EKS-POA-00315

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-POA-00315

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	324.3	5.8E-97	379	626	248

Status

Unreviewed

Ensembl Protein

ENSPPYP00000011145

UniProt Accession

H2NYR3;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK4

Gene Synonyms/Alias

PAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPPYG00000009955	ENSPPYP00000011145	ENSPPYT00000011580

Organism

Pongo abelii

Functional Description

Protein Length

645

Protein Sequence
(FASTA)

MGWVSFCPPS PQPRRAGLFH QCREQEKNKG GLSRVQPSPE GSSLAMAITP LAPAAASPGR 60

EGAAPPMPLS LHGISSLRLC LVSVCVVLSC PCVSDARPVC PTPCWAPTHH CLGPQTIVRG 120

SKGAKDGALT LLLDEFENMS VTRSNSLRRD SPPPPARARQ ENGMPEELAT TARGGPGKAG 180

SRGRFAGHSE AGGGSGDRRR AGPEKRPKSS REGSGGPQES SRDKRPLSGP DVGTPQPAGL 240

ASGAKLAAGR PFNTYPRADT DHPSRGAQGE PHDVAPNGPS AGGLAVPQSS SSSSSRPPTR 300

ARGAPSPGVL GPHASEPQLA PPARTPATPA APVAPAVPGP PGPCSPQREP QRVSHEQFRA 360

ALQLVVDPGD PRSYLDNFIK IGEGSTGIVC IATVRSSGKL VAVKKMDLRK QQRRELLFNE 420

VVIMRDYQHE NVVEMYNSYL VGDELWVVME FLEGGALTDI VTHTRMNEEQ IAAVCLAVLQ 480

ALSVLHAQGV IHRDIKSDSI LLTHDGRVKL SDFGFCAQVS KEVPRRKSLV GTPYWMAPEL 540

ISRLPYGPEV DIWSLGIMVI EMVDGEPPYF NEPPLKAMKM IRDNLPPRLK NLHKVSPSLK 600

GFLDRLLVRD PAQRATAAEL LKHPFLAKAG PPASIVPLMR QNRTR 645

Nucleotide Sequence
(FASTA)

