EPS-POA-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-POA-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	210.1	5.0E-62	1163	1408	246

Status

Unreviewed

Ensembl Protein

ENSPPYP00000010337

UniProt Accession

H2NWH3;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1

Gene Synonyms/Alias

PHLPP1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000009209	ENSPPYP00000010337	ENSPPYT00000010748

Organism

Pongo abelii

Functional Description

Protein Length

1707

Protein Sequence
(FASTA)

MEPAAAATAQ RLPEPGREDL ASAPAAAAAA LAAAAGGGRS PEPALTPAAP SGGNGSGGGA 60

REEAPGEAPP GPLPGRAGGA GRRRRRGAPQ PIAGGAAPVP GAGGGANSLL LRRGRLKRNL 120

SAAASSSSSS SAAAASHSPG AAGLPASCSA SASLCTRSLD RKTLLLKHRQ TLQLQPSDRD 180

WVRHQLQRGC VHIFDRHMAS TYLRPVLCTL DTTAGEVAAR LLQLGHKGGG VVKVLGQGPG 240

AAAAREPAEP PPEAGPRLAP PEPQDSEVQP ARSAPGAVGG PPRAPPADLP LPAGGPGMWS 300

RRASPAPSDS SPGEPFVGGP ASSPRAPRPV ASDTESFSLS PSAESVSDRL DPYSSGGGGS 360

SSSSEELEAD AVSAPTGVPG QPRRPGHPAQ PLPPPQTASS PRPQQKAPRA IDSPGGAVRE 420

GSCEEKAAAA VAPGGLQSTP GRSGVTAEKA PPPPPPPTLY VQLHGETTRR LEAEEKPLQI 480

QNDYLFQLGF GELWRVQEEG MDSEIGCLIR FYAGKPHSTG SSERIQLSGM YNVRKGKMQL 540

PVNRWTRRQV ILCGTCLIVS SVKDSLTGKM HVLPLIGGKV EEVKKHQHCL AFSSSGPQSQ 600

TYYICFDTFT EYLRWLRQVS KVASQRISSV DLSCCSLEHL PANLFYSQDL THLNLKQNFL 660

RQNPSLPAVR GLNELQRFTK LKSLNLSNNH LGDFPLAVCS IPTLAELNVS CNALRSVPSA 720

VGVMHNLQTF LLDGNFLQSL PAELENMKQL SYLGLSFNEF TDIPEVLEKL TAVDKLCMSG 780

NCMETLRLQA LRKMPHIKHV DLRLNVIRKL IADEVDFLQH VTQLDLRDNK LGDLDAMIFN 840

NIEVLHCERN QLVTLDICGY FLKALYASSN ELVQLDVYPV PNYLSYMDVS RNRLENVPEW 900

VCESRKLEVL DIGYNQICEL PARLFCNSSL RKLLAGHNQL ARLPERLERT SVEVLDVQHN 960

QLLELPPNLL MKADSLRFLN ASANKLESLP PATLSEETNS ILQELYLTNN SLTDKCVPLL 1020

TGHPHLKILH MAYNRLQSFP ASKMAKLEEL EEIDLSGNKL KAIPTTIMNC RRMHTVIAHS 1080

NCIEVFPEVM QLPEIKCVDL SCNELSEVTL PENLPPKLQE LDLTGNPRLV LDHKTLELLN 1140

NIRCFKIDQP STGDASGAPA VWSHGYTEAS GVKNKLCVAA LSVNNFCDNR EALYGVFDGD 1200

RNVEVPYLLQ CTMSDILAEE LQKTKNEEEY MVNTFIVMQR KLGTAGQKLG GAAVLCHIKH 1260

DPVDPGGSFT LTSANVGKCQ TVLCRNGKPL PLSRSYIMSC EEELKRIKQH KAIITEDGKV 1320

NGVTESTRIL GYTFLHPSVV PRPHVQSVLL TPQDEFFILG SKGLWDSLSV EEAVEAVRNV 1380

PDALAAAKKL CTLAQSYGCH DSISAVVVQL SVTEDSFCCC ELSAGGAAPP PSPGLFPPSV 1440

SMVIKDRPSD GLGVPSSSSG MASEISSELS ASEMSSEVGS TASDEPPPGA LSENSPAYPS 1500

EQRCMLHPVC LSNSFQRQLS SATFSSAFSD NGLDSDDEEP IEGVFTNGSR VEVEVDIHCS 1560

RAKEKEKQQH LLQVPAEASD EGIVISANED EPGLPRKADF SAVGTIGRRR ANGSVAPQER 1620

SHNVIEVATD APLRKPGGYF AAPAQPDPDD QFIIPPELEE EVKEIMKHHQ EQQQQQQQQL 1680

PPPPQLQPQL PRHYQLDQLP DYYDTPL 1707

Nucleotide Sequence
(FASTA)

