EKS-POA-00029
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00029
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak330.21.1E-98593863271
StatusUnreviewed
Ensembl ProteinENSPPYP00000011782
UniProt AccessionH2P0I2;
Protein Name
Protein Synonyms/Alias
Gene NameTYK2
Gene Synonyms/Alias TYK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000010516ENSPPYP00000011782ENSPPYT00000012231
OrganismPongo abelii
Functional Description
Protein Length883
Protein Sequence
(FASTA)
GKHEFVNDVA SLWDLSSEEE IHHFKNESLG MAFLHLCHLA LRHGISLEEV AKKTSFKDCI 60
PRSFRRHIQQ HSALTRLRLR NVFRRFLRDF QPGRLSQQMV MVKYLATLER LAPRFGTERV 120
PVCHLRLLAQ AEGEPCYIRD SGVAPTDPGP ESGAGPPTHE VLVTGTGGIQ WWPVQEEVNK 180
EEEPFVQAKL RPEDGLYLIH WSTSHPYRLI LTVAQRSQAP DGMQSLRLRK FPIEQQDGAF 240
VLEGWGRSFP SVRELGAALQ GCLLRAGDDC FSLRRCCLPQ PGETSNLIIM RGARASTRTL 300
NLSQLSFHRV DQKEITQLSH LGQGTRTNVY EGRLRVEGSR DTEEGKMDDE DPLVPGREHG 360
QELRVVLKVL DPSHHDIALI MVTEYVEHGP LDVWLRRERG HVPMAWKMVV AQQLASALSY 420
LENKNLVHGN VCGRNILLAR LGLAEGTSPF IKLSDPGVGL GALSREERVE RIPWMAPECL 480
TGGPNSLSTA MDKWGFGATL LEICFDGEAP LQNRSPSEKE HFYQRQHRLP EPSCPELATL 540
TSQCLTYEPT QRPSFRTILR DLTRLQPHNL ADVLTVNPDS PASDPTVFHK RYLKKIRDLG 600
EGHFGKVSLY CYDPTNDGTG EMVAVKALKA DCAPQHRSGW KQEIDILRTL YHEHIVKYKG 660
CCEDQGEKSL QLVMEYVPLG SLRDYLPRHS VRLAQLLLFA QQICEGMAYL HAQHYIHRDL 720
AARNVLLDND RLVKIGDFGL AKAVPEGHEY YRVREDGDSP VFWYAPECLK EYKFYYASDV 780
WSFGVTLYEL LTHCDSNQSP PTKFLELIGV AQGQMTVLRL TELLERGERL PRPDKCPCEV 840
YHFMKNCWET EASFRPTFEN LIPILKTVHE KYQGQAPSVF SVC 883
Nucleotide Sequence
(FASTA)
GGCAAGCATG AGTTTGTGAA TGACGTGGCA TCACTGTGGG ATCTGTCGAG CGAGGAGGAG 60
ATCCACCACT TTAAGAATGA GAGCCTGGGC ATGGCCTTTC TGCACCTCTG TCACCTCGCT 120
CTCCGCCATG GCATCTCCCT GGAGGAGGTG GCCAAGAAGA CCAGCTTCAA GGACTGCATC 180
CCACGCTCCT TCCGTCGGCA TATCCAGCAG CACAGTGCCC TGACCCGGCT GCGCCTTCGG 240
AACGTCTTCC GCAGGTTCCT GCGGGACTTC CAGCCGGGCC GACTCTCCCA GCAGATGGTC 300
ATGGTTAAAT ACCTAGCCAC ACTTGAGCGG CTGGCACCCC GCTTCGGCAC AGAGCGTGTG 360
CCCGTGTGCC ACCTGAGGCT ACTGGCCCAG GCCGAGGGGG AGCCCTGCTA CATCCGGGAC 420
AGCGGGGTGG CCCCTACAGA CCCTGGCCCC GAGTCTGGTG CTGGGCCCCC AACCCATGAG 480
GTGCTGGTGA CTGGCACTGG TGGCATCCAG TGGTGGCCAG TACAGGAGGA GGTGAACAAG 540
GAGGAGGAGC CATTTGTGCA GGCCAAGCTG CGGCCCGAGG ACGGCCTGTA CCTCATTCAC 600
TGGAGCACCA GCCACCCCTA CCGCCTGATC CTCACAGTGG CCCAGCGTAG CCAGGCACCA 660
