EKS-POA-00389
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00389
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl544.83.4E-164226490265
StatusUnreviewed
Ensembl ProteinENSPPYP00000011205
UniProt AccessionH2NYX2;
Protein Name
Protein Synonyms/Alias
Gene NameAXL
Gene Synonyms/Alias AXL;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000010010ENSPPYP00000011205ENSPPYT00000011643
OrganismPongo abelii
Functional Description
Protein Length583
Protein Sequence
(FASTA)
MAWRCPRMGR VPLAWCLALC GWACMAPRQV PLGEEITSLQ LSDTGQYQCL VFLGHQTFVS 60
QPGYVGLEGL PYFLEEPEDR TVAANTPFNL SCQAQGPPEP VDLLWLQDAV PLATAPGYGP 120
QRSLHVPVKE PSTPAFSWPW WYVLLGAVVA AACVLILALF LVHRRKKETR YGEVFEPTVE 180
RGELVVRYRV RKSYSRRTTE ATLNSLGISE ELKEKLRDVM VDRHKVALGK TLGEGEFGAV 240
MEGQLNQDDS ILKVAVKTMK IAICTRSELE DFLSEAVCMK EFDHPNVMRL IGVCFQGSER 300
ESFPAPVVIL PFMKHGDLHS FLLYSRLGDQ PVYLPTQMLV KFMADIASGM EYLSTKRFIH 360
RDLAARNCML NENMSVCVAD FGLSKKIYNG DYYRQGRIAK MPVKWIAIES LDRVYTSKSD 420
VWSFGVTMWE IATRGQTPYP GVENSEIYDY LRQGNRLKQP ADCLDGLYAL MSRCWELNPQ 480
DRPSFTELRE DLENTLKALP PAQEPDEILY VNMDEGGGYP EPPGAAGGAD PPTQPDPKDS 540
CSCLTAAEVH PAGRYVLCPS TTPSPPQPAD RGSPAAPGQE DGA 583
Nucleotide Sequence
(FASTA)
ATGGCGTGGC GGTGCCCCAG GATGGGCAGG GTCCCACTGG CCTGGTGCTT GGCGCTGTGC 60
GGCTGGGCAT GCATGGCCCC CAGGCAGGTG CCCCTGGGTG AGGAAATCAC CTCCCTGCAG 120
CTTTCCGACA CGGGACAGTA CCAGTGTTTG GTGTTTCTGG GACATCAGAC CTTCGTGTCC 180
CAGCCTGGCT ACGTTGGGCT GGAGGGCTTG CCTTACTTCC TGGAGGAGCC TGAGGACAGG 240
ACTGTGGCCG CCAACACCCC CTTCAACCTG AGCTGCCAAG CCCAGGGACC CCCAGAGCCC 300
GTGGACCTAC TCTGGCTCCA GGATGCTGTC CCCCTGGCCA CAGCTCCAGG TTACGGCCCC 360
CAGCGCAGCC TGCATGTTCC AGTGAAGGAA CCTTCAACTC CTGCCTTCTC GTGGCCCTGG 420
TGGTATGTAC TGCTAGGAGC AGTCGTGGCC GCTGCCTGTG TCCTCATCTT GGCTCTCTTC 480
CTTGTCCACC GGCGAAAGAA GGAGACCCGT TATGGAGAAG TGTTTGAACC AACAGTGGAA 540
AGAGGTGAAC TGGTAGTCAG GTACCGCGTG CGCAAGTCCT ACAGTCGTCG GACCACTGAA 600
GCTACCTTGA ACAGCCTGGG CATCAGTGAA GAGCTGAAGG AGAAGCTGCG GGATGTGATG 660
GTGGACCGGC ACAAGGTGGC CCTGGGGAAG ACTCTGGGAG AGGGAGAGTT TGGAGCTGTG 720
ATGGAAGGCC AGCTCAACCA GGACGACTCC ATCCTCAAGG TGGCTGTGAA GACGATGAAG 780
ATTGCCATCT GCACGAGGTC AGAGCTGGAG GATTTCCTGA GTGAAGCGGT CTGCATGAAG 840
GAATTCGACC ATCCCAACGT CATGAGGCTC ATCGGTGTCT GTTTCCAGGG TTCTGAAAGA 900
GAGAGCTTCC CAGCACCTGT GGTCATTTTA CCTTTCATGA AACATGGAGA CCTACACAGC 960
TTCCTCCTCT ATTCCCGGCT CGGGGACCAG CCAGTGTATC TGCCCACTCA GATGCTGGTG 1020
AAGTTCATGG CAGACATTGC CAGTGGCATG GAGTATCTGA GTACCAAGAG ATTCATACAC 1080
CGGGACCTGG CGGCCAGGAA CTGCATGCTG AATGAGAACA TGTCCGTGTG TGTGGCGGAC 1140
TTCGGGCTCT CCAAGAAGAT CTACAATGGG GACTACTACC GCCAGGGACG TATCGCCAAG 1200
ATGCCAGTCA AGTGGATTGC CATTGAGAGT CTAGACCGAG TCTACACCAG CAAGAGCGAT 1260
GTGTGGTCCT TCGGGGTGAC AATGTGGGAG ATTGCCACAA GAGGCCAAAC CCCATATCCA 1320
GGCGTGGAGA ACAGCGAGAT TTATGACTAT CTGCGCCAGG GAAATCGCCT GAAGCAGCCT 1380
GCGGACTGTC TGGATGGACT GTATGCCTTG ATGTCGCGGT GCTGGGAGCT AAATCCCCAG 1440
GACCGGCCAA GTTTTACAGA GCTGCGGGAA GATTTGGAGA ACACACTGAA GGCCTTGCCT 1500
CCTGCCCAGG AGCCTGACGA AATCCTCTAT GTCAACATGG ATGAGGGTGG AGGTTATCCT 1560
GAACCCCCTG GAGCTGCGGG AGGAGCTGAC CCCCCAACCC AGCCAGACCC TAAGGATTCC 1620
TGTAGCTGCC TCACTGCGGC TGAGGTCCAT CCTGCTGGAC GCTATGTCCT CTGCCCTTCC 1680
