRVM PSFVSSTWEV KRPLRKLLPE VNSEAIDFLE KILTFNPMDR 300

LTAEMGLQHP YMSPYSCPED EPTSQHPFRI EDEIDDIVLM AANQSQLSNW DTCSSRYPVS 360

LSSDLEWRPD RCQDASEVQR DPRAGSAPLA EDVQVDPRKD SHSSSERFLE QSHSSMERAF 420

EADYGRSCDY KVGSPSYLDK LLWRDNKPHH YSEPKLILDL SHWKQAAGAP PTATGLADTG 480

AREDEPASLF LEIAQWVKST QGGPEHASPP ADDPERRLSA SPPGHPAPVD GGASPQFDLD 540

VFISRALKLC TKPEDLPDNK LGDLNGACIP EHPGDLVQTE AFSKERW 587

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AGGGTGACTG CATCGCCAGT GCCTACGGAT ATGACCTCGG TGGGCGCTTT 60

GTTGACTTCC AACCCCTGGG CTTCGGTGTC AATGGTTTGG TGCTGTCAGC CATGGACAGC 120

CGGGCCTGCC GAAAGGTCGC CGTGAAGAAG ATTGCCCTGA GCGACGCCCG CAGCATGAAG 180

CATGCGCTCC GAGAGATCAA GATCATTCGG CGCCTGGACC ATGACAACAT CGTCAAAGTG 240

TACGAGGTGC TCGGGCCCAA GGGCACTGAC CTGCAGGGTG AGCTGTTCAA GTTCAGCGTG 300

GCCTACATCG TCCAGGAGTA CATGGAGACC GACCTGGCAC GCCTGCTGGA GCAGGGCACG 360

CTGGCAGAAG AGCATGCCAA GCTGTTCATG TACCAGCTGC TCCGTGGGCT CAAGTACATC 420

CACTCCGCCA ACGTGCTGCA CAGGGACCTG AAGCCCGCCA ACATCTTCAT CAGCACAGAG 480

GACCTCGTGC TCAAGATTGG GGATTTCGGG TTGGCAAGGA TCGTTGATCA GCATTACTCC 540

CACAAGGGTT ATCTGTCAGA AGGGTTGGTA ACAAAGTGGT ACCGTTCCCC ACGACTGCTC 600

CTTTCCCCCA ATAACTACAC CAAAGCCATC GACATGTGGG CCGCCGGCTG CATCCTGGCT 660

GAGATGCTTA CGGGGAGAAT GCTCTTTGCT GGGGCCCATG AGCTGGAGCA GATGCAACTG 720

ATCCTGGAGA CCATCCCTGT AATCCGGGAG GAAGACAAGG ACGAGCTGCT CAGGGTGATG 780

CCTTCCTTTG TCAGCAGCAC CTGGGAGGTG AAGAGGCCTC TGCGCAAGCT GCTCCCCGAA 840

GTGAACAGTG AAGCCATCGA CTTTCTGGAG AAGATCCTGA CCTTTAACCC CATGGATCGC 900

CTAACAGCTG AGATGGGGCT GCAACACCCC TACATGAGCC CATACTCGTG CCCTGAGGAC 960

GAGCCCACCT CGCAACACCC CTTCCGCATT GAGGATGAGA TTGACGACAT CGTGCTGATG 1020

GCCGCTAACC AGAGCCAGCT GTCCAACTGG GACACGTGCA GTTCCAGGTA CCCTGTGAGC 1080

CTGTCGTCGG ACCTGGAGTG GCGGCCTGAC CGGTGCCAGG ACGCCAGCGA GGTGCAGCGC 1140

GACCCGCGCG CGGGTTCGGC GCCGCTGGCC GAGGACGTGC AGGTGGACCC GCGCAAGGAC 1200

TCGCACAGCA GCTCCGAGCG CTTCCTAGAG CAGTCGCATT CGTCCATGGA GCGTGCCTTC 1260

GAGGCCGACT ACGGGCGCTC CTGCGACTAC AAGGTGGGGT CGCCGTCCTA CCTGGACAAG 1320

CTGCTGTGGC GCGATAACAA GCCGCACCAC TACTCGGAGC CCAAGCTCAT CCTGGACCTG 1380

TCGCACTGGA AGCAGGCGGC CGGCGCGCCC CCTACGGCAA CGGGGCTGGC AGACACGGGG 1440

GCGCGCGAGG ACGAGCCGGC CAGCCTCTTC CTGGAGATCG CGCAGTGGGT CAAGAGCACG 1500

CAGGGCGGCC CCGAGCACGC CAGCCCGCCC GCCGACGACC CCGAGCGCCG CTTGTCTGCC 1560

TCGCCCCCCG GCCACCCGGC CCCGGTGGAC GGCGGCGCCA GCCCCCAGTT CGACCTGGAC 1620

GTGTTCATCT CCCGCGCCCT GAAGCTCTGC ACCAAGCCCG AGGACCTGCC GGACAATAAA 1680

CTGGGCGACC TCAATGGTGC GTGCATCCCC GAGCACCCTG GCGACCTCGT GCAGACCGAG 1740

GCCTTCTCCA AAGAAAGGTG GTGA 1764

Domain Profile

S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62

         + +plg G +g+v+sa+d+r+ ++va+kk++  ++++ s+k++lRE+k++++l+h+Ni+k

Q: 22    DFQPLGFGVNGLVLSAMDSRACRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDNIVK  79

         6799**************************9..9**************************

S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117

         +++v+ p+      el +++  Y+v+e+metdL++++++ +l +eh+kl++yq+lrglky

Q: 80    VYEVLGPKGtdlqgELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKY  139

         *******9888888899*******************************************

S: 118   lHsanviHrDlKPsNllvnedc.elkildFGlarsadkekekk..lteyvatrwYraPei  174

         +Hsanv+HrDlKP+N++++++   lki dFGlar+ d+++++k  l+e ++t+wYr+P++

Q: 140   IHSANVLHRDLKPANIFISTEDlVLKIGDFGLARIVDQHYSHKgyLSEGLVTKWYRSPRL  199

         ******************8765169**************999999***************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         lls ++ytka+D+W++GCIlaE+ltg++lf+g++e++q+++ile+++  +ee+ +++ +

Q: 200   LLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRV  259

         **********************************************************95

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          + ++++s+++ k+ ++++l+p+ ++ea+d+lek+L+++p++R+++e+ L+hpY+

Q: 260   -MPSFVSSTWEVKR-PLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM  312

         .9*******99988.9**************************************7

Domain Sequence
(FASTA)

DFQPLGFGVN GLVLSAMDSR ACRKVAVKKI ALSDARSMKH ALREIKIIRR LDHDNIVKVY 60

EVLGPKGTDL QGELFKFSVA YIVQEYMETD LARLLEQGTL AEEHAKLFMY QLLRGLKYIH 120

SANVLHRDLK PANIFISTED LVLKIGDFGL ARIVDQHYSH KGYLSEGLVT KWYRSPRLLL 180

SPNNYTKAID MWAAGCILAE MLTGRMLFAG AHELEQMQLI LETIPVIREE DKDELLRVMP 240

SFVSSTWEVK RPLRKLLPEV NSEAIDFLEK ILTFNPMDRL TAEMGLQHPY M 291

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013