EKS-POA-00074
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00074
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/GSK448.21.2E-134120403284
StatusUnreviewed
Ensembl ProteinENSPPYP00000011236
UniProt AccessionH2NZ02;
Protein Name
Protein Synonyms/Alias
Gene NameGSK3A
Gene Synonyms/Alias GSK3A;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000010039ENSPPYP00000011236ENSPPYT00000011674
OrganismPongo abelii
Functional Description
Protein Length483
Protein Sequence
(FASTA)
MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK ASVGAMGGGV 60
GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATLGQG PERSQEVAYT 120
DIKVIGNGSF GVVYQARLAE TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY 180
SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLTIPILY VKVYMYQLFR SLAYIHSQGV 240
CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS 300
IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN YTEFKFPQIK 360
AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH SFFDELRCLG TQLPNNRPLP 420
PLFNFSAGEL SIQPSLNAIL IPPHLRSPAG TTTLTQSSQA LTETPTSSDW QSTDATPTLT 480
NSS 483
Nucleotide Sequence
(FASTA)
ATGAGCGGCG GCGGGCCTTC GGGAGGCGGC CCTGGGGGCT CGGGCAGGGC GCGGACCAGC 60
TCGTTCGCGG AGCCAGGCGG CGGAGGCGGA GGCGGCGGCG GCGGCCCCGG AGGCTCGGCC 120
TCTGGCCCAG GCGGCACCGG CGGCGGAAAG GCATCTGTCG GGGCCATGGG TGGGGGCGTC 180
GGGGCCTCGA GCTCCGGGGG TGGACCCGGC GGCAGCGGCG GAGGAGGCAG CGGAGGCCCC 240
GGCGCAGGCA CTAGCTTCCC GCCGCCCGGG GTGAAGCTGG GCCGTGACAG CGGGAAGGTG 300
ACCACAGTGG TAGCCACTCT AGGCCAAGGC CCAGAGCGCT CCCAAGAGGT GGCTTACACG 360
GACATCAAAG TGATTGGCAA TGGCTCATTT GGGGTTGTGT ACCAGGCACG GCTGGCAGAG 420
ACCAGGGAAC TGGTCGCCAT CAAGAAGGTT CTCCAGGACA AGAGGTTCAA GAACCGAGAG 480
CTGCAGATCA TGCGTAAGCT GGACCACTGC AATATTGTGA GGCTGAGATA CTTTTTCTAC 540
TCCAGTGGCG AGAAGAAAGA CGAGCTTTAC CTAAATCTGG TGCTGGAATA TGTGCCCGAG 600
ACAGTGTACC GGGTGGCCCG CCACTTCACC AAGGCCAAGT TGACCATCCC TATCCTCTAT 660
GTCAAGGTGT ACATGTACCA GCTCTTCCGC AGCTTGGCCT ACATCCACTC CCAGGGCGTG 720
TGTCACCGCG ACATCAAGCC CCAGAACCTG CTGGTGGACC CTGACACTGC TGTCCTCAAG 780
CTCTGCGATT TTGGCAGTGC AAAGCAGTTG GTCCGAGGGG AGCCCAATGT CTCCTACATC 840
TGTTCTCGCT ACTACCGGGC CCCAGAGCTC ATCTTTGGAG CCACTGATTA CACCTCATCC 900
ATCGATGTTT GGTCAGCTGG CTGTGTACTG GCGGAGCTCC TCCTGGGCCA GCCCATCTTC 960
CCTGGGGACA GTGGGGTGGA CCAGCTGGTG GAGATCATCA AGGTGCTGGG AACACCAACC 1020
CGGGAACAAA TCCGAGAGAT GAACCCCAAC TACACGGAGT TCAAGTTCCC TCAGATTAAA 1080
GCTCACCCCT GGACAAAGGT GTTCAAATCT CGAACGCCGC CAGAGGCCAT CGCGCTCTGC 1140
TCTAGCCTGC TGGAGTACAC CCCGTCCTCA AGGCTCTCCC CGCTAGAGGC CTGTGCGCAC 1200
AGCTTCTTTG ATGAACTGCG ATGTCTGGGA ACCCAGCTGC CTAACAACCG CCCACTTCCC 1260
CCTCTCTTCA ACTTCAGTGC TGGTGAACTC TCCATCCAAC CGTCTCTCAA CGCCATTCTC 1320
ATCCCTCCTC ACTTGAGGTC CCCAGCGGGC ACTACCACCC TCACCCAGTC CTCACAAGCT 1380
TTAACTGAGA CTCCGACCAG CTCAGACTGG CAGTCGACCG ATGCCACACC TACCCTCACT 1440
AACTCCTCCT GA 1452
Domain Profile
S: 2     eelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyf  61
         +++k+ig+GsFg+Vyqa+l+e++e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+yf
Q: 120   TDIKVIGNGSFGVVYQARLAETREL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF  178
         789**********************.**********************************