ATGGAGCCCG CCGCCGCGGC CACGGCACAG CGACTCCCCG AGCCCGGCAG GGAGGACCTA 60

GCTTCGGCTC CGGCGGCCGC CGCTGCGGCT CTGGCGGCGG CGGCCGGGGG CGGCCGGAGT 120

CCGGAGCCCG CGCTGACCCC GGCGGCCCCG AGCGGCGGGA ACGGCAGCGG CGGCGGGGCG 180

CGTGAAGAGG CCCCGGGCGA GGCGCCGCCG GGGCCGTTGC CGGGCAGAGC AGGGGGTGCC 240

GGGCGCAGGA GGCGGCGCGG GGCGCCCCAG CCCATTGCCG GCGGGGCTGC CCCCGTACCC 300

GGAGCCGGCG GCGGCGCCAA CTCCCTCCTG CTGAGGAGAG GGCGGCTGAA GAGGAATCTG 360

TCCGCGGCCG CCTCGTCGTC GTCGTCGTCC TCGGCCGCTG CTGCCTCGCA CTCCCCCGGC 420

GCTGCTGGCC TCCCCGCCTC CTGCTCGGCC TCGGCGTCGC TGTGCACCCG GAGCCTGGAC 480

AGGAAGACGC TGCTCCTGAA GCACCGGCAG ACGCTGCAGC TGCAGCCGTC GGACCGGGAC 540

TGGGTGAGGC ACCAGCTCCA GCGCGGCTGC GTGCATATCT TCGACCGCCA CATGGCCTCG 600

ACCTACCTGC GCCCGGTGCT CTGCACACTG GACACCACGG CCGGCGAGGT GGCCGCCCGC 660

CTGCTGCAGC TGGGACACAA AGGCGGCGGC GTGGTGAAGG TGCTGGGCCA GGGGCCCGGA 720

GCCGCCGCCG CCCGGGAGCC CGCTGAGCCG CCCCCCGAGG CCGGCCCCCG GCTGGCGCCC 780

CCGGAGCCGC AGGACTCGGA GGTACAGCCC GCGAGGAGCG CGCCGGGTGC CGTCGGGGGT 840

CCTCCGCGCG CGCCCCCCGC CGACCTACCC CTGCCCGCCG GCGGCCCGGG CATGTGGTCG 900

CGCCGCGCCA GCCCAGCGCC CTCGGACTCC AGCCCGGGCG AGCCGTTCGT TGGGGGCCCT 960

GCCTCTTCGC CCCGCGCCCC GCGGCCTGTG GCCTCCGACA CCGAGAGCTT CAGCCTGAGT 1020

CCCAGCGCCG AGAGCGTGTC TGACCGGCTG GACCCCTACA GCAGCGGCGG CGGCGGCTCC 1080

TCGTCGTCGT CGGAAGAGCT CGAGGCCGAC GCAGTCTCGG CCCCGACGGG GGTCCCGGGC 1140

CAGCCCCGCC GTCCCGGCCA CCCCGCGCAG CCCCTCCCGC CTCCCCAGAC GGCTTCCTCC 1200

CCTCGGCCGC AGCAGAAAGC CCCGAGGGCC ATTGACAGTC CGGGCGGGGC CGTCCGCGAG 1260

GGGTCGTGCG AGGAGAAGGC GGCGGCCGCC GTGGCCCCGG GAGGCCTCCA GTCGACCCCC 1320

GGGAGGAGCG GGGTGACCGC GGAGAAAGCG CCTCCGCCGC CCCCGCCGCC CACCCTGTAC 1380

GTGCAGCTCC ACGGAGAGAC CACCCGGCGC TTGGAGGCGG AGGAGAAGCC ATTGCAGATC 1440

CAAAATGACT ACCTCTTCCA ACTGGGATTT GGGGAGCTGT GGAGGGTGCA GGAGGAAGGC 1500

ATGGACTCGG AGATTGGCTG CCTCATCCGC TTCTATGCAG GAAAACCTCA CAGCACGGGT 1560

AGCTCTGAAC GGATTCAGCT CTCAGGAATG TATAATGTCC GTAAAGGCAA GATGCAGTTG 1620