GACGGCATGC AGAGCTTGCG GCTCCGGAAG TTCCCCATTG AGCAGCAGGA CGGGGCCTTC 720
GTGCTGGAGG GCTGGGGCCG GTCCTTCCCC AGCGTTCGGG AACTTGGGGC TGCCTTGCAG 780
GGCTGCTTGC TGAGGGCTGG GGACGACTGC TTCTCTCTGC GTCGCTGTTG CCTGCCCCAA 840
CCAGGAGAAA CCTCCAATCT CATCATCATG CGGGGGGCTC GGGCCAGCAC CAGGACACTC 900
AACCTCAGCC AGCTCAGCTT CCACCGCGTT GACCAGAAGG AGATCACCCA GCTGTCCCAC 960
TTGGGCCAGG GCACAAGGAC CAATGTGTAT GAGGGCCGCC TGCGAGTGGA GGGCAGCAGG 1020
GACACTGAGG AGGGCAAGAT GGATGACGAG GACCCTCTCG TGCCTGGCAG GGAGCATGGG 1080
CAGGAGCTAC GAGTGGTGCT CAAAGTGCTG GACCCTAGTC ACCATGACAT CGCCCTGATC 1140
ATGGTGACAG AGTATGTGGA GCACGGACCC CTGGATGTGT GGCTGCGGAG GGAGCGGGGC 1200
CATGTGCCCA TGGCTTGGAA GATGGTGGTG GCCCAGCAAC TGGCCAGCGC CCTCAGCTAC 1260
CTGGAGAACA AGAACCTGGT TCATGGTAAT GTGTGTGGCC GGAACATCCT GCTGGCCCGA 1320
CTGGGGCTGG CAGAGGGCAC CAGCCCCTTC ATCAAGCTGA GTGATCCCGG CGTGGGCCTG 1380
GGCGCCCTCT CCAGGGAGGA GCGGGTGGAG AGGATCCCCT GGATGGCCCC CGAATGCCTA 1440
ACAGGTGGGC CCAACAGCCT AAGCACCGCC ATGGACAAGT GGGGGTTTGG CGCCACCCTC 1500
TTGGAGATCT GCTTTGACGG AGAGGCCCCT CTGCAGAACC GCAGCCCCTC CGAGAAGGAG 1560
CATTTCTACC AAAGGCAGCA CCGGCTGCCC GAGCCCTCCT GCCCAGAGCT GGCCACACTC 1620
ACCAGCCAGT GTCTGACCTA TGAGCCAACC CAGAGGCCAT CATTCCGCAC CATCCTGCGT 1680
GACCTCACCC GGCTGCAGCC CCACAATCTT GCTGACGTCT TGACTGTGAA CCCGGACTCA 1740
CCAGCCTCAG ACCCTACGGT TTTCCACAAG CGCTATTTGA AAAAGATCCG AGATCTGGGC 1800
GAGGGTCACT TCGGCAAGGT CAGCTTGTAC TGCTACGATC CGACCAACGA CGGCACTGGC 1860
GAGATGGTGG CGGTGAAAGC CCTCAAGGCA GACTGCGCTC CCCAGCACCG CTCCGGCTGG 1920
AAGCAGGAGA TTGACATTCT GCGCACGCTC TATCACGAGC ACATCGTCAA GTACAAGGGC 1980
TGCTGCGAGG ACCAAGGCGA GAAGTCTCTG CAGCTGGTCA TGGAGTACGT GCCCCTGGGC 2040
AGCCTCCGAG ACTACCTGCC CCGGCACAGC GTCCGGCTGG CCCAGCTGCT GCTCTTCGCC 2100
CAGCAGATCT GCGAGGGCAT GGCCTATCTG CACGCGCAGC ACTACATCCA CCGAGACTTA 2160
GCCGCGCGCA ACGTACTGCT GGACAACGAC AGGCTGGTCA AGATCGGGGA CTTTGGCCTA 2220
GCCAAGGCCG TGCCCGAAGG CCACGAGTAC TACCGCGTGC GCGAGGATGG GGACAGCCCT 2280
GTGTTCTGGT ATGCCCCAGA GTGCCTGAAG GAGTATAAGT TCTACTATGC GTCCGATGTC 2340
TGGTCCTTCG GGGTGACCCT GTATGAGCTG CTGACGCACT GTGACTCCAA CCAGAGCCCC 2400
CCCACGAAAT TCCTTGAGCT CATAGGCGTT GCTCAGGGTC AGATGACAGT TCTGAGACTC 2460
ACCGAGTTGC TGGAACGAGG GGAGAGGCTG CCACGGCCCG ACAAATGTCC CTGTGAGGTC 2520
TATCATTTCA TGAAGAACTG CTGGGAGACA GAGGCGTCCT TCCGCCCAAC CTTCGAGAAC 2580
CTCATACCCA TCCTGAAGAC AGTCCATGAG AAGTACCAAG GCCAGGCCCC TTCAGTGTTC 2640
AGCGTGTGCT GA 2652
