EKS-POA-00365
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-POA-00365
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src169.01.3E-4933843497
StatusUnreviewed
Ensembl ProteinENSPPYP00000012176
UniProt AccessionH2P1L5;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPPYG00000010900ENSPPYP00000012176ENSPPYT00000012655
OrganismPongo abelii
Functional Description
Protein Length449
Protein Sequence
(FASTA)
LGGRSSCEDP GCPRDEERAP RMGCMRSKFL QVGGNTFSKS ETSANPHCPV YVPDPTSTIK 60
PGPNSNNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ KGDKMVVLEE SGEWWKARSL 120
ATGKEGYIPS NYVARVDSLE TEEWFFKGIS RKDAERQLLA PGNMLGSFMI RDSETTKGSY 180
SLSVRDYDPR QGDTVKHYKI RTLDNGGFYI SPRSTFSTLQ ELVDHYKKGN DGLCQKLSVP 240
CMSSKPQKPW EKDAWEIPRE SLKLEKKLGA GQFGEVWMAT YNKHTKVAVK TMKPGSMSVE 300
AFLAEANVMK TLQHDKLVKL HAVVTEEPIY IITEFMAKGA KFPIKWTAPE AINFGSFTIK 360
SDVWSFGILL MEIVTYGRIP YPGMSNPEVI RALERGYRMP RPENCPEELY NIMMRCWKNR 420
PEERPTFEYI QSVLDDFYTA TESQYQQQP 449
Nucleotide Sequence
(FASTA)
CTGGGGGGGC GCTCAAGCTG CGAGGATCCG GGCTGCCCGC GAGACGAGGA GCGGGCGCCC 60
AGGATGGGGT GCATGAGGTC CAAGTTCCTC CAGGTCGGAG GCAATACATT CTCAAAAAGT 120
GAAACCAGCG CCAACCCACA CTGCCCTGTG TACGTGCCGG ATCCCACATC CACCATCAAG 180
CCAGGGCCTA ATAGCAACAA CAGCAACACA CCAGGAATCA GGGAGGCAGG CTCTGAGGAC 240
ATCATCGTGG TTGCCCTGTA TGATTATGAG GCCATTCACC ATGAAGACCT CAGTTTCCAG 300
AAGGGGGACA AGATGGTGGT CCTAGAGGAA TCCGGGGAGT GGTGGAAGGC TCGATCCCTG 360
GCCACCGGGA AGGAGGGCTA CATCCCAAGC AACTATGTCG CCCGCGTTGA CTCTCTGGAG 420
ACAGAGGAGT GGTTTTTCAA GGGCATCAGC CGGAAGGACG CAGAGCGCCA ACTCCTGGCT 480
CCCGGCAACA TGCTGGGCTC CTTCATGATC CGGGATAGCG AGACTACTAA AGGAAGCTAC 540
TCTTTGTCCG TGCGAGACTA CGACCCTCGG CAGGGAGATA CTGTGAAACA TTACAAGATC 600
CGGACCCTAG ACAACGGGGG CTTCTACATA TCCCCCCGAA GCACCTTCAG CACTCTGCAG 660
GAGCTGGTGG ACCACTACAA GAAGGGGAAC GATGGGCTCT GCCAGAAACT GTCGGTGCCC 720
TGCATGTCTT CCAAGCCCCA GAAGCCTTGG GAGAAAGATG CCTGGGAGAT CCCTCGGGAA 780
TCCCTCAAGC TGGAGAAGAA ACTTGGAGCT GGGCAGTTTG GGGAAGTCTG GATGGCCACC 840
TACAACAAGC ACACCAAGGT GGCAGTGAAG ACGATGAAGC CAGGGAGCAT GTCGGTGGAG 900
GCCTTCCTGG CAGAGGCCAA CGTGATGAAA ACTCTGCAGC ATGACAAGCT GGTCAAACTT 960
CATGCGGTGG TCACCGAGGA GCCCATCTAC ATCATCACGG AGTTCATGGC CAAAGGGGCC 1020
AAGTTCCCCA TCAAGTGGAC AGCTCCTGAA GCCATCAACT TTGGCTCCTT CACCATCAAG 1080
TCAGACGTGT GGTCCTTTGG TATCCTGCTG ATGGAGATTG TCACCTATGG CCGGATCCCT 1140
TACCCAGGGA TGTCAAATCC TGAAGTGATC CGAGCTCTGG AGCGTGGATA CCGGATGCCT 1200
CGCCCGGAGA ACTGCCCAGA GGAGCTCTAC AACATCATGA TGCGCTGCTG GAAAAACCGT 1260
CCGGAGGAGC GGCCGACCTT CGAATACATC CAGAGTGTGC TGGATGACTT TTACACGGCC 1320
ACAGAGAGCC AGTACCAACA GCAGCCATGA 1350
Domain Profile
S: 155   egaklPikWtaPeaiklgkftiksdvWsfGillteivtkGkvPypGmtneevleqvergy  214
         +gak+PikWtaPeai++g+ftiksdvWsfGill+eivt+G++PypGm+n ev++++ergy
Q: 338   KGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGY  397
         689*********************************************************
S: 215   rlprpeecpeelyelllecwkkdpeerPtfetlqevl  251
         r+prpe+cpeely+++++cwk++peerPtfe++q+vl
Q: 398   RMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVL  434
         *********************************9976
Domain Sequence
(FASTA)
KGAKFPIKWT APEAINFGSF TIKSDVWSFG ILLMEIVTYG RIPYPGMSNP EVIRALERGY 60
RMPRPENCPE ELYNIMMRCW KNRPEERPTF EYIQSVL 97
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Nomascus leucogenys"; ?>Pan troglodytes"; ?>
EKS-GOG-00360
EKS-HOS-00375
EKS-MAM-00369
EKS-NOL-00337
EKS-PAT-00354
Gene Ontology
GO:0005884; C:actin filament
GO:0005901; C:caveola
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005764; C:lysosome
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0006909; P:phagocytosis
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013