EKS-POA-00170
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00170
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC428.88.7E-129351609259
StatusUnreviewed
Ensembl ProteinENSPPYP00000011609
UniProt AccessionH2P012;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCG
Gene Synonyms/Alias PRKCG;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000010365ENSPPYP00000011609ENSPPYT00000012053
OrganismPongo abelii
Functional Description
Protein Length692
Protein Sequence
(FASTA)
MAGLGPGGGD SEGGPRPLFC RKGALRQKVV HEVKSHKFTA RFFKQPTFCS HCTDFIWGIG 60
KQGLQCQVCS FVVHRRCHEF VTFECPGAGK GPQTDDPRSK HKFRLHSYSS PTFCDHCGSL 120
LYGLVHQGMK CSCCEMNVHR RCVRSVPSLC GVDHTERRGR LQLEIRAPTA DEIHITVGEA 180
RNLIPMDPNG LSDPYVKLKL IPDPRNLTKQ KTRTVKATLN PVWNETFVFN LKPGDVERRL 240
SVEVWDWDRT SRNDFMGAMS FGVSELLKAP VDGWYKLLNQ EEGEYYNVPV ADADNCSLLQ 300
KFEACNYPLE LYERVRMGPS SSPIPSPSPS PTDPKRCFFG ASPGRLHISD FSFLMVLGKG 360
SFGKVMLAER RGSDELYAIK ILKKDVIVQD DDVDCTLVEK RVLALGGRGP GGRPHFLTQL 420
HSTFQTPVME YVTGGDLMYH IQQLIKFKEP HAAFYAAEIA IGLFFLHNQG IIYRDLKLDN 480
VMLDAEGHIK ITDFGMCKEN VFPGTTTRTF CGTPDYIAPE IIAYQPYGKS VDWWSFGVLL 540
YEMLAGQPPF DGEDEEELFQ AIMEQTVTYP KSLSREAVAI CKGFLTKHPG KRLGSGPDGE 600
PTIRAHGFFR WIDWERLERL EIPPPFRPRP CGRSGENFDK FFTRAAPALT PPDRLVLASI 660
DQADFQGFTY VNPDFVHPDA RSPTSPVPVP VM 692
Nucleotide Sequence
(FASTA)
ATGGCTGGTC TGGGCCCCGG CGGAGGCGAT TCAGAGGGGG GACCCCGGCC CCTGTTTTGC 60
AGAAAGGGGG CTCTGAGGCA GAAGGTGGTC CACGAAGTCA AGAGCCACAA GTTCACCGCT 120
CGCTTCTTCA AGCAGCCCAC CTTCTGCAGC CACTGCACCG ACTTCATCTG GGGTATCGGA 180
AAGCAGGGCC TGCAATGTCA AGTCTGCAGC TTTGTGGTTC ATCGACGATG CCACGAATTT 240
GTGACCTTCG AGTGTCCAGG CGCTGGGAAG GGCCCCCAGA CGGACGACCC CCGGAGCAAA 300
CACAAGTTCC GCTTGCATAG CTACAGCAGC CCCACCTTCT GCGACCACTG TGGTTCCCTC 360
CTCTACGGGC TTGTGCACCA GGGCATGAAA TGCTCCTGCT GCGAGATGAA CGTGCACAGG 420
CGCTGTGTGC GTAGCGTGCC CTCCCTGTGC GGTGTGGACC ACACCGAGCG CCGCGGGCGC 480
CTGCAGCTGG AGATCCGGGC TCCCACAGCA GATGAGATCC ACATAACGGT TGGCGAGGCC 540
CGTAACCTAA TTCCTATGGA CCCCAATGGT CTCTCTGATC CCTATGTGAA ACTGAAGCTC 600
ATCCCAGACC CTCGGAACCT GACGAAACAG AAGACCCGAA CAGTGAAAGC CACGCTAAAC 660
CCTGTGTGGA ATGAGACCTT TGTGTTCAAC CTGAAGCCAG GGGATGTGGA GCGCCGGCTC 720
AGCGTGGAGG TGTGGGACTG GGACCGGACC TCCCGCAACG ACTTCATGGG GGCCATGTCC 780
TTTGGCGTCT CGGAGCTGCT CAAGGCGCCC GTGGATGGCT GGTACAAGTT ACTGAACCAG 840
GAGGAGGGCG AGTATTACAA TGTGCCGGTG GCCGATGCTG ACAACTGCAG CCTCCTCCAG 900
AAATTTGAGG CTTGTAACTA CCCCTTGGAA TTGTACGAGC GGGTGCGAAT GGGCCCCTCT 960
TCCTCTCCCA TCCCCTCCCC TTCCCCTAGT CCCACCGACC CCAAGCGCTG CTTCTTCGGG 1020
GCGAGCCCAG GACGCCTGCA CATCTCCGAC TTCAGCTTCC TCATGGTTCT AGGAAAAGGC 1080
AGTTTTGGGA AGGTGATGCT GGCCGAGCGC AGGGGCTCTG ATGAGCTCTA CGCCATCAAG 1140
ATCTTGAAAA AGGACGTGAT CGTCCAGGAC GACGATGTGG ACTGCACGCT GGTGGAGAAA 1200
CGTGTGCTGG CGCTGGGGGG CCGGGGTCCT GGCGGCCGGC CCCACTTCCT CACCCAGCTC 1260
CACTCCACCT TCCAGACCCC GGTGATGGAG TACGTCACCG GGGGAGACTT GATGTACCAC 1320
ATTCAACAGC TGATAAAATT TAAGGAGCCC CATGCAGCGT TCTACGCGGC AGAAATCGCC 1380
ATCGGCCTCT TCTTCCTTCA CAATCAGGGC ATCATCTACA GGGACCTGAA GCTGGACAAT 1440
GTGATGCTGG ATGCTGAGGG ACACATCAAG ATCACTGACT TCGGCATGTG TAAGGAGAAC 1500
GTCTTCCCCG GGACGACAAC CCGCACCTTC TGCGGGACCC CGGACTACAT AGCCCCGGAG 1560
ATCATTGCCT ACCAGCCCTA CGGGAAGTCT GTCGATTGGT GGTCCTTTGG AGTTCTGCTG 1620
TATGAGATGT TGGCAGGACA GCCTCCCTTC GATGGGGAGG ACGAGGAGGA GCTGTTTCAG 1680