CCAGTGAACC GATGGACAAG ACGCCAAGTC ATCCTATGTG GGACCTGCCT GATAGTATCA 1680

TCTGTGAAAG ACAGCTTGAC CGGAAAGATG CATGTTCTGC CACTAATTGG TGGAAAAGTA 1740

GAAGAAGTGA AAAAGCACCA ACACTGTTTA GCATTTAGCT CCTCTGGACC CCAAAGCCAG 1800

ACTTACTACA TTTGCTTTGA TACTTTCACA GAATACTTAA GGTGGCTGCG TCAAGTCTCC 1860

AAGGTTGCAT CCCAGCGCAT TAGCTCAGTG GACCTCTCAT GTTGTAGCCT GGAACATCTG 1920

CCTGCCAACC TCTTCTACAG CCAAGACCTC ACTCATCTGA ATTTAAAACA AAACTTCCTA 1980

AGGCAAAACC CTAGCCTTCC AGCTGTCAGG GGGCTTAATG AACTGCAAAG GTTCACCAAG 2040

TTGAAGAGTC TTAACCTTTC CAATAATCAT TTAGGGGACT TCCCACTGGC AGTCTGCAGT 2100

ATTCCAACCC TGGCAGAGCT GAACGTGTCC TGCAATGCCC TGCGATCAGT CCCGTCAGCC 2160

GTTGGAGTGA TGCACAACTT ACAGACATTT TTGTTGGATG GAAACTTTCT CCAATCCCTT 2220

CCTGCTGAGT TGGAGAACAT GAAGCAGCTT AGTTATCTGG GTCTTTCTTT CAATGAATTT 2280

ACTGACATTC CCGAAGTATT GGAGAAATTG ACTGCTGTGG ATAAACTTTG TATGTCCGGA 2340

AACTGTATGG AGACCCTTAG GCTACAGGCT TTAAGAAAAA TGCCTCACAT TAAACATGTG 2400

GATCTAAGGT TGAACGTAAT TAGGAAGCTG ATAGCAGATG AAGTGGACTT TCTACAGCAT 2460

GTTACTCAGC TTGACCTACG AGACAATAAG CTTGGTGATC TAGATGCCAT GATTTTCAAC 2520

AACATTGAAG TTTTACACTG TGAAAGGAAT CAACTGGTCA CATTAGACAT CTGTGGCTAT 2580

TTCCTAAAAG CACTCTATGC CTCTTCTAAT GAACTTGTTC AACTTGATGT TTACCCAGTT 2640

CCAAATTATC TGTCCTACAT GGATGTTTCA AGGAACCGTT TAGAAAATGT GCCTGAGTGG 2700

GTATGTGAAA GCCGAAAGCT AGAAGTTTTG GATATTGGCT ATAATCAAAT ATGTGAACTT 2760

CCTGCCCGCT TATTTTGTAA TAGCAGTCTC CGGAAACTAC TGGCAGGACA CAACCAGTTG 2820

GCAAGGCTGC CTGAAAGGCT AGAAAGAACC TCAGTGGAGG TCTTGGATGT GCAACACAAC 2880

CAGCTCCTTG AGCTCCCGCC TAACCTTCTG ATGAAGGCTG ACAGCCTGAG ATTCCTGAAT 2940

GCATCTGCGA ACAAATTGGA AAGCCTTCCT CCAGCCACGC TTTCCGAAGA GACAAACAGT 3000

ATCTTACAAG AGTTGTATTT GACAAATAAC AGCCTCACAG ACAAATGTGT GCCCTTGTTA 3060

ACGGGACACC CCCATTTGAA GATCCTTCAC ATGGCCTATA ACCGACTTCA GAGTTTTCCA 3120

GCAAGTAAAA TGGCGAAACT GGAGGAACTT GAAGAAATTG ATCTCAGTGG GAATAAGCTG 3180

