EKS-POA-00030
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00030
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak313.91.0E-93520776257
StatusUnreviewed
Ensembl ProteinENSPPYP00000010896
UniProt AccessionH2NY19;
Protein Name
Protein Synonyms/Alias
Gene NameJAK3
Gene Synonyms/Alias JAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000009724ENSPPYP00000010896ENSPPYT00000011320
OrganismPongo abelii
Functional Description
Protein Length1013
Protein Sequence
(FASTA)
MAPPSEETPL IPQRSCSLLS TEAGALHVLL PARGPGPPQH LSFSFGDHLA EDLCVQAKAS 60
GILPVYHSLF ALATEDLSCW FPPSHIFSVE DASTQVLLYR IRFYFPNWFG LEKCHRFGLR 120
KDLASAILDL PVLEHLFAQH RSDLVSGRLP VGLSLKEQGE CLSLAVLDLA RMAREQSQRP 180
GELLKTISYK ACLPPSLRDL IQGLSFVTRR RIRRTVRRAL RRVAACQADR HSLMAKYIMD 240
LERLDPAGAA ETFHVGLPGA LGGQDGLGLL RVAGDSGISW TQGEQEVLQP FCDFPEIVDI 300
SIKQAPRVGP AGEHRLVTLT RTDNQILEAE FPGLPEALSF VALVDGYFRL TTDSQHFFCK 360
EVAPPRLLEE VAEQCHGPIT LDFAINKLKT GGSHPGSYVL RRSPQDFDSF LLTVCVQTPL 420
GPDYKGCLIR RSPTGTFLLV GLSRPHSSLR ELLATCWDGG LHVDGVAVTL TSCCIPRPKE 480
KSNLIVVQRG HSPPTSSLVQ PQSQYQLSQM TFHKIPADSL EWHENLGHGS FTKIYRGCRH 540
EVVDGEARKT EVLLKVMDAK HKNCMESFLE AASLMSQVSY RHLVLLHGVC MAGDSTMVQE 600
FVHLGAIDMY LRKRGHLVPA SWKLQVVKQL AYALNYLEDK GLPHGNVSAR KVLLAREGAD 660
GSPPFIKLSD PGVSPAVLSL EMLTDRIPWV APECLREAQT LSLEADKWGF GATVWEVFSG 720
VTMPISALDP AKKLQFYEDQ QQLPAPKWTE LALLIQQCMA YEPVQRPSFR AVIRDLNSLI 780
SSGRQSLRLV MEYLPSGCLR DFLQRHRARL DASRLLLYSS QICKGMEYLG SRRCVHRDLA 840
ARNILVESEA HVKIADFGLA KLLPLDKDYY VVREPGQSPI FWYAPESLSD NIFSRQSDVW 900
SFGVVLYELF TYCDKSCSPS AEFLRMMGCE RDVPALCRLL ELLEEGQRLP APPACPAEVH 960
ELMKLCWAPS PQDRPSFSTL GPQLDMLWSG SRGCETHAFT AHPEGKPHSL SFL 1013
Nucleotide Sequence
(FASTA)
ATGGCACCTC CAAGTGAAGA GACGCCCCTG ATCCCTCAGC GTTCATGCAG CCTCTTGTCC 60
ACGGAGGCTG GTGCCCTGCA TGTGCTGCTG CCCGCTCGGG GCCCCGGGCC CCCCCAGCAC 120
CTATCTTTCT CCTTTGGGGA CCACTTGGCT GAGGACCTGT GCGTGCAGGC CAAGGCCAGC 180
GGCATCCTGC CTGTGTACCA CTCCCTCTTT GCTCTGGCCA CGGAGGACCT GTCCTGCTGG 240
TTCCCCCCGA GCCACATCTT TTCAGTGGAG GATGCCAGCA CCCAAGTCCT GCTCTACAGG 300
ATTCGCTTTT ACTTCCCCAA TTGGTTTGGG CTGGAGAAGT GCCACCGCTT TGGGCTACGC 360
AAGGATTTGG CCAGCGCTAT CCTTGACCTG CCAGTCCTGG AGCACCTCTT TGCCCAGCAC 420
CGCAGTGACC TGGTGAGTGG GCGCCTCCCC GTGGGCCTCA GTCTCAAGGA GCAGGGTGAG 480
TGTCTCAGCC TGGCCGTGTT GGACCTGGCC CGGATGGCGC GAGAGCAGTC CCAGCGGCCG 540
GGAGAGCTGC TGAAGACTAT CAGCTACAAG GCCTGCCTAC CCCCAAGCCT GCGCGACCTG 600
ATCCAGGGCC TGAGCTTCGT GACGCGGAGG CGTATTCGGA GGACGGTGCG CAGGGCCCTG 660
CGCCGCGTGG CCGCCTGCCA GGCAGACCGG CACTCGCTCA TGGCCAAGTA CATCATGGAC 720
CTGGAGCGGC TGGATCCAGC CGGGGCCGCC GAGACCTTCC ACGTGGGCCT CCCTGGGGCC 780
CTTGGTGGCC AGGACGGGCT GGGGCTGCTC CGCGTGGCTG GTGACAGCGG CATCTCCTGG 840
ACCCAGGGAG AACAGGAGGT CCTCCAGCCC TTCTGCGACT TTCCAGAAAT CGTAGACATT 900
AGCATCAAGC AGGCCCCGCG CGTTGGCCCG GCCGGGGAGC ACCGCCTGGT CACTCTTACC 960