ATGGGGTGGG TCAGCTTCTG CCCTCCCTCC CCCCAACCCC GCAGGGCAGG ACTATTCCAC 60

CAGTGTAGGG AACAGGAGAA AAACAAGGGG GGCCTCTCCA GGGTCCAACC GAGCCCAGAG 120

GGCAGCAGCC TGGCCATGGC GATCACTCCT CTGGCCCCTG CAGCTGCGTC CCCAGGGAGG 180

GAAGGGGCCG CACCGCCCAT GCCATTGTCA CTCCATGGCA TCTCTTCATT GCGTCTCTGT 240

CTTGTCTCTG TGTGTGTCGT GCTGTCTTGT CCCTGCGTGT CGGATGCACG TCCTGTGTGC 300

CCCACTCCTT GCTGGGCCCC CACCCACCAT TGCCTGGGAC CCCAGACCAT CGTGCGGGGC 360

AGCAAAGGTG CCAAGGATGG GGCCCTCACG CTGCTACTGG ACGAGTTTGA GAACATGTCG 420

GTGACACGCT CCAACTCCCT GCGGAGAGAC AGCCCGCCGC CGCCCGCCCG TGCCCGGCAG 480

GAAAATGGGA TGCCAGAGGA GCTGGCCACC ACGGCCAGAG GGGGCCCGGG GAAGGCAGGC 540

AGCCGAGGCC GGTTCGCCGG TCACAGCGAG GCGGGTGGCG GCAGTGGTGA CAGGCGACGG 600

GCGGGGCCAG AGAAGAGGCC CAAGTCTTCC AGGGAGGGCT CAGGGGGGCC CCAGGAGTCC 660

TCCCGGGACA AACGCCCCCT CTCCGGGCCT GACGTCGGCA CCCCCCAGCC TGCTGGTCTG 720

GCCAGTGGGG CGAAACTGGC AGCTGGCCGG CCCTTTAACA CCTACCCGAG GGCTGACACG 780

GACCACCCAT CCCGGGGTGC CCAGGGGGAG CCTCATGACG TGGCCCCTAA CGGGCCATCA 840

GCAGGGGGCC TGGCCGTCCC CCAGTCCTCC TCCTCCTCCT CCTCCCGGCC TCCCACCCGA 900

GCCCGAGGTG CCCCCAGCCC TGGAGTACTG GGCCCCCACG CCTCGGAGCC CCAGCTGGCC 960

CCTCCAGCCC GCACCCCTGC CACCCCTGCC GCCCCTGTCG CCCCTGCTGT TCCTGGGCCC 1020

CCTGGCCCCT GCTCACCACA GCGGGAGCCA CAGCGAGTAT CCCATGAGCA GTTCCGGGCT 1080

GCCCTGCAGC TGGTGGTGGA CCCAGGCGAC CCCCGTTCCT ACCTGGACAA CTTCATCAAG 1140

ATCGGCGAGG GCTCCACGGG CATCGTGTGC ATCGCCACCG TGCGCAGCTC GGGCAAGCTG 1200

GTGGCCGTCA AGAAGATGGA CCTGCGCAAG CAGCAGAGGC GCGAGTTGCT CTTCAACGAG 1260

GTGGTGATCA TGAGGGACTA CCAGCACGAG AATGTGGTGG AGATGTACAA CAGCTACCTG 1320

GTGGGGGACG AGCTCTGGGT GGTCATGGAG TTCCTGGAAG GAGGCGCCCT CACCGACATC 1380

GTCACCCACA CCAGGATGAA CGAGGAGCAG ATCGCGGCCG TGTGCCTGGC AGTGCTGCAG 1440

GCCCTGTCGG TGCTCCACGC CCAGGGCGTC ATCCACCGGG ACATCAAGAG TGACTCAATC 1500

CTGCTGACCC ATGACGGCAG GGTGAAGCTG TCAGACTTCG GGTTCTGTGC CCAGGTGAGC 1560

AAGGAAGTGC CCCGAAGGAA GTCGCTGGTC GGCACGCCCT ACTGGATGGC CCCAGAGCTC 1620

ATCTCCCGCC TTCCCTACGG GCCAGAGGTG GACATCTGGT CGCTGGGGAT AATGGTGATT 1680

GAGATGGTAG ACGGAGAGCC CCCCTACTTC AACGAGCCAC CCCTCAAAGC CATGAAGATG 1740

ATTCGGGACA ACCTGCCACC CCGACTGAAG AACCTGCACA AGGTGTCGCC ATCCCTGAAG 1800

GGCTTCCTGG ACCGCCTGCT GGTGCGGGAC CCTGCCCAGC GGGCCACGGC AGCCGAGCTG 1860

CTGAAGCACC CATTCCTGGC CAAGGCAGGG CCGCCCGCCA GCATCGTGCC CCTCATGCGC 1920

CAGAACCGCA CCAGATGA 1938

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++a+ +++g+lva+kk++l+kq++ e+l++e+ ++++++h+n+ve+++s

Q: 379   IKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNS  438

         68**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++  vl+aL+ lH+++viHrdi

Q: 439   YLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDI  495

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g+VkLsdfg++aq++k++ +rk++vgtpywmAPE+i+  +  Y  ++Diw

Q: 496   KSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS--RLPYGPEVDIW  553

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slGI++ie+++gepP+++++plka+ +i +n pp+lk+ +k+s+++k f++++l ++p++

Q: 554   SLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ  613

         ************************************************************

S: 245   RpsasellkhkFl  257

         R++a+ellkh+Fl

Q: 614   RATAAELLKHPFL  626

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGI VCIATVRSSG KLVAVKKMDL RKQQRRELLF NEVVIMRDYQ HENVVEMYNS 60

YLVGDELWVV MEFLEGGALT DIVTHTRMNE EQIAAVCLAV LQALSVLHAQ GVIHRDIKSD 120

SILLTHDGRV KLSDFGFCAQ VSKEVPRRKS LVGTPYWMAP ELISRLPYGP EVDIWSLGIM 180

VIEMVDGEPP YFNEPPLKAM KMIRDNLPPR LKNLHKVSPS LKGFLDRLLV RDPAQRATAA 240

ELLKHPFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013