AAAGCCATCC CTACAACGAT CATGAATTGC AGGCGCATGC ACACCGTGAT TGCTCACTCC 3240

AACTGCATCG AGGTCTTTCC CGAAGTTATG CAGCTCCCAG AGATCAAGTG TGTGGACCTG 3300

AGCTGTAATG AGCTAAGCGA AGTCACATTA CCAGAAAACC TGCCTCCCAA ACTGCAGGAG 3360

CTAGACCTGA CTGGAAACCC TCGCCTTGTC CTTGATCACA AAACCCTGGA ACTACTGAAT 3420

AATATCCGCT GTTTCAAGAT TGATCAGCCT TCTACAGGAG ACGCTTCCGG AGCCCCAGCT 3480

GTATGGAGTC ATGGTTACAC TGAAGCTTCG GGGGTAAAAA ACAAGTTGTG TGTCGCAGCC 3540

CTGTCAGTGA ATAACTTCTG TGACAACCGC GAAGCCCTGT ATGGTGTGTT TGATGGAGAC 3600

CGGAATGTGG AGGTGCCCTA CCTTCTCCAG TGCACTATGA GTGACATTTT GGCTGAAGAG 3660

CTGCAAAAAA CAAAAAATGA AGAAGAATAC ATGGTCAATA CGTTCATTGT CATGCAAAGG 3720

AAACTTGGAA CTGCTGGGCA GAAGCTTGGC GGTGCCGCTG TCCTTTGTCA TATCAAGCAT 3780

GACCCTGTGG ACCCAGGAGG ATCCTTCACC TTGACCTCTG CTAATGTGGG CAAGTGCCAA 3840

ACAGTTCTCT GTCGAAATGG AAAACCGCTG CCTCTGTCCA GATCTTACAT CATGAGCTGT 3900

GAAGAAGAGC TGAAGAGGAT TAAACAGCAC AAGGCCATTA TCACTGAGGA TGGCAAGGTG 3960

AACGGAGTGA CTGAGTCCAC GCGTATCCTG GGCTACACCT TCCTCCATCC CAGTGTGGTG 4020

CCTCGTCCCC ACGTGCAGTC CGTGCTCCTG ACCCCCCAGG ATGAGTTCTT CATCCTAGGC 4080

AGTAAGGGGT TGTGGGACAG CCTGTCCGTC GAGGAGGCCG TGGAGGCCGT GCGCAACGTG 4140

CCCGACGCCC TGGCTGCTGC CAAGAAGCTG TGTACCCTGG CCCAGAGCTA CGGCTGCCAC 4200

GACAGCATCA GCGCTGTGGT GGTGCAGCTC AGTGTCACTG AGGACAGCTT CTGCTGCTGC 4260

GAGCTCAGCG CCGGTGGGGC TGCGCCACCA CCCAGTCCTG GCCTCTTCCC TCCCTCAGTG 4320

AGCATGGTGA TCAAGGATCG GCCCTCAGAT GGGCTGGGCG TGCCGTCCTC CAGCAGCGGC 4380

ATGGCTTCCG AGATTAGCAG CGAGCTCTCC GCTTCTGAGA TGAGCAGTGA GGTGGGGTCA 4440

ACGGCCTCCG ATGAGCCCCC GCCCGGAGCC CTAAGCGAGA ACAGCCCTGC CTACCCCAGT 4500

GAGCAGCGCT GCATGCTCCA CCCCGTCTGT CTGTCCAACT CCTTCCAGCG CCAGCTATCT 4560

AGCGCCACAT TCTCTAGCGC CTTCTCCGAC AATGGCCTTG ACAGTGACGA TGAGGAGCCC 4620

ATCGAGGGCG TCTTCACCAA TGGCAGCCGG GTGGAGGTGG AGGTGGACAT CCACTGCAGC 4680

CGGGCCAAGG AGAAGGAGAA ACAGCAGCAC CTGCTTCAGG TGCCAGCAGA GGCCAGCGAT 4740