S: 62    fsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsl  121
         f++s ekkd++ylnlvley+Pet+++v+r+++++k ++++l+vk+y+yQlfr+lay+hs+
Q: 179   FYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQ  238
         ************************************************************
S: 122   eivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeyt  181
         +++HrDiKPqNllvd++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++yt
Q: 239   GVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT  298
         ************************************************************
S: 182   tkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkk  241
         ++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf++
Q: 299   SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ  358
         ************************************************************
S: 242   ikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286
         ik+++++kv+k+++++ea++l++++l+y+p++Rls+le++ah+ff
Q: 359   IKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF  403
         ********************************************9
Domain Sequence
(FASTA)
TDIKVIGNGS FGVVYQARLA ETRELVAIKK VLQDKRFKNR ELQIMRKLDH CNIVRLRYFF 60
YSSGEKKDEL YLNLVLEYVP ETVYRVARHF TKAKLTIPIL YVKVYMYQLF RSLAYIHSQG 120
VCHRDIKPQN LLVDPDTAVL KLCDFGSAKQ LVRGEPNVSY ICSRYYRAPE LIFGATDYTS 180
SIDVWSAGCV LAELLLGQPI FPGDSGVDQL VEIIKVLGTP TREQIREMNP NYTEFKFPQI 240
KAHPWTKVFK SRTPPEAIAL CSSLLEYTPS SRLSPLEACA HSFF 284
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00074
EKS-ANC-00071
EKS-BOT-00080
EKS-CAE-00055
EKS-CAJ-00082
EKS-CAF-00081
EKS-CII-00034
EKS-CIS-00077
EKS-DAR-00331
EKS-DRM-00034
EKS-EQC-00079
EKS-FEC-00077
EKS-GAM-00044
EKS-GAA-00099
EKS-GOG-00079
EKS-HOS-00083
EKS-LAC-00086
EKS-LOA-00076
EKS-MAM-00080
EKS-MAE-00033
EKS-MUM-00081
EKS-MUP-00081
EKS-MYL-00088
EKS-NOL-00077
EKS-OCP-00051
EKS-ORN-00109
EKS-ORC-00076
EKS-ORL-00101
EKS-OTG-00084
EKS-PAT-00072
EKS-PRC-00044
EKS-PTV-00065
EKS-RAN-00077
EKS-SAH-00076
EKS-SUS-00072
EKS-TAR-00109
EKS-TEN-00106
EKS-TUT-00070
EKS-XET-00076
EKS-XIM-00104
EKS-SAC-00071
EKS-SCP-00065
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0003214; P:cardiac left ventricle morphogenesis
GO:0016477; P:cell migration
GO:0071285; P:cellular response to lithium ion
GO:0071407; P:cellular response to organic cyclic compound
GO:0044027; P:hypermethylation of CpG island
GO:0008286; P:insulin receptor signaling pathway
GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development
GO:0046325; P:negative regulation of glucose import
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0032007; P:negative regulation of TOR signaling cascade
GO:0051348; P:negative regulation of transferase activity
GO:0071879; P:positive regulation of adrenergic receptor signaling pathway
GO:0030819; P:positive regulation of cAMP biosynthetic process
GO:2000467; P:positive regulation of glycogen (starch) synthase activity
GO:0045823; P:positive regulation of heart contraction
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006349; P:regulation of gene expression by genetic imprinting
GO:0003073; P:regulation of systemic arterial blood pressure
KEGG
pon:100444083;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013