EKS-POA-00368
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00368
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK342.71.4E-10299356258
StatusUnreviewed
Ensembl ProteinENSPPYP00000011177
UniProt AccessionH2NYU5;
Protein Name
Protein Synonyms/Alias
Gene NameMAP3K10
Gene Synonyms/Alias MAP3K10;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000009985ENSPPYP00000011177ENSPPYT00000011614
OrganismPongo abelii
Functional Description
Protein Length863
Protein Sequence
(FASTA)
MEEEEGAVAK EWGTTPAGPV WTAVFDYEAA GDEELTLRRG DRVQVLSQDC AVSGDEGWWT 60
GQLPSGRVGV FPSNYVAPGA PAAPAGLQLP QEIPFHELQL EEIIGVGGFG KVYRALWRGE 120
EVAVKAARLD PEKDPAVTAE QVCQEARLFG ALQHPNIIAL RGACLNPPHL CLVMEYARGG 180
ALSRVLAGRR VPPHVLVNWA VQVARGMNYL HNDAPVPIIH RDLKSINILI LEAIENHNLA 240
DTVLKITDFG LAREWHKTTK MSAAGTYAWM APEVIRLSLF SKSSDVWSFG VLLWELLTGE 300
VPYREIDALA VAYGVAMNKL TLPIPSTCPE PFARLLEECW DPDPHGRPDF GSILKRLEVI 360
EQSALFQMPL ESFHSLQEDW KLEIQHMFDD LRTKEKELRS REEELLRAAQ EQRFQEEQLR 420
RREQELAERE MDIVERELHL LMCQLSQEKP RVRKRKGNFK RSRLLKLREG GSHISLPSGF 480
EHKITVQASP TLDKRKGSDG ASPPASPSII PRLRAIRLTP VDCGGSSSGS SSGGSGTWSR 540
GGPPKKEELV GGKKKGRTWG PSSTLQKERV GGEERLKGLG EGSKQWSSSA PNLGKSPKHT 600
PIAPGFASLN EMEEFAEAED GGSSVPPSPY STPSYLSVPL PAEPSPGARA PWEPTPSAPP 660
AWGNGARGRC DLALLGCATL GAPSPPPSPP APTPTPSPST NPLVDLELES FKKDPRQSLT 720
PTHVTAACAV SREHRRTPSD GALGQRGPPE PTGHGPGPRD LLDFPRLPDP QALFPARRRP 780
PEFPGRPTTL TFAPRPRPAA SRPRLDPWKL VSFGRTLTIS PPSRPDTPES PGPPSMQPTL 840
LDMDMEGQNQ DSTVPLCGAH GSH 863
Nucleotide Sequence
(FASTA)
ATGGAGGAGG AGGAGGGGGC GGTGGCCAAG GAGTGGGGCA CGACCCCCGC GGGGCCCGTC 60
TGGACCGCAG TGTTCGACTA CGAGGCGGCG GGCGACGAGG AGCTGACCCT GCGGAGGGGC 120
GATCGCGTCC AGGTGCTTTC CCAAGACTGT GCGGTGTCCG GCGACGAGGG CTGGTGGACC 180
GGGCAGCTCC CCAGCGGCCG CGTGGGCGTC TTCCCCAGCA ACTACGTGGC CCCCGGCGCC 240
CCCGCTGCAC CCGCGGGCCT CCAGCTGCCC CAGGAGATCC CCTTCCACGA GCTGCAGCTA 300
GAGGAGATCA TCGGTGTGGG GGGCTTTGGC AAGGTCTATC GGGCCCTGTG GCGTGGCGAG 360
GAGGTGGCAG TCAAGGCCGC CCGGCTGGAC CCTGAGAAGG ACCCGGCAGT GACAGCGGAG 420
CAGGTGTGCC AGGAAGCCCG GCTCTTTGGA GCCCTGCAGC ACCCCAACAT AATTGCCCTT 480
AGGGGCGCCT GCCTCAACCC CCCACACCTC TGCCTAGTGA TGGAGTATGC CCGGGGTGGC 540
GCACTGAGCA GGGTGCTGGC AGGTCGCCGG GTGCCACCTC ACGTGCTGGT CAACTGGGCT 600
GTGCAGGTGG CCCGGGGCAT GAACTACCTA CACAATGATG CCCCTGTGCC CATCATCCAC 660
CGGGACCTCA AGTCCATCAA CATCCTGATC CTGGAGGCCA TCGAGAACCA CAACCTCGCA 720
GACACGGTGC TCAAGATCAC GGACTTTGGC CTCGCCCGCG AGTGGCACAA GACCACCAAG 780