GAGGGCATTG TCATCAGCGC CAACGAGGAT GAGCCAGGTC TGCCCAGGAA GGCAGACTTC 4800

TCTGCCGTTG GGACCATTGG GCGCCGGAGG GCCAATGGCT CTGTTGCGCC CCAGGAAAGG 4860

AGCCACAATG TGATAGAGGT GGCTACAGAT GCACCTCTTC GAAAGCCTGG AGGCTATTTT 4920

GCTGCCCCGG CTCAGCCGGA TCCCGATGAT CAGTTTATCA TACCCCCGGA GCTGGAAGAG 4980

GAGGTCAAAG AAATCATGAA GCATCACCAG GAGCAACAGC AGCAGCAGCA GCAGCAGCTG 5040

CCACCACCCC CTCAGCTCCA GCCGCAGCTG CCGCGGCACT ACCAGCTGGA CCAGCTGCCA 5100

GATTATTACG ACACACCACT ATGA 5124

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s++nf++++e+     ++gv+DG+++ ev + +++++++il

Q: 1163  SHGYTEASGVKNKLCVAALSVNNFCDNREA-----LYGVFDGDRNVEVPYLLQCTMSDIL  1217

         689***********************9885.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aeel+    ++++ ++++ ++F+ ++++l       ++ +k G +av+++ik++

Q: 1218  AEELQ----KTKNEEEYMVNTFIVMQRKL------GTAGQKLGGAAVLCHIKHDpvdpgg  1267

         ***99....999*****************......99***********************

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +l+ anvG++++vLcrngk+++ls+ + +s+e+El+Ri+++++ ++++   +v+Gv++

Q: 1268  sfTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIKQHKAIITEDG--KVNGVTE  1325

         *99*****************************************9999998..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R lG ++l+p v+p+P+v+s+ lt++def+iL+s+Glwd +s eeav++vr+v +

Q: 1326  STRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPD---  1382

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

          + +aakkL++la+++g++d++sa+vv

Q: 1383  -ALAAAKKLCTLAQSYGCHDSISAVVV  1408

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VNNFCDNREA LYGVFDGDRN VEVPYLLQCT MSDILAEELQ 60

KTKNEEEYMV NTFIVMQRKL GTAGQKLGGA AVLCHIKHDP VDPGGSFTLT SANVGKCQTV 120

LCRNGKPLPL SRSYIMSCEE ELKRIKQHKA IITEDGKVNG VTESTRILGY TFLHPSVVPR 180

PHVQSVLLTP QDEFFILGSK GLWDSLSVEE AVEAVRNVPD ALAAAKKLCT LAQSYGCHDS 240

ISAVVV 246

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>