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59
         lk+i++Lg+g+f+kv ++++d+++d t+e+va+k+Lk ++ +++++++k+e++il++l+h
Q: 593   LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKaDCAPQHRSGWKQEIDILRTLYH  652
         6899********************************************************
S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117
         ehivk+kg+c ++ge+  +lVmeyv+ GsL++yL+++  ++ l++ll +a+q++++m+YL
Q: 653   EHIVKYKGCCEDQGEKslQLVMEYVPLGSLRDYLPRH--SVRLAQLLLFAQQICEGMAYL  710
         ****************9********************..9********************
S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176
         ++++++hrd+aarnvL+++++       vk++d+glakav+++ eYy vre++ds+++w+
Q: 711   HAQHYIHRDLAARNVLLDNDRL------VKIGDFGLAKAVPEGhEYYRVREDGDSPVFWY  764
         **********************......********************************
S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224
         apecl+e+k +++asdvWsFgvtlyellt c++++sp    l+ ++ +       r++el
Q: 765   APECLKEYK-FYYASDVWSFGVTLYELLThCDSNQSPptkfLELIGVAqgqmtvlRLTEL  823
         *********.****************************88855555556667789*****
S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263
         le++erlp+p+ cp+e++++m+nc+++e+s+rp+F++++ 
Q: 824   LERGERLPRPDkCPCEVYHFMKNCWETEASFRPTFENLIP  863
         ************************************9975
Domain Sequence
(FASTA)
LKKIRDLGEG HFGKVSLYCY DPTNDGTGEM VAVKALKADC APQHRSGWKQ EIDILRTLYH 60
EHIVKYKGCC EDQGEKSLQL VMEYVPLGSL RDYLPRHSVR LAQLLLFAQQ ICEGMAYLHA 120
QHYIHRDLAA RNVLLDNDRL VKIGDFGLAK AVPEGHEYYR VREDGDSPVF WYAPECLKEY 180
KFYYASDVWS FGVTLYELLT HCDSNQSPPT KFLELIGVAQ GQMTVLRLTE LLERGERLPR 240
PDKCPCEVYH FMKNCWETEA SFRPTFENLI P 271
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>
EKS-AIM-00028
EKS-BOT-00034
EKS-CAJ-00031
EKS-CAF-00033
EKS-CAP-00033
EKS-EQC-00392
EKS-FEC-00030
EKS-GOG-00031
EKS-HOS-00033
EKS-ICT-00028
EKS-LOA-00031
EKS-MAM-00032
EKS-MUM-00034
EKS-MUP-00034
EKS-MYL-00034
EKS-NOL-00030
EKS-OCP-00021
EKS-OTG-00034
EKS-PAT-00030
EKS-PRC-00015
EKS-PTV-00032
EKS-RAN-00033
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016020; C:membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR016045; Tyr_kinase_non-rcpt_TYK2_N.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00252; SH2; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR00109; TYRKINASE.
PR01827; YKINASETYK2.
Created Date20-Feb-2013