ATGAGCGCTG CGGGGACCTA CGCCTGGATG GCGCCGGAGG TTATCCGTCT CTCCCTCTTC 840
TCCAAAAGCA GTGATGTCTG GAGCTTCGGG GTGCTGCTGT GGGAGCTGCT GACGGGGGAG 900
GTCCCCTACC GTGAGATCGA CGCCTTGGCC GTGGCGTATG GCGTGGCTAT GAATAAGCTG 960
ACGCTGCCCA TTCCCTCCAC GTGCCCCGAG CCCTTTGCCC GCCTCCTGGA GGAATGCTGG 1020
GACCCAGACC CCCATGGGCG GCCAGATTTT GGCAGCATCT TGAAGCGGCT TGAAGTCATC 1080
GAACAGTCAG CCCTGTTCCA GATGCCACTG GAGTCCTTCC ACTCGCTGCA GGAAGACTGG 1140
AAGCTGGAGA TTCAGCACAT GTTTGATGAC CTTCGGACCA AGGAGAAGGA GCTTCGGAGC 1200
CGTGAGGAGG AGCTGCTGCG GGCGGCGCAG GAGCAGCGCT TCCAGGAAGA GCAGCTGCGG 1260
CGGCGGGAGC AGGAGCTGGC AGAACGCGAG ATGGACATCG TGGAACGGGA GCTGCACCTG 1320
CTCATGTGCC AGCTGAGCCA GGAGAAGCCC CGGGTCCGCA AGCGCAAGGG CAACTTCAAG 1380
CGCAGCCGCC TGCTCAAGCT GCGGGAAGGC GGCAGCCACA TCAGCCTGCC CTCTGGCTTT 1440
GAGCATAAGA TCACAGTCCA GGCCTCTCCA ACTCTGGATA AGCGGAAAGG ATCCGATGGG 1500
GCCAGCCCCC CTGCAAGCCC CAGTATCATC CCCCGGCTGA GGGCCATTCG CCTGACTCCC 1560
GTGGACTGTG GTGGCAGCAG CAGTGGCAGC AGCAGTGGAG GAAGTGGGAC ATGGAGCCGC 1620
GGTGGGCCCC CAAAGAAGGA AGAACTGGTC GGGGGCAAGA AGAAGGGCCG AACGTGGGGG 1680
CCCAGCTCCA CCCTGCAGAA GGAGCGGGTG GGAGGAGAGG AGAGGCTGAA GGGGCTGGGG 1740
GAAGGAAGCA AACAGTGGTC ATCAAGTGCC CCCAACCTGG GCAAGTCCCC CAAACACACA 1800
CCCATCGCCC CTGGCTTCGC CAGCCTCAAT GAGATGGAGG AGTTCGCGGA GGCAGAGGAT 1860
GGAGGCAGCA GCGTGCCCCC TTCCCCCTAC TCGACCCCGT CCTACCTCTC AGTACCACTG 1920
CCTGCCGAGC CCTCCCCGGG GGCGCGGGCG CCATGGGAGC CGACGCCGTC CGCGCCCCCC 1980
GCTTGGGGAA ACGGCGCCCG GGGGCGCTGC GACCTGGCGC TGCTAGGCTG CGCCACACTG 2040
GGGGCTCCCT CCCCACCACC CTCCCCGCCC GCGCCCACGC CCACGCCCTC GCCCAGCACC 2100
AACCCCCTGG TGGACCTGGA GCTGGAGAGC TTCAAGAAGG ACCCCCGCCA GTCGCTCACG 2160
CCCACCCACG TCACGGCTGC CTGCGCTGTG AGCCGCGAGC ACAGGCGGAC GCCATCGGAC 2220
GGGGCGCTGG GGCAGCGGGG GCCGCCCGAG CCCACCGGCC ATGGCCCTGG CCCTCGTGAC 2280
CTTCTGGACT TCCCCCGCCT GCCCGACCCC CAGGCCCTGT TCCCAGCCCG CCGCCGGCCC 2340
CCTGAGTTCC CAGGCCGCCC CACCACCCTG ACCTTTGCCC CGAGACCTCG GCCGGCTGCC 2400
AGTCGCCCCC GCTTGGACCC CTGGAAACTG GTCTCCTTCG GCCGGACACT CACCATCTCG 2460
CCTCCCAGCA GGCCAGACAC TCCAGAGAGC CCTGGGCCCC CCAGCATGCA GCCCACACTG 2520
CTGGACATGG ACATGGAGGG GCAGAACCAA GACAGCACAG TGCCCCTGTG CGGGGCCCAC 2580
GGCTCCCACT AA 2592
Domain Profile
S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59
         +lee+ig g fgkvy+a wr++evavK++r + e+  + ++e++++ea+l+ +l+hpnii
Q: 99    QLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKdpAVTAEQVCQEARLFGALQHPNII  158
         789******************************9988999********************