GCCATCATGG AACAAACTGT CACCTACCCC AAGTCGCTTT CCCGGGAAGC CGTGGCCATC 1740
TGCAAGGGGT TCCTGACCAA GCACCCAGGG AAGCGTCTGG GCTCAGGGCC TGATGGGGAA 1800
CCTACCATCC GTGCACATGG CTTTTTCCGC TGGATTGACT GGGAGCGGCT GGAACGATTG 1860
GAGATCCCGC CTCCTTTCAG ACCCCGCCCG TGTGGCCGCA GCGGCGAGAA CTTTGACAAG 1920
TTCTTCACGC GGGCGGCGCC AGCGCTGACC CCTCCAGACC GCCTAGTCCT GGCCAGCATC 1980
GACCAGGCCG ATTTCCAGGG CTTCACCTAC GTGAACCCCG ACTTCGTGCA CCCGGATGCC 2040
CGCAGCCCCA CCAGCCCAGT GCCTGTGCCC GTCATGTAA 2079
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlal.....  55
         f++l+vlGkGsfgkv+lae++++delyaik+lkkdv++qdddv++tlvekrvlal     
Q: 351   FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALggrgp  410
         89*****************************************************66666
S: 56    askkpflvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkf  115
           +++fl+ql+s+fqt      v+eyv+GGdlm+hiq+  k+ke++a+fyaaei+++l+f
Q: 411   GGRPHFLTQLHSTFQTP-----VMEYVTGGDLMYHIQQLIKFKEPHAAFYAAEIAIGLFF  465
         67889***********8.....9*************************************
S: 116   lhekgiiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkee  175
         lh++giiyrdlkldnv+ldaeGhik++dfG+cke+++ g+tt+tfcGtPdyiaPei++++
Q: 466   LHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQ  525
         ************************************************************
S: 176   eygksvdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkgll  235
         +ygksvdww++Gvllyemlagq+Pf+gede+elf++i+e++v+yPksls+eav+i+kg+l
Q: 526   PYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFL  585
         ************************************************************
S: 236   tkdpekrlGvkeegeedikehaff  259
         tk+p krlG+ ++ge +i++h ff
Q: 586   TKHPGKRLGSGPDGEPTIRAHGFF  609
         ***********************8
Domain Sequence
(FASTA)
FSFLMVLGKG SFGKVMLAER RGSDELYAIK ILKKDVIVQD DDVDCTLVEK RVLALGGRGP 60
GGRPHFLTQL HSTFQTPVME YVTGGDLMYH IQQLIKFKEP HAAFYAAEIA IGLFFLHNQG 120
IIYRDLKLDN VMLDAEGHIK ITDFGMCKEN VFPGTTTRTF CGTPDYIAPE IIAYQPYGKS 180
VDWWSFGVLL YEMLAGQPPF DGEDEEELFQ AIMEQTVTYP KSLSREAVAI CKGFLTKHPG 240
KRLGSGPDGE PTIRAHGFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00164
EKS-ANC-00163
EKS-BOT-00172
EKS-CAJ-00176
EKS-CAF-00179
EKS-CAP-00172
EKS-EQC-00169
EKS-FEC-00162
EKS-GOG-00170
EKS-HOS-00178
EKS-ICT-00167
EKS-LOA-00170
EKS-MAM-00170
EKS-MUM-00177
EKS-MUP-00176
EKS-NOL-00165
EKS-ORC-00161
EKS-OTG-00178
EKS-RAN-00167
EKS-SUS-00147
EKS-TUT-00154
Gene Ontology
GO:0005737; C:cytoplasm
GO:0030425; C:dendrite
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0097060; C:synaptic membrane
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0007635; P:chemosensory behavior
GO:0060384; P:innervation
GO:0035556; P:intracellular signal transduction
GO:0042177; P:negative regulation of protein catabolic process
GO:0031397; P:negative regulation of protein ubiquitination
GO:0032425; P:positive regulation of mismatch repair
GO:0043278; P:response to morphine
GO:0048265; P:response to pain
GO:0007268; P:synaptic transmission
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 2.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 2.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 2.
PS50081; ZF_DAG_PE_2; 2.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013