AGGACAGACA ACCAGATTTT GGAGGCCGAG TTCCCAGGGC TGCCCGAGGC TCTGTCGTTC 1020
GTGGCGCTCG TGGACGGCTA CTTCCGGCTG ACCACGGACT CCCAGCACTT CTTCTGCAAG 1080
GAGGTGGCAC CGCCGAGGCT GCTGGAGGAA GTGGCCGAGC AGTGCCACGG CCCCATCACT 1140
CTGGACTTTG CCATCAACAA GCTTAAGACT GGGGGCTCAC ATCCTGGCTC CTATGTTCTC 1200
CGCCGCAGCC CCCAGGACTT TGACAGCTTC CTCCTCACTG TCTGTGTCCA GACCCCCCTT 1260
GGTCCTGATT ATAAGGGCTG CCTCATCCGG CGCAGCCCCA CAGGAACCTT CCTTCTGGTT 1320
GGCCTCAGCC GACCCCACAG CAGTCTTCGA GAGCTCCTGG CAACGTGCTG GGATGGGGGG 1380
CTGCACGTAG ATGGGGTGGC AGTGACCCTC ACCTCCTGCT GTATCCCCAG ACCCAAAGAA 1440
AAGTCCAACC TGATCGTGGT CCAGAGAGGT CACAGCCCAC CCACATCATC CTTGGTTCAG 1500
CCCCAATCCC AATACCAGCT GAGTCAGATG ACATTTCACA AGATCCCTGC TGACAGCCTG 1560
GAGTGGCATG AGAACCTGGG CCATGGGTCC TTCACCAAGA TTTACCGGGG CTGTCGCCAT 1620
GAGGTGGTGG ATGGAGAGGC CCGAAAGACA GAGGTGCTGC TGAAGGTGAT GGATGCTAAG 1680
CACAAGAACT GCATGGAGTC ATTCCTGGAA GCAGCGAGCT TGATGAGCCA AGTGTCGTAC 1740
CGGCATCTCG TGCTGCTCCA CGGCGTGTGC ATGGCTGGAG ACAGCACCAT GGTGCAGGAA 1800
TTTGTACACC TGGGGGCGAT AGACATGTAT CTTCGAAAAC GTGGCCACCT GGTGCCAGCC 1860
AGCTGGAAGC TGCAGGTGGT CAAACAGCTG GCCTACGCCC TCAACTATCT GGAGGACAAA 1920
GGCCTCCCCC ATGGCAATGT CTCTGCCCGG AAGGTGCTCC TGGCTCGGGA GGGGGCTGAT 1980
GGGAGCCCGC CCTTCATCAA GCTGAGTGAC CCTGGGGTCA GCCCCGCTGT GTTAAGCCTG 2040
GAGATGCTCA CTGACAGGAT CCCCTGGGTG GCCCCCGAGT GTCTCCGGGA GGCCCAGACA 2100
CTTAGCTTGG AAGCTGACAA GTGGGGCTTC GGCGCCACGG TCTGGGAAGT GTTTAGTGGC 2160
GTCACCATGC CCATCAGCGC CCTGGATCCT GCTAAGAAAC TCCAATTTTA TGAGGACCAG 2220
CAGCAGCTGC CGGCCCCCAA GTGGACAGAG CTGGCCCTGC TGATTCAACA GTGCATGGCC 2280
TATGAGCCAG TCCAGAGGCC CTCCTTCCGA GCCGTCATTC GTGACCTAAA TAGCCTCATC 2340
TCTTCAGGCC GCCAGAGCCT GCGGCTGGTC ATGGAGTACC TGCCCAGCGG CTGCTTGCGC 2400
GACTTCCTGC AGCGGCACCG TGCGCGCCTC GATGCCAGCC GCCTCCTTCT CTATTCCTCA 2460
CAGATCTGCA AGGGCATGGA GTACCTAGGC TCCCGCCGCT GCGTGCACCG CGACCTGGCC 2520
GCCCGAAACA TCCTCGTGGA GAGCGAGGCA CACGTCAAGA TCGCTGACTT CGGCCTAGCT 2580
AAGCTGCTGC CGCTTGACAA AGACTACTAC GTCGTCCGCG AGCCGGGCCA GAGCCCCATT 2640
TTCTGGTATG CCCCCGAATC CCTCTCGGAC AATATCTTCT CTCGCCAGTC AGACGTCTGG 2700
AGCTTTGGGG TCGTCCTGTA CGAGCTCTTC ACCTACTGCG ACAAAAGCTG CAGTCCCTCG 2760
GCCGAGTTCC TGCGGATGAT GGGATGTGAG CGGGATGTCC CCGCCCTCTG CCGCCTCCTG 2820
GAACTGCTGG AGGAGGGCCA GAGGCTGCCG GCGCCTCCTG CCTGCCCTGC AGAGGTTCAC 2880
GAGCTCATGA AGCTGTGCTG GGCCCCTAGC CCACAGGACC GGCCATCATT CAGCACCCTG 2940
GGCCCCCAGC TGGACATGCT GTGGAGCGGA AGCCGGGGGT GTGAGACTCA TGCCTTCACT 3000
GCTCACCCAG AGGGCAAACC CCACTCCCTG TCCTTTTTAT AG 3042
Domain Profile
S: 1     lkqiesLgkgtftkvfevred..aegdsteeevalkvLkesgedisrdfkreaeilsqls  58
         l+++e+Lg+g+ftk+++++++   +g+++++ev+lkv++ ++++++++f ++a+++sq+s
Q: 520   LEWHENLGHGSFTKIYRGCRHevVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVS  579
         689*****************8899************************************