S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119
         +l+G+cl++p+l+lvmey++gg+Ls+vl++   r+++++vlv+wa+q+ArGm+YLh++ap
Q: 159   ALRGACLNPPHLCLVMEYARGGALSRVLAG---RRVPPHVLVNWAVQVARGMNYLHNDAP  215
         ******************************...9**************************
S: 120   kkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvl  172
         ++iihrdLks n+L+       + ++++lki+dFG are++k+tkmsaagt+awmaPEv+
Q: 216   VPIIHRDLKSINILIleaienhNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVI  275
         ********************99999***********************************
S: 173   keekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkL  232
         + + +s++sDvwS+gv+LWellt+evPy++++ la+ay+va+++l+lpips+cpe++++L
Q: 276   RLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARL  335
         ************************************************************
S: 233   mkecwnedpekRpsfseivks  253
         ++ecw+ dp+ Rp+f +i+k 
Q: 336   LEECWDPDPHGRPDFGSILKR  356
         *****************9986
Domain Sequence
(FASTA)
QLEEIIGVGG FGKVYRALWR GEEVAVKAAR LDPEKDPAVT AEQVCQEARL FGALQHPNII 60
ALRGACLNPP HLCLVMEYAR GGALSRVLAG RRVPPHVLVN WAVQVARGMN YLHNDAPVPI 120
IHRDLKSINI LILEAIENHN LADTVLKITD FGLAREWHKT TKMSAAGTYA WMAPEVIRLS 180
LFSKSSDVWS FGVLLWELLT GEVPYREIDA LAVAYGVAMN KLTLPIPSTC PEPFARLLEE 240
CWDPDPHGRP DFGSILKR 258
KeywordComplete proteome; Kinase; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00351
EKS-ANC-00366
EKS-BOT-00379
EKS-CAJ-00382
EKS-CAF-00385
EKS-CAP-00410
EKS-FEC-00366
EKS-GAA-00461
EKS-GOG-00369
EKS-HOS-00385
EKS-ICT-00357
EKS-LOA-00388
EKS-MOD-00368
EKS-MUM-00411
EKS-MUP-00371
EKS-MYL-00376
EKS-NOL-00352
EKS-ORC-00355
EKS-OTG-00380
EKS-PAT-00359
EKS-RAN-00393
EKS-SUS-00331
EKS-TUT-00103
EKS-XIM-00474
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0003714; F:transcription corepressor activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892; P:negative regulation of transcription, DNA-dependent
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0046330; P:positive regulation of JNK cascade
GO:0043507; P:positive regulation of JUN kinase activity
GO:0007224; P:smoothened signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR016231; MAPKKK9/10/11.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR011511; SH3_2.
IPR001452; SH3_domain.
Pfam
PF07714; Pkinase_Tyr; 1.
PF07653; SH3_2; 1.
SMARTs
SM00326; SH3; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013