ACAACCCCTA GCCCCCCTCA GCCTGCTGAT AGGGGCTCCC CAGCAGCCCC AGGGCAGGAG 1740
GATGGTGCCT GA 1752
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lgk+lgegefg+vmegql+q+d silkvavkt+k++i++rse+e+flsea+cmkefdh
Q: 226   VALGKTLGEGEFGAVMEGQLNQDD-SILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDH  284
         68**********************.***********************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnv+rl+gv++++se++++p+pvvilpfmk+gdlh+fllysrlg++pvylp+q+lvkfm+
Q: 285   PNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMA  344
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         diasgmeyls+++fihrdlaarncml+e+m+vcvadfglskkiy+gdyyrqgriak+pvk
Q: 345   DIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVK  404
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wiaiesl drvytsksdvw+fgvtmweiatrgqtpy+gven+eiydyl+qgnrlkqp+dc
Q: 405   WIAIESL-DRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADC  463
         ******9.9***************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlre  267
         ld+ly+lm+rcwe++p+drpsf++lre
Q: 464   LDGLYALMSRCWELNPQDRPSFTELRE  490
         *************************96
Domain Sequence
(FASTA)
VALGKTLGEG EFGAVMEGQL NQDDSILKVA VKTMKIAICT RSELEDFLSE AVCMKEFDHP 60
NVMRLIGVCF QGSERESFPA PVVILPFMKH GDLHSFLLYS RLGDQPVYLP TQMLVKFMAD 120
IASGMEYLST KRFIHRDLAA RNCMLNENMS VCVADFGLSK KIYNGDYYRQ GRIAKMPVKW 180
IAIESLDRVY TSKSDVWSFG VTMWEIATRG QTPYPGVENS EIYDYLRQGN RLKQPADCLD 240
GLYALMSRCW ELNPQDRPSF TELRE 265
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00371
EKS-ANC-00385
EKS-BOT-00398
EKS-CAJ-00402
EKS-CAP-00425
EKS-CII-00235
EKS-CIS-00152
EKS-EQC-00386
EKS-GAA-00486
EKS-GOG-00386
EKS-HOS-00402
EKS-ICT-00374
EKS-LAC-00413
EKS-LOA-00405
EKS-MAM-00398
EKS-MOD-00383
EKS-MUM-00431
EKS-MUP-00391
EKS-MYL-00394
EKS-ORN-00509
EKS-ORC-00373
EKS-ORL-00466
EKS-OTG-00401
EKS-PAT-00376
EKS-PEM-00218
EKS-RAN-00410
EKS-SAH-00366
EKS-SUS-00348
EKS-TAR-00500
EKS-TEN-00498
EKS-XET-00509
EKS-XIM-00501
Gene Ontology
GO:0009986; C:cell surface
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0001786; F:phosphatidylserine binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0001974; P:blood vessel remodeling
GO:0048469; P:cell maturation
GO:0031668; P:cellular response to extracellular stimulus
GO:0035457; P:cellular response to interferon-alpha
GO:0071222; P:cellular response to lipopolysaccharide
GO:0097028; P:dendritic cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0034101; P:erythrocyte homeostasis
GO:0021885; P:forebrain cell migration
GO:0006954; P:inflammatory response
GO:0001779; P:natural killer cell differentiation
GO:2000669; P:negative regulation of dendritic cell apoptotic process
GO:0032689; P:negative regulation of interferon-gamma production
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0032720; P:negative regulation of tumor necrosis factor production
GO:0001764; P:neuron migration
GO:0042698; P:ovulation cycle
GO:0030168; P:platelet activation
GO:0001961; P:positive regulation of cytokine-mediated signaling pathway
GO:0032825; P:positive regulation of natural killer cell differentiation
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013