S: 59    hehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118
         ++h+v l+gvc+a++++ +V+e+v+ G++d+yLrk+ + +++s++l+v+kqla+a++YLe
Q: 580   YRHLVLLHGVCMAGDST-MVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLE  638
         ****************8.******************************************
S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqdeYylvreerdsripwlap  178
         dk l h++v+ar+vL++re+ +g+ppf+klsdpg++ av      l+ e+ ++ripw+ap
Q: 639   DKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAV------LSLEMLTDRIPWVAP  692
         ***************************************......***************
S: 179   eclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlpkpkcpa  238
         ecl+ea++ls+++d+W+Fg+t++e+  +s  ++p+++ ++++kl+++e++++lp+pk++ 
Q: 693   ECLREAQTLSLEADKWGFGATVWEV--FSGVTMPISALDPAKKLQFYEDQQQLPAPKWT-  749
         *************************..9*******************************.
S: 239   elaelmtnclsyepsqrpsFrailedl  265
         ela l+++c++yep+qrpsFra+++dl
Q: 750   ELALLIQQCMAYEPVQRPSFRAVIRDL  776
         *************************98
Domain Sequence
(FASTA)
LEWHENLGHG SFTKIYRGCR HEVVDGEARK TEVLLKVMDA KHKNCMESFL EAASLMSQVS 60
YRHLVLLHGV CMAGDSTMVQ EFVHLGAIDM YLRKRGHLVP ASWKLQVVKQ LAYALNYLED 120
KGLPHGNVSA RKVLLAREGA DGSPPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLREAQ 180
TLSLEADKWG FGATVWEVFS GVTMPISALD PAKKLQFYED QQQLPAPKWT ELALLIQQCM 240
AYEPVQRPSF RAVIRDL 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>
EKS-AIM-00027
EKS-BOT-00033
EKS-CAF-00032
EKS-CAP-00034
EKS-EQC-00030
EKS-FEC-00029
EKS-GOG-00029
EKS-HOS-00030
EKS-ICT-00030
EKS-LOA-00032
EKS-MAM-00030
EKS-MEG-00028
EKS-MOD-00032
EKS-MUM-00033
EKS-MUP-00033
EKS-MYL-00033
EKS-NOL-00031
EKS-OTG-00032
EKS-PAT-00027
EKS-PTV-00031
EKS-RAN-00034
EKS-SUS-00027
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030183; P:B cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0035771; P:interleukin-4-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0002731; P:negative regulation of dendritic cell cytokine production
GO:0045221; P:negative regulation of FasL biosynthetic process
GO:0032693; P:negative regulation of interleukin-10 production
GO:0032695; P:negative regulation of interleukin-12 production
GO:0045626; P:negative regulation of T-helper 1 cell differentiation
GO:0070244; P:negative regulation of thymocyte apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0043029; P:T cell homeostasis
KEGG
InterPros
IPR019749; Band_41_domain.
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775; Tyr_kinase_non-rcpt_Jak3.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00295; B41; 1.
SM00252; SH2; 1.
Prosites
PS50057; FERM_3; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR01826; JANUSKINASE3.
PR00109; TYRKINASE.
Created Date20-